Email

panigrah@bcm.edu

Positions

Assistant Professor

Molecular & Cellular Biology
Baylor College of Medicine
Houston, TX US

Professional Interests

• Mechanism of enhancer action; Cell-free assays for transcription; Proteomics of transcriptional dynamics

Professional Statement

I recognize the fact that many questions in biology cannot be answered in their strictly cellular or organismal contexts, necessitating development of cell-free (in vitro) approaches. I have been always interested in understanding the intricacies of eukaryotic transcription regulation. I began my doctoral training in India by developing assays for ATP-dependent chromatin remodeling. Here at BCM, I developed cell-free assays to quantify enhancer-promoter communications and consequent transcription activation. I aim to employ these assays to further understand the proteomic dynamics at the enhancer-promoter contacts that result in actual transcriptional potentiation. Additionally, my work has provided evidence that different regions within a gene's coding and regulatory domains physically and dynamically interact during the gene's transcription. I aim to further understand how and why such interactions occur.

Websites

Selected Publications

• Panigrahi A.K., Foulds C.E., Lanz R.B., Hamilton R.A., Yi P., Lonard D.M., Tsai M-J., Tsai S.Y., O’Malley B.W. "SRC-3 governs dynamic estrogen-induced chromatin looping interactions during transcription." Molec Cell. 2018;70:679-694.e7. Pubmed PMID: 29775582
• Bader D., Hartig S., Putluri V., Foley S., Hamilton M., Smith E., Saha P., Panigrahi A., Walker C., Zong L., Martini-Stoica H., Chen R., Rajapakshe K., Coarfa C., Sreekumar A., Mitsiades N., Bankson J., Ittmann M., O'Malley B.W., Putluri N. & McGuire S. "Mitochondrial Pyruvate Import is a Metabolic Vulnerability in AR-Driven Prostate Cancer.." Nature Metabolism. 2019;1:70-85. Pubmed PMID: 31198906
• Panigrahi AK, Zhang N, Mao Q, Pati D "Calpain-1 cleaves rad21 to promote sister chromatid separation.." Mol. Cell. Biol.. 2011 Nov;31(21):4335-47. Pubmed PMID: 21876002
• Panigrahi AK, Zhang N, Otta SK, Pati D "A cohesin-RAD21 interactome.." Biochem. J.. 2012 Mar 15;442(3):661-70. Pubmed PMID: 22145905