Positions
- Associate Professor
-
Department of Pathology & Immunology Center for Drug Discovery
Baylor College of Medicine
Houston, TX US
- Associate Professor
-
Department of Pharmacology and Chemical Biology
Baylor College of Medicine
- Member
-
Center for Drug Discovery
Baylor College of Medicine
Houston, Texas United States
Professional Interests
- LC-MS-based metabolomics
- Drug metabolism and pharmacokinetics
- Drug-induced liver injury
- Blood testis barrrier
Websites
Selected Publications
- Xing Liu, Yuanfu Lu, Xinfu Guan, Bingning Dong, Hemantkumar Chavan, Jin Wang, Yiqing Zhang, Partha Krishnamurthy, Feng Li* "Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism." Biochem Pharmacol.. 2015 Sep 1;97(1):111-121. Pubmed PMID: 26212543
- Feng Li, Jie Lu, Jie Cheng, Laiyou Wang, Tsutomu Matsubara, Ivan Csanaky, Curtis D. Klaassen, Frank J. Gonzalez, Xiaochao Ma "Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy." Nat. Med.. 2013;19:418-420. Pubmed PMID: 23475203
- Xing Liu, Yuan-Fu Lu, Xinfu Guan, Mingkun Zhao, Jin Wang, Feng Li* "Characterizing novel metabolic pathways of melatonin receptors agonist agomelatine using metabolomics approaches." Biochem Pharmacol.. 2016 Jun 1;109:70-82. Pubmed PMID: 27021842
- Michelle L Spruill, Mirjana Maletic-Savatic, Howard Martin, Feng Li*, Xinli Liu* "Spatial analysis of drug absorption, distribution, metabolism, and toxicology using mass spectrometry imaging." Biochem Pharmacol. 2022;201:115080.
- Xuan Qin, John M Hakenjos , Kevin R MacKenzie, Mercedes Barzi, Jin Wang, Sung Yun Jung, Martin M Matzuk, Feng Li "Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice." Drug Metab Dispos. 2022;50:128-139. Pubmed PMID: 34785568
- Mercedes Barzi, Francis P Pankowicz, Barry Zorman, Xing Liu, Xavier Legras, Diane Yang, Malgorzata Borowiak, Beatrice Bissig-Choisat, Pavel Sumazin, Feng Li, Karl-Dimiter Bissig "A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism." Nat Commun. 2017;8:39. Pubmed PMID: 28659616
Funding
- Mechanisms of Liver Toxicity of Anti-Depressant Duloxetine - #R01DK121970 Grant funding from NIH/NIDDK
- Elucidating Chemical Features that Block or Facilitate Passage across the BloodTestis and/or Blood-Epidydimal Barriers in Mice - #R61HD099995 Grant funding from NIH/NICHD
- Elucidating Chemical Features that Block or Facilitate Passage across the BloodTestis and/or Blood-Epidydimal Barriers in Mice - #R33HD099995 Grant funding from NIH/NICHD
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