Email

howard.lin@bcm.edu

Education

BS from University of Texas at Austin

05/2013 - Austin, Texas United States

Biomedical Engineering

Professional Interests

• Mentor: Donald W. Parsons, MD, PhD
• Department: Molecular & Human Genetics

Professional Statement

My research interest involves applying computational and OMICS approaches to the translational research of pediatric histiocytic and lymphoproliferative disorders. As a student, I enjoy learning how data science and statistical approaches can be applied to solve biological questions. Recently, my focus has been on transcriptional regulation and machine learning, as well as the integration of multiple data types to advance our understanding of pediatric cancers.

Websites

Selected Publications

• Daniel Zinn, Amanda Grimes, Howard Lin, Rachel Bingham, Olive Eckstein, Carl Allen, Kenneth McClain "Hydroxyurea: A New Old Therapy for Langerhans Cell Histiocytosis." Blood. 2016 Nov 17;128(20):2462-2465. Pubmed PMID: 27688802
• B. Hogstad, ML. Berres, R. Chakraborty, J. Tang, C. Bigenwald, M. Serasinghe, K. Lim, H. Lin, TK. Man, R. Remark, S.Baxter, V.Kana, S.Jordan, Z.Karoulia, W.Kwan, M.Leboeuf, E. Brandt, H.Salmon, K.McClain, P.Poulikakos, J.Chipuk, W.Mulder, C.Allen, M.Merad "RAF/MEK/ERK pathway suppresses dendritic cell migration and traps dendritic cells in LCH lesions." J. Exp. Med. 2017 Dec 20;215(1):319-336. Pubmed PMID: 29263218
• K.McClain, J.Picarsic, R.Chakraborty, D.Zinn, H.Lin, H.Abhyankar, B.Scull, A.Shih, K.Lim, O.Eckstein, J.Lubega, T.Peters, W.Olea, T.Burke, N.Ahmed, J.Hicks, B.Tran, J.Jones, R.Dauser, M.Jeng, R.Baiocchi, D.Schiff, S.Goldman, K.Heym *not all shown* "CNS Langerhans cell histiocytosis: Common hematopoietic origin for LCH‐associated neurodegeneration and mass lesions." CA. 2018 Apr 6;124(12):2607-2620. Pubmed PMID: 29624648
• O.Eckstein, J.Visser, H.Lin, N.Karras, R.Chu, O.Abla, N.Hijiya, S.Kim, P.Campbell, W.Swafford, L.Ramirez, C.Fernandes, M.Murray, H.Abhyankar, A.Sher, M.Hermiston, M.Hogarty, M.Jordan, M.Merad, B.Rollins, K.McClain, C.Galindo, C.Allen *not all shown* "Clinical responses and persistent BRAF V600E+ blood cells in children with LCH treated with MAPK pathway inhibition." Blood. 2019 Apr 11;133(15):1691-1694. Pubmed PMID: 30718231