Positions
- Professor
-
Center for Drug Discovery; Department of Pathology & Immunology
Baylor College of Medicine
Houston, TX US
- Professor
-
Department of Biochemistry and Molecular Pharmacology
Baylor College of Medicine
- Member
-
Center for Drug Discovery
Baylor College of Medicine
Houston, Texas United States
Professional Interests
- LC-MS-based metabolomics
- Drug metabolism and pharmacokinetics
- Drug-induced liver injury
- Blood testis barrrier
- Imaging Mass Spectrometry
Websites
Selected Publications
- Feng Li, Jie Lu, Jie Cheng, Laiyou Wang, Tsutomu Matsubara, Ivan Csanaky, Curtis D. Klaassen, Frank J. Gonzalez, Xiaochao Ma "Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy." Nat. Med.. 2013;19:418-420. Pubmed PMID: 23475203
- Xuan Qin , Yong Wang, Qiuji Ye, John M Hakenjos , Jin Wang , Mingxing Teng , Lei Guo, Zhi Tan , Damian W Young, Kevin R MacKenzie, Feng Li* "CYP3A Mediates an Unusual C(sp)−C(sp) Bond Cleavage via Ipso‐Addition of Oxygen in Drug Metabolism." Angew Chem Int Ed Engl .. 2024;63(23):e202405197. Pubmed PMID: 38574245
- Saleh M Khalil , Xuan Qin, John M Hakenjos, Jian Wang, Zhaoyong Hu, Xinli Liu, Jin Wang, Mirjana Maletic-Savatic, Kevin R MacKenzie, Martin M Matzuk, Feng Li* "MALDI Imaging Mass Spectrometry Visualizes the Distribution of Antidepressant Duloxetine and Its Major Metabolites in Mouse Brain, Liver, Kidney, and Spleen Tissues." Drug Metab Dispos.. 2024;52(7):673-680. Pubmed PMID: 38658163
- Shenzhi Zhou, Xuan Qin, Kevin Tran, Jian Wang, Xingyu Ji, Kevin R. MacKenzie, Srinivas Chamakuri, Jin Wang, Feng Li* "Metabolism, Pharmacokinetics, and Tissue Distribution of a Selective FK506-Binding Protein 12 F36V Mutant Degrader in Mice." ACS Pharmacol Transl Sci.. 2025;8:4410-4422.
- Xuan Qin , Cen Xie , John M Hakenjos, Kevin R MacKenzie , Shelton R Boyd, Mercedes Barzi, Karl-Dimiter Bissig , Damian W Young , Feng Li* "The roles of Cyp1a2 and Cyp2d in pharmacokinetic profiles of serotonin and norepinephrine reuptake inhibitor duloxetine and its metabolites in mice." Eur J Pharm Sci.. 2023;181:106358. Pubmed PMID: 36513193
Funding
- Mechanisms of Liver Toxicity of Anti-Depressant Duloxetine - #R01DK121970 Grant funding from NIH/NIDDK
- Elucidating Chemical Features that Block or Facilitate Passage across the BloodTestis and/or Blood-Epidydimal Barriers in Mice - #R33HD099995 Grant funding from NIH/NICHD
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