Email

karch@bcm.edu

Positions

Assistant Professor

Molec. Physiology/Karch
Baylor College of Medicine

Education

PhD from University of Cincinnati

11/2012 - Cincinnati, Ohio United States

Cell and Cancer Biology

BA from Dakota Wesleyan University

05/2005 - Mitchell, South Dakota United States

Biology

Professional Statement

Aberrant cell death is a common thread that binds various human diseases such as ischemic injuries, degenerative diseases, many types of cancer, and aging. Further mechanistic detail of the cell death pathways during these disease states is needed to identify efficacious novel therapeutic targets to prevent or induce cell death as needed. Specifically, we are interested in defining the regulated necrotic cell death pathway that leads to cardiomyocyte death during an ischemic event.

Selected Publications

• Jason Karch, Michael J Bround, Hadi Khalil, Michelle A Sargent, Nadina Latchman, Naohiro Terada, Pablo M Peixoto, Jeffery D Molkentin "Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD." Science Advances. 2019 August 1; : Pubmed PMID: 31489369
• Jason Karch, Jennifer Q Kwong, Adam R Burr, Michelle A Sargent, John W Elrod, Pablo M Peixoto, Sonia Martinez-Caballero, Hanna Osinska, Emily HY Cheng, Jeffrey Robbins, Kathleen W Kinnally, Jeffery D Molkentin "Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice." ELife. 2013 August 27; 2 : Pubmed PMID: 23991283
• Jason Karch, Jeffery D Molkentin "Regulated necrotic cell death: the passive aggressive side of Bax and Bak." Circulation Research. 2015 May 22; 116 : Pubmed PMID: 25999420
• Jason Karch, Onur Kanisicak, Matthew J Brody, Michelle A Sargent, Demetria M Michael, Jeffery D Molkentin "Necroptosis interfaces with MOMP and the MPTP in mediating cell death." PloS one. 2015 June 10; 10 : Pubmed PMID: 26061004