Jeanine L Van Nostrand

Jeanine L Van Nostrand, Ph.D.

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Jeanine L Van Nostrand, Ph.D.

Assistant Professor

Email

jeanine.vannostrand@bcm.edu

Positions

Assistant Professor: Molecular and Cellular Biology
Baylor College of Medicine
Houston, TX

CPRIT Scholar in Cancer Research: Cancer Prevention and Research Institute of Texas (CPRIT)

Member: Dan L Duncan Comprehensive Cancer Center (BCM)
Houston,, TX

Member: Center for Metabolism and Experimental Therapeutics (BCM)

Faculty Member: Development, Disease Models & Therapeutics Graduate Program

Faculty Member: Cancer & Cell Biology Graduate Program

Education

Postdoctoral Fellowship at Reuben Shaw Lab, The Salk Institute for Biological Studies: La Jolla, California

PhD from Laura Attardi Lab, Stanford University: 06/2014 - Stanford, California; Cancer Biology

BS from University of Nebraska- Lincoln: 05/2003 - Lincoln, Nebraska; Biochemistry

Professional Interests

Mouse models of cancer and metabolic disease
AMPK and mTOR pathways
Hepatocellular carcinoma and Non-small cell lung Cancer

Professional Statement

Cells require energy to grow. Cancer occurs when cells find ways to circumvent limitations on energy, either through inhibiting pathways that prevent growth, activating pathways that promote growth, or finding new sources of energy. Two pathways critical for sensing the amount of energy in the cell and deciding whether cells should grow are the AMPK and mTOR pathways. Alterations in both of these pathways are implicated in cancer and metabolic disease. My lab is focused on 1) understanding the causative role of AMPK in hepatocellular carcinoma and 2) dissecting the role of AMPK-dependent regulation of mTOR in metabolic disease and cancer.

Selected Publications

Van Nostrand, J.L., Hellberg, K., Luo, E.C., Van Nostrand, E.L., Dayn, A., Yu, J., Shokhirev, M.N., Dayn, Y., Yeo, G.W., Shaw, R.J. "AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation." Genes Dev. 2020;34:1330-1344. Pubmed PMID: 32912901
Van Nostrand, J.L., Attardi, L.D "Guilty as CHARGED: p53’s expanding role in disease.." Cell Cycle. 2014;13(24):3798-807. Pubmed PMID: 25483057
Van Nostrand JL, Brady CA, Jung H, Fuentes DR, Kozak MM, Johnson TM, Lin CY, Lin CJ, Swiderski DL, Vogel H, Bernstein JA, Attié-Bitach T, Chang CP, Wysocka J, Martin DM, Attardi LD "Inappropriate p53 activation during development induces features of CHARGE syndrome.." Nature. 2014;514:228-32. Pubmed PMID: 25119037
Jacob, S.B.R., Van Nostrand, J.L., Bowen, M.E., Baker, J.C., Attardi, L.D. "SIVA plays a critical role in mouse embryonic development." Cell Death Differ. 2019;27(1):297-309. Pubmed PMID: 31164717

Van Nostrand, J.L., Bowen, M.E., Vogel, H., Barna, M., Attardi, L.D., "The p53 family members have distinct roles during mammalian embryonic development.." Cell Death Differ. 2017;24(4):575-579. Pubmed PMID: 28211873
Van Nostrand, J.L., Brisac, A., Mello S.S., Jacobs, S.B., Luong, R., Attardi, L.D. "The p53 target gene SIVA enables non-small cell lung cancer development.." Cancer Discov. 2015;5(6):622-35. Pubmed PMID: 25813352