Positions

Assistant Professor of Surgery

David J. Sugarbaker Division of Thoracic Surgery
Baylor College of Medicine

Addresses

Margaret Alkek Biomedical Research Building1 Baylor Plaza (Lab)

1 Baylor Plaza
Houston, TX 77030
United States

Education

PhD from Capital Normal University

Beijing, China

Genetics

Professional Statement

Guanxing Chen is an Assistant Professor in the Michael E. DeBakey Department of Surgery at Baylor College of Medicine. His research focuses on identifying key mitochondrial regulators that drive endothelial and epithelial cell vulnerability during lung ischemia–reperfusion injury (IRI). He aims to determine whether targeting these mitochondrial pathways can mitigate cellular dysfunction and establish the feasibility of mitochondrial-targeted therapeutic strategies to prevent primary graft dysfunction (PGD) following lung transplantation. Another focus of his research is identifying molecular regulators that contribute to chronic lung allograft dysfunction (CLAD). Guanxing earned his Ph.D. in Genetics and Proteomics from Capital Normal University in China. He completed his postdoctoral training at MD Anderson Cancer Center, where his research focused on integrating mass spectrometry–based proteomic screening with the study of ion channels and their roles in human disease.

Selected Publications

• G Chen, Q Li, J Yan "Concatenated modular BK channel constructs reveal divergent stoichiometry in gating control by LRRC26 (γ1), pore, and selectivity Filter." eLife.;
• Q Li, G Chen, J Yan "Transmembrane determinants of voltage-gating differences between BK (Slo1) and Slo3 channels." Biophysical Journal.;
• L Li, Q Ru, Y Lu, A Saifullah, G Chen, A Saifullah, C Yao, K Tolias "Tiam1 coordinates synaptic structural and functional plasticity underpinning the pathophysiology of neuropathic pain." Neuron.;
• G Chen, Q Li, J Yan "BK channel modulation by the -subunit positively charged peptides via electrostatic interactions with the calcium-bowl site." Journal of General Physiology.;