Cliona
Middle Name
M
Rooney, Ph.D.
Middle Name
M
Picture
Positions
- Professor
-
Pediatrics-Hem-Onc Cell and Gene
Baylor College of Medicine
Houston, TX US
Education
- Advanced Training from Yale University School Of Medicine
- 01/1987 - New Haven, CT United States
- Advanced Training from University Of Birmingham
- 01/1985 - Birmingham, United Kingdom
- Advanced Training from University Of Bristol
- 01/1984 - Bristol, United Kingdom
- Ph.D. from University Of Cambridge
- 01/1981 - Cambridge, United Kingdom
- B.Sc. from University Of East Anglia
- 01/1978 - Norwich, United Kingdom
Professional Interests
- Virus-specific T cells for treatment of viral diseases
Websites
Selected Publications
- Pulè MA, Straathof KC, Dotti G, Heslop HE, Rooney CM, Brenner MK "A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells.." Mol. Ther..2005/November;12(5):933-41. Pubmed PMID: 15979412
- Song XT, Turnis ME, Zhou X, Zhu W, Hong BX, Rollins L, Rabinovich B, Chen SY, Rooney CM, Gottschalk S "A Th1-inducing Adenoviral Vaccine for Boosting Adoptively Transferred T Cells.." Mol. Ther..2011/January;19(1):211-7. Pubmed PMID: 20959814
- Leen AM, Bollard CM, Myers GD, Rooney CM "Adenoviral infections in hematopoietic stem cell transplantation.." Biol. Blood Marrow Transplant..2006/March;12(3):243-51. Pubmed PMID: 16503493
- Smith CA, Woodruff LS, Kitchingman GR, Rooney CM "Adenovirus-pulsed dendritic cells stimulate human virus-specific T-cell responses in vitro.." J. Virol..1996/October;70(10):6733-40. Pubmed PMID: 8794310
- Suzuki M, Rooney CM "Adenovirus immunity: x marks the spot.." Mol. Ther.. 2012 December ; 20 (12): 2197-8. Pubmed PMID: 23201614
- Leen AM, Rooney CM "Adenovirus as an emerging pathogen in immunocompromised patients.." Br. J. Haematol.. 2005 January ; 128 (2): 135-44. Pubmed PMID: 15638847
- Foster AE, Bradstock KF, Sili U, Marangolo M, Rooney CM, Gottlieb DJ "A comparison of gene transfer and antigen-loaded dendritic cells for the generation of CD4+ and CD8+ cytomegalovirus-specific T cells in HLA-A2+ and HLA-A2- donors.." Biol. Blood Marrow Transplant.. 2004 November ; 10 (11): 761-71. Pubmed PMID: 15505607
- Wagner HJ, Bollard CM, Vigouroux S, Huls MH, Anderson R, Prentice HG, Brenner MK, Heslop HE, Rooney CM "A strategy for treatment of Epstein-Barr virus-positive Hodgkin's disease by targeting interleukin 12 to the tumor environment using tumor antigen-specific T cells.." Cancer Gene Ther.. 2004 February ; 11 (2): 81-91. Pubmed PMID: 14685154
- Vera JF, Brenner LJ, Gerdemann U, Ngo MC, Sili U, Liu H, Wilson J, Dotti G, Heslop HE, Leen AM, Rooney CM "Accelerated production of antigen-specific T cells for preclinical and clinical applications using gas-permeable rapid expansion cultureware (G-Rex).." J. Immunother.. 2010 April ; 33 (3): 305-15. Pubmed PMID: 20445351
- Muralidharan S, Hanley PJ, Liu E, Chakraborty R, Bollard C, Shpall E, Rooney C, Savoldo B, Rodgers J, Dotti G "Activation of wnt signaling arrests effector differentiation in human peripheral and cord blood-derived T lymphocytes.." J. Immunol.. 2011 November 15; 187 (10): 5221-32. Pubmed PMID: 22013128
- Bollard CM, Rössig C, Calonge MJ, Huls MH, Wagner HJ, Massague J, Brenner MK, Heslop HE, Rooney CM "Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity.." Blood. 2002 May 1; 99 (9): 3179-87. Pubmed PMID: 11964281
- Dotti G, Savoldo B, Takahashi S, Goltsova T, Brown M, Rill D, Rooney C, Brenner M "Adenovector-induced expression of human-CD40-ligand (hCD40L) by multiple myeloma cells. A model for immunotherapy.." Exp. Hematol.. 2001 August ; 29 (8): 952-61. Pubmed PMID: 11495701
- Gahn B, Siller-Lopez F, Pirooz AD, Yvon E, Gottschalk S, Longnecker R, Brenner MK, Heslop HE, Aguilar-Cordova E, Rooney CM "Adenoviral gene transfer into dendritic cells efficiently amplifies the immune response to LMP2A antigen: a potential treatment strategy for Epstein-Barr virus--positive Hodgkin's lymphoma.." Int. J. Cancer. 2001 September 1; 93 (5): 706-13. Pubmed PMID: 11477583
- Bollard CM, Huls MH, Buza E, Weiss H, Torrano V, Gresik MV, Chang J, Gee A, Gottschalk SM, Carrum G, Brenner MK, Rooney CM, Heslop HE "Administration of latent membrane protein 2-specific cytotoxic T lymphocytes to patients with relapsed Epstein-Barr virus-positive lymphoma.." 2006 January ; 6 (4): 342-7. Pubmed PMID: 16507214
- Roskrow MA, Rooney CM, Heslop HE, Brenner MK, Krance RA, Gresik MV, McClain K, Aguilar LK, Grilley B, Rob E, Carrum G "Administration of neomycin resistance gene marked EBV specific cytotoxic T-lymphocytes to patients with relapsed EBV-positive Hodgkin disease.." Hum. Gene Ther.. 1998 May 20; 9 (8): 1237-50. Pubmed PMID: 9625264
- Heslop H, Rooney C, Brenner M, Krance R, Carrum G, Gahn B, Bollard C, Khan S, Gee A, Popat U, Gresik M, Przepiorka D, Kuehnle I, Grilley B "Administration of neomycin resistance gene-marked EBV-specific cytotoxic T-lymphocytes as therapy for patients receiving a bone marrow transplant for relapsed EBV-positive Hodgkin disease.." Hum. Gene Ther.. 2000 July 1; 11 (10): 1465-75. Pubmed PMID: 10910143
- Heslop HE, Brenner MK, Rooney C, Krance RA, Roberts WM, Rochester R, Smith CA, Turner V, Sixbey J, Moen R "Administration of neomycin-resistance-gene-marked EBV-specific cytotoxic T lymphocytes to recipients of mismatched-related or phenotypically similar unrelated donor marrow grafts.." Hum. Gene Ther.. 1994 March ; 5 (3): 381-97. Pubmed PMID: 8018749
- Heslop HE, Rooney CM "Adoptive cellular immunotherapy for EBV lymphoproliferative disease.." Immunol. Rev.. 1997 June ; 157 : 217-22. Pubmed PMID: 9255632
- Fujita Y, Rooney CM, Heslop HE "Adoptive cellular immunotherapy for viral diseases.." Bone Marrow Transplant.. 2008 January ; 41 (2): 193-8. Pubmed PMID: 17982497
- Gottschalk S, Heslop HE, Rooney CM "Adoptive immunotherapy for EBV-associated malignancies.." Leuk. Lymphoma. 2005 January ; 46 (1): 41284. Pubmed PMID: 15621775
- Smith CA, Ng CY, Loftin SK, Li C, Heslop HE, Brenner MK, Rooney CM "Adoptive immunotherapy for Epstein-Barr virus-related lymphoma.." Leuk. Lymphoma. 1996 October ; 23 (41337): 213-20. Pubmed PMID: 9031101
- Kennedy-Nasser AA, Bollard CM, Rooney CM "Adoptive immunotherapy for Hodgkin's lymphoma.." Int. J. Hematol.. 2006 June ; 83 (5): 385-90. Pubmed PMID: 16787867
- Bollard CM, Kuehnle I, Leen A, Rooney CM, Heslop HE "Adoptive immunotherapy for posttransplantation viral infections.." Biol. Blood Marrow Transplant.. 2004 March ; 10 (3): 143-55. Pubmed PMID: 14993880
- Kaka AS, Rooney CM, Savoldo B "What influence has B-cell depletion on viral infections?." Leuk. Lymphoma. 2007 July ; 48 (7): 1257-8. Pubmed PMID: 17613749
- Pule MA, Savoldo B, Myers GD, Rossig C, Russell HV, Dotti G, Huls MH, Liu E, Gee AP, Mei Z, Yvon E, Weiss HL, Liu H, Rooney CM, Heslop HE, Brenner MK "Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma.." Nat. Med.. 2008 November ; 14 (11): 1264-70. Pubmed PMID: 18978797
- Johnson S, Hall J, Barnett S, Draper M, Derbyshire G, Haynes L, Rooney C, Cameron H, Moseley GL, de C Williams AC, McCabe C, Goebel A "Using graded motor imagery for complex regional pain syndrome in clinical practice: Failure to improve pain.." Eur J Pain. 2012 April ; 16 (4): 550-61. Pubmed PMID: 22337591
- Kaka AS, Foster AE, Weiss HL, Rooney CM, Leen AM "Using dendritic cell maturation and IL-12 producing capacity as markers of function: a cautionary tale.." J. Immunother.. 2008 May ; 31 (4): 359-69. Pubmed PMID: 18391760
- Rooney CM, Smith CA, Ng CY, Loftin S, Li C, Krance RA, Brenner MK, Heslop HE "Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation.." Lancet. 1995 January 7; 345 (8941): 41530. Pubmed PMID: 7799740
- Heslop HE, Rooney CM, Rill DR, Krance RA, Brenner MK "Use of gene marking in bone marrow transplantation.." Cancer Detect. Prev.. 1996 20 (2): 108-13. Pubmed PMID: 8706035
- Lee TC, Savoldo B, Barshes NR, Rooney CM, Heslop HE, Gee AP, Caldwell Y, Scott JD, Goss JA "Use of cytokine polymorphisms and Epstein-Barr virus viral load to predict development of post-transplant lymphoproliferative disorder in paediatric liver transplant recipients.." Clin Transplant. 20 (3): 389-93. Pubmed PMID: 16824159
- Savoldo B, Goss JA, Hammer MM, Zhang L, Lopez T, Gee AP, Lin YF, Quiros-Tejeira RE, Reinke P, Schubert S, Gottschalk S, Finegold MJ, Brenner MK, Rooney CM, Heslop HE "Treatment of solid organ transplant recipients with autologous Epstein Barr virus-specific cytotoxic T lymphocytes (CTLs).." Blood. 2006 November 1; 108 (9): 2942-9. Pubmed PMID: 16835376
- Rooney CM, Roskrow MA, Suzuki N, Ng CY, Brenner MK, Heslop H "Treatment of relapsed Hodgkin's disease using EBV-specific cytotoxic T cells.." Ann. Oncol.. 1998 9 : S129-32. Pubmed PMID: 9926252
- Straathof KC, Bollard CM, Popat U, Huls MH, Lopez T, Morriss MC, Gresik MV, Gee AP, Russell HV, Brenner MK, Rooney CM, Heslop HE "Treatment of nasopharyngeal carcinoma with Epstein-Barr virus--specific T lymphocytes.." Blood. 2005 March 1; 105 (5): 1898-904. Pubmed PMID: 15542583
- Pakakasama S, Eames GM, Morriss MC, Huls MH, Rooney CM, Heslop HE, Krance RA "Treatment of Epstein-Barr virus lymphoproliferative disease after hematopoietic stem-cell transplantation with hydroxyurea and cytotoxic T-cell lymphocytes.." Transplantation. 2004 September 15; 78 (5): 755-7. Pubmed PMID: 15371682
- Brenner MK, Heslop HE, Rill D, Li C, Smith C, Krance R, Rooney C "Transfer of marker genes into hemopoietic progenitor cells.." Cytokines Mol Ther. 1996 September ; 2 (3): 193-200. Pubmed PMID: 9384704
- Heslop HE, Perez M, Benaim E, Rochester R, Brenner MK, Rooney CM "Transfer of EBV-specific CTL to prevent EBV lymphoma post bone marrow transplant.." J Clin Apher. 1999 14 (3): 154-6. Pubmed PMID: 10540372
- Buschle M, Brenner MK, Chen IS, Drexler HG, Gignac SM, Rooney CM "Transfection and gene expression in normal and malignant primary B lymphocytes.." J. Immunol. Methods. 1990 October 4; 133 (1): 77-85. Pubmed PMID: 1698880
- Schroers R, Sinha I, Segall H, Schmidt-Wolf IG, Rooney CM, Brenner MK, Sutton RE, Chen SY "Transduction of human PBMC-derived dendritic cells and macrophages by an HIV-1-based lentiviral vector system.." Mol. Ther.. 2000 February ; 1 (2): 171-9. Pubmed PMID: 10933928
- Melcher A, Parato K, Rooney CM, Bell JC "Thunder and lightning: immunotherapy and oncolytic viruses collide.." Mol. Ther.. 2011 June ; 19 (6): 1008-16. Pubmed PMID: 21505424
- Savoldo B, Heslop HE, Rooney CM "The use of cytotoxic t cells for the prevention and treatment of Epstein-Barr virus induced lymphoma in transplant recipients.." Leuk. Lymphoma. 2000 November ; 39 (41400): 455-64. Pubmed PMID: 11342329
- Pebody RG, Chand MA, Thomas HL, Green HK, Boddington NL, Carvalho C, Brown CS, Anderson SR, Rooney C, Crawley-Boevey E, Irwin DJ, Aarons E, Tong C, Newsholme W, Price N, Langrish C, Tucker D, Zhao H, Phin N, Crofts J, Bermingham A, Gilgunn-Jones E, Brown "The United Kingdom public health response to an imported laboratory confirmed case of a novel coronavirus in September 2012.." Euro Surveill.. 2012 17 (40): 20292. Pubmed PMID: 23078799
- Rooney CM, Rowe DT, Ragot T, Farrell PJ "The spliced BZLF1 gene of Epstein-Barr virus (EBV) transactivates an early EBV promoter and induces the virus productive cycle.." J. Virol.. 1989 July ; 63 (7): 3109-16. Pubmed PMID: 2542618
- Stewart JP, Rooney CM "The interleukin-10 homolog encoded by Epstein-Barr virus enhances the reactivation of virus-specific cytotoxic T cell and HLA-unrestricted killer cell responses.." Virology. 1992 December ; 191 (2): 773-82. Pubmed PMID: 1333123
- Bollard CM, Straathof KC, Huls MH, Leen A, Lacuesta K, Davis A, Gottschalk S, Brenner MK, Heslop HE, Rooney CM "The generation and characterization of LMP2-specific CTLs for use as adoptive transfer from patients with relapsed EBV-positive Hodgkin disease.." J. Immunother.. 27 (4): 317-27. Pubmed PMID: 15235393
- Ling PD, Lednicky JA, Keitel WA, Poston DG, White ZS, Peng R, Liu Z, Mehta SK, Pierson DL, Rooney CM, Vilchez RA, Smith EO, Butel JS "The dynamics of herpesvirus and polyomavirus reactivation and shedding in healthy adults: a 14-month longitudinal study.." J. Infect. Dis.. 2003 May 15; 187 (10): 1571-80. Pubmed PMID: 12721937
- Roessig C, Scherer SP, Baer A, Vormoor J, Rooney CM, Brenner MK, Juergens H "Targeting CD19 with genetically modified EBV-specific human T lymphocytes.." Ann. Hematol.. 2002 81 : S42-3. Pubmed PMID: 12611072
- Yotnda P, Savoldo B, Charlet-Berguerand N, Rooney C, Brenner M "Targeted delivery of adenoviral vectors by cytotoxic T cells.." Blood. 2004 October 15; 104 (8): 2272-80. Pubmed PMID: 15161664
- Rossig C, Bär A, Pscherer S, Altvater B, Pule M, Rooney CM, Brenner MK, Jürgens H, Vormoor J "Target antigen expression on a professional antigen-presenting cell induces superior proliferative antitumor T-cell responses via chimeric T-cell receptors.." J. Immunother.. 29 (1): 21-31. Pubmed PMID: 16365597
- Bollard CM, Rooney CM, Heslop HE "T-cell therapy in the treatment of post-transplant lymphoproliferative disease.." Nat Rev Clin Oncol. 2012 August 14; 9 (9): 510-9. Pubmed PMID: 22801669
- Leen AM, Myers GD, Bollard CM, Huls MH, Sili U, Gee AP, Heslop HE, Rooney CM "T-cell immunotherapy for adenoviral infections of stem-cell transplant recipients.." Ann. N. Y. Acad. Sci.. 2005 December ; 1062 : 104-15. Pubmed PMID: 16461793
- Vera J, Savoldo B, Vigouroux S, Biagi E, Pule M, Rossig C, Wu J, Heslop HE, Rooney CM, Brenner MK, Dotti G "T lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells.." Blood. 2006 December 1; 108 (12): 3890-7. Pubmed PMID: 16926291
- Di Stasi A, De Angelis B, Rooney CM, Zhang L, Mahendravada A, Foster AE, Heslop HE, Brenner MK, Dotti G, Savoldo B "T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model.." Blood. 2009 June 18; 113 (25): 6392-402. Pubmed PMID: 19377047
- Sun J, Dotti G, Huye LE, Foster AE, Savoldo B, Gramatges MM, Spencer DM, Rooney CM "T Cells Expressing Constitutively Active Akt Resist Multiple Tumor-associated Inhibitory Mechanisms.." Mol. Ther.. 2010 November ; 18 (11): 2006-17. Pubmed PMID: 20842106
- Gottschalk S, Bollard CM, Straathof KC, Louis CU, Savoldo B, Dotti G, Brenner MK, Heslop HE, Rooney CM "T cell therapies.." Ernst Schering Found Symp Proc. 2006 (4): 69-82. Pubmed PMID: 17824182
- Straathof KC, Spencer DM, Sutton RE, Rooney CM "Suicide genes as safety switches in T lymphocytes.." Cytotherapy. 2003 5 (3): 227-30. Pubmed PMID: 12850790
- Packham G, Economou A, Rooney CM, Rowe DT, Farrell PJ "Structure and function of the Epstein-Barr virus BZLF1 protein.." J. Virol.. 1990 May ; 64 (5): 2110-6. Pubmed PMID: 2157874
- Barshes NR, Lee TR, Goss JA, Goodpastor SE, Huls MH, Rooney CM, Karpen SJ, Wyllie S "Slc11a1 (formerly Nramp1) polymorphisms and susceptibility to post-transplant lymphoproliferative disease following pediatric liver transplantation.." Transpl Infect Dis. 2006 June ; 8 (2): 108-12. Pubmed PMID: 16734634
- Miller G, Grogan E, Rowe D, Rooney C, Heston L, Eastman R, Andiman W, Niederman J, Lenoir G, Henle W "Selective lack of antibody to a component of EB nuclear antigen in patients with chronic active Epstein-Barr virus infection.." J. Infect. Dis.. 1987 July ; 156 (1): 26-35. Pubmed PMID: 3036961
- Amrolia PJ, Muccioli-Casadei G, Yvon E, Huls H, Sili U, Wieder ED, Bollard C, Michalek J, Ghetie V, Heslop HE, Molldrem JJ, Rooney CM, Schlinder J, Vitetta E, Brenner MK "Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responses.." Blood. 2003 September 15; 102 (6): 2292-9. Pubmed PMID: 12763937
- Chakraborty R, Mahendravada A, Perna SK, Rooney CM, Heslop HE, Vera JF, Savoldo B, Dotti G "Robust and cost effective expansion of human regulatory T cells highly functional in a xenograft model of graft-versus-host disease.." Haematologica. 2013 April ; 98 (4): 533-7. Pubmed PMID: 23242592
- Bear AS, Morgan RA, Cornetta K, June CH, Binder-Scholl G, Dudley ME, Feldman SA, Rosenberg SA, Shurtleff SA, Rooney CM, Heslop HE, Dotti G "Replication-competent retroviruses in gene-modified T cells used in clinical trials: is it time to revise the testing requirements?." Mol. Ther.. 2012 February ; 20 (2): 246-9. Pubmed PMID: 22297819
- Ahmed N, Ratnayake M, Savoldo B, Perlaky L, Dotti G, Wels WS, Bhattacharjee MB, Gilbertson RJ, Shine HD, Weiss HL, Rooney CM, Heslop HE, Gottschalk S "Regression of experimental medulloblastoma following transfer of HER2-specific T cells.." Cancer Res.. 2007 June 15; 67 (12): 5957-64. Pubmed PMID: 17575166
- Myers GD, Bollard CM, Wu MF, Weiss H, Rooney CM, Heslop HE, Leen AM "Reconstitution of adenovirus-specific cell-mediated immunity in pediatric patients after hematopoietic stem cell transplantation.." Bone Marrow Transplant.. 2007 June ; 39 (11): 677-86. Pubmed PMID: 17417664
- Gerdemann U, Keirnan JM, Katari UL, Yanagisawa R, Christin AS, Huye LE, Perna SK, Ennamuri S, Gottschalk S, Brenner MK, Heslop HE, Rooney CM, Leen AM "Rapidly Generated Multivirus-specific Cytotoxic T Lymphocytes for the Prophylaxis and Treatment of Viral Infections.." Mol. Ther.. 2012 August ; 20 (8): 1622-32. Pubmed PMID: 22801446
- Heo J, Reid T, Ruo L, Breitbach CJ, Rose S, Bloomston M, Cho M, Lim HY, Chung HC, Kim CW, Burke J, Lencioni R, Hickman T, Moon A, Lee YS, Kim MK, Daneshmand M, Dubois K, Longpre L, Ngo M, Rooney C, Bell JC, Rhee BG, Patt R, Hwang TH, Kirn DH "Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer.." Nat. Med.. 2013 February 10; 19 (3): 329-36. Pubmed PMID: 23396206
- Lee TC, Savoldo B, Rooney CM, Heslop HE, Gee AP, Caldwell Y, Barshes NR, Scott JD, Bristow LJ, O'Mahony CA, Goss JA "Quantitative EBV viral loads and immunosuppression alterations can decrease PTLD incidence in pediatric liver transplant recipients.." Am. J. Transplant.. 2005 September ; 5 (9): 2222-8. Pubmed PMID: 16095501
- Lee TC, Goss JA, Rooney CM, Heslop HE, Barshes NR, Caldwell YM, Gee AP, Scott JD, Savoldo B "Quantification of a low cellular immune response to aid in identification of pediatric liver transplant recipients at high-risk for EBV infection.." Clin Transplant. 20 (6): 689-94. Pubmed PMID: 17100717
- Wagner HJ, Cheng YC, Huls MH, Gee AP, Kuehnle I, Krance RA, Brenner MK, Rooney CM, Heslop HE "Prompt versus preemptive intervention for EBV lymphoproliferative disease.." Blood. 2004 May 15; 103 (10): 3979-81. Pubmed PMID: 14751931
- Sili U, Leen AM, Vera JF, Gee AP, Huls H, Heslop HE, Bollard CM, Rooney CM "Production of good manufacturing practice-grade cytotoxic T lymphocytes specific for Epstein-Barr virus, cytomegalovirus and adenovirus to prevent or treat viral infections post-allogeneic hematopoietic stem cell transplant.." Cytotherapy. 2012 January ; 14 (1): 41466. Pubmed PMID: 22172091
- Smith CA, Ng CY, Heslop HE, Holladay MS, Richardson S, Turner EV, Loftin SK, Li C, Brenner MK, Rooney CM "Production of genetically modified Epstein-Barr virus-specific cytotoxic T cells for adoptive transfer to patients at high risk of EBV-associated lymphoproliferative disease.." J Hematother. 1995 April ; 4 (2): 73-9. Pubmed PMID: 7633844
- McCullough J, Wagner J, Key N, Gee A, Rooney C, Whiteside T, Donnenberg A, Lindblad R "Production assistance for cellular therapies.." Transfusion. 2004 December ; 44 (12): 1793-5. Pubmed PMID: 15584997
- Reed W, Noga SJ, Gee AP, Rooney CM, Wagner JE, McCullough J, McKenna DH, Whiteside TL, Donnenberg AD, Baker AK, Lindblad RW, Wagner EL, Mondoro TH "Production Assistance for Cellular Therapies (PACT): four-year experience from the United States National Heart, Lung, and Blood Institute (NHLBI) contract research program in cell and tissue therapies.." Transfusion. 2009 April ; 49 (4): 786-96. Pubmed PMID: 19170985
- Kamdar KY, Rooney CM, Heslop HE "Posttransplant lymphoproliferative disease following liver transplantation.." Curr Opin Organ Transplant. 2011 June ; 16 (3): 274-80. Pubmed PMID: 21467936
- Gottschalk S, Rooney CM, Heslop HE "Post-transplant lymphoproliferative disorders.." Annu. Rev. Med.. 2005 56 : 29-44. Pubmed PMID: 15660500
- Rooney CM, Aguilar LK, Huls MH, Brenner MK, Heslop HE "Adoptive immunotherapy of EBV-associated malignancies with EBV-specific cytotoxic T-cell lines.." Curr. Top. Microbiol. Immunol.. 2001 258 : 221-9. Pubmed PMID: 11443864
- Bollard CM, Savoldo B, Rooney CM, Heslop HE "Adoptive T-cell therapy for EBV-associated post-transplant lymphoproliferative disease.." Acta Haematol.. 2003 110 (41308): 139-48. Pubmed PMID: 14583674
- Huls MH, Rooney CM, Heslop HE "Adoptive T-cell therapy for Epstein-Barr virus-positive Hodgkin's disease.." Acta Haematol.. 2003 110 (41308): 149-53. Pubmed PMID: 14583675
- Louis CU, Straathof K, Bollard CM, Ennamuri S, Gerken C, Lopez TT, Huls MH, Sheehan A, Wu MF, Liu H, Gee A, Brenner MK, Rooney CM, Heslop HE, Gottschalk S "Adoptive Transfer of EBV-specific T Cells Results in Sustained Clinical Responses in Patients With Locoregional Nasopharyngeal Carcinoma.." J. Immunother.. 33 (9): 983-90. Pubmed PMID: 20948438
- Rooney CM "Adoptive transfer of virus-directed T cells: will this fly for flu?." Cytotherapy. 2012 February ; 14 (2): 133-4. Pubmed PMID: 22149160
- Cruz CR, Hanley PJ, Liu H, Torrano V, Lin YF, Arce JA, Gottschalk S, Savoldo B, Dotti G, Louis CU, Leen AM, Gee AP, Rooney CM, Brenner MK, Bollard CM, Heslop HE "Adverse events following infusion of T cells for adoptive immunotherapy: a 10-year experience.." Cytotherapy. 2010 October ; 12 (6): 743-9. Pubmed PMID: 20429793
- Shaffer DR, Sheehan AM, Yi Z, Rodgers CC, Bollard CM, Brenner MK, Rooney CM, Heslop HE, Gottschalk S "Aggressive peripheral CD70-positive t-cell lymphoma associated with severe chronic active EBV infection.." Pediatr Blood Cancer. 2012 October ; 59 (4): 758-61. Pubmed PMID: 21994111
- Melenhorst JJ, Leen AM, Bollard CM, Quigley MF, Price DA, Rooney CM, Brenner MK, Barrett AJ, Heslop HE "Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects.." Blood. 2010 November 25; 116 (22): 4700-2. Pubmed PMID: 20709906
- Gottschalk S, Ng CY, Perez M, Smith CA, Sample C, Brenner MK, Heslop HE, Rooney CM "An Epstein-Barr virus deletion mutant associated with fatal lymphoproliferative disease unresponsive to therapy with virus-specific CTLs.." Blood. 2001 February 15; 97 (4): 835-43. Pubmed PMID: 11159505
- de Witte MA, Jorritsma A, Swart E, Straathof KC, de Punder K, Haanen JB, Rooney CM, Schumacher TN "An inducible caspase 9 safety switch can halt cell therapy-induced autoimmune disease.." J. Immunol.. 2008 May 1; 180 (9): 6365-73. Pubmed PMID: 18424760
- Straathof KC, Pulè MA, Yotnda P, Dotti G, Vanin EF, Brenner MK, Heslop HE, Spencer DM, Rooney CM "An inducible caspase 9 safety switch for T-cell therapy.." Blood. 2005 June 1; 105 (11): 4247-54. Pubmed PMID: 15728125
- Ramos CA, Asgari Z, Liu E, Yvon E, Heslop HE, Rooney CM, Brenner MK, Dotti G "An inducible caspase 9 suicide gene to improve the safety of mesenchymal stromal cell therapies.." Stem Cells. 2010 June ; 28 (6): 1107-15. Pubmed PMID: 20506146
- Tanner JE, Diaz-Mitoma F, Rooney CM, Alfieri C "Anti-interleukin-10 antibodies in patients with chronic active Epstein-Barr virus infection.." J. Infect. Dis.. 1997 December ; 176 (6): 1454-61. Pubmed PMID: 9395354
- Shafer JA, Cruz CR, Leen AM, Ku S, Lu A, Rousseau A, Heslop HE, Rooney CM, Bollard CM, Foster AE "Antigen-specific cytotoxic T lymphocytes can target chemoresistant side-population tumor cells in Hodgkin lymphoma.." Leuk. Lymphoma. 2010 May ; 51 (5): 870-80. Pubmed PMID: 20367572
- Louis CU, Savoldo B, Dotti G, Pule M, Yvon E, Myers GD, Rossig C, Russell HV, Diouf O, Liu E, Liu H, Wu MF, Gee AP, Mei Z, Rooney CM, Heslop HE, Brenner MK "Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma.." Blood. 2011 December 1; 118 (23): 6050-6. Pubmed PMID: 21984804
- Foster AE, Dotti G, Lu A, Khalil M, Brenner MK, Heslop HE, Rooney CM, Bollard CM "Antitumor activity of EBV-specific T lymphocytes transduced with a dominant negative TGF-beta receptor.." J. Immunother.. 2008 June ; 31 (5): 500-5. Pubmed PMID: 18463534
- Lacuesta K, Buza E, Hauser H, Granville L, Pule M, Corboy G, Finegold M, Weiss H, Chen SY, Brenner MK, Heslop HE, Rooney CM, Bollard CM "Assessing the safety of cytotoxic T lymphocytes transduced with a dominant negative transforming growth factor-beta receptor.." J. Immunother.. 29 (3): 250-60. Pubmed PMID: 16699368
- Roskrow MA, Dilloo D, Suzuki N, Zhong W, Rooney CM, Brenner MK "Autoimmune disease induced by dendritic cell immunization against leukemia.." Leuk. Res.. 1999 June ; 23 (6): 549-57. Pubmed PMID: 10374848
- Foster AE, Leen AM, Lee T, Okamura T, Lu A, Vera J, Atkinson R, Bollard CM, Dotti G, Rooney CM "Autologous designer antigen-presenting cells by gene modification of T lymphocyte blasts with IL-7 and IL-12.." J. Immunother.. 30 (5): 506-16. Pubmed PMID: 17589291
- Savoldo B, Huls MH, Liu Z, Okamura T, Volk HD, Reinke P, Sabat R, Babel N, Jones JF, Webster-Cyriaque J, Gee AP, Brenner MK, Heslop HE, Rooney CM "Autologous Epstein-Barr virus (EBV)-specific cytotoxic T cells for the treatment of persistent active EBV infection.." Blood. 2002 December 1; 100 (12): 4059-66. Pubmed PMID: 12393655
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- Straathof KC, Leen AM, Buza EL, Taylor G, Huls MH, Heslop HE, Rooney CM, Bollard CM "Characterization of latent membrane protein 2 specificity in CTL lines from patients with EBV-positive nasopharyngeal carcinoma and lymphoma.." J. Immunol.. 2005 September 15; 175 (6): 4137-47. Pubmed PMID: 16148164
- Quintarelli C, Vera JF, Savoldo B, Giordano Attianese GM, Pule M, Foster AE, Heslop HE, Rooney CM, Brenner MK, Dotti G "Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes.." Blood. 2007 October 15; 110 (8): 2793-802. Pubmed PMID: 17638856
- Huye LE, Nakazawa Y, Patel MP, Yvon E, Sun J, Savoldo B, Wilson MH, Dotti G, Rooney CM "Combining mTor Inhibitors With Rapamycin-resistant T Cells: A Two-pronged Approach to Tumor Elimination.." Mol. Ther.. 2011 December ; 19 (12): 2239-48. Pubmed PMID: 21878902
- Sanchez C, Chan R, Bajgain P, Rambally S, Palapattu G, Mims M, Rooney CM, Leen AM, Brenner MK, Vera JF "Combining T-cell immunotherapy and anti-androgen therapy for prostate cancer.." Prostate Cancer Prostatic Dis.. 2013 June ; 16 (2): 123-31. Pubmed PMID: 23295316
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- Leen AM, Christin A, Myers GD, Liu H, Cruz CR, Hanley PJ, Kennedy-Nasser AA, Leung KS, Gee AP, Krance RA, Brenner MK, Heslop HE, Rooney CM, Bollard CM "Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation.." Blood. 2009 November 5; 114 (19): 4283-92. Pubmed PMID: 19700662
- Quintarelli C, Dotti G, De Angelis B, Hoyos V, Mims M, Luciano L, Heslop HE, Rooney CM, Pane F, Savoldo B "Cytotoxic T lymphocytes directed to the preferentially expressed antigen of melanoma (PRAME) target chronic myeloid leukemia.." Blood. 2008 September 1; 112 (5): 1876-85. Pubmed PMID: 18591381
- Gerdemann U, Katari U, Christin AS, Cruz CR, Tripic T, Rousseau A, Gottschalk SM, Savoldo B, Vera JF, Heslop HE, Brenner MK, Bollard CM, Rooney CM, Leen AM "Cytotoxic T Lymphocytes Simultaneously Targeting Multiple Tumor-associated Antigens to Treat EBV Negative Lymphoma.." Mol. Ther.. 2011 December ; 19 (12): 2258-68. Pubmed PMID: 21915103
- Seiler MP, Gottschalk S, Cerullo V, Ratnayake M, Mane VP, Clarke C, Palmer DJ, Ng P, Rooney CM, Lee B "Dendritic cell function after gene transfer with adenovirus-calcium phosphate co-precipitates.." Mol. Ther.. 2007 February ; 15 (2): 386-92. Pubmed PMID: 17235318
- Micklethwaite KP, Savoldo B, Hanley PJ, Leen AM, Demmler-Harrison GJ, Cooper LJ, Liu H, Gee AP, Shpall EJ, Rooney CM, Heslop HE, Brenner MK, Bollard CM, Dotti G "Derivation of human T lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation.." Blood. 2010 April 1; 115 (13): 2695-703. Pubmed PMID: 20110422
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- Turnis ME, Rooney CM "Enhancement of dendritic cells as vaccines for cancer.." Immunotherapy. 2010 November ; 2 (6): 847-62. Pubmed PMID: 21091116
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- Nakazawa Y, Saha S, Galvan DL, Huye L, Rollins L, Rooney CM, Wilson MH "Evaluation of Long-term Transgene Expression in piggyBac-Modified Human T Lymphocytes.." J. Immunother.. 2013 January ; 36 (1): 41343. Pubmed PMID: 23211626
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- Leen AM, Rooney CM, Foster AE "Improving T cell therapy for cancer.." Annu. Rev. Immunol.. 2007 25 : 243-65. Pubmed PMID: 17129181
- Foster AE, Rooney CM "Improving T cell therapy for cancer.." Expert Opin Biol Ther. 2006 March ; 6 (3): 215-29. Pubmed PMID: 16503732
- Cruz CR, Gerdemann U, Leen AM, Shafer JA, Ku S, Tzou B, Horton TM, Sheehan A, Copeland A, Younes A, Rooney CM, Heslop HE, Bollard CM "Improving T-cell Therapy for Relapsed EBV-Negative Hodgkin Lymphoma by Targeting Upregulated MAGE-A4.." Clin. Cancer Res.. 2011 November 15; 17 (22): 7058-66. Pubmed PMID: 21908573
- Bollard CM, Gottschalk S, Huls MH, Molldrem J, Przepiorka D, Rooney CM, Heslop HE "In vivo expansion of LMP 1- and 2-specific T-cells in a patient who received donor-derived EBV-specific T-cells after allogeneic stem cell transplantation.." Leuk. Lymphoma. 2006 May ; 47 (5): 837-42. Pubmed PMID: 16753867
- Foster AE, Kwon S, Ke S, Lu A, Eldin K, Sevick-Muraca E, Rooney CM "In vivo fluorescent optical imaging of cytotoxic T lymphocyte migration using IRDye800CW near-infrared dye.." Appl Opt. 2008 November 1; 47 (31): 5944-52. Pubmed PMID: 19122737
- Di Stasi A, Tey SK, Dotti G, Fujita Y, Kennedy-Nasser A, Martinez C, Straathof K, Liu E, Durett AG, Grilley B, Liu H, Cruz CR, Savoldo B, Gee AP, Schindler J, Krance RA, Heslop HE, Spencer DM, Rooney CM, Brenner MK "Inducible apoptosis as a safety switch for adoptive cell therapy.." N. Engl. J. Med.. 2011 November 3; 365 (18): 1673-83. Pubmed PMID: 22047558
- Tey SK, Dotti G, Rooney CM, Heslop HE, Brenner MK "Inducible caspase 9 suicide gene to improve the safety of allodepleted T cells after haploidentical stem cell transplantation.." Biol. Blood Marrow Transplant.. 2007 August ; 13 (8): 913-24. Pubmed PMID: 17640595
- Vigouroux S, Yvon E, Wagner HJ, Biagi E, Dotti G, Sili U, Lira C, Rooney CM, Brenner MK "Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes.." J. Virol.. 2003 October ; 77 (20): 10872-80. Pubmed PMID: 14512537
- You Z, Huang XF, Hester J, Rollins L, Rooney C, Chen SY "Induction of vigorous helper and cytotoxic T cell as well as B cell responses by dendritic cells expressing a modified antigen targeting receptor-mediated internalization pathway.." J. Immunol.. 2000 October 15; 165 (8): 4581-91. Pubmed PMID: 11035100
- Rooney C, Howe JG, Speck SH, Miller G "Influence of Burkitt's lymphoma and primary B cells on latent gene expression by the nonimmortalizing P3J-HR-1 strain of Epstein-Barr virus.." J. Virol.. 1989 April ; 63 (4): 1531-9. Pubmed PMID: 2538644
- Rooney CM, Smith CA, Ng CY, Loftin SK, Sixbey JW, Gan Y, Srivastava DK, Bowman LC, Krance RA, Brenner MK, Heslop HE "Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients.." Blood. 1998 September 1; 92 (5): 1549-55. Pubmed PMID: 9716582
- Perna SK, De Angelis B, Pagliara D, Hasan ST, Zhang L, Mahendravada A, Heslop HE, Brenner MK, Rooney CM, Dotti G, Savoldo B "Interleukin 15 Provides Relief to CTLs from Regulatory T Cell-Mediated Inhibition: Implications for Adoptive T Cell-Based Therapies for Lymphoma.." Clin. Cancer Res.. 2013 January 1; 19 (1): 106-17. Pubmed PMID: 23149818
- Turnis ME, Song XT, Bear A, Foster AE, Gottschalk S, Brenner MK, Chen SY, Rooney CM "IRAK-M Removal Counteracts Dendritic Cell Vaccine Deficits in Migration and Longevity.." J. Immunol.. 2010 October 1; 185 (7): 4223-32. Pubmed PMID: 20817880
- Lapteva N, Durett AG, Sun J, Rollins LA, Huye LL, Fang J, Dandekar V, Mei Z, Jackson K, Vera J, Ando J, Ngo MC, Coustan-Smith E, Campana D, Szmania S, Garg T, Moreno-Bost A, Vanrhee F, Gee AP, Rooney CM "Large-scale ex vivo expansion and characterization of natural killer cells for clinical applications.." Cytotherapy. 2012 October ; 14 (9): 1131-43. Pubmed PMID: 22900959
- Sili U, Huls MH, Davis AR, Gottschalk S, Brenner MK, Heslop HE, Rooney CM "Large-scale expansion of dendritic cell-primed polyclonal human cytotoxic T-lymphocyte lines using lymphoblastoid cell lines for adoptive immunotherapy.." J. Immunother.. 26 (3): 241-56. Pubmed PMID: 12806278
- Heslop HE, Slobod KS, Pule MA, Hale GA, Rousseau A, Smith CA, Bollard CM, Liu H, Wu MF, Rochester RJ, Amrolia PJ, Hurwitz JL, Brenner MK, Rooney CM "Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients.." Blood. 2010 February 4; 115 (5): 925-35. Pubmed PMID: 19880495
- Heslop HE, Ng CY, Li C, Smith CA, Loftin SK, Krance RA, Brenner MK, Rooney CM "Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virus-specific T lymphocytes.." Nat. Med.. 1996 May ; 2 (5): 551-5. Pubmed PMID: 8616714
- Aguilar LK, Rooney CM, Heslop HE "Lymphoproliferative disorders involving Epstein-Barr virus after hemopoietic stem cell transplantation.." Curr Opin Oncol. 1999 March ; 11 (2): 96-101. Pubmed PMID: 10188073
- Rooney CM, Kaye EM, Scott RM, Klucznik RP, Rosman NP "Modified encephaloduroarteriosynangiosis as a surgical treatment of childhood moyamoya disease: report of five cases.." J. Child Neurol.. 1991 January ; 6 (1): 24-31. Pubmed PMID: 2002197
- Leen AM, Myers GD, Sili U, Huls MH, Weiss H, Leung KS, Carrum G, Krance RA, Chang CC, Molldrem JJ, Gee AP, Brenner MK, Heslop HE, Rooney CM, Bollard CM "Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals.." Nat. Med.. 2006 October ; 12 (10): 1160-6. Pubmed PMID: 16998485
- Rooney C, Leen A "Moving Successful Virus-specific T-cell Therapy for Hematopoietic Stem Cell Recipients to Late Phase Clinical Trials.." Mol Ther Nucleic Acids. 2012 1 : e55. Pubmed PMID: 23629030
- Rooney CM, Wimperis JZ, Brenner MK, Patterson J, Hoffbrand AV, Prentice HG "Natural killer cell activity following T-cell depleted allogeneic bone marrow transplantation.." Br. J. Haematol.. 1986 March ; 62 (3): 413-20. Pubmed PMID: 3513817
- Young LS, Yao QY, Rooney CM, Sculley TB, Moss DJ, Rupani H, Laux G, Bornkamm GW, Rickinson AB "New type B isolates of Epstein-Barr virus from Burkitt's lymphoma and from normal individuals in endemic areas.." J. Gen. Virol.. 1987 November ; 68 : 2853-62. Pubmed PMID: 2824665
- Rooney CM, Munro AJ "NK cells can recognize asialylated autologous lymphocytes and ABO-mismatched lymphocytes.." Immunology. 1984 January ; 51 (1): 193-9. Pubmed PMID: 6418639
- Gerdemann U, Christin AS, Vera JF, Ramos CA, Fujita Y, Liu H, Dilloo D, Heslop HE, Brenner MK, Rooney CM, Leen AM "Nucleofection of DCs to generate Multivirus-specific T cells for prevention or treatment of viral infections in the immunocompromised host.." Mol. Ther.. 2009 September ; 17 (9): 1616-25. Pubmed PMID: 19584818
- Nakazawa Y, Huye LE, Dotti G, Foster AE, Vera JF, Manuri PR, June CH, Rooney CM, Wilson MH "Optimization of the PiggyBac transposon system for the sustained genetic modification of human T lymphocytes.." J. Immunother.. 2009 October ; 32 (8): 826-36. Pubmed PMID: 19752751
- Heslop HE, Gottschalk SM, Bollard CM, Straathof KC, Huls MH, Brenner MK, Rooney CM "Options for T-cell based therapies.." Vox Sang.. 2004 July ; 87 : 230-4. Pubmed PMID: 15209923
- Cohen AR, Rooney C "Osteolysis circumscripta evanescans.." Pediatr Neurosurg. 1996 September ; 25 (3): 156-8; discussi. Pubmed PMID: 9144716
- Rooney CM, Rickinson AB, Moss DJ, Lenoir GM, Epstein MA "Paired Epstein-Barr virus-carrying lymphoma and lymphoblastoid cell lines from Burkitt's lymphoma patients: comparative sensitivity to non-specific and to allo-specific cytotoxic responses in vitro.." Int. J. Cancer. 1984 September 15; 34 (3): 339-48. Pubmed PMID: 6090321
- Saha S, Nakazawa Y, Huye LE, Doherty JE, Galvan DL, Rooney CM, Wilson MH "piggyBac Transposon System Modification of Primary Human T Cells.." J Vis Exp. 2012 (69): Pubmed PMID: 23149543
- Nakazawa Y, Huye LE, Salsman VS, Leen AM, Ahmed N, Rollins L, Dotti G, Gottschalk SM, Wilson MH, Rooney CM "PiggyBac-mediated Cancer Immunotherapy Using EBV-specific Cytotoxic T-cells Expressing HER2-specific Chimeric Antigen Receptor.." Mol. Ther.. 2011 December ; 19 (12): 2133-43. Pubmed PMID: 21772253
- Wrightham MN, Stewart JP, Janjua NJ, Pepper SD, Sample C, Rooney CM, Arrand JR "Antigenic and sequence variation in the C-terminal unique domain of the Epstein-Barr virus nuclear antigen EBNA-1.." Virology. 1995 April 20; 208 (2): 521-30. Pubmed PMID: 7538250
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- Baylor College of Medicine Faculty Senate.
- Senator
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