Indira Mysorekar, PhD
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Indira Mysorekar, PhD
Professor of Medicine; Chief of Basic and Translational Research
Positions
- Professor of Medicine; Chief of Basic and Translational Research
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Medicine
Infectious Diseases
Baylor College of Medicine
Houston, TX USA
- E.I. Wagner Endowed, M.D., Chair Internal Medicine II
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Department of Medicine
Infectious Diseases
Baylor College of Medicine
Houston, Texas United States
Education
- BS from University of Lund
- 05/1994 - Lund, Sweden
- MS from University of Lund
- 05/1995 - Lund, Sweden
- PhD from Washington University School of Medicine
- 05/2002 - St. Louis, Missouri United States
Honors & Awards
- J. Christian Herr Award from the American Society for Reproductive Immunology
- 01/2021
- Wagner Endowed Chair in Medicine
- 07/2021
- Woman Leader in Global Health-Midwest
- 01/2019
- James P. Crane Endowed Chair in Obstetrics and Gynecology
- 01/2019
- Outstanding Graduate Student Mentor award (2019 Mentor of the Year at Washington University)
- 01/2019
- Academic Women's Network Award for Outstanding Mentor, WUSM
- 01/2013
Professional Interests
- Urinary Tract Infections
Websites
Selected Publications
- Verma S, Joshi CS, Silverstein RB, He M, Carter EB, Mysorekar IU "SARS-CoV-2 colonization of maternal and fetal cells of the human placenta promotes alteration of local renin-angiotensin system.." Med (N Y). 2021 May 14;2303-2313. Pubmed PMID: 33870242
- Cao B, Parnell LA, Diamond MS, Mysorekar IU "Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice.." J Exp Med. 2017 Aug 7;575-590. Pubmed PMID: 28694387
- Miner JJ, Cao B, Govero J, Smith AM, Fernandez E, Cabrera OH, Garber C, Noll M, Klein RS, Noguchi KK, Mysorekar IU, Diamond MS. "Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise.." 2016 May 19;1081-1091. Pubmed PMID: 27180225
- Ligon MM, Wang C, DeJong EN, Schulz C, Bowdish DME, Mysorekar IU. "Single cell and tissue-transcriptomic analysis of murine bladders reveals age- and TNFα-dependent but microbiota-independent tertiary lymphoid tissue formation.." 2020 Nov 13;908-918. Pubmed PMID: 32366865
- Meister MR, Wang C, Lowder JL, Mysorekar IU. "Vaginal Estrogen Therapy Is Associated With Decreased Inflammatory Response in Postmenopausal Women With Recurrent Urinary Tract Infections.." 2021 Jan 1;e39-e44. Pubmed PMID: 31725016
- Wang C, Bauckman KA, Ross ASB, Symington JW, Ligon MM, Scholtes G, Kumar A, Chang HW, Twentyman J, Fashemi BE, Xavier RJ, Mysorekar IU "A non-canonical autophagy-dependent role of the ATG16L1T300A variant in urothelial vesicular trafficking and uropathogenic Escherichia coli persistence.." 2019 Mar 15;527-542. Pubmed PMID: 30335568
Funding
- Interleukin-6 and Aging: Impact on Immune Defense and Tissue Repair in Urinary Bladder - #R01AG052494 (09/30/2016 - 05/31/2021) Grant funding from NIH NIA
- Recurrent urinary tract infections afflict millions of post-menopausal women in the US each year, imposing a tremendous personal and financial burden on society. Our goal here is to understand how the sex hormone estrogen regulates the course of UTIs and bladder recovery after the infection. This work will lead to development of therapeutic interventions for this recalcitrant disease in aging menopausal populations.
- Mechanisms of Zika Virus Maternal-Fetal Transmission - #R01HD091218 (04/01/2017 - 03/31/2022) Grant funding from NIH NICHD
- The goal of this proposal is to identify how ZIKV is able to cross the placental barrier to cause adverse outcomes in the baby. This work has significant clinical implications for understanding ZIKV-pathology and for developing strategies for mitigating ZIKV trafficking through the placenta and thus reducing adverse outcomes.
- Molecular and neuro-inflammatory biology of aging bladder in normal and disease states - #P20DK119840 (12/01/2018 - 03/01/2021) Grant funding from NIH NIDDK
- This goal of this project is to facilitate collaborations between IIT Mandi (Giri lab) and Washington University (Mysorekar lab) to understand the biophysics of Zika virus membrane fusion and host placental pathogenesis
- Mechanism of age-associated inflammation and lymphoid neogenesis in the urinary bladder - #R56 AG064634 (07/01/2019 - 06/30/2024) Grant funding from NIH NIA
- The goal of this project is to define the cellular mechanisms driving chronic inflammation and response to recurrent urinary tract infections in the elderly, to develop and identify biomarkers of age-related immune function changes that can be used to guide future clinical trials and treatment strategies to improve responses to infections in the elderly.
- Molecular and neuro-inflammatory biology of aging bladder in normal and disease states: Administrative Core - #P20DK119840-01(5404) (09/01/2018 - 06/01/2021) Grant funding from NIH NIDDK
- Safety, Testing/Transmission, and Outcomes in Pregnancy with COVID-19 (STOP-COVID19) - #3R01HD091218-04S1 (11/01/2020 - 10/31/2022) NIH NICHD RADX-UP
- The goal of the study is to examine the factors that impede testing for SARS-CoV-2, help determine optimal testing strategies, inform prenatal care plans, and contribute to our ability to counsel women and create prenatal care plans if they are pregnant or considering pregnancy.
- Role of Gut Microbiota in Endometriosis - #R01HD102680 (04/01/2021 - 03/31/2026) Grant funding from NIH NICHD
- The goal of the project is to test that whereas some gut bacteria promote endometriosis by inducing inflammation, others protect against endometriosis by fermenting fiber to produce short chain fatty acids.
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