Positions
- Associate Professor
-
Pediatrics - Neurology
Baylor College of Medicine
Houston, Texas USA
- Director
-
In Vivo Neurophysiology Core
Jan and Dan Duncan Neurological Research Institute
Houston, Texas USA
Addresses
- Jan and Dan Duncan Neurological Research Institute (Lab)
-
1250 Moursund St., Suite 1025
Houston, TX 77030
United States
Phone: (832) 824-8866
Fax: (832) 825-1271
jtang1@bcm.edu
- Jan and Dan Duncan Neurological Research Institute (Office)
-
1250 Moursund St., Suite 1025
Houston, TX 77030
United States
Phone: (832) 824-8866
Fax: (832) 825-1271
jtang1@bcm.edu
Education
- PhD from East China Normal University
- 07/1997 - Shanghai, China
- BSc from Southwest University
- 07/1984 - Chongqing, China
- Postdoctoral Fellowship at University Of Hamburg
- 08/2000 - Hamburg, Germany
- Postdoctoral Fellowship at Max Planck Institute Of Psychiatry
- 01/2002 - Munich, Germany
Websites
Selected Publications
- Wu Chen, Zhao-Lin Cai, Eugene S Chao, Hongmei Chen, Colleen M Longley, Shuang Hao, Hsiao-Tuan Chao, Joo Hyun Kim, Jessica E Messier, Huda Y Zoghbi, Jianrong Tang, John W Swann, Mingshan Xue "Stxbp1/Munc18-1 haploinsufficiency impairs inhibition and mediates key neurological features of STXBP1 encephalopathy." eLIFE.2020/February;: Pubmed PMID: 32073399
- Thomas K Creson, Camilo Rojas, Ernie Hwaun, Thomas Vaissiere, Murat Kilinc, Andres Jimenez-Gomez, Jimmy Lloyd Holder Jr, Jianrong Tang, Laura L Colgin, Courtney A Miller, Gavin Rumbaugh "Re-expression of SynGAP protein in adulthood improves translatable measures of brain function and behavior." eLIFE.2019/April;: Pubmed PMID: 31025938
- Amy E Pohodich, Hari Yalamanchili, Ayush T Raman, Ying-Wooi Wan, Michael Gundry, Shuang Hao, Haijing Jin, Jianrong Tang, Zhandong Liu, Huda Y Zoghbi "Forniceal deep brain stimulation induces gene expression and splicing changes that promote neurogenesis and plasticity." eLIFE.2018/March;: Pubmed PMID: 29570050
- James P. Orengo, Meike E. van der Heijden, Shuang Hao, Jianrong Tang, Harry T. Orr, Huda Y. Zoghbi "Motor neuron degeneration correlates with respiratory dysfunction in SCA1." Dis Model Mech.2018/February;: Pubmed PMID: 29419414
- Vincenzo A. Gennarino, Elizabeth E. Palmer, Laura M. McDonell, Li Wang, Carolyn J. Adamski, Amanda Koire, Lauren See, Christian P. Schaaf, Shuang Hao, Olivier Lichtarge, Jianrong Tang, Kym M. Boycott, J. Lloyd Holder, Jr., Huda Y. Zoghbi "A Mild PUM1 Mutation Is Associated with Adult-Onset Ataxia, whereas Haploinsufficiency Causes Developmental Delay and Seizures." Cell. 2018 February ; : Pubmed PMID: 29474920
- Yeh SY, Huang WH, Wang W, Ward CS, Chao ES, Wu Z, Tang B, Tang J, Sun JJ, Esther van der Heijden M, Gray PA, Xue M, Ray RS, Ren D, Zoghbi HY "Respiratory Network Stability and Modulatory Response to Substance P Require Nalcn." Neuron. 2017 April 19; 94 (2): 294-303. Pubmed PMID: 28392070
- Lasagna-Reeves CA, de Haro M, Hao S, Park J, Rousseaux MW, Al-Ramahi I, Jafar-Nejad P, Vilanova-Velez L, See L, De Maio A, Nitschke L, Wu Z, Troncoso JC, Westbrook TF, Tang J, Botas J, Zoghbi HY "Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model.." Neuron. 2016 October 19; 92 (2): 407-418. Pubmed PMID: 27720485
- Lu H, Ash RT, He L, Kee SE, Wang W, Yu D, Hao S, Meng X, Ure K, Ito-Ishida A, Tang B, Sun Y, Ji D, Tang J, Arenkiel BR, Smirnakis SM, Zoghbi HY "Loss and Gain of MeCP2 Cause Similar Hippocampal Circuit Dysfunction that Is Rescued by Deep Brain Stimulation in a Rett Syndrome Mouse Model." Neuron. 2016 August 17; 91 (4): 739-747. Pubmed PMID: 27499081
- Meng X, Wang W, Lu H, He LJ, Chen W, Chao ES, Fiorotto ML, Tang B, Herrera JA, Seymour ML, Neul JL, Pereira FA, Tang J, Xue M, Zoghbi HY. "Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders.." eLIFE. 2016 June 21; : e14199. Pubmed PMID: 27328325
- Ure K, Lu H, Wang W, Ito-Ishida A, Wu Z, He LJ, Sztainberg Y, Chen W, Tang J, Zoghbi HY. "Restoration of Mecp2 expression in GABAergic neurons is sufficient to rescue multiple disease features in a mouse model of Rett syndrome.." eLIFE. 2016 June 21; : e14198. Pubmed PMID: 27328321
- Sztainberg Y, Chen HM, Swann JW, Hao S, Tang B, Wu Z, Tang J, Wan YW, Liu Z, Rigo F, Zoghbi HY "Reversal of phenotypes in MECP2 duplication mice using genetic rescue or antisense oligonucleotides." Nature. 2015 December 3; 528 (7580): 123-126. Pubmed PMID: 26605526
- Hao S, Tang B, Wu Z, Ure K, Sun Y, Tao H, Gao Y, Patel AJ, Curry DJ, Samaco RC, Zoghbi HY, Tang J "Forniceal deep brain stimulation rescues hippocampal memory in Rett syndrome mice." Nature. 2015 October 15; 526 (7573): 430-434. Pubmed PMID: 26469053
- Jenson D, Yang K, Acevedo-Rodriguez A, Levine A, Broussard JI, Tang J, Dani JA "Dopamine and norepinephrine receptors participate in methylphenidate enhancement of in vivo hippocampal synaptic plasticity.." Neuropharmacology. 2015 March ; 90 : 23-32. Pubmed PMID: 25445492
- Han K, Holder JL, Schaaf CP, Lu H, Chen H, Kang H, Tang J, Wu Z, Hao S, Cheung SW, Yu P, Sun H, Breman AM, Patel A, Lu HC, Zoghbi HY "SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties." Nature. 2013 November 7; 503 (7474): 72-77. Pubmed PMID: 24153177
- Zhang TA, Tang J, Pidoplichko VI, Dani JA "Addictive nicotine alters local circuit inhibition during the induction of in vivo hippocampal synaptic potentiation.." J. Neurosci.. 2010 May 5; 30 (18): 6443-53. Pubmed PMID: 20445070
- Tang J, Dani JA "Dopamine enables in vivo synaptic plasticity associated with the addictive drug nicotine.." Neuron. 2009 September 10; 63 (5): 673-82. Pubmed PMID: 19755109
- Kamprath K, Marsicano G, Tang J, Monory K, Bisogno T, Di Marzo V, Lutz B, Wotjak CT "Cannabinoid CB1 receptor mediates fear extinction via habituation-like processes.." J. Neurosci.. 2006 June 21; 26 (25): 6677-86. Pubmed PMID: 16793875
- Wu LJ, Toyoda H, Zhao MG, Lee YS, Tang J, Ko SW, Jia YH, Shum FW, Zerbinatti CV, Bu G, Wei F, Xu TL, Muglia LJ, Chen ZF, Auberson YP, Kaang BK, Zhuo M "Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation.." J. Neurosci.. 2005 November 30; 25 (48): 11107-16. Pubmed PMID: 16319310
- Wanisch K, Tang J, Mederer A, Wotjak CT "Trace fear conditioning depends on NMDA receptor activation and protein synthesis within the dorsal hippocampus of mice.." Behav. Brain Res.. 2005 February 10; 157 (1): 63-9. Pubmed PMID: 15617772
- Tang J, Ko S, Ding HK, Qiu CS, Calejesan AA, Zhuo M "Pavlovian fear memory induced by activation in the anterior cingulate cortex.." Mol Pain. 2005 1 : 6. Pubmed PMID: 15813993
- Wei F, Xia XM, Tang J, Ao H, Ko S, Liauw J, Qiu CS, Zhuo M "Calmodulin regulates synaptic plasticity in the anterior cingulate cortex and behavioral response: a microelectroporation study in adult rodents." J Neurosci. 2003 September 10; 23 (23): 8402-8409. Pubmed PMID: 12968002
- Tang J, Wagner S, Schachner M, Dityatev A, Wotjak CT "Potentiation of amygdaloid and hippocampal auditory-evoked potentials in a discriminatory fear-conditioning task in mice as a function of tone pattern and context.." Eur. J. Neurosci.. 2003 August ; 18 (3): 639-50. Pubmed PMID: 12911760
- Tang J, Wotjak CT, Wagner S, Williams G, Melitta Schachner M, Dityatev A "Potentiated amygdaloid auditory-evoked potentials and freezing behavior after fear conditioning in mice." Brain Res. 2001 919 : 232-241. Pubmed PMID: 11701135
- Marsicano G, Wotjak CT, Azad SC, Bisogno T, Rammes G, Cascio MG, Hermann H, Tang J, Hofmann C, Zieglgänsberger W, Di Marzo V, Lutz B "The endogenous cannabinoid system controls extinction of aversive memories.." Nature. 2002 August 1; 418 (6897): 530-4. Pubmed PMID: 12152079
- Alcott CE, Yalamanchili HK, Ji P, van der Heijden ME, Saltzman A, Elrod N, Lin A, Leng, Bhatt B, Hao S, Wang Q, Saliba A, Tang J, Malovannaya A, Wagner EJ, Liu Z, Zoghbi HY "Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation." eLIFE. 2020 April ; 9 : 50895. Pubmed PMID: 32319885
- Shao Y, Sztainberg Y, Wang Q, Bajikar SS, Trostle AJ, Wan YW, Jafar-Nejad P, Rigo F, Liu Z, Tang J, Zoghbi HY. "Antisense oligonucleotide therapy in a humanized mouse model of MECP2 duplication syndrome." Sci Transl Med. 2021 March 3; 13 (583): aaz7785. Pubmed PMID: 33658357
- Shuang Hao, Qi Wang, Bin Tang, Zhenyu Wu, Tingting Yang, Jianrong Tang "CDKL5 deficiency augments inhibitory input into the dentate gyrus that can be reversed by deep brain stimulation." J Neurosci. 2021 September 17; : Pubmed PMID: 34544833
- Shuang Hao, Qi Wang, Bin Tang, Zhenyu Wu, Tingting Yang, Jianrong Tang "CDKL5 deficiency augments inhibitory input into the dentate gyrus that can be reversed by deep brain stimulation." J Neurosci. 2021 October 27; 41 (43): 9031-46. Pubmed PMID: 34544833
Projects
- In vivo analysis of neural network activities in mouse models of neurological disorders
- Jan and Dan Duncan Neurological Research Institute (07/2010 - present)
- Houston, Texas
Memberships
- Society for Neuroscience
- Regular member (01/2002)
- Molecular and Cellular Cognition Society
- Regular member (01/2002)
Funding
- Deep brain stimulation in Rett syndrome mice: cognitive benefits and their mechanisms - #R56NS100738
- $213,040.00 (04/01/2017 - 03/31/2018) Grant funding from NIH
- Deep brain stimulation in Rett syndrome mice: cognitive benefits and their mechanisms - #R01NS100738
- $886,193.00 (04/01/2018 - 03/31/2022) Grant funding from NIH
- Studies of forniceal deep brain stimulation and hippocampal memory in CDKL5 mice - #CDKL5–16–108–01
- $150,000.00 (05/01/2016 - 04/30/2017) Grant funding from LouLou Foundation
Skills
- system neuroscience
- cognitive neuroscience
- in vivo neurophysiology
- mouse behavior
- deep brain stimulation
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