Email

jpang@bcm.edu

Positions

Associate Professor

Department of Ophthalmology
Baylor College of Medicine
Houston, Texas United States

Addresses

Neurosensory Center (Office)

Baylor College of Medicine
Houston, TX 77030
United States
Phone: (713) 798-5527

Education

MD from Medical school, Xi'an Jiaotong University

Xi'an, P. R. China

PhD from Medical school, Xi'an Jiaotong University

Xi'an, P. R. China

Postdoctoral Fellowship at Baylor College of Medicine

01/2000 - Houston, Texas United States

Neurology

Postdoctoral Fellowship at Baylor College of Medicine

Houston, Texas United States

Ophthalmology

Professional Interests

• Complete identification of all retinal neurons with light-evoked activities and morphological features
• Retinal ion channels, synapses and neuronal circuitry
• Mechanosensitive ion channels in retinal function and diseases

Professional Statement

My work focuses on retinal visual signaling in physiological and pathological conditions. I characterize retinal photoreceptors, bipolar cells, amacrine cells, and ganglion cells with light-evoked activities and single-cell immunofluorescence. Based on such neuronal identities, I further study the signaling between photoreceptors and bipolar cells and synapses among bipolar cells, amacrine cells, and ganglion cells, primarily by using one- to eight-cell patch-clamp technologies, in conjunction with genetic engineering, electron microscopy, confocal microscopy, and immunocytochemistry. Built on these physiological data, my study further explores the role of mechanical-sensitive ion channels in normal retinal visual functions and the pathogenesis of glaucoma, traumatic retinal injury, and other pressure-related retinal disorders.

Websites

Selected Publications

• Frankfort BJ, Khan AK, Tse DY, Chung I, Pang JJ, Yang Z, Gross RL, Wu SM "Elevated intraocular pressure causes inner retinal dysfunction before cell loss in a mouse model of experimental glaucoma.." Invest. Ophthalmol. Vis. Sci.. 2013;54(1):762-70. Pubmed PMID: 23221072
• Pang JJ, Gao F, Lem J, Bramblett DE, Paul DL, Wu SM "Direct rod input to cone BCs and direct cone input to rod BCs challenge the traditional view of mammalian BC circuitry.." Proc. Natl. Acad. Sci. U.S.A.. 2010 Jan 5;107(1):395-400. Pubmed PMID: 20018684
• Pang JJ, Gao F, Wu SM "Light-evoked excitatory and inhibitory synaptic inputs to ON and OFF alpha ganglion cells in the mouse retina.." J. Neurosci.. 2003 Jul 9;23(14):6063-73. Pubmed PMID: 12853425
• Pang JJ, Gao F, Wu SM "Segregation and integration of visual channels: layer-by-layer computation of ON-OFF signals by amacrine cell dendrites.." J. Neurosci.. 2002 Jun 1;22(11):4693-701. Pubmed PMID: 12040076

Memberships

Association for Research in Vision and Ophthalmology

Member

Society for Neuroscience

Member

Royal Society of Medicine (London)

Member