Hadley Stevens Smith

Hadley Stevens Smith, PhD, MPSA

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Hadley Stevens Smith, PhD, MPSA

Health Policy Fellow

Email

hadley.smith@bcm.edu

Positions

Health Policy Fellow: Center for Medical Ethics and Health Policy
Houston, Texas United States

Research Associate: Center For Medical Ethics and Healthy Policy
Baylor College of Medicine
Houston, TX

Research Associate: Mol. & Human Gen./Admin.
Baylor College of Medicine
Houston, TX US

Education

PhD from The University of Texas Health Science Center School of Public Health: 05/2019 - Houston; Health Economics

MPA from Texas A&M University: 05/2015 - College Station, Texas; Health Policy Analysis

BS from Texas A&M University: College Station, Texas; Political Science, Genetics

Professional Interests

Evaluation of clinical genomic sequencing, especially in newborn and pediatric populations
Ethical, Legal, and Social Implications (ELSI) of genomics
Public health genomics
Health equity and precision medicine
Child health and wellbeing
Patient-centered outcomes
Health outcome measurement
Economic evaluation of health care programs
Applied econometrics

Professional Statement

Hadley Stevens Smith is the Health Policy Fellow in the Center for Medical Ethics and Health Policy at Baylor College of Medicine. Dr. Smith is a health economist working at the intersection of health economics and the ethical, legal, and social implications (ELSI) of genomics. Her research examines precision medicine applications from patient-centered, clinical, and economic perspectives. Dr. Smith evaluates implementation of clinical genomics services using both quantitative and qualitative approaches. She is particularly interested in genomic sequencing of newborn and pediatric patient populations and assessment of family-level effects, including cascade screening of family members. She aims to inform policies that advance equitable and efficient implementation of genomic medicine to improve population health.

Additionally, Dr. Smith incorporates her training in public health and health policy to study equity and access issues in genomic medicine and co-leads a journal club on Social Determinants of Health, Medicine, and Ethics.

Dr. Smith earned a PhD in Health Economics from the University of Texas Health Science Center at Houston School of Public Health. She also holds a Master of Public Service and Administration with a concentration in Health Policy Analysis from the Bush School of Government and Public Service at Texas A&M University. Dr. Smith received her Bachelor of Science in Political Science with a minor in Genetics from Texas A&M University. She has also completed a Certificate in Genetics and Genomics from the Stanford University Center for Professional Development.

Selected Publications

Pereira S, Smith HS, Frankel LA, Christensen KD, Islam R, Robinson JO, Genetti CA, Blout Zawatsky CL, Zettler B, Parad RB, Waisbren SE, Beggs AH, Green RC, Holm IA, McGuire AL "Psychosocial Effect of Newborn Genomic Sequencing on Families in the BabySeq Project: A Randomized Clinical Trial." JAMA Pediatrics.;175(11):1132–1141. Pubmed PMID: 34424265
Smith HS, Brothers KB, Knight SJ, Ackerman SL, Rini C, Veenstra DL, McGuire AL, Wilfond BS, Malek J. "Conceptualization of utility in translational clinical genomics research." American Journal of Human Genetics. 2021 Nov 4;108(11)
Smith HS, Franciskovich R, Lewis AM, Gerard A, Littlejohn RJ, Nugent K, Rodriguez J, Streff H "Outcomes of Prior Authorization Requests for Genetic Testing in Outpatient Pediatric Genetics Clinics." Genet Med. 2021 May;23:950–955.
23. Smith HS, Swint JM, Lalani SR, Yamal JM, de Oliveira Otto MC, Castellanos S, Taylor A, Lee BH, Russell HV "Clinical Application of Genome and Exome Sequencing as a Diagnostic Tool for Pediatric Patients: a Scoping Review of the Literature." Genet Med. 2019 Jan;21(1) Pubmed PMID: 29760485

20. Smith HS, Swint JM, Lalani SR, de Oliveira Otto MC, Yamal JM, Russell HV, Lee BH. "Exome sequencing compared with standard genetic tests for critically ill infants with suspected genetic conditions." Genet Med. 2020 Aug;22(8):1303-1310. Pubmed PMID: 32336750
Smith HS, Russell HV, Lee BH, Morain SR. "Using the Delphi method to identify clinicians’ perceived importance of pediatric exome sequencing results." Genet Med. 2020 Jan;22(1) Pubmed PMID: 31273346
Smith HS, McGuire AL, Wittenberg E, Lavelle TA "Family-level Impact of Genetic Testing: Integrating Health Economics and Ethical, Legal, and Social Implications." Personalized Medicine. 2021 May 18;3:209-212. Pubmed PMID: 33728981
10. Smith HS, Morain SR, Robinson JO, Canfield I, Malek J, Rubanovich CK, Bloss CS, Ackerman SL, Biesecker B, Brothers KB, Goytia CN, Horowitz CR, Knight SJ, Koenig B, Kraft SA, Outram S, Rini C, Shipman KJ, Waltz M, Wilfond B, McGuire AL "Perceived utility of genomic sequencing: Qualitative analysis and synthesis of a conceptual model to inform instrument development.." Patient. 2021 Oct 18; Pubmed PMID: 34658003
Phillips KA, Trosman JR, Douglas MP, Gelb BD, Ferket BS, Hindorff LA, Slavotinek AM, Berg JS, Russell HV, Devine B, Greve V, Smith HS "US private payers’ perspectives on insurance coverage for genome sequencing versus exome sequencing: A study by the Clinical Sequencing Evidence-generating Research Consortium (CSER)." Genet Med.; Pubmed PMID: 4906461

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Funding

An ELSI-Integrated Evaluation of the Family-Level Utility of Pediatric Genomic Sequencing - #K99HG011491: The goal of the proposed research is to investigate how clinical genomic sequencing impacts families of pediatric patients. This research will develop an empirically informed framework of normative values important to families of pediatric patients, including ethical, legal, and social implications (ELSI), which will then be used to elicit preferences for features of sequencing from a nationally representative sample of parents in the US. The results of this work will lead to a measure of family utility that integrates ELSI and can be used in a decision analytic model to assess the impact of genomic sequencing and the importance of including family- level ELSI considerations in such analyses.

Health-related quality of life and family well-being in pediatric patients with genetic conditions and their families: A scoping review of the literature: The objective of this project is to systematically describe empirical literature on health-related quality of life measurement in pediatric patients with genetic conditions and their family members and on family well-being measurement in the context of genetic conditions.

Value ethics: Mapping strategies for value assessment and reimbursement of gene therapies for rare diseases: This Working Group will engage a broad range of stakeholders in developing guidance for ethically justified and patient-centered value assessment and reimbursement strategies for gene therapies.