Jason
Middle Name
M.
Karch
Middle Name
M.
Picture

Jason
Middle Name
M.
Karch
Middle Name
M.
Assistant Professor
Positions
- Assistant Professor
-
Integrative Physiology
Baylor College of Medicine
Houston, TX US
Education
- PhD from University of Cincinnati
- 11/2012 - Cincinnati, Ohio United States
- Cell and Cancer Biology
- BA from Dakota Wesleyan University
- 05/2005 - Mitchell, South Dakota United States
- Biology
Professional Statement
Aberrant cell death is a common thread that binds various human diseases such as ischemic injuries, degenerative diseases, many types of cancer, and aging. Further mechanistic detail of the cell death pathways during these disease states is needed to identify efficacious novel therapeutic targets to prevent or induce cell death as needed. Specifically, we are interested in defining the regulated necrotic cell death pathway that leads to cardiomyocyte death during an ischemic event.Selected Publications
- Jason Karch, Michael J Bround, Hadi Khalil, Michelle A Sargent, Nadina Latchman, Naohiro Terada, Pablo M Peixoto, Jeffery D Molkentin "Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD." Science Advances.2019/August1;: Pubmed PMID: 31489369
- Jason Karch, Jennifer Q Kwong, Adam R Burr, Michelle A Sargent, John W Elrod, Pablo M Peixoto, Sonia Martinez-Caballero, Hanna Osinska, Emily HY Cheng, Jeffrey Robbins, Kathleen W Kinnally, Jeffery D Molkentin "Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice." ELife.2013/August27;2: Pubmed PMID: 23991283
- Jason Karch, Jeffery D Molkentin "Regulated necrotic cell death: the passive aggressive side of Bax and Bak." Circulation Research.2015/May22;116: Pubmed PMID: 25999420
- Jason Karch, Onur Kanisicak, Matthew J Brody, Michelle A Sargent, Demetria M Michael, Jeffery D Molkentin "Necroptosis interfaces with MOMP and the MPTP in mediating cell death." PloS one.2015/June10;10: Pubmed PMID: 26061004
- Jason Karch, Tobias G Schips, Bryan D Maliken, Matthew J Brody, Michelle A Sargent, Onur Kanisicak, Jeffery D Molkentin "Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak." Elife. 2017 November 17; 6 : Pubmed PMID: 29148970
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