Positions
- Professor
-
Medicine-Nephrology
Baylor College of Medicine
Houston, TX US
Education
- B.Sc. from Hebrew University Of Jerusalem
- 01/1976 - Jerusalem, Israel
- M.D. from Hadassah Medical School
- 01/1981 - Jerusalem, Israel
- Advanced Training from University Of California, Los Angeles
- 01/1984 - Los Angeles, CA United States
- Advanced Training from National Institutes Of Health
- 01/1991 - Bethesda, MD United States
Certifications
- ABIM-Medicine
- #115454
- ABIM
- Valid indefinitely
- ABIM-Nephrology
- #115454
- ABIM
- Re-certified 2002
Honors & Awards
- Fulbright & Jaworski L. L. P. Faculty Excellence Award
- Recipient of Baylor College of Medicine Fulbright & Jaworski L. L. P. Faculty Excellence Award for Teaching and Evaluation (8/2007).
- Baylor College of Medicine (08/2007)
- Award for Excellence in Teaching
- Award for Excellence in Teaching (2001-2002): Department of Medicine, Baylor College of Medicine.
- BCM (07/2002)
- Elected Member, Leadership Committee of KCVD
- Member at-Large (Elected): Leadership Committee of the Council on the Kidney in Cardiovascular Disease (KCVD); AHA, 7/2005 - 2010.
- AHA (07/2005)
- Member, Nominating Committee, KCVD
- Member: Nominating Committee of the AHA Council on Kidney in Cardiovascular Disease (KCVVD), 2004-2010.
- AHA (07/2004 - 06/2010)
- Member of the Academy of Distinguished Educators
- Member of the Academy of Distinguished Educators, Baylor College of Medicine (8/2007)
- BCM (07/2007)
Professional Interests
- Riverside Clinic
- Kidney Protection via Metabolic Sensors
Websites
Publications on PubMed
Professional Development
- Renal Grand Rounds
- Conference (Organizer, 2009)
- Sponsor: BCM/Methodist Hospital
- Weekly conference presented by national and international nephrology leaders, and features state-of-the-art lectures and new advances in nephrology.
Selected Publications
- "http://www-ncbi-nlm-nih-gov.ezproxyhost.library.tmc.edu/pubmed/?term=sheikh-hamad." ;
- Christensen BM, Marples D, Jensen UB, Frokiaer J, Sheikh-Hamad D, Knepper M, Nielsen S "Acute effects of vasopressin V2-receptor antagonist on kidney AQP2 expression and subcellular distribution.." Am. J. Physiol.. 1998 Aug;275(2):F285-97. Pubmed PMID: 9691020
- Morduchowicz GA, Sheikh-Hamad D, Dwyer BE, Stern N, Jo OD, Yanagawa N "Angiotensin II directly increases rabbit renal brush-border membrane sodium transport: presence of local signal transduction system.." J. Membr. Biol.. 1991 May;122(1):43-53. Pubmed PMID: 1652030
- Huang L, Garcia G, Lou Y, Zhou Q, Truong LD, DiMattia G, Lan XR, Lan HY, Wang Y, Sheikh-Hamad D "Anti-inflammatory and renal protective actions of stanniocalcin-1 in a model of anti-glomerular basement membrane glomerulonephritis.." Am. J. Pathol.. 2009 Apr;174(4):1368-78. Pubmed PMID: 19246645
- Sheikh-Hamad D, Ayus CJ "Antidiuretic hormone and renal clearance of uric acid.." Am. J. Kidney Dis.. 1998 Oct;32(4):692-3; discussi. Pubmed PMID: 9774136
- Wamsley-Davis A, Padda R, Truong LD, Tsao CC, Zhang P, Sheikh-Hamad D "AT1A-mediated activation of kidney JNK1 and SMAD2 in obstructive uropathy: preservation of kidney tissue mass using candesartan.." Am. J. Physiol. Renal Physiol.. 2004 Sep;287(3):F474-80. Pubmed PMID: 15126250
- Truong LD, Yakupoglu U, Feig D, Hicks J, Cartwight J, Sheikh-Hamad D, Suki WN "Calcium oxalate deposition in renal allografts: morphologic spectrum and clinical implications.." Am. J. Transplant.. 2004 Aug;4(8):1338-44. Pubmed PMID: 15268737
- Sule N, Yakupoglu U, Shen SS, Krishnan B, Yang G, Lerner S, Sheikh-Hamad D, Truong LD "Calcium oxalate deposition in renal cell carcinoma associated with acquired cystic kidney disease: a comprehensive study.." Am. J. Surg. Pathol.. 2005 Apr;29(4):443-51. Pubmed PMID: 15767796
- Sheikh-Hamad D, Paiuk E, Wright AJ, Kleinmann C, Khosla U, Shandera WX "Care for immigrants with end-stage renal disease in Houston: a comparison of two practices.." Tex Med. 2007 Apr;103(4):54-8, 53. Pubmed PMID: 17494250
- Sheikh-Hamad D, Ferraris JD, Dragolovich J, Preuss HG, Burg MB, García-Pérez A "CD9 antigen mRNA is induced by hypertonicity in two renal epithelial cell lines.." Am. J. Physiol.. 1996 Jan;270(1):C253-8. Pubmed PMID: 8772451
- Truong LD, Sheikh-Hamad D, Chakraborty S, Suki WN "Cell apoptosis and proliferation in obstructive uropathy.." Semin. Nephrol.. 1998 Nov;18(6):641-51. Pubmed PMID: 9819155
- Sheikh-Hamad D, Cacini W, Buckley AR, Isaac J, Truong LD, Tsao CC, Kishore BK "Cellular and molecular studies on cisplatin-induced apoptotic cell death in rat kidney.." Arch. Toxicol.. 2004 Mar;78(3):147-55. Pubmed PMID: 14551673
- Sheikh-Hamad D "Cisplatin-induced cytoxicity: is the nucleus relevant?." Am. J. Physiol. Renal Physiol.. 2008 Jul;295(1):F42-3. Pubmed PMID: 18480173
- Sheikh-Hamad D, Timmins K, Jalali Z "Cisplatin-induced renal toxicity: possible reversal by N-acetylcysteine treatment.." J. Am. Soc. Nephrol.. 1997 Oct;8(10):1640-4. Pubmed PMID: 9335396
- Kagan A, Sheikh-Hamad D "Contrast-induced kidney injury: focus on modifiable risk factors and prophylactic strategies.." Clin Cardiol. 2010 Feb;33(2):62-6. Pubmed PMID: 20186983
- Sheikh-Hamad D, Nadkarni V, Choi YJ, Truong LD, Wideman C, Hodjati R, Gabbay KH "Cyclosporine A inhibits the adaptive responses to hypertonicity: a potential mechanism of nephrotoxicity.." J. Am. Soc. Nephrol.. 2001 Dec;12(12):2732-41. Pubmed PMID: 11729242
- Ayus JC, Sheikh-Hamad D "Dialysis therapy.." N. Engl. J. Med.. 1998 Oct 1;339(14):1003-4; author . Pubmed PMID: 9766986
- Stephen MJ, Poindexter BJ, Moolman JA, Sheikh-Hamad D, Bick RJ "Do binucleate cardiomyocytes have a role in myocardial repair? Insights using isolated rodent myocytes and cell culture.." Open Cardiovasc Med J. 2009;3:41281. Pubmed PMID: 19430572
- Sheikh-Hamad D, Wang YP, Jo OD, Yanagawa N "Dopamine antagonizes the actions of angiotensin II in renal brush-border membrane.." Am. J. Physiol.. 1993 Apr;264(4):F737-43. Pubmed PMID: 8386474
- Faustinella F, Uzoh C, Sheikh-Hamad D, Truong LD, Olivero JJ "Glomerulomegaly and proteinuria in a patient with idiopathic pulmonary hypertension.." J. Am. Soc. Nephrol.. 1997 Dec;8(12):1966-70. Pubmed PMID: 9402101
- Chen C, Jamaluddin MS, Yan S, Sheikh-Hamad D, Yao Q "Human stanniocalcin-1 blocks TNF-alpha-induced monolayer permeability in human coronary artery endothelial cells.." Arterioscler. Thromb. Vasc. Biol.. 2008 May;28(5):906-12. Pubmed PMID: 18309109
- Liu D, Huang L, Wang Y, Wang W, Wehrens XH, Belousova T, Abdelrahim M, Dimattia G, Sheikh-Hamad D "Human Stanniocalcin-1 Suppresses Angiotensin II-Induced Superoxide Generation in Cardiomyocytes through UCP3-Mediated Anti-Oxidant Pathway.." PLoS ONE. 2012;7(5):e36994. Pubmed PMID: 22693564
- Sheikh-Hamad D, Suki WN, Zhao W "Hypertonic induction of the cell adhesion molecule beta 1-integrin in MDCK cells.." Am. J. Physiol.. 1997 Sep;273(3):C902-8. Pubmed PMID: 9316411
- Mai HL, Sheikh-Hamad D, Herrera GA, Gu X, Truong LD "Immunoglobulin heavy chain can be amyloidogenic: morphologic characterization including immunoelectron microscopy.." Am. J. Surg. Pathol.. 2003 Apr;27(4):541-5. Pubmed PMID: 12657941
- Morduchowicz GA, Sheikh-Hamad D, Jo OD, Nord EP, Lee DB, Yanagawa N "Increased Na+/H+ antiport activity in the renal brush border membrane of SHR.." Kidney Int.. 1989 Oct;36(4):576-81. Pubmed PMID: 2554051
- Sheikh-Hamad D, García-Pérez A, Ferraris JD, Peters EM, Burg MB "Induction of gene expression by heat shock versus osmotic stress.." Am. J. Physiol.. 1994 Jul;267(1):F28-34. Pubmed PMID: 8048561
- Sheikh-Hamad D "Mammalian stanniocalcin-1 activates mitochondrial antioxidant pathways: new paradigms for regulation of macrophages and endothelium.." Am. J. Physiol. Renal Physiol.. 2010 Feb;298(2):F248-54. Pubmed PMID: 19656913
- Sheikh-Hamad D, Gustin MC "MAP kinases and the adaptive response to hypertonicity: functional preservation from yeast to mammals.." Am. J. Physiol. Renal Physiol.. 2004 Dec;287(6):F1102-10. Pubmed PMID: 15522988
- Choi YJ, Baranowska-Daca E, Nguyen V, Koji T, Ballantyne CM, Sheikh-Hamad D, Suki WN, Truong LD "Mechanism of chronic obstructive uropathy: increased expression of apoptosis-promoting molecules.." Kidney Int.. 2000 Oct;58(4):1481-91. Pubmed PMID: 11012883
- Padda R, Wamsley-Davis A, Gustin MC, Ross R, Yu C, Sheikh-Hamad D "MEKK3-mediated signaling to p38 kinase and TonE in hypertonically stressed kidney cells.." Am. J. Physiol. Renal Physiol.. 2006 Oct;291(4):F874-81. Pubmed PMID: 16684924
- Nadkarni V, Gabbay KH, Bohren KM, Sheikh-Hamad D "Osmotic response element enhancer activity. Regulation through p38 kinase and mitogen-activated extracellular signal-regulated kinase kinase.." J. Biol. Chem.. 1999 Jul 16;274(29):20185-90. Pubmed PMID: 10400634
- Sheikh-Hamad D, Youker K, Truong LD, Nielsen S, Entman ML "Osmotically relevant membrane signaling complex: association between HB-EGF, beta(1)-integrin, and CD9 in mTAL.." Am. J. Physiol., Cell Physiol.. 2000 Jul;279(1):C136-46. Pubmed PMID: 10898725
- Huang L, Belousova T, Chen M, Dimattia G, Liu D, Sheikh-Hamad D "Overexpression of stanniocalcin-1 inhibits reactive oxygen species and renal ischemia/reperfusion injury in mice.." Kidney Int.. 2012 Oct;82(8):867-77. Pubmed PMID: 22695329
- Sheikh-Hamad D, Di Mari J, Suki WN, Safirstein R, Watts BA, Rouse D "p38 kinase activity is essential for osmotic induction of mRNAs for HSP70 and transporter for organic solute betaine in Madin-Darby canine kidney cells.." J. Biol. Chem.. 1998 Jan 16;273(3):1832-7. Pubmed PMID: 9430735
- Bassan MM, Sheikh-Hamad D "Prevention of lidocaine-infusion phlebitis by heparin and hydrocortisone.." Chest. 1983 Oct;84(4):439-41. Pubmed PMID: 6617280
- Sheikh-Hamad D, Rouse D, Yang Y "Regulation of stanniocalcin in MDCK cells by hypertonicity and extracellular calcium.." Am. J. Physiol. Renal Physiol.. 2000 Mar;278(3):F417-24. Pubmed PMID: 10710546
- Abdelrahim M, Baker CH, Abbruzzese JL, Sheikh-Hamad D, Liu S, Cho SD, Yoon K, Safe S "Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells.." Cancer Res.. 2007 Apr 1;67(7):3286-94. Pubmed PMID: 17409437
- Truong LD, Choi YJ, Tsao CC, Ayala G, Sheikh-Hamad D, Nassar G, Suki WN "Renal cell apoptosis in chronic obstructive uropathy: the roles of caspases.." Kidney Int.. 2001 Sep;60(3):924-34. Pubmed PMID: 11532087
- Choi YJ, Mendoza L, Rha SJ, Sheikh-Hamad D, Baranowska-Daca E, Nguyen V, Smith CW, Nassar G, Suki WN, Truong LD "Role of p53-dependent activation of caspases in chronic obstructive uropathy: evidence from p53 null mutant mice.." J. Am. Soc. Nephrol.. 2001 May;12(5):983-92. Pubmed PMID: 11316857
- Ayus JC, Sheikh-Hamad D "Silent infection in clotted hemodialysis access grafts.." J. Am. Soc. Nephrol.. 1998 Jul;9(7):1314-7. Pubmed PMID: 9644644
- Sheikh-Hamad D, Bick R, Wu GY, Christensen BM, Razeghi P, Poindexter B, Taegtmeyer H, Wamsley A, Padda R, Entman M, Nielsen S, Youker K "Stanniocalcin-1 is a naturally occurring L-channel inhibitor in cardiomyocytes: relevance to human heart failure.." Am. J. Physiol. Heart Circ. Physiol.. 2003 Jul;285(1):H442-8. Pubmed PMID: 12663264
- Chakraborty A, Brooks H, Zhang P, Smith W, McReynolds MR, Hoying JB, Bick R, Truong L, Poindexter B, Lan H, Elbjeirami W, Sheikh-Hamad D "Stanniocalcin-1 regulates endothelial gene expression and modulates transendothelial migration of leukocytes.." Am. J. Physiol. Renal Physiol.. 2007 Feb;292(2):F895-904. Pubmed PMID: 17032941
- Wang Y, Huang L, Abdelrahim M, Cai Q, Truong A, Bick R, Poindexter B, Sheikh-Hamad D "Stanniocalcin-1 suppresses superoxide generation in macrophages through induction of mitochondrial UCP2.." J. Leukoc. Biol.. 2009 Oct;86(4):981-8. Pubmed PMID: 19602668
- Kanellis J, Bick R, Garcia G, Truong L, Tsao CC, Etemadmoghadam D, Poindexter B, Feng L, Johnson RJ, Sheikh-Hamad D "Stanniocalcin-1, an inhibitor of macrophage chemotaxis and chemokinesis.." Am. J. Physiol. Renal Physiol.. 2004 Feb;286(2):F356-62. Pubmed PMID: 14570698
- Sheikh-Hamad D, Ayus JC "The patient with a clotted PTFE graft developing fever.." Nephrol. Dial. Transplant.. 1998 Sep;13(9):2392-3. Pubmed PMID: 9761534
- Colon J, Basha MR, Madero-Visbal R, Konduri S, Baker CH, Herrera LJ, Safe S, Sheikh-Hamad D, Abudayyeh A, Alvarado B, Abdelrahim M "Tolfenamic acid decreases c-Met expression through Sp proteins degradation and inhibits lung cancer cells growth and tumor formation in orthotopic mice.." Invest New Drugs. 2011 Feb;29(1):41-51. Pubmed PMID: 19851711
- Hou CC, Wang W, Huang XR, Fu P, Chen TH, Sheikh-Hamad D, Lan HY "Ultrasound-microbubble-mediated gene transfer of inducible Smad7 blocks transforming growth factor-beta signaling and fibrosis in rat remnant kidney.." Am. J. Pathol.. 2005 Mar;166(3):761-71. Pubmed PMID: 15743788
- Kanellis J, Watanabe S, Li JH, Kang DH, Li P, Nakagawa T, Wamsley A, Sheikh-Hamad D, Lan HY, Feng L, Johnson RJ "Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2.." Hypertension. 2003 Jun;41(6):1287-93. Pubmed PMID: 12743010
- Jenny Szu-Chin Pan, Luping Huang, Tatiana Belousova, Lianghao Lu, Yongjie Yang, Roger Reddel, Andy Chang, Huiming Ju, Gabriel DiMattia, Qiang Tong and David Sheikh-Hamad "Stanniocalcin-1 Inhibits Renal Ischemia/Reperfusion Injury via an AMP-Activated Protein Kinase-Dependent Pathway." JASN. 2014 Jul 10; Pubmed PMID: 25012175
- Luping Huang, Tatiana Belousova, Jenny Szu-Chin Pan, Jie Du, Huiming Ju, Lianghao Lu, Pumin Zhang, Luan D Truong, Alli Nuotio-Antar and David Sheikh-Hamad "AKI after Conditional and Kidney-Specific Knockdown of Stanniocalcin-1." JASN. 2014 Apr 3; Pubmed PMID: 24700878
- X Ma, L Lin, J Yue, G Pradhan, G Qin, L J Minze, H Wu, D Sheikh-Hamad, C W Smith, Y Sun "Ghrelin receptor regulates HFCS-induced adipose inflammation and insulin resistance." Nutr Diabetes. 2013 Dec 3; Pubmed PMID: 24366371
- Sheikh-Hamad D "From TOR and SMAD, why HIF-1α can be bad." AJP-Renal. 2014 Jan; Pubmed PMID: 24049143
- Luping Huang, Tatiana Belousova, Minyi Chen, Gabriel DiMattia, Dajun Liu, and David Sheikh-Hamad "Overexpression of stanniocalcin-1 inhibits reactive oxygen species and renal ischemia/reperfusion injury in mice." KI. 2012 Jun 13; Pubmed PMID: 22695329
- Liu D, Huang L, Wang Y, Wang W, Wehrens XH, Belousova T, Abdelrahim M, DiMattia G, Sheikh-Hamad D "Human stanniocalcin-1 suppresses angiotensin II-induced superoxide generation in cardiomyocytes through UCP3-mediated anti-oxidant pathway." PLoS One. 2012 May 31; Pubmed PMID: 22693564
Funding
- Stanniocalcin-1: New paradigms for cytoprotection and anti-inflammation - #I01BX002006
- $600,000.00 (04/01/2014 - 09/30/2018) Grant funding from Veteran Administration
- Reactive oxygen species (ROS), endothelial injury and macrophages play critical roles in ischemia/reperfusion (I/R) kidney injury. Our data show stanniocalcin-1 (STC1) diminishes superoxide generation in macrophages, through induction of uncoupling protein-2 (UCP2), decreases the response of macrophages to chemoattractants- and migration across an endothelial monolayer. In cultured endothelial cells, STC1 preserve barrier function. STC1: diminishes superoxide generation; inhibits cytokine-induced activation of Jun-N-terminal kinase (JNK) and loss of tight junction proteins expression. STC1 transgenic mice, which exhibit elevated serum levels and preferential expression of STC1 in macrophages and endothelium, display resistance to I/R kidney injury. Overall hypothesis: STC1 protects from I/R kidney injury through: suppression of superoxide generation; maintenance of normal endothelial barrier function following I/R kidney injury; and inhibition of macrophages. In Objective I, we will determine the role of superoxide and Daxx in STC1-mediated inhibition of JNK in endothelial cells. In Objective II, we will determine the effect of STC1 on hypoxia/reoxygenation (H/RO)-induced changes in the expression and assembly of tight junction proteins in cultured primary kidney endothelial cells. In the context of I/R kidney injury, Objective III will examine endothelial leakage to macromolecules, kidney inflammation and function after kidney endothelium-specific or macrophage-specific overexpression or deletion of STC1. Few therapeutic options are currently available for acute kidney injury (AKI). Our data identify STC1 as a potential therapeutic target for ischemic injury in the kidney and other organs, and our proposed studies will further elucidate STC1 mechanisms of action.
- Stanniocalcin-1, a novel anti-inflammatory protein - #R01DK080306
- $1,738,389.00 (08/01/2009 - 07/31/2015) Grant funding from NIH
- Macrophages are important mediators of inflammation. Our data show stanniocalcin-1 (STC1) decreases macrophage response to chemoattractants and migration across an endothelial monolayer. STC1 also diminishes superoxide generation in macrophages, by inducing uncoupling protein-2 (UCP2), and inhibits the NF-B pathway. In cultured endothelial cells, STC1 inhibits cytokine-induced changes in permeability and tight junction protein expression. STC1 transgenic mice, which exhibit elevated serum levels and preferential expression of STC1 in macrophages and endothelium, display less inflammatory macrophages in the glomeruli during anti-glomerular basement membrane (GBM) disease, resulting in kidney protection. Overall hypothesis: STC1 suppresses inflammation through inhibition of macrophage recruitment and function, and cytokine-induced increase in endothelial permeability. In Specific Aim I, we will determine mechanisms of UCP2 upregulation by STC1 and the role of superoxide in STC1-mediated inhibition of NF-B in macrophages. In Specific Aim II, we will determine the effect of STC1 on cytokine–induced changes in expression and assembly of tight junction proteins in cultured primary kidney endothelial cells. In Specific Aim III, in the context of anti-GBM disease, we will examine endothelial permeability of native kidney vessels, as well as kidney inflammation and function, after kidney endothelium-specific or macrophage-specific overexpression or deletion of STC1.
Languages
Hebrew, Arabic
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