Blesson Chellakkan Selvanesan
Picture
Positions
- Associate Professor
-
Obstetrics and Gynecology
Reproductive Endocrinology and Infertlity
Baylor College of Medicine
Houston, Texas United States
Addresses
- Texas Children's Hospital Pavilion for Women (Office)
-
6651 Main Street, Suite F 1050.36
Houston, TX 77030
United States
Phone: (832) 826-7462
- REI Research Laboratory (Lab)
-
Texas Children's Pavilion for Women
E.0350.81-84
Houston, TX 77030
United States
Phone: (832) 826-7273
Education
- BSc from Madras Christian College
- 04/1999 - Chennai, TN India
- Zoology, Botany
- M.Sc from Madras Christian College
- 05/2001 - Chennai, TN India
- Zoology
- M.Phil from Madras Christian College
- 09/2002 - Chennai, TN India
- Zoology, Reproductive Endocrinology
- Ph.D from Central Drug Research Institute/ Jawaharlal Nehru University
- 03/2008 - Lucknow, UP India
- Endocrinology
- Postdoctoral Fellowship at Karolinska Institute
- 02/2012 - Stockholm, Sweden
- Reproductive Endocrinology
- Postdoctoral Fellowship at UTMB
- 08/2013 - Galveston, Texas United States
- Reproductive Endocrinology and Developmental Programming of Diabetes and Hypertension
- Postdoctoral Fellowship at Baylor College of Medicine
- 03/2016 - Houston, Texas United States
- Reproductive Endocrinology and Developmental Programming of Diabetes
Certifications
- • High-complexity Clinical Laboratory Director
- American Board of Bioanalysis
Professional Interests
- Reproductive Endocrinology
- Developmental origin of Polycystic Ovary Syndrome
- Developmental origin of Type 2 Diabetes
- Mitochondria and Metabolism
- Metabolic diseases and Early Development
Professional Statement
I am a reproductive biologist specialized in reproductive endocrinology and metabolism. I have vast experience in the field of sex hormone signaling and its relevance in reproduction and metabolism. I am involved in translational research and teaching. I am passionate about applying my research expertise to improve health care. I also teach and mentor residents and fellows.My research team is working towards understanding the developmental origins of diseases and its role in reproduction and metabolism. Developmental programming is a recent concept whereby adverse environment during critical periods of early development predisposes the organism to increased risk of metabolic diseases in adult life. We are currently investigating the roles of hormones and nutrition during early development and its implication in the developmental origin of polycystic ovary syndrome (PCOS) and type 2 diabetes respectively.
We use mouse PCOS models to investigate the effects of the disease on ovary, oocytes and embryos. We are currently studying the role of androgens in mitochondrial function and metabolism. We also recently developed a novel low protein programmed lean type 2 diabetic rat model to investigate the role of developmental programming of type 2 diabetes.
Our team is also involved in improving quality and developing novel technologies to assist in fertility treatments. My lab’s mission is to improve reproductive success by (i) bringing new cutting edge assisted reproductive technologies and to apply it to our patients, (ii) understanding the mechanisms of reproductive diseases and (iii) fostering an environment of knowledge driven patient care and education in the center.
Other than research and teaching, I also work as an andrologist and junior embryologist at the Family Fertility Center, Texas Children’s Hospital.
Websites
Selected Publications
- "Gestational protein restriction impairs insulin-regulated glucose transport mechanisms in gastrocnemius muscles of adult male offspring.." ; Pubmed PMID: 24797633
- "Novel lean type 2 diabetic rat model using gestational low-protein programming.." ; Pubmed PMID: 26874300
- "Prenatal testosterone exposure induces hypertension in adult females via androgen receptor-dependent protein kinase Cδ-mediated mechanism.." ; Pubmed PMID: 25489059
- "Prenatal Testosterone Exposure Leads to Gonadal Hormone-Dependent Hyperinsulinemia and Gonadal Hormone-Independent Glucose Intolerance in Adult Male Rat Offspring.." ; Pubmed PMID: 26586841
- "Pregnancy is a new window of susceptibility for bisphenol a exposure.." ; Pubmed PMID: 25886069
- "Adrenomedullin2 (ADM2)/intermedin (IMD) in rat ovary: changes in estrous cycle and pregnancy and its role in ovulation and steroidogenesis.." ; Pubmed PMID: 25395681
- "Elevated testosterone levels during rat pregnancy cause hypersensitivity to angiotensin II and attenuation of endothelium-dependent vasodilation in uterine arteries.." ; Pubmed PMID: 24842922
- "Gestational Protein Restriction Impairs Glucose Disposal in the Gastrocnemius Muscles of Female Rats.." ; Pubmed PMID: 28324067
- "Folate treatment partially reverses gestational low-protein diet-induced glucose intolerance and the magnitude of reversal is age and sex dependent.." ; Pubmed PMID: 29500969
- "Involvement of Gas6 protein in mouse model of lipopolysaccharide-induced lung inflammation." ;
- "Polycystic Ovary Syndrome: A Multifaceted Enigma. Endocrinology and Diabetes Open Access." ;
Memberships
- Society for Reproductive Investigation
- Member (07/2010)
- American Society for Reproductive Medicine
- Member (07/2016)
- Society for Reproductive Biology and Comparative Endocrinology
- Member (01/2005)
- Texas Forum for Reproductive Sciences
- Member (04/2013)
Log In to edit your profile
