Positions
- Assistant Professor
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Medicine and Molecular & Cellular Biology
Baylor College of Medicine
Houston, TX US
Addresses
- BCM (Lab)
-
Room: 527E
Houston, TX 77030
United States
Education
- PhD from Baylor College of Medicine
- HOUSTON, Texas
Professional Interests
- Regulation of liver metabolism and cancer development
Professional Statement
My research investigates the mechanisms that regulate liver energy metabolism and liver cancer development. We focus on (1) elucidating how the metabolic properties are reprogrammed in liver cancer development; (2) dissecting the role of hepatic macrophages and other immune cells in mouse models of diabetes and liver cancer; (3) discovering novel therapeutic targets and agents in chronic liver disease including liver cancer, hepatic insulin resistance, NAFLD, and NASH.Websites
Selected Publications
- Dong B*, Zhou Y, Wang W, Scott J, Kim K, Sun Z, Guo Q, Yang L, Gonzales N, Wu H, Hartig S, York R, Yang F, and Moore D* "Vitamin D receptor activation in liver macrophages ameliorates hepatic inflammation, steatosis, and insulin resistance in mice." Hepatology. 2019 Sep 11; Pubmed PMID: 31506976
- Zhou Y, Dong B, Kim K, Choi S, Sun Z, Wu N, Wu Y, Scott J, Moore D "Vitamin D receptor activation in liver macrophages protects against hepatic endoplasmic reticulum stress in mice." Hepatology. 2019 Aug 5; Pubmed PMID: 31381163
- Choi S, Dong B, Lin, C, Sun Z, Heo M, Kim K, Wagner M, Wang M, Moore D "Methyl-sensing nuclear receptor Liver Receptor Homolog-1 regulates mitochondrial function in mouse hepatocytes." Hepatology. 2019; Pubmed PMID: 31355949
- Dong B, Lee JS, Park YY, Yang F, Xu G, Huang W, Finegold MJ, Moore DD "Activating CAR and β-catenin induces uncontrolled liver growth and tumorigenesis." Nat Commun. 2015 Feb;9:6:5944.. Pubmed PMID: 25661872
- Dong B, Saha PK, Huang W, Chen W, Abu-Elheiga LA, Wakil SJ, Stevens RD, Ilkayeva O, Newgard CB, Chan L, Moore DD "Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease." Proc Natl Acad Sci U S A. 2009 Nov;106:(44):18831-6. Pubmed PMID: 19850873
- Dong B, Qatanani M, Moore DD "Constitutive androstane receptor mediates the induction of drug metabolism in mouse models of type 1 diabetes." Hepatology. 2009 Aug;50:(2):622-9. Pubmed PMID: 19489075
- Fu X, Dong B, Tian Y, Lefebvre P, Meng Z, Wang X, Pattou F, Han W, Wang X, Lou F, Jove R, Staels B, Moore DD, Huang W "MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids." J Clin Invest. 2015 Jun;125:(6):2497-509. Pubmed PMID: 25961460
- Wang W, Shen T, Dong B, Creighton CJ, Meng Y, Zhou W, Shi Q, Zhou H, Zhang Y, Moore DD, and Yang F "MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling." J Clin Invest. 2019;129(3):1015-29. Pubmed PMID: 30688659
- Kim KH, Choi JM, Li F, Dong B, Wooton-Kee CR, Arizpe A, Anakk S, Jung SY, Hartig SM, Moore DD. "Constitutive Androstane Receptor Differentially Regulates Bile Acid Homeostasis in Mouse Models of Intrahepatic Cholestasis." Hepatol Commun.. 2018 Dec 4; Pubmed PMID: 30620001
- Wang W, Meng Y, Dong B, Dong J, Ittmann MM, Creighton CJ, Lu Y, Zhang H, Shen T, Wang J, Rowley DR, Li Y, Chen F, Moore DD, Yang F "A Versatile Tumor Gene Deletion System Reveals a Crucial Role for FGFR1 in Breast Cancer Metastasis." 2017 May 19; Pubmed PMID: 28433771
- Ding L, Sousa KM, Jin L, Dong B, Kim BW, Ramirez R, Xiao Z, Gu Y, Yang Q, Wang J, Yu D, Pigazzi A, Schones D, Yang L, Moore D, Wang Z, Huang W "Vertical sleeve gastrectomy activates GPBAR-1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in mice." Hepatology. 2016 Sep;64:(3):760-73. Pubmed PMID: 27312543
- Huang W, Ma K, Zhang J, Qatanani M, Cuvillier J, Liu J, Dong B, Huang X, Moore DD "Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration." Science. 2006 Apr;312:(5771):233-6. Pubmed PMID: 16614213
- Chen WD, Fu X, Dong B, Wang YD, Shiah S, Moore DD, Huang W "Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver." Hepatology. 2012 Oct;56:(4):1499-509. Pubmed PMID: 22488010
- Smetanina MA, Pakharukova MY, Kurinna SM, Dong B, Hernandez JP, Moore DD, Merkulova TI "Ortho-aminoazotoluene activates mouse constitutive androstane receptor (mCAR) and increases expression of mCAR target genes." Toxicol Appl Pharmacol. 2011 Aug;255:(1):76-85.. Pubmed PMID: 21672546
- Zhang L, Huang X, Meng Z, Dong B, Shiah S, Moore DD, Huang W "Significance and mechanism of CYP7a1 gene regulation during the acute phase of liver regeneration." Mol Endocrinol. 2009 Feb;23:(2):137-45. Pubmed PMID: 19056864
- Liu X, Lu Y, Guan X, Dong B, Chavan H, Wang J, Zhang Y, Krishnamurthy P, Li F "Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism." Biochem Pharmacol. 2015 Sep;97:(1):111-21. Pubmed PMID: 26212543
- Wang W, Dong B, Yang F. "Avian Retrovirus-Mediated Tumor-Specific Gene Knockout." 2018 Jan 16; Pubmed PMID: 29337371
Funding
- R37 Merit Award (09/01/2021 - 09/01/2028) Grant funding from NCI
- Targeting Fatty Acid Synthesis in NAFLD Related HCC (10/01/2020 - 10/01/2022) Grant funding from CPRIT
- AASLD Pinnacle Research Award in Liver Research (07/01/2018 - 07/01/2021) AASLD
- Dan L Duncan Comprehensive Cancer Center Pilot Grant (01/01/2019 - 09/01/2020) NIH P30 CA125123
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