Jacob Mandel, M.D.
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Positions
- Assistant Professor
-
Neurology
Baylor College of Medicine
Houston, TX US
- Member
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Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
Addresses
- Baylor Neurology (Clinic)
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Baylor College of Medicine Medical Center
McNair Campus
Houston, TX 77030
United States
Phone: (713) 798-2273
https://www.bcm.edu/healthcare/care-centers/neurology
Education
- Clinical Fellowship at MD Anderson Cancer Center
- 06/2014 - Houston, Texas United States
- Residency at Ohio State University Medical Center
- 06/2012 - Columbus, Ohio United States
- Internship at Ohio State University Medical Center
- 06/2009 - Columbus, Ohio United States
- MD from Rush Medical College
- 06/2008 - Chicago, Illinois United States
- BS from University of Illinois-Chicago
- 05/2004 - Chicago, Illinois United States
Certifications
- Board Certified in Neurology
- #57665 (09/20/2012 - 09/20/2022)
- American Board of Psychiatry and Neurology
- Board Certified in Neuro-Oncology
- #NO385-15 (08/31/2015 - 08/31/2025)
- United Council of Neurologic Subspecialties (UCNS)
Professional Interests
- Neuro-oncology
- Primary brain tumors
- Paraneoplastic syndromes
- Leptomeningeal disease
- Brain metastasis
- Clinical trials for primary brain tumors
- Venous thromboembolism in malignant brain tumors
Professional Statement
I am a board certified neuro-oncologist at Baylor College of Medicine responsible for treating patients with brain tumors, brain metastases, and neurologic complications of cancer. I am a co-leader for the Dan L Duncan Cancer center Glioma working group and co-moderator of a biweekly brain tumor board. My research has been accepted for oral presentations at the Society of Neuro-Oncology, the American Academy of Neurology and the European Neurological Society. I have published retrospective studies, topic reviews, case series and reports in several prestigious journals including Neurology, Neuro-Oncology, Journal of Neuro-oncology, Current Oncology Reports, Journal of Neurological Sciences as well as a few book chapters. I am also responsible for the education of heme/onc fellows and neurology residents regarding neuro-oncology at Baylor.Websites
Comprehensive list of publications and presentations
Selected Publications
- de Groot JF, Mandel JJ "Update on anti-angiogenic treatment for malignant gliomas." Curr Oncol Rep.2014/April16;: Pubmed PMID: 24510742
- Hamza MA, Mandel JJ, Conrad CA, Gilbert MR, Yung WK, Puduvalli VK, Degroot JF "Survival outcome of early versus delayed bevacizumab treatment in patients with recurrent glioblastoma." J Neurooncol.2014/May7;: Pubmed PMID: 24803001
- Mandel JJ, Olar A, Aldape KD, Tremont-Lukats IW "Lambrolizumab induced central nervous system (CNS) toxicity." J Neurol Sci.2014/June20;: Pubmed PMID: 24980937
- Mandel JJ, Yust-Katz S, Cachia D, Wu J, Liu D, de Groot JF, Yung AW, Gilbert MR. "Leptomeningeal dissemination in glioblastoma; an inspection of risk factors, treatment, and outcomes at a single institution.." J Neurooncol.2014/August29;: Pubmed PMID: 25168214
- Mandel JJ, Tummala S, Woodman KH, Tremont-Lukats I. "Delayed imaging abnormalities of neuro-invasive West Nile virus in cancer patients.." J Neurol Sci.. 2015 March 15; : Pubmed PMID: 25702151
- Yust-Katz S, Mandel JJ, Wu J, Yuan Y, Webre C, Pawar TA, Lhadha HS, Gilbert MR, Armstrong TS "Venous thromboembolism (VTE) and glioblastoma.." J Neurooncol.. 2015 August ; : Pubmed PMID: 25985958
- Ladha H, Pawar T, Gilbert MR, Mandel J, O-Brien B, Conrad C, Fields M, Hanna T, Loch C, Armstrong TS. "Wound healing complications in brain tumor patients on Bevacizumab." J Neurooncol.. 2015 August 23; : Pubmed PMID: 26298437
- Pacheco JM, Goodman JC, Mandel J. "Intracranial epithelioid hemangioendothelioma causing subacute loss of vision.." Neurology. 2015 August 25; : Pubmed PMID: 26304679
- Cachia D, Kamiya-Matsuoka C, Mandel JJ, Olar A, Cykowski MD, Armstrong TS, Fuller GN, Gilbert MR, De Groot JF. "Primary and secondary gliosarcomas: clinical, molecular and survival characteristics." J Neurooncol.. 2015 October 9; : Pubmed PMID: 26354773
- Mandel JJ, Cachia D, Liu D, Wilson C, Aldape K, Fuller G, de Groot JF. "Impact of IDH1 mutation status on outcome in clinical trials for recurrent glioblastoma." J Neurooncol. 2016 June 7; : Pubmed PMID: 27270908
- Mandel JJ, Goethe EA, Patel AJ, Heck K, Hutton GJ "Newly diagnosed ganglioglioma in an adult patient with multiple sclerosis.." J Neurol Sci. 2016 October 15; : Pubmed PMID: 27653865
- • Beechar VB, Srinivasan VM, Reznik OE, Sen A, Klisch TJ, Ropper AE, Mandel JJ, Heck KA, Seipel TJ, Patel AJ "Intraventricular Cavernomas of the Third Ventricle: Report of 2 Cases and a Systematic Review of the Literature." World Neurosurg. 2017 June 23; : Pubmed PMID: 28648908
- • Cachia D, Elshafeey NA, Kamiya-Matsuoka C, Hatami M, Alfaro-Munoz KD, Mandel JJ, Colen R, DeGroot JF. "Radiographic patterns of progression with associated outcomes after bevacizumab therapy in glioblastoma patients." J Neurooncol. 2017 July 12; : Pubmed PMID: 28702781
- Mandel JJ, Yust-Katz S, Patel AJ, Cachia D, Liu D, Park M, Yuan Y, A Kent T, de Groot JF "Inability of positive phase II clinical trials of investigational treatments to subsequently predict positive phase III clinical trials in glioblastoma." Neuro Oncol. 2017 July 31; : Pubmed PMID: 29016865
- Nascimento FA, Kan P, Sharp L, Mandel JJ "Spinal Dural Arteriovenous Fistula and Concomitant Intramedullary Spinal Lesion." Can J Neurol Sci.. 2017 December 18; : Pubmed PMID: 29251587
- Wagner KM, Mandel JJ, Goodman JC, Gopinath S, Patel AJ. "Intracranial Erdheim-Chester Disease mimicking parafalcine meningioma: report of two cases and review of the literature.." World Neurosurg. 2017 November 27; : Pubmed PMID: 29191545
- Fellner A, Makranz C, Lotem M, Bokstein F, Taliansky A, Rosenberg S, Blumenthal DT, Mandel J, Fichman S, Kogan E, Steiner I, Siegal T, Lossos A, Yust-Katz S "Neurologic complications of immune checkpoint inhibitors." J Neurooncol. 2018 January 13; : Pubmed PMID: 29332184
- Mandel JJ, Youssef M, Ludmir E, Yust-Katz S, Patel AJ, De Groot JF "Highlighting the need for reliable clinical trials in glioblastoma." Expert Rev Anticancer Ther.. 2018 July 12; : Pubmed PMID: 29973092
- Ludmir EB, Mandel JJ, McAleer MF, de Groot J "Disparities along the glioblastoma clinical trials landscape.." Neuro Oncol. 2018 November 26; : Pubmed PMID: 30476295
- Mandel JJ, Youssef M, Nam J, Patel AJ, Jalali A, Ludmir EB, Liu D, Wu J, Armstrong G, Huse J, Bondy M, de Groot JF. "Effect of health disparities on overall survival of patients with glioblastoma.." J Neurooncol. 2019 January 22; : Pubmed PMID: 30671709
- Bayley V JC, Goethe EA, Srinivasan VM, Klisch TK, Mandel JJ, Patel AJ "Newly-diagnosed Optic Pathway Glioma During Pregnancy: A Case Report.." World Neurosurg. 2019 March 13; : Pubmed PMID: 30878749
- • Ludmir EB, Mainwaring W, Lin TA, Miller AB, Jethanandani A, Espinoza AF, Mandel JJ, Lin SH, Smith BD, Smith GL, VanderWalde NA, Minsky BD, Koong AC, Stinchcombe TE, Jagsi R, Gomez DR, Thomas CR, Fuller CD "Factors Associated With Age Disparities Among Cancer Clinical Trial Participants." JAMA Oncology. 2019 June 3; : Pubmed PMID: 31158272
- Goethe, E. A.,Youssef, M.,Patel, A. J.,Jalali, A.,Goodman, J. C, Mandel, JJ "Recurrent Papillary Glioneuronal Tumor." World Neurosurg. 2019 May 13; : Pubmed PMID: 31078809
- Youssef M, Ludmir EB, Mandel JJ, Patel AJ, Jalali A, Treiber J, Wu J, McAleer MF, de Groot JF "Treatment Strategies for Glioblastoma in Older Patients: Age Is Just a Number.." J Neurooncol. 2019 October 13; : Pubmed PMID: 31643011
- Ludmir, E. B., Subbiah, I. M., Mainwaring, W., Miller, A. B., Lin, T. A., Jethanandani, A., Espinoza, A. F., Mandel, JJ., Fang, P., Smith, B. D., et al. "Decreasing incidence of upper age restriction enrollment criteria among cancer clinical trials." Journal of geriatric oncology. 2019 November 8; : Pubmed PMID: 31711757
- Prablek, M., Srinivasan, V. M., Srivatsan, A., Holdener, S., Oneissi, M., Heck, K. A., Jalali, A., Mandel, J, Viswanathan, A., & Patel, A. J. "Gastrointestinal stromal tumor with intracranial metastasis: case presentation and systematic review of literature." BMC cancer. 2019 November 15; : Pubmed PMID: 31730471
- Patel, R. R., Verma, V., Miller, A. B., Lin, T. A., Jethanandani, A., Espinoza, A. F., Mainwaring, W., Augustyn, A., Fuller, C. D., Sulman, E. P., Yeboa, D. N., Chung, C. C., McAleer, M. F., et al. "Exclusion of patients with brain metastases from cancer clinical trials." Neuro-oncology. 2020 April 15; : Pubmed PMID: 31900480
- de Groot, J., Penas-Prado, M., Alfaro-Munoz, K., Hunter, K., Pei, B. L., O'Brien, B., Weathers, S. P., Loghin, M., Kamiya Matsouka, C., Yung, W., Mandel, J., Wu, J., Yuan, Y., Zhou, S., Fuller, G. N., Huse, J., Rao, G., et al. "Window-of-opportunity clinical trial of pembrolizumab in patients with recurrent glioblastoma reveals predominance of immune-suppressive macrophages." Neuro-oncology. 2020 April 15; : Pubmed PMID: 31755915
- Nam JY, Gilbert A, Cachia D, Mandel J, Fuller GN, Penas-Prado M, de Groot J, Kamiya-Matsuoka C. "Pineal parenchymal tumor of intermediate differentiation: a single-institution experience." Neurooncol Pract. 2020 May 12; : Pubmed PMID: 33312675
- Torrealba-Acosta G., Mandel J. "Hyperostosis frontalis interna diagnosed after a provoked seizure." BMJ Case Rep. 2020 July ; : Pubmed PMID: 32611657
- Gopakumar S, Daou M, Gadot R, Ropper AE, Mandel J "Spinal meningioma in a patient with multiple sclerosis." Surg Neurol Int. 2020 July 18; : Pubmed PMID: 32754367
- e. Ben-Zion Berliner M, Katz LH, Derazne E, Levine H, Keinan-Boker L, Benouaich-Amiel A, Gal O, Kanner AA, Laviv Y, Honig A, Siegal T, Mandel J, Twig G, Yust-Katz S "Height as a risk factor in meningioma: a study of 2 million Israeli adolescents." BMC Cancer. 2020 August 20; : Pubmed PMID: 32819306
- d. Gal O, Dudnik E, Rotem O, Finkel I, Peretz I, Zer A, Mandel J, Amiel A, Siegal T, Bar J, Lobachov A, Yust S "Tyrosine Kinase Inhibitors as a Treatment of Symptomatic CNS Metastases in Oncogene-Driven NSCLC." J Oncol.. 2020 September 3; : Pubmed PMID: 32963526
- c. Soomro Z, Youssef M, Yust-Katz S, Jalali A, Patel AJ, Mandel J. "Paraneoplastic syndromes in small cell lung cancer." J Thorac Dis. 2020 October 12; : Pubmed PMID: 33209464
- b. Gopakumar S, Srinivasan VM, Hadley CC, Anand A, Daou M, Karas PJ, Mandel J, Gopinath SP, Patel AJ "Intracranial Solitary Fibrous Tumor of the Skull Base: Two Cases and Systematic Review of the Literature.." World Neurosurg. 2021 February 17; : Pubmed PMID: 33609763
- a. Benouaich-Amiel A, Khasminsky V, Gal O, Weiss T, Fichman S, Kanner AA, Berkowitz S, Laviv Y, Mandel J, Dudnik E, Siegal T, Yust-Katz S. "Multicentric non-enhancing lesions in glioblastoma: A retrospective study." J Clin Neurosci. 2021 January 3; : Pubmed PMID: 33581785
- • Jackson HN, Hadley CC, Khan AB, Gadot R, Bayley JC 5th, Shetty A, Mandel J, Jalali A, Gallagher KK, Sweeney AD, Harmanci AO, Harmanci AS, Klisch T, Gopinath SP, Rao G, Yoshor D, Patel AJ. "Racial and Socioeconomic Disparities in Patients With Meningioma: A Retrospective Cohort Study." Neurosurgery. 2022 January ; : Pubmed PMID: 34982878
- Mandel JJ, Youssef M, Yust-Katz S, Patel AJ, Jalali A, Li Z, Wu J, Ludmir EB, de Groot JF. IDH mutation status and the development of venous thromboembolism in astrocytoma patients. "IDH mutation status and the development of venous thromboembolism in astrocytoma patients.." J Neurol Sci.. 2021 August ; : Pubmed PMID: 34146775
- Tschernichovsky R, Katz LH, Derazne E, Berliner MB, Simchoni M, Levine H, Keinan-Boker L, Benouaich-Amiel A, Kanner AA, Laviv Y, Honig A, Dudnik E, Siegal T, Mandel J, Twig G, Yust-Katz S. "Height in adolescence as a risk factor for glioma subtypes: a nationwide retrospective cohort study of 2.2 million subject." NEURO-ONCOLOGY. 2021 August ; : Pubmed PMID: 33631004
- Sapienza LG, Ludwig MS, Mandel JJ, Nguyen DH, Echeverria AE "Could patients benefit from whole-brain radiotherapy with unilateral hippocampus sparing." Rep Pract Oncol Radiother.. 2021 June ; : Pubmed PMID: 34277100
- Alkabie S, Castrodad-Molina R, Heck KA, Mandel J, Hutton GJ "The concurrence of multiple sclerosis and glioblastoma." Mult Scler Relat Disord.. 2021 May ; : Pubmed PMID: 33711579
- Flores A, Gadot R, Noorbhai I, Hall H, Heck KA, Raper DMS, Xu D, Karas P, Mandel JJ, Ropper AE.” "S-100-negative, GNA11 mutation-positive intramedullary meningeal melanocytoma of the thoracic spine: A radiographic challenge and histologic anomaly." Surg Neurol Int.. 2021 June ; : Pubmed PMID: 34345456
Memberships
- American Academy of Neurology
- Society of Neuro-oncology
- American Society of Clinical Oncology
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