Positions
- Professor
-
Pediatrics-Hem-Onc Cell and Gene
Baylor College of Medicine
Houston, TX US
Education
- Advanced Training from Yale University School Of Medicine
- 01/1987 - New Haven, CT United States
- Advanced Training from University Of Birmingham
- 01/1985 - Birmingham, United Kingdom
- Advanced Training from University Of Bristol
- 01/1984 - Bristol, United Kingdom
- Ph.D. from University Of Cambridge
- 01/1981 - Cambridge, United Kingdom
- B.Sc. from University Of East Anglia
- 01/1978 - Norwich, United Kingdom
Professional Interests
- Virus-specific T cells for treatment of viral diseases
Websites
Selected Publications
- Pulè MA, Straathof KC, Dotti G, Heslop HE, Rooney CM, Brenner MK "A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells.." Mol. Ther.. 2005 Nov;12(5):933-41. Pubmed PMID: 15979412
- Song XT, Turnis ME, Zhou X, Zhu W, Hong BX, Rollins L, Rabinovich B, Chen SY, Rooney CM, Gottschalk S "A Th1-inducing Adenoviral Vaccine for Boosting Adoptively Transferred T Cells.." Mol. Ther.. 2011 Jan;19(1):211-7. Pubmed PMID: 20959814
- Leen AM, Bollard CM, Myers GD, Rooney CM "Adenoviral infections in hematopoietic stem cell transplantation.." Biol. Blood Marrow Transplant.. 2006 Mar;12(3):243-51. Pubmed PMID: 16503493
- Smith CA, Woodruff LS, Kitchingman GR, Rooney CM "Adenovirus-pulsed dendritic cells stimulate human virus-specific T-cell responses in vitro.." J. Virol.. 1996 Oct;70(10):6733-40. Pubmed PMID: 8794310
- Suzuki M, Rooney CM "Adenovirus immunity: x marks the spot.." Mol. Ther.. 2012 Dec;20(12):2197-8. Pubmed PMID: 23201614
- Leen AM, Rooney CM "Adenovirus as an emerging pathogen in immunocompromised patients.." Br. J. Haematol.. 2005 Jan;128(2):135-44. Pubmed PMID: 15638847
- Foster AE, Bradstock KF, Sili U, Marangolo M, Rooney CM, Gottlieb DJ "A comparison of gene transfer and antigen-loaded dendritic cells for the generation of CD4+ and CD8+ cytomegalovirus-specific T cells in HLA-A2+ and HLA-A2- donors.." Biol. Blood Marrow Transplant.. 2004 Nov;10(11):761-71. Pubmed PMID: 15505607
- Wagner HJ, Bollard CM, Vigouroux S, Huls MH, Anderson R, Prentice HG, Brenner MK, Heslop HE, Rooney CM "A strategy for treatment of Epstein-Barr virus-positive Hodgkin's disease by targeting interleukin 12 to the tumor environment using tumor antigen-specific T cells.." Cancer Gene Ther.. 2004 Feb;11(2):81-91. Pubmed PMID: 14685154
- Vera JF, Brenner LJ, Gerdemann U, Ngo MC, Sili U, Liu H, Wilson J, Dotti G, Heslop HE, Leen AM, Rooney CM "Accelerated production of antigen-specific T cells for preclinical and clinical applications using gas-permeable rapid expansion cultureware (G-Rex).." J. Immunother.. 2010 Apr;33(3):305-15. Pubmed PMID: 20445351
- Muralidharan S, Hanley PJ, Liu E, Chakraborty R, Bollard C, Shpall E, Rooney C, Savoldo B, Rodgers J, Dotti G "Activation of wnt signaling arrests effector differentiation in human peripheral and cord blood-derived T lymphocytes.." J. Immunol.. 2011 Nov 15;187(10):5221-32. Pubmed PMID: 22013128
- Bollard CM, Rössig C, Calonge MJ, Huls MH, Wagner HJ, Massague J, Brenner MK, Heslop HE, Rooney CM "Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity.." Blood. 2002 May 1;99(9):3179-87. Pubmed PMID: 11964281
- Dotti G, Savoldo B, Takahashi S, Goltsova T, Brown M, Rill D, Rooney C, Brenner M "Adenovector-induced expression of human-CD40-ligand (hCD40L) by multiple myeloma cells. A model for immunotherapy.." Exp. Hematol.. 2001 Aug;29(8):952-61. Pubmed PMID: 11495701
- Gahn B, Siller-Lopez F, Pirooz AD, Yvon E, Gottschalk S, Longnecker R, Brenner MK, Heslop HE, Aguilar-Cordova E, Rooney CM "Adenoviral gene transfer into dendritic cells efficiently amplifies the immune response to LMP2A antigen: a potential treatment strategy for Epstein-Barr virus--positive Hodgkin's lymphoma.." Int. J. Cancer. 2001 Sep 1;93(5):706-13. Pubmed PMID: 11477583
- Bollard CM, Huls MH, Buza E, Weiss H, Torrano V, Gresik MV, Chang J, Gee A, Gottschalk SM, Carrum G, Brenner MK, Rooney CM, Heslop HE "Administration of latent membrane protein 2-specific cytotoxic T lymphocytes to patients with relapsed Epstein-Barr virus-positive lymphoma.." 2006 Jan;6(4):342-7. Pubmed PMID: 16507214
- Roskrow MA, Rooney CM, Heslop HE, Brenner MK, Krance RA, Gresik MV, McClain K, Aguilar LK, Grilley B, Rob E, Carrum G "Administration of neomycin resistance gene marked EBV specific cytotoxic T-lymphocytes to patients with relapsed EBV-positive Hodgkin disease.." Hum. Gene Ther.. 1998 May 20;9(8):1237-50. Pubmed PMID: 9625264
- Heslop H, Rooney C, Brenner M, Krance R, Carrum G, Gahn B, Bollard C, Khan S, Gee A, Popat U, Gresik M, Przepiorka D, Kuehnle I, Grilley B "Administration of neomycin resistance gene-marked EBV-specific cytotoxic T-lymphocytes as therapy for patients receiving a bone marrow transplant for relapsed EBV-positive Hodgkin disease.." Hum. Gene Ther.. 2000 Jul 1;11(10):1465-75. Pubmed PMID: 10910143
- Heslop HE, Brenner MK, Rooney C, Krance RA, Roberts WM, Rochester R, Smith CA, Turner V, Sixbey J, Moen R "Administration of neomycin-resistance-gene-marked EBV-specific cytotoxic T lymphocytes to recipients of mismatched-related or phenotypically similar unrelated donor marrow grafts.." Hum. Gene Ther.. 1994 Mar;5(3):381-97. Pubmed PMID: 8018749
- Heslop HE, Rooney CM "Adoptive cellular immunotherapy for EBV lymphoproliferative disease.." Immunol. Rev.. 1997 Jun;157:217-22. Pubmed PMID: 9255632
- Fujita Y, Rooney CM, Heslop HE "Adoptive cellular immunotherapy for viral diseases.." Bone Marrow Transplant.. 2008 Jan;41(2):193-8. Pubmed PMID: 17982497
- Gottschalk S, Heslop HE, Rooney CM "Adoptive immunotherapy for EBV-associated malignancies.." Leuk. Lymphoma. 2005 Jan;46(1):41284. Pubmed PMID: 15621775
- Smith CA, Ng CY, Loftin SK, Li C, Heslop HE, Brenner MK, Rooney CM "Adoptive immunotherapy for Epstein-Barr virus-related lymphoma.." Leuk. Lymphoma. 1996 Oct;23(41337):213-20. Pubmed PMID: 9031101
- Kennedy-Nasser AA, Bollard CM, Rooney CM "Adoptive immunotherapy for Hodgkin's lymphoma.." Int. J. Hematol.. 2006 Jun;83(5):385-90. Pubmed PMID: 16787867
- Bollard CM, Kuehnle I, Leen A, Rooney CM, Heslop HE "Adoptive immunotherapy for posttransplantation viral infections.." Biol. Blood Marrow Transplant.. 2004 Mar;10(3):143-55. Pubmed PMID: 14993880
- Kaka AS, Rooney CM, Savoldo B "What influence has B-cell depletion on viral infections?." Leuk. Lymphoma. 2007 Jul;48(7):1257-8. Pubmed PMID: 17613749
- Pule MA, Savoldo B, Myers GD, Rossig C, Russell HV, Dotti G, Huls MH, Liu E, Gee AP, Mei Z, Yvon E, Weiss HL, Liu H, Rooney CM, Heslop HE, Brenner MK "Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma.." Nat. Med.. 2008 Nov;14(11):1264-70. Pubmed PMID: 18978797
- Johnson S, Hall J, Barnett S, Draper M, Derbyshire G, Haynes L, Rooney C, Cameron H, Moseley GL, de C Williams AC, McCabe C, Goebel A "Using graded motor imagery for complex regional pain syndrome in clinical practice: Failure to improve pain.." Eur J Pain. 2012 Apr;16(4):550-61. Pubmed PMID: 22337591
- Kaka AS, Foster AE, Weiss HL, Rooney CM, Leen AM "Using dendritic cell maturation and IL-12 producing capacity as markers of function: a cautionary tale.." J. Immunother.. 2008 May;31(4):359-69. Pubmed PMID: 18391760
- Rooney CM, Smith CA, Ng CY, Loftin S, Li C, Krance RA, Brenner MK, Heslop HE "Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation.." Lancet. 1995 Jan 7;345(8941):41530. Pubmed PMID: 7799740
- Heslop HE, Rooney CM, Rill DR, Krance RA, Brenner MK "Use of gene marking in bone marrow transplantation.." Cancer Detect. Prev.. 1996;20(2):108-13. Pubmed PMID: 8706035
- Lee TC, Savoldo B, Barshes NR, Rooney CM, Heslop HE, Gee AP, Caldwell Y, Scott JD, Goss JA "Use of cytokine polymorphisms and Epstein-Barr virus viral load to predict development of post-transplant lymphoproliferative disorder in paediatric liver transplant recipients.." Clin Transplant.;20(3):389-93. Pubmed PMID: 16824159
- Savoldo B, Goss JA, Hammer MM, Zhang L, Lopez T, Gee AP, Lin YF, Quiros-Tejeira RE, Reinke P, Schubert S, Gottschalk S, Finegold MJ, Brenner MK, Rooney CM, Heslop HE "Treatment of solid organ transplant recipients with autologous Epstein Barr virus-specific cytotoxic T lymphocytes (CTLs).." Blood. 2006 Nov 1;108(9):2942-9. Pubmed PMID: 16835376
- Rooney CM, Roskrow MA, Suzuki N, Ng CY, Brenner MK, Heslop H "Treatment of relapsed Hodgkin's disease using EBV-specific cytotoxic T cells.." Ann. Oncol.. 1998;9:S129-32. Pubmed PMID: 9926252
- Straathof KC, Bollard CM, Popat U, Huls MH, Lopez T, Morriss MC, Gresik MV, Gee AP, Russell HV, Brenner MK, Rooney CM, Heslop HE "Treatment of nasopharyngeal carcinoma with Epstein-Barr virus--specific T lymphocytes.." Blood. 2005 Mar 1;105(5):1898-904. Pubmed PMID: 15542583
- Pakakasama S, Eames GM, Morriss MC, Huls MH, Rooney CM, Heslop HE, Krance RA "Treatment of Epstein-Barr virus lymphoproliferative disease after hematopoietic stem-cell transplantation with hydroxyurea and cytotoxic T-cell lymphocytes.." Transplantation. 2004 Sep 15;78(5):755-7. Pubmed PMID: 15371682
- Brenner MK, Heslop HE, Rill D, Li C, Smith C, Krance R, Rooney C "Transfer of marker genes into hemopoietic progenitor cells.." Cytokines Mol Ther. 1996 Sep;2(3):193-200. Pubmed PMID: 9384704
- Heslop HE, Perez M, Benaim E, Rochester R, Brenner MK, Rooney CM "Transfer of EBV-specific CTL to prevent EBV lymphoma post bone marrow transplant.." J Clin Apher. 1999;14(3):154-6. Pubmed PMID: 10540372
- Buschle M, Brenner MK, Chen IS, Drexler HG, Gignac SM, Rooney CM "Transfection and gene expression in normal and malignant primary B lymphocytes.." J. Immunol. Methods. 1990 Oct 4;133(1):77-85. Pubmed PMID: 1698880
- Schroers R, Sinha I, Segall H, Schmidt-Wolf IG, Rooney CM, Brenner MK, Sutton RE, Chen SY "Transduction of human PBMC-derived dendritic cells and macrophages by an HIV-1-based lentiviral vector system.." Mol. Ther.. 2000 Feb;1(2):171-9. Pubmed PMID: 10933928
- Melcher A, Parato K, Rooney CM, Bell JC "Thunder and lightning: immunotherapy and oncolytic viruses collide.." Mol. Ther.. 2011 Jun;19(6):1008-16. Pubmed PMID: 21505424
- Savoldo B, Heslop HE, Rooney CM "The use of cytotoxic t cells for the prevention and treatment of Epstein-Barr virus induced lymphoma in transplant recipients.." Leuk. Lymphoma. 2000 Nov;39(41400):455-64. Pubmed PMID: 11342329
- Pebody RG, Chand MA, Thomas HL, Green HK, Boddington NL, Carvalho C, Brown CS, Anderson SR, Rooney C, Crawley-Boevey E, Irwin DJ, Aarons E, Tong C, Newsholme W, Price N, Langrish C, Tucker D, Zhao H, Phin N, Crofts J, Bermingham A, Gilgunn-Jones E, Brown "The United Kingdom public health response to an imported laboratory confirmed case of a novel coronavirus in September 2012.." Euro Surveill.. 2012;17(40):20292. Pubmed PMID: 23078799
- Rooney CM, Rowe DT, Ragot T, Farrell PJ "The spliced BZLF1 gene of Epstein-Barr virus (EBV) transactivates an early EBV promoter and induces the virus productive cycle.." J. Virol.. 1989 Jul;63(7):3109-16. Pubmed PMID: 2542618
- Stewart JP, Rooney CM "The interleukin-10 homolog encoded by Epstein-Barr virus enhances the reactivation of virus-specific cytotoxic T cell and HLA-unrestricted killer cell responses.." Virology. 1992 Dec;191(2):773-82. Pubmed PMID: 1333123
- Bollard CM, Straathof KC, Huls MH, Leen A, Lacuesta K, Davis A, Gottschalk S, Brenner MK, Heslop HE, Rooney CM "The generation and characterization of LMP2-specific CTLs for use as adoptive transfer from patients with relapsed EBV-positive Hodgkin disease.." J. Immunother..;27(4):317-27. Pubmed PMID: 15235393
- Ling PD, Lednicky JA, Keitel WA, Poston DG, White ZS, Peng R, Liu Z, Mehta SK, Pierson DL, Rooney CM, Vilchez RA, Smith EO, Butel JS "The dynamics of herpesvirus and polyomavirus reactivation and shedding in healthy adults: a 14-month longitudinal study.." J. Infect. Dis.. 2003 May 15;187(10):1571-80. Pubmed PMID: 12721937
- Roessig C, Scherer SP, Baer A, Vormoor J, Rooney CM, Brenner MK, Juergens H "Targeting CD19 with genetically modified EBV-specific human T lymphocytes.." Ann. Hematol.. 2002;81:S42-3. Pubmed PMID: 12611072
- Yotnda P, Savoldo B, Charlet-Berguerand N, Rooney C, Brenner M "Targeted delivery of adenoviral vectors by cytotoxic T cells.." Blood. 2004 Oct 15;104(8):2272-80. Pubmed PMID: 15161664
- Rossig C, Bär A, Pscherer S, Altvater B, Pule M, Rooney CM, Brenner MK, Jürgens H, Vormoor J "Target antigen expression on a professional antigen-presenting cell induces superior proliferative antitumor T-cell responses via chimeric T-cell receptors.." J. Immunother..;29(1):21-31. Pubmed PMID: 16365597
- Bollard CM, Rooney CM, Heslop HE "T-cell therapy in the treatment of post-transplant lymphoproliferative disease.." Nat Rev Clin Oncol. 2012 Aug 14;9(9):510-9. Pubmed PMID: 22801669
- Leen AM, Myers GD, Bollard CM, Huls MH, Sili U, Gee AP, Heslop HE, Rooney CM "T-cell immunotherapy for adenoviral infections of stem-cell transplant recipients.." Ann. N. Y. Acad. Sci.. 2005 Dec;1062:104-15. Pubmed PMID: 16461793
- Vera J, Savoldo B, Vigouroux S, Biagi E, Pule M, Rossig C, Wu J, Heslop HE, Rooney CM, Brenner MK, Dotti G "T lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells.." Blood. 2006 Dec 1;108(12):3890-7. Pubmed PMID: 16926291
- Di Stasi A, De Angelis B, Rooney CM, Zhang L, Mahendravada A, Foster AE, Heslop HE, Brenner MK, Dotti G, Savoldo B "T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model.." Blood. 2009 Jun 18;113(25):6392-402. Pubmed PMID: 19377047
- Sun J, Dotti G, Huye LE, Foster AE, Savoldo B, Gramatges MM, Spencer DM, Rooney CM "T Cells Expressing Constitutively Active Akt Resist Multiple Tumor-associated Inhibitory Mechanisms.." Mol. Ther.. 2010 Nov;18(11):2006-17. Pubmed PMID: 20842106
- Gottschalk S, Bollard CM, Straathof KC, Louis CU, Savoldo B, Dotti G, Brenner MK, Heslop HE, Rooney CM "T cell therapies.." Ernst Schering Found Symp Proc. 2006;(4):69-82. Pubmed PMID: 17824182
- Straathof KC, Spencer DM, Sutton RE, Rooney CM "Suicide genes as safety switches in T lymphocytes.." Cytotherapy. 2003;5(3):227-30. Pubmed PMID: 12850790
- Packham G, Economou A, Rooney CM, Rowe DT, Farrell PJ "Structure and function of the Epstein-Barr virus BZLF1 protein.." J. Virol.. 1990 May;64(5):2110-6. Pubmed PMID: 2157874
- Barshes NR, Lee TR, Goss JA, Goodpastor SE, Huls MH, Rooney CM, Karpen SJ, Wyllie S "Slc11a1 (formerly Nramp1) polymorphisms and susceptibility to post-transplant lymphoproliferative disease following pediatric liver transplantation.." Transpl Infect Dis. 2006 Jun;8(2):108-12. Pubmed PMID: 16734634
- Miller G, Grogan E, Rowe D, Rooney C, Heston L, Eastman R, Andiman W, Niederman J, Lenoir G, Henle W "Selective lack of antibody to a component of EB nuclear antigen in patients with chronic active Epstein-Barr virus infection.." J. Infect. Dis.. 1987 Jul;156(1):26-35. Pubmed PMID: 3036961
- Amrolia PJ, Muccioli-Casadei G, Yvon E, Huls H, Sili U, Wieder ED, Bollard C, Michalek J, Ghetie V, Heslop HE, Molldrem JJ, Rooney CM, Schlinder J, Vitetta E, Brenner MK "Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responses.." Blood. 2003 Sep 15;102(6):2292-9. Pubmed PMID: 12763937
- Chakraborty R, Mahendravada A, Perna SK, Rooney CM, Heslop HE, Vera JF, Savoldo B, Dotti G "Robust and cost effective expansion of human regulatory T cells highly functional in a xenograft model of graft-versus-host disease.." Haematologica. 2013 Apr;98(4):533-7. Pubmed PMID: 23242592
- Bear AS, Morgan RA, Cornetta K, June CH, Binder-Scholl G, Dudley ME, Feldman SA, Rosenberg SA, Shurtleff SA, Rooney CM, Heslop HE, Dotti G "Replication-competent retroviruses in gene-modified T cells used in clinical trials: is it time to revise the testing requirements?." Mol. Ther.. 2012 Feb;20(2):246-9. Pubmed PMID: 22297819
- Ahmed N, Ratnayake M, Savoldo B, Perlaky L, Dotti G, Wels WS, Bhattacharjee MB, Gilbertson RJ, Shine HD, Weiss HL, Rooney CM, Heslop HE, Gottschalk S "Regression of experimental medulloblastoma following transfer of HER2-specific T cells.." Cancer Res.. 2007 Jun 15;67(12):5957-64. Pubmed PMID: 17575166
- Myers GD, Bollard CM, Wu MF, Weiss H, Rooney CM, Heslop HE, Leen AM "Reconstitution of adenovirus-specific cell-mediated immunity in pediatric patients after hematopoietic stem cell transplantation.." Bone Marrow Transplant.. 2007 Jun;39(11):677-86. Pubmed PMID: 17417664
- Gerdemann U, Keirnan JM, Katari UL, Yanagisawa R, Christin AS, Huye LE, Perna SK, Ennamuri S, Gottschalk S, Brenner MK, Heslop HE, Rooney CM, Leen AM "Rapidly Generated Multivirus-specific Cytotoxic T Lymphocytes for the Prophylaxis and Treatment of Viral Infections.." Mol. Ther.. 2012 Aug;20(8):1622-32. Pubmed PMID: 22801446
- Heo J, Reid T, Ruo L, Breitbach CJ, Rose S, Bloomston M, Cho M, Lim HY, Chung HC, Kim CW, Burke J, Lencioni R, Hickman T, Moon A, Lee YS, Kim MK, Daneshmand M, Dubois K, Longpre L, Ngo M, Rooney C, Bell JC, Rhee BG, Patt R, Hwang TH, Kirn DH "Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer.." Nat. Med.. 2013 Feb 10;19(3):329-36. Pubmed PMID: 23396206
- Lee TC, Savoldo B, Rooney CM, Heslop HE, Gee AP, Caldwell Y, Barshes NR, Scott JD, Bristow LJ, O'Mahony CA, Goss JA "Quantitative EBV viral loads and immunosuppression alterations can decrease PTLD incidence in pediatric liver transplant recipients.." Am. J. Transplant.. 2005 Sep;5(9):2222-8. Pubmed PMID: 16095501
- Lee TC, Goss JA, Rooney CM, Heslop HE, Barshes NR, Caldwell YM, Gee AP, Scott JD, Savoldo B "Quantification of a low cellular immune response to aid in identification of pediatric liver transplant recipients at high-risk for EBV infection.." Clin Transplant.;20(6):689-94. Pubmed PMID: 17100717
- Wagner HJ, Cheng YC, Huls MH, Gee AP, Kuehnle I, Krance RA, Brenner MK, Rooney CM, Heslop HE "Prompt versus preemptive intervention for EBV lymphoproliferative disease.." Blood. 2004 May 15;103(10):3979-81. Pubmed PMID: 14751931
- Sili U, Leen AM, Vera JF, Gee AP, Huls H, Heslop HE, Bollard CM, Rooney CM "Production of good manufacturing practice-grade cytotoxic T lymphocytes specific for Epstein-Barr virus, cytomegalovirus and adenovirus to prevent or treat viral infections post-allogeneic hematopoietic stem cell transplant.." Cytotherapy. 2012 Jan;14(1):41466. Pubmed PMID: 22172091
- Smith CA, Ng CY, Heslop HE, Holladay MS, Richardson S, Turner EV, Loftin SK, Li C, Brenner MK, Rooney CM "Production of genetically modified Epstein-Barr virus-specific cytotoxic T cells for adoptive transfer to patients at high risk of EBV-associated lymphoproliferative disease.." J Hematother. 1995 Apr;4(2):73-9. Pubmed PMID: 7633844
- McCullough J, Wagner J, Key N, Gee A, Rooney C, Whiteside T, Donnenberg A, Lindblad R "Production assistance for cellular therapies.." Transfusion. 2004 Dec;44(12):1793-5. Pubmed PMID: 15584997
- Reed W, Noga SJ, Gee AP, Rooney CM, Wagner JE, McCullough J, McKenna DH, Whiteside TL, Donnenberg AD, Baker AK, Lindblad RW, Wagner EL, Mondoro TH "Production Assistance for Cellular Therapies (PACT): four-year experience from the United States National Heart, Lung, and Blood Institute (NHLBI) contract research program in cell and tissue therapies.." Transfusion. 2009 Apr;49(4):786-96. Pubmed PMID: 19170985
- Kamdar KY, Rooney CM, Heslop HE "Posttransplant lymphoproliferative disease following liver transplantation.." Curr Opin Organ Transplant. 2011 Jun;16(3):274-80. Pubmed PMID: 21467936
- Gottschalk S, Rooney CM, Heslop HE "Post-transplant lymphoproliferative disorders.." Annu. Rev. Med.. 2005;56:29-44. Pubmed PMID: 15660500
- Rooney CM, Aguilar LK, Huls MH, Brenner MK, Heslop HE "Adoptive immunotherapy of EBV-associated malignancies with EBV-specific cytotoxic T-cell lines.." Curr. Top. Microbiol. Immunol.. 2001;258:221-9. Pubmed PMID: 11443864
- Bollard CM, Savoldo B, Rooney CM, Heslop HE "Adoptive T-cell therapy for EBV-associated post-transplant lymphoproliferative disease.." Acta Haematol.. 2003;110(41308):139-48. Pubmed PMID: 14583674
- Huls MH, Rooney CM, Heslop HE "Adoptive T-cell therapy for Epstein-Barr virus-positive Hodgkin's disease.." Acta Haematol.. 2003;110(41308):149-53. Pubmed PMID: 14583675
- Louis CU, Straathof K, Bollard CM, Ennamuri S, Gerken C, Lopez TT, Huls MH, Sheehan A, Wu MF, Liu H, Gee A, Brenner MK, Rooney CM, Heslop HE, Gottschalk S "Adoptive Transfer of EBV-specific T Cells Results in Sustained Clinical Responses in Patients With Locoregional Nasopharyngeal Carcinoma.." J. Immunother..;33(9):983-90. Pubmed PMID: 20948438
- Rooney CM "Adoptive transfer of virus-directed T cells: will this fly for flu?." Cytotherapy. 2012 Feb;14(2):133-4. Pubmed PMID: 22149160
- Cruz CR, Hanley PJ, Liu H, Torrano V, Lin YF, Arce JA, Gottschalk S, Savoldo B, Dotti G, Louis CU, Leen AM, Gee AP, Rooney CM, Brenner MK, Bollard CM, Heslop HE "Adverse events following infusion of T cells for adoptive immunotherapy: a 10-year experience.." Cytotherapy. 2010 Oct;12(6):743-9. Pubmed PMID: 20429793
- Shaffer DR, Sheehan AM, Yi Z, Rodgers CC, Bollard CM, Brenner MK, Rooney CM, Heslop HE, Gottschalk S "Aggressive peripheral CD70-positive t-cell lymphoma associated with severe chronic active EBV infection.." Pediatr Blood Cancer. 2012 Oct;59(4):758-61. Pubmed PMID: 21994111
- Melenhorst JJ, Leen AM, Bollard CM, Quigley MF, Price DA, Rooney CM, Brenner MK, Barrett AJ, Heslop HE "Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects.." Blood. 2010 Nov 25;116(22):4700-2. Pubmed PMID: 20709906
- Gottschalk S, Ng CY, Perez M, Smith CA, Sample C, Brenner MK, Heslop HE, Rooney CM "An Epstein-Barr virus deletion mutant associated with fatal lymphoproliferative disease unresponsive to therapy with virus-specific CTLs.." Blood. 2001 Feb 15;97(4):835-43. Pubmed PMID: 11159505
- de Witte MA, Jorritsma A, Swart E, Straathof KC, de Punder K, Haanen JB, Rooney CM, Schumacher TN "An inducible caspase 9 safety switch can halt cell therapy-induced autoimmune disease.." J. Immunol.. 2008 May 1;180(9):6365-73. Pubmed PMID: 18424760
- Straathof KC, Pulè MA, Yotnda P, Dotti G, Vanin EF, Brenner MK, Heslop HE, Spencer DM, Rooney CM "An inducible caspase 9 safety switch for T-cell therapy.." Blood. 2005 Jun 1;105(11):4247-54. Pubmed PMID: 15728125
- Ramos CA, Asgari Z, Liu E, Yvon E, Heslop HE, Rooney CM, Brenner MK, Dotti G "An inducible caspase 9 suicide gene to improve the safety of mesenchymal stromal cell therapies.." Stem Cells. 2010 Jun;28(6):1107-15. Pubmed PMID: 20506146
- Tanner JE, Diaz-Mitoma F, Rooney CM, Alfieri C "Anti-interleukin-10 antibodies in patients with chronic active Epstein-Barr virus infection.." J. Infect. Dis.. 1997 Dec;176(6):1454-61. Pubmed PMID: 9395354
- Shafer JA, Cruz CR, Leen AM, Ku S, Lu A, Rousseau A, Heslop HE, Rooney CM, Bollard CM, Foster AE "Antigen-specific cytotoxic T lymphocytes can target chemoresistant side-population tumor cells in Hodgkin lymphoma.." Leuk. Lymphoma. 2010 May;51(5):870-80. Pubmed PMID: 20367572
- Louis CU, Savoldo B, Dotti G, Pule M, Yvon E, Myers GD, Rossig C, Russell HV, Diouf O, Liu E, Liu H, Wu MF, Gee AP, Mei Z, Rooney CM, Heslop HE, Brenner MK "Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma.." Blood. 2011 Dec 1;118(23):6050-6. Pubmed PMID: 21984804
- Foster AE, Dotti G, Lu A, Khalil M, Brenner MK, Heslop HE, Rooney CM, Bollard CM "Antitumor activity of EBV-specific T lymphocytes transduced with a dominant negative TGF-beta receptor.." J. Immunother.. 2008 Jun;31(5):500-5. Pubmed PMID: 18463534
- Lacuesta K, Buza E, Hauser H, Granville L, Pule M, Corboy G, Finegold M, Weiss H, Chen SY, Brenner MK, Heslop HE, Rooney CM, Bollard CM "Assessing the safety of cytotoxic T lymphocytes transduced with a dominant negative transforming growth factor-beta receptor.." J. Immunother..;29(3):250-60. Pubmed PMID: 16699368
- Roskrow MA, Dilloo D, Suzuki N, Zhong W, Rooney CM, Brenner MK "Autoimmune disease induced by dendritic cell immunization against leukemia.." Leuk. Res.. 1999 Jun;23(6):549-57. Pubmed PMID: 10374848
- Foster AE, Leen AM, Lee T, Okamura T, Lu A, Vera J, Atkinson R, Bollard CM, Dotti G, Rooney CM "Autologous designer antigen-presenting cells by gene modification of T lymphocyte blasts with IL-7 and IL-12.." J. Immunother..;30(5):506-16. Pubmed PMID: 17589291
- Savoldo B, Huls MH, Liu Z, Okamura T, Volk HD, Reinke P, Sabat R, Babel N, Jones JF, Webster-Cyriaque J, Gee AP, Brenner MK, Heslop HE, Rooney CM "Autologous Epstein-Barr virus (EBV)-specific cytotoxic T cells for the treatment of persistent active EBV infection.." Blood. 2002 Dec 1;100(12):4059-66. Pubmed PMID: 12393655
- Kuehnle I, Huls MH, Liu Z, Semmelmann M, Krance RA, Brenner MK, Rooney CM, Heslop HE "CD20 monoclonal antibody (rituximab) for therapy of Epstein-Barr virus lymphoma after hemopoietic stem-cell transplantation.." Blood. 2000 Feb 15;95(4):1502-5. Pubmed PMID: 10666232
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- Quintarelli C, Dotti G, De Angelis B, Hoyos V, Mims M, Luciano L, Heslop HE, Rooney CM, Pane F, Savoldo B "Cytotoxic T lymphocytes directed to the preferentially expressed antigen of melanoma (PRAME) target chronic myeloid leukemia.." Blood. 2008 Sep 1;112(5):1876-85. Pubmed PMID: 18591381
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- Seiler MP, Gottschalk S, Cerullo V, Ratnayake M, Mane VP, Clarke C, Palmer DJ, Ng P, Rooney CM, Lee B "Dendritic cell function after gene transfer with adenovirus-calcium phosphate co-precipitates.." Mol. Ther.. 2007 Feb;15(2):386-92. Pubmed PMID: 17235318
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- Foster AE, Rooney CM "Improving T cell therapy for cancer.." Expert Opin Biol Ther. 2006 Mar;6(3):215-29. Pubmed PMID: 16503732
- Cruz CR, Gerdemann U, Leen AM, Shafer JA, Ku S, Tzou B, Horton TM, Sheehan A, Copeland A, Younes A, Rooney CM, Heslop HE, Bollard CM "Improving T-cell Therapy for Relapsed EBV-Negative Hodgkin Lymphoma by Targeting Upregulated MAGE-A4.." Clin. Cancer Res.. 2011 Nov 15;17(22):7058-66. Pubmed PMID: 21908573
- Bollard CM, Gottschalk S, Huls MH, Molldrem J, Przepiorka D, Rooney CM, Heslop HE "In vivo expansion of LMP 1- and 2-specific T-cells in a patient who received donor-derived EBV-specific T-cells after allogeneic stem cell transplantation.." Leuk. Lymphoma. 2006 May;47(5):837-42. Pubmed PMID: 16753867
- Foster AE, Kwon S, Ke S, Lu A, Eldin K, Sevick-Muraca E, Rooney CM "In vivo fluorescent optical imaging of cytotoxic T lymphocyte migration using IRDye800CW near-infrared dye.." Appl Opt. 2008 Nov 1;47(31):5944-52. Pubmed PMID: 19122737
- Di Stasi A, Tey SK, Dotti G, Fujita Y, Kennedy-Nasser A, Martinez C, Straathof K, Liu E, Durett AG, Grilley B, Liu H, Cruz CR, Savoldo B, Gee AP, Schindler J, Krance RA, Heslop HE, Spencer DM, Rooney CM, Brenner MK "Inducible apoptosis as a safety switch for adoptive cell therapy.." N. Engl. J. Med.. 2011 Nov 3;365(18):1673-83. Pubmed PMID: 22047558
- Tey SK, Dotti G, Rooney CM, Heslop HE, Brenner MK "Inducible caspase 9 suicide gene to improve the safety of allodepleted T cells after haploidentical stem cell transplantation.." Biol. Blood Marrow Transplant.. 2007 Aug;13(8):913-24. Pubmed PMID: 17640595
- Vigouroux S, Yvon E, Wagner HJ, Biagi E, Dotti G, Sili U, Lira C, Rooney CM, Brenner MK "Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes.." J. Virol.. 2003 Oct;77(20):10872-80. Pubmed PMID: 14512537
- You Z, Huang XF, Hester J, Rollins L, Rooney C, Chen SY "Induction of vigorous helper and cytotoxic T cell as well as B cell responses by dendritic cells expressing a modified antigen targeting receptor-mediated internalization pathway.." J. Immunol.. 2000 Oct 15;165(8):4581-91. Pubmed PMID: 11035100
- Rooney C, Howe JG, Speck SH, Miller G "Influence of Burkitt's lymphoma and primary B cells on latent gene expression by the nonimmortalizing P3J-HR-1 strain of Epstein-Barr virus.." J. Virol.. 1989 Apr;63(4):1531-9. Pubmed PMID: 2538644
- Rooney CM, Smith CA, Ng CY, Loftin SK, Sixbey JW, Gan Y, Srivastava DK, Bowman LC, Krance RA, Brenner MK, Heslop HE "Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients.." Blood. 1998 Sep 1;92(5):1549-55. Pubmed PMID: 9716582
- Perna SK, De Angelis B, Pagliara D, Hasan ST, Zhang L, Mahendravada A, Heslop HE, Brenner MK, Rooney CM, Dotti G, Savoldo B "Interleukin 15 Provides Relief to CTLs from Regulatory T Cell-Mediated Inhibition: Implications for Adoptive T Cell-Based Therapies for Lymphoma.." Clin. Cancer Res.. 2013 Jan 1;19(1):106-17. Pubmed PMID: 23149818
- Turnis ME, Song XT, Bear A, Foster AE, Gottschalk S, Brenner MK, Chen SY, Rooney CM "IRAK-M Removal Counteracts Dendritic Cell Vaccine Deficits in Migration and Longevity.." J. Immunol.. 2010 Oct 1;185(7):4223-32. Pubmed PMID: 20817880
- Lapteva N, Durett AG, Sun J, Rollins LA, Huye LL, Fang J, Dandekar V, Mei Z, Jackson K, Vera J, Ando J, Ngo MC, Coustan-Smith E, Campana D, Szmania S, Garg T, Moreno-Bost A, Vanrhee F, Gee AP, Rooney CM "Large-scale ex vivo expansion and characterization of natural killer cells for clinical applications.." Cytotherapy. 2012 Oct;14(9):1131-43. Pubmed PMID: 22900959
- Sili U, Huls MH, Davis AR, Gottschalk S, Brenner MK, Heslop HE, Rooney CM "Large-scale expansion of dendritic cell-primed polyclonal human cytotoxic T-lymphocyte lines using lymphoblastoid cell lines for adoptive immunotherapy.." J. Immunother..;26(3):241-56. Pubmed PMID: 12806278
- Heslop HE, Slobod KS, Pule MA, Hale GA, Rousseau A, Smith CA, Bollard CM, Liu H, Wu MF, Rochester RJ, Amrolia PJ, Hurwitz JL, Brenner MK, Rooney CM "Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients.." Blood. 2010 Feb 4;115(5):925-35. Pubmed PMID: 19880495
- Heslop HE, Ng CY, Li C, Smith CA, Loftin SK, Krance RA, Brenner MK, Rooney CM "Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virus-specific T lymphocytes.." Nat. Med.. 1996 May;2(5):551-5. Pubmed PMID: 8616714
- Aguilar LK, Rooney CM, Heslop HE "Lymphoproliferative disorders involving Epstein-Barr virus after hemopoietic stem cell transplantation.." Curr Opin Oncol. 1999 Mar;11(2):96-101. Pubmed PMID: 10188073
- Rooney CM, Kaye EM, Scott RM, Klucznik RP, Rosman NP "Modified encephaloduroarteriosynangiosis as a surgical treatment of childhood moyamoya disease: report of five cases.." J. Child Neurol.. 1991 Jan;6(1):24-31. Pubmed PMID: 2002197
- Leen AM, Myers GD, Sili U, Huls MH, Weiss H, Leung KS, Carrum G, Krance RA, Chang CC, Molldrem JJ, Gee AP, Brenner MK, Heslop HE, Rooney CM, Bollard CM "Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals.." Nat. Med.. 2006 Oct;12(10):1160-6. Pubmed PMID: 16998485
- Rooney C, Leen A "Moving Successful Virus-specific T-cell Therapy for Hematopoietic Stem Cell Recipients to Late Phase Clinical Trials.." Mol Ther Nucleic Acids. 2012;1:e55. Pubmed PMID: 23629030
- Rooney CM, Wimperis JZ, Brenner MK, Patterson J, Hoffbrand AV, Prentice HG "Natural killer cell activity following T-cell depleted allogeneic bone marrow transplantation.." Br. J. Haematol.. 1986 Mar;62(3):413-20. Pubmed PMID: 3513817
- Young LS, Yao QY, Rooney CM, Sculley TB, Moss DJ, Rupani H, Laux G, Bornkamm GW, Rickinson AB "New type B isolates of Epstein-Barr virus from Burkitt's lymphoma and from normal individuals in endemic areas.." J. Gen. Virol.. 1987 Nov;68:2853-62. Pubmed PMID: 2824665
- Rooney CM, Munro AJ "NK cells can recognize asialylated autologous lymphocytes and ABO-mismatched lymphocytes.." Immunology. 1984 Jan;51(1):193-9. Pubmed PMID: 6418639
- Gerdemann U, Christin AS, Vera JF, Ramos CA, Fujita Y, Liu H, Dilloo D, Heslop HE, Brenner MK, Rooney CM, Leen AM "Nucleofection of DCs to generate Multivirus-specific T cells for prevention or treatment of viral infections in the immunocompromised host.." Mol. Ther.. 2009 Sep;17(9):1616-25. Pubmed PMID: 19584818
- Nakazawa Y, Huye LE, Dotti G, Foster AE, Vera JF, Manuri PR, June CH, Rooney CM, Wilson MH "Optimization of the PiggyBac transposon system for the sustained genetic modification of human T lymphocytes.." J. Immunother.. 2009 Oct;32(8):826-36. Pubmed PMID: 19752751
- Heslop HE, Gottschalk SM, Bollard CM, Straathof KC, Huls MH, Brenner MK, Rooney CM "Options for T-cell based therapies.." Vox Sang.. 2004 Jul;87:230-4. Pubmed PMID: 15209923
- Cohen AR, Rooney C "Osteolysis circumscripta evanescans.." Pediatr Neurosurg. 1996 Sep;25(3):156-8; discussi. Pubmed PMID: 9144716
- Rooney CM, Rickinson AB, Moss DJ, Lenoir GM, Epstein MA "Paired Epstein-Barr virus-carrying lymphoma and lymphoblastoid cell lines from Burkitt's lymphoma patients: comparative sensitivity to non-specific and to allo-specific cytotoxic responses in vitro.." Int. J. Cancer. 1984 Sep 15;34(3):339-48. Pubmed PMID: 6090321
- Saha S, Nakazawa Y, Huye LE, Doherty JE, Galvan DL, Rooney CM, Wilson MH "piggyBac Transposon System Modification of Primary Human T Cells.." J Vis Exp. 2012;(69) Pubmed PMID: 23149543
- Nakazawa Y, Huye LE, Salsman VS, Leen AM, Ahmed N, Rollins L, Dotti G, Gottschalk SM, Wilson MH, Rooney CM "PiggyBac-mediated Cancer Immunotherapy Using EBV-specific Cytotoxic T-cells Expressing HER2-specific Chimeric Antigen Receptor.." Mol. Ther.. 2011 Dec;19(12):2133-43. Pubmed PMID: 21772253
- Wrightham MN, Stewart JP, Janjua NJ, Pepper SD, Sample C, Rooney CM, Arrand JR "Antigenic and sequence variation in the C-terminal unique domain of the Epstein-Barr virus nuclear antigen EBNA-1.." Virology. 1995 Apr 20;208(2):521-30. Pubmed PMID: 7538250
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- Baylor College of Medicine Faculty Senate.
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