Email

indira.mysorekar@bcm.edu

Positions

Professor of Medicine; Chief of Basic and Translational Research

Medicine
Infectious Diseases
Baylor College of Medicine
Houston, TX USA

E.I. Wagner Endowed, M.D., Chair Internal Medicine II

Department of Medicine
Infectious Diseases
Baylor College of Medicine
Houston, Texas United States

Education

BS from University of Lund

05/1994 - Lund, Sweden

MS from University of Lund

05/1995 - Lund, Sweden

PhD from Washington University School of Medicine

05/2002 - St. Louis, Missouri United States

Honors & Awards

J. Christian Herr Award from the American Society for Reproductive Immunology

01/2021

Wagner Endowed Chair in Medicine

07/2021

Woman Leader in Global Health-Midwest

01/2019

James P. Crane Endowed Chair in Obstetrics and Gynecology

01/2019

Outstanding Graduate Student Mentor award (2019 Mentor of the Year at Washington University)

01/2019

Academic Women's Network Award for Outstanding Mentor, WUSM

01/2013

Professional Interests

• Urinary Tract Infections

Websites

Selected Publications

• Verma S, Joshi CS, Silverstein RB, He M, Carter EB, Mysorekar IU "SARS-CoV-2 colonization of maternal and fetal cells of the human placenta promotes alteration of local renin-angiotensin system.." Med (N Y). 2021 May 14;2303-2313. Pubmed PMID: 33870242
• Cao B, Parnell LA, Diamond MS, Mysorekar IU "Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice.." J Exp Med. 2017 Aug 7;575-590. Pubmed PMID: 28694387
• Miner JJ, Cao B, Govero J, Smith AM, Fernandez E, Cabrera OH, Garber C, Noll M, Klein RS, Noguchi KK, Mysorekar IU, Diamond MS. "Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise.." 2016 May 19;1081-1091. Pubmed PMID: 27180225
• Ligon MM, Wang C, DeJong EN, Schulz C, Bowdish DME, Mysorekar IU. "Single cell and tissue-transcriptomic analysis of murine bladders reveals age- and TNFα-dependent but microbiota-independent tertiary lymphoid tissue formation.." 2020 Nov 13;908-918. Pubmed PMID: 32366865

Funding

Interleukin-6 and Aging: Impact on Immune Defense and Tissue Repair in Urinary Bladder - #R01AG052494

(09/30/2016 - 05/31/2021) Grant funding from NIH NIA

Recurrent urinary tract infections afflict millions of post-menopausal women in the US each year, imposing a tremendous personal and financial burden on society. Our goal here is to understand how the sex hormone estrogen regulates the course of UTIs and bladder recovery after the infection. This work will lead to development of therapeutic interventions for this recalcitrant disease in aging menopausal populations.

Mechanisms of Zika Virus Maternal-Fetal Transmission - #R01HD091218

(04/01/2017 - 03/31/2022) Grant funding from NIH NICHD

The goal of this proposal is to identify how ZIKV is able to cross the placental barrier to cause adverse outcomes in the baby. This work has significant clinical implications for understanding ZIKV-pathology and for developing strategies for mitigating ZIKV trafficking through the placenta and thus reducing adverse outcomes.

Molecular and neuro-inflammatory biology of aging bladder in normal and disease states - #P20DK119840

(12/01/2018 - 03/01/2021) Grant funding from NIH NIDDK

This goal of this project is to facilitate collaborations between IIT Mandi (Giri lab) and Washington University (Mysorekar lab) to understand the biophysics of Zika virus membrane fusion and host placental pathogenesis

Mechanism of age-associated inflammation and lymphoid neogenesis in the urinary bladder - #R56 AG064634

(07/01/2019 - 06/30/2024) Grant funding from NIH NIA

The goal of this project is to define the cellular mechanisms driving chronic inflammation and response to recurrent urinary tract infections in the elderly, to develop and identify biomarkers of age-related immune function changes that can be used to guide future clinical trials and treatment strategies to improve responses to infections in the elderly.