Positions
- Associate Professor
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Medicine-Nephrology
Baylor College of Medicine
Houston, TX US
Addresses
- Alkek Building for Biomedical Research (Lab)
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Room: ABBR-R702
Houston, TX 77030
United States
Education
- Advanced Training from University Of Texas Medical Branch
- 01/2003 - Galveston, TX United States
- Advanced Training from University Of Texas Medical Branch
- 01/2001 - Galveston, TX United States
- M.S. from Tongji Medical University
- 01/1994 - Wuhan, China, People's Rep
- M.D. from Tongji Medical University
- 01/1991 - Wuhan, China, People's Rep
Professional Interests
- Cellular and molecular mechanisms underlying arteriovenous fistula (AVF)
- Chronic kidney diseases (CKD)
Websites
Selected Publications
- Zhang L, Ma Y, Zhang J, Cheng J, Du J "A new cellular signaling mechanism for angiotensin II activation of NF-kappaB: An IkappaB-independent, RSK-mediated phosphorylation of p65.." Arterioscler. Thromb. Vasc. Biol.. 2005 Jun;25(6):1148-53. Pubmed PMID: 15802625
- Qi G, Jia L, Li Y, Bian Y, Cheng J, Li H, Xiao C, Du J "Angiotensin II infusion-induced inflammation, monocytic fibroblast precursor infiltration, and cardiac fibrosis are pressure dependent.." Cardiovasc. Toxicol.. 2011 Jun;11(2):157-67. Pubmed PMID: 21373977
- Ma Y, Zhang L, Peng T, Cheng J, Taneja S, Zhang J, Delafontaine P, Du J "Angiotensin II stimulates transcription of insulin-like growth factor I receptor in vascular smooth muscle cells: role of nuclear factor-kappaB.." Endocrinology. 2006 Mar;147(3):1256-63. Pubmed PMID: 16322063
- Pan L, Li Y, Jia L, Qin Y, Qi G, Cheng J, Qi Y, Li H, Du J "Cathepsin S Deficiency Results in Abnormal Accumulation of Autophagosomes in Macrophages and Enhances Ang II-Induced Cardiac Inflammation.." PLoS ONE. 2012;7(4):e35315. Pubmed PMID: 22558139
- Liang A, Wang Y, Han G, Truong L, Cheng J "Chronic kidney disease accelerates endothelial barrier dysfunction in a mouse model of an arteriovenous fistula.." Am. J. Physiol. Renal Physiol.. 2013 Jun;304(12):F1413-20. Pubmed PMID: 23576636
- Zhang L, Cheng J, Ma Y, Thomas W, Zhang J, Du J "Dual pathways for nuclear factor kappaB activation by angiotensin II in vascular smooth muscle: phosphorylation of p65 by IkappaB kinase and ribosomal kinase.." Circ. Res.. 2005 Nov 11;97(10):975-82. Pubmed PMID: 16224066
- Cheng J, Wang Y, Liang A, Jia L, Du J "FSP-1 Silencing in Bone Marrow Cells Suppresses Neointima Formation in Vein Graft.." Circ. Res.. 2012 Jan 20;110(2):230-40. Pubmed PMID: 22116816
- Li Y, Zhang C, Wu Y, Han Y, Cui W, Jia L, Cai L, Cheng J, Li H, Du J "Interleukin-12p35 Deletion Promotes CD4 T-Cell-Dependent Macrophage Differentiation and Enhances Angiotensin II-Induced Cardiac Fibrosis.." Arterioscler. Thromb. Vasc. Biol.. 2012 Jul;32(7):1662-74. Pubmed PMID: 22556333
- Ma F, Li Y, Jia L, Han Y, Cheng J, Li H, Qi Y, Du J "Macrophage-Stimulated Cardiac Fibroblast Production of IL-6 Is Essential for TGF ß/Smad Activation and Cardiac Fibrosis Induced by Angiotensin II.." PLoS ONE. 2012;7(5):e35144. Pubmed PMID: 22574112
- Cheng J, Zhang J, Merched A, Zhang L, Zhang P, Truong L, Boriek AM, Du J "Mechanical stretch inhibits oxidized low density lipoprotein-induced apoptosis in vascular smooth muscle cells by up-regulating integrin alphavbeta3 and stablization of PINCH-1.." J. Biol. Chem.. 2007 Nov 23;282(47):34268-75. Pubmed PMID: 17878168
- Cheng J, Du J "Mechanical stretch simulates proliferation of venous smooth muscle cells through activation of the insulin-like growth factor-1 receptor.." Arterioscler. Thromb. Vasc. Biol.. 2007 Aug;27(8):1744-51. Pubmed PMID: 17541019
- Wu X, Cheng J, Li P, Yang M, Qiu S, Liu P, Du J "Mechano-sensitive transcriptional factor egr-1 regulates insulin-like growth factor-1 receptor expression and contributes to neointima formation in vein grafts.." Arterioscler. Thromb. Vasc. Biol.. 2010 Mar;30(3):471-6. Pubmed PMID: 19965784
- Haudek SB, Cheng J, Du J, Wang Y, Hermosillo-Rodriguez J, Trial J, Taffet GE, Entman ML "Monocytic fibroblast precursors mediate fibrosis in angiotensin-II-induced cardiac hypertrophy.." J. Mol. Cell. Cardiol.. 2010 Sep;49(3):499-507. Pubmed PMID: 20488188
- Cheng J, Cui R, Chen CH, Du J "Oxidized low-density lipoprotein stimulates p53-dependent activation of proapoptotic Bax leading to apoptosis of differentiated endothelial progenitor cells.." Endocrinology. 2007 May;148(5):2085-94. Pubmed PMID: 17289842
- Ren J, Yang M, Qi G, Zheng J, Jia L, Cheng J, Tian C, Li H, Lin X, Du J "Proinflammatory protein CARD9 is essential for infiltration of monocytic fibroblast precursors and cardiac fibrosis caused by Angiotensin II infusion.." Am. J. Hypertens.. 2011 Jun;24(6):701-7. Pubmed PMID: 21436792
- Zhang L, Dong Y, Dong Y, Cheng J, Du J "Role of Integrin-ß3 Protein in Macrophage Polarization and Regeneration of Injured Muscle.." J. Biol. Chem.. 2012 Feb 24;287(9):6177-86. Pubmed PMID: 22210777
- Cheng J, Truong LD, Wu X, Kuhl D, Lang F, Du J "Serum- and glucocorticoid-regulated kinase 1 is upregulated following unilateral ureteral obstruction causing epithelial-mesenchymal transition.." Kidney Int.. 2010 Oct;78(7):668-78. Pubmed PMID: 20631674
- Yang M, Zheng J, Miao Y, Wang Y, Cui W, Guo J, Qiu S, Han Y, Jia L, Li H, Cheng J, Du J "Serum-Glucocorticoid Regulated Kinase 1 Regulates Alternatively Activated Macrophage Polarization Contributing to Angiotensin II-Induced Inflammation and Cardiac Fibrosis.." Arterioscler. Thromb. Vasc. Biol.. 2012 Jul;32(7):1675-86. Pubmed PMID: 22556335
- Cheng J, Wang Y, Ma Y, Chan BT, Yang M, Liang A, Zhang L, Li H, Du J "The mechanical stress-activated serum-, glucocorticoid-regulated kinase 1 contributes to neointima formation in vein grafts.." Circ. Res.. 2010 Nov 12;107(10):1265-74. Pubmed PMID: 20884880
- 1. Luo J, Liang A, Liang M, Xia R, Rizvi Y, Wang Y, Cheng J. "Serum Glucocorticoid-Regulated Kinase 1 Blocks CKD-Induced Muscle Wasting Via Inactivation of FoxO3a and Smad2/3." J Am Soc Nephrol. 2016 Sep;(2797):808.
- 2. Liang M, Wang Y, Liang A, Mitch, WE, Roy-Chaudhury P, Han G, Cheng J. "Migration of smooth muscle cells from the arterial anastomosis of arteriovenous fistulas requires Notch activation to form neointima." Kidney International. 2015;88:490-502.
- 3. Luo, J., Liang, M., Mitch, W. E., Danesh, F., Yu, Z., Cheng, J. "FSP-1 Impairs the function of Endothelium leading to Failure of Arteriovenous Grafts in Diabetic Mice.." Endocrinology. 2015;(185):1234-50.
- 4. Liang, M., Woodard, L., Luo, J., Wilson, M., Mitch, W.E., Cheng, J. "Protective Role of Insulin-Like Growth Factor-1 Receptor in Endothelial Cells against Unilateral Ureteral Obstruction-Induced Renal Fibrosis.." Am J Pathol.. 2015;5(185):1234-50.
Funding
- CHRONIC KIDNEY DISEASE ADVERSELY INFLUENCES VASCULAR FUNCTIONS - #1R01DK095867
- $217,000.00 (03/15/2013 - 02/01/2018) Grant funding from NIH/NIDDK
- The major goals of this project are to study the role of Notch signaling in CKD-induced neointima formation in arteriovenous fistula.
- Epigenetic alterations of GSTA4 regulate CKD-induced vascular remodeling - #15GRNT25700209
- $150,000.00 (07/01/2015 - 06/30/2017) Grant funding from American Heart Association
- The goal of this project is to investigate the influence of the CKD on GSTA4 expression and neointima formation in arteriovenous fistula.
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