Eric Van Nostrand, Ph.D.
Eric Van Nostrand, Ph.D.
- Assistant Professor
Baylor College of Medicine
- PhD from Stanford University School of Medicine
- 09/2012 - Stanford, California United States
- BS from Massachusetts Institute of Technology
- 06/2005 - Cambridge, Massachusetts United States
- Postdoctoral Fellowship at University of California San Diego
- 03/2020 - La Jolla, California United States
- RNA genomics technologies
- Mechanisms of RNA processing
- Host:RNA viral interactions
Professional StatementI am an Assistant Professor in the Department of Biochemistry and Molecular Biology, and member of the Therapeutic Innovation Center.
“I know that mutation of my RNA binding protein causes disease – but how do I know which of thousands of targets drive this phenotype?” The simplicity of this question belies the challenges involved in both identifying the direct and regulatory targets of the RNA binding protein (RBP), as well as narrowing the list of (often thousands or more) targets down to a set of phenotypically-relevant ones. My group uses a variety of genomics, molecular biology, and computational approaches to map and understand RNA processing regulatory networks, with the goals of uncovering new mechanisms in RNA processing and characterizing their roles in human physiology. We particularly focus on two biological systems: how RNA viruses hijack host RNA processing machineries to ensure proper replication and assembly, and how altered regulation of mRNA translation drives breast cancer.
- Van Nostrand EL, Pratt GA, Yee BA, Wheeler EC, Blue SM, Mueller J, Park SS, Garcia KE, Gelboin-Burkhart C, Nguyen TB, Rabano I, Stanton R, Sundararaman B, Wang R, Fu XD, Graveley BR, Yeo GW "Principles of RNA processing from analysis of enhanced CLIP maps for 150 RNA binding proteins." Genome Biology.2020/April6;: Pubmed PMID: 32252787
- Van Nostrand EL*, Freese P*, Pratt GA*, Wang X*, Wei X*, Xiao R*, et al, Fu XD, Lécuyer E, Burge CB, Graveley BR, Yeo GW "A Large-Scale Binding and Functional Map of Human RNA Binding Proteins." Nature.2020/July;583:711-719.
- Yee BA, Pratt GA, Graveley BR, Van Nostrand EL†, Yeo GW† "RBP-Maps enables robust generation of splicing regulatory maps." RNA.2019/February;: Pubmed PMID: 30413564
- Van Nostrand EL, Pratt GA, Shishkin AA, Gelboin-Burkhart C, Fang MY, Sundararaman B, Blue SM, Nguyen TB, Surka C, Elkins K, Stanton R, Rigo F, Guttman M, Yeo GW "Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP)." Nature Methods.2016/June;: Pubmed PMID: 27018577
- Conway AE*, Van Nostrand EL*, Pratt GA, Aigner S, Wilbert ML, Sundararaman B, Freese P, Lambert NJ, Sathe S, Liang TY, Essex A, Landais S, Burge CB, Jones DL, Yeo GW "Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival." Cell Reports. 2016 April ; : Pubmed PMID: 27068461
- Van Nostrand EL, Sánchez-Blanco A, Wu B, Nguyen A, Kim SK "Roles of the developmental regulator unc-62/Homothorax in limiting longevity in Caenorhabditis elegans." PLoS Genetics. 2013 : Pubmed PMID: 23468654
- Van Nostrand EL, Kim SK "Integrative analysis of C elegans modENCODE ChIP-seq data sets to infer gene regulatory interactions." Genome Research. 2013 June ; : Pubmed PMID: 23531767
- 13. Gerstein MB*, Lu ZJ*, Van Nostrand EL*, Cheng C*, Arshinoff BI*, Liu T*, Yip KY*, Robilotto R*, Rechtsteiner A*, Ikegami K*, Alves P*, Chateigner A*, Perry M*, Morris M*, Auerbach RK*, Feng X*, Leng J*, Vielle A*, Niu W*, Rhrissorrakrai K*, et al. "Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project." Science. 2010 : Pubmed PMID: 21177976
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