Email

hadrogue@bcm.edu

Positions

Professor

Medicine-Nephrology
Baylor College of Medicine
Houston, TX US

Education

MD from Fac. de Ciencias Med., U. De Buenos Aires

12/1965 - Buenos Aires, Argentina

Internship at University Hospital School Of Medicine

12/1966 - Buenos Aires, Argentina

Fellowship at University Hospital School Of Medicine

01/1969 - Buenos Aires, Argentina

Internal Medicine

Fellowship at Tufts University: New England Medical Center

01/1978 - Boston, Massachusetts United States

Nephrology

Fellowship at University Hospital School Of Medicine

01/1971 - Buenos Aires, Argentina

Certifications

Clinical Hypertension

American Society of Hypertension

Nephrology

American Board of Internal Medicine

Internal Medicine

American Board of Internal Medicine

Professional Interests

• Acid-base and electrolyte disorders
• Hypertension
• Dialysis
• Acute kidney disease
• Chronic kidney disease

Professional Statement

The overall goal of my clinical and research professional interests is to deepen our understanding of disorders of fluid, electrolyte, and acid-base balance, as well as the role of sodium and potassium in the pathogenesis of primary hypertension. We have done original investigations that uncovered a number of fundamental issues, some of them listed below, including the determinants of hyperchloremic acidosis in diabetic ketoacidosis; maladaptation of the kidney in both metabolic acidosis and alkalosis; role of normal variations in PCO2 as determinants of plasma bicarbonate; changes in plasma anion gap during acid-base disorders; determinants of the changes in serum potassium in acid-base disorders; changes in bicarbonate space caused by titration of non-bicarbonate buffers; effect of respiratory and metabolic acid-base disorders on carbon dioxide titration curve in vivo; impairment in distal nephron acidification in chronic respiratory acidosis; acid-base patterns in patients with status asthmaticus; role of intracellular pH in acidification by the proton pump in turtle urinary bladder; uniformity of the ventilatory response (ΔPCO2 / ΔHCO3‾) in metabolic acid-base disorders; mechanisms of the arteriovenous acid-base disparity in circulatory failure; impairment of tissues glucose consumption in acidemic states; the salutary effects of modest fluid replacement in the management of diabetic ketoacidosis; impact of acute and chronic respiratory acid-base disorders on preexisting metabolic acidosis; demonstration of an apical chloride conductive pathway and GTP-binding proteins in turtle urinary bladder epithelial cells; mechanism of acetazolamide-induced rise in renal vascular resistance in the intact dog; and the regulation of potassium excretion in chronic renal failure.
Our interest in hyponatremia and hypernatremia led to the introduction of the Infusate formula and the Fluid-loss formula that allow quantitative projections of prescribed fluid therapy and ongoing fluid losses on the patient’s serum sodium. These simple equations known as the Adrogué-Madias formulas, have gained popularity among clinicians. More importantly, studies by other investigators have corroborated the predictive accuracy of these formulas.
Our focus on the role of sodium and potassium in the pathogenesis of hypertension allowed us to demonstrate the role of the Na+ / K+ ATPase on the K+-induced vascular relaxation; the rebound hypertension and impaired urea reduction ratio post-dialysis with low potassium dialysate; the interdependency of sodium and potassium intake in the pathogenesis of hypertension; and the role of potassium as a true antidote with respect to the non-salutary effect of sodium in primary hypertension.

Websites

Selected Publications

• Okuda Y, Adrogue HJ, Field JB, Nohara H, Yamashita K "Counterproductive effects of sodium bicarbonate in diabetic ketoacidosis.." J. Clin. Endocrinol. Metab.. 1996 Jan;81(1):314-20. Pubmed PMID: 8550770
• Adrogué HJ, Madias NE "Diagnosis and Treatment of Hyponatremia." 2014; Pubmed PMID: 24996937
• Adrogue HJ, Pena J, Comstock JP "Glyburide increases the secretion, tissue uptake, and action of insulin in conscious normal dogs.." Metab. Clin. Exp.. 1996 May;45(5):579-86. Pubmed PMID: 8622600
• Okuda Y, Adrogue HJ, Nakajima T, Mizutani M, Asano M, Tachi Y, Suzuki S, Yamashita K "Increased production of PDGF by angiotensin and high glucose in human vascular endothelium.." Life Sci.. 1996;59(17):1455-61. Pubmed PMID: 8890924