John Moore Vierling, MD, FACP, FAASLD, AGAF
Picture
John Moore Vierling, MD, FACP, FAASLD, AGAF
Professor of Medicine, Transplant Hepatology Medical Director
Phone
Phone
Positions
- Professor of Medicine, Transplant Hepatology Medical Director
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Medicine
Section of Gastroenterology and Hepatology
Baylor College of Medicine
Houston, Texas United States
Tenured
- Chief of Hepatology
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Medicine
Section of Gastroenterology and Hepatology
Baylor College of Medicine
Houston, Texas United States
- Director, Baylor Liver Health
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Medicine
Section of Gastroenterology and Hepatology
Baylor College of Medicine
Houston, Texas United States
- Professor of Surgery
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Surgey
Division of Abdominal Transplantation
Baylor College of Medicine
Houston, Texas United States
Tenured
- Director, Advanced Liver Therapies at St. Luke's Medical Center
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Medicine
Section of Gastroenterology and Hepatology
Baylor College of Medicine
Houston, Texas United States
Addresses
- Abdominal Transplant & Liver Disease (Clinic)
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Baylor Clinic
6620 Main Street, Suite 1450
Houston, TX 77030
United States
SCHEDULE APPOINTMENT - (832) 355-1400
- Department of Surgery (Office)
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Baylor College of Medicine
One Baylor Plaza
Houston, TX 77030
United States
- Advanced Liver Therapies (Lab)
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Baylor Clinic
6620 Main Street
Houston, TX 77030
United States
Phone: (713) 798-1966
https://www.bcm.edu/research/labs-and-centers/research-centers/advanced-liver-therapies-research/clinical-trials
Education
- Residency at University of Rochester Strong Memorial Hospital
- 06/1974 - Rochester, New York United States
- MD from Stanford University School of Medicine
- 06/1972 - Stanford, California United States
- Medicine
- Fellowship at University of California, San Francisco School Of Medicine
- 06/1978 - San Francisco, California United States
- Research Fellowship at National Institutes of Health
- 06/1977 - Bethesda, Maryland United States
Certifications
- Diplomate - Internal Medicine
- American Board of Internal Medicine
- Diplomate - Gastroenterology
- American Board of Internal Medicine
- Diplomate - Transplant Hepatology
- American Board of Internal Medicine
- Diplomate
- National Board of Medical Examiners
Honors & Awards
- Distinguished Scientist Award
- St. Luke's Hospital
- George Jamieson Award for Outstanding Public Service
- American Liver Foundation
- Best Doctors in America
- Awardee of 20 Consecutive Years of Selection by Peers
- American Health (01/2000)
- America’s Top Doctors
- Castle Connolly Medical Ltd.
- Who’s Who in America
- America’s Registry of Outstanding Professionals
- Who’s Who in Science and Engineering
- Who's Who in the World
- Selected annually since 2017
- Marquis Who's Who (01/2017)
- Chairman, Board of Directors
- Development of SEPET (TM) Liver Assist Device
- Arbios Systems, Inc. (01/1999 - 08/2008)
- Member, Board of Directors
- Independent Member of BOD for Athenex, Inc. that focuses on the discovery, development and commercialization of novel therapeutics for cancer.
- Athenex, Inc. (01/2019)
Professional Interests
- Transplant Hepatology
- Pre- and post-liver transplantation care
- Liver failure
- Hepatitis
- Cirrhosis
- Primary sclerosing cholangitis
- Drug-induced liver injury
- Wilson disease
- Hemochromatosis
- Alpha-1-antitrypsin deficiency
- Hepatocellular carcinoma (HCC) and cholangocarcinoma,
- Gastroesophageal varices
- Hepatic encephalopathy
Professional Statement
Dr. Vierling is board certified in internal medicine and gastroenterology and was previously certified in Transplant Hepatology from 2006-2016. He is a Fellow of the American College of Physicians, Fellow of the American Association for the Study of Liver Diseases and an American Gastroenterology Association Fellow. He was the founding Medical Director of Liver Transplantation and Director of Hepatology and instrumental in the founding of the current liver transplant program at the University of Colorado Health Sciences Center. He was subsequently the founding Medical Director of Liver Transplantation and Director of Hepatology at Cedars-Sinai Medical Center/UCLA. After 10 years as Medical Director of Liver Transplantation, he became the Medical Director of Multi-Organ Transplantation at Cedars-Sinai/UCLA.Dr. John M. Vierling directs Advanced Liver Therapies, a clinical research unit devoted to hepatobiliary diseases. He and his research staff are conducting phase 1-3 studies of diagnostics and therapies in chronic hepatitis B, chronic hepatitis C, primary biliary cirrhosis, non-alcoholic fatty liver disease, anti-fibrotic therapy to prevent cirrhosis, hepatic encephalopathy, and measurement of hepatocellular function using 13C-labeled compounds. Dr. Vierling’s primary research interests are the immunopathogenic mechanisms involved in hepatobiliary injury caused by viral infection, autoimmunity, alloimmunity, and non-alcoholic fatty liver disease. By emphasizing a "laboratory bench to bedside" philosophy, Dr. Vierling has also been active in the design and execution of clinical therapeutic trials of antiviral agents for treatment of hepatitis B and C infections in patients before and after liver transplantation, and trials of immunosuppressive drugs in liver transplantation and autoimmune liver diseases. Dr. Vierling’s basic science laboratory investigations have used murine models to study the immunopathogenesis of non-suppurative destructive cholangitis, which destroys bile ducts in primary biliary cirrhosis, an autoimmune liver disease, as well as in two alloimmune diseases, hepatic allograft rejection and chronic graft-versus-host disease. Dr. Vierling is the author of numerous research publications.
Websites
Abdominal Transplant and Liver Disease Clinic
The transplant hepatology team has provided leadership for an ambitious international initiative to formally change the name of PBC from “Primary Biliary Cirrhosis” to “Primary Biliary Cholangitis.”
Videos
Selected Publications
- Bourlière M, Gordon SC, Flamm SL, Cooper CL, Ramji A, Tong M, Ravendhran N, Vierling JM, et al "Sofosbuvir, Velpatasvir, and Voxilaprevir for Previously Treated HCV Infection." N Engl J Med.; Pubmed PMID: 28564569
- Bacon BR, Gordon SC, Lawitz E, Marcellin P, Vierling JM, Zeuzem S, Poordad F, Goodman ZD, Sings HL, Boparai N, Burroughs M, Brass CA, Albrecht JK, Esteban R "Boceprevir for previously treated chronic HCV genotype 1 infection.." N. Engl. J. Med.. 2011 Mar 31;364(13):1207-17. Pubmed PMID: 21449784
- Hwang JP, Mohseni M, Gor BJ, Wen S, Guerrero H, Vierling JM "Hepatitis B and hepatitis C prevalence and treatment referral among Asian Americans undergoing community-based hepatitis screening.." Am J Public Health. 2010 Apr 1;100:S118-24. Pubmed PMID: 20147697
- Ilyas JA, Vierling JM "An overview of emerging therapies for the treatment of chronic hepatitis C.." Clin Liver Dis. 2011 Aug;15(3):515-36. Pubmed PMID: 21867934
- Kwo PY, Lawitz EJ, McCone J, Schiff ER, Vierling JM, Pound D, Davis MN, Galati JS, Gordon SC, Ravendhran N, Rossaro L, Anderson FH, Jacobson IM, Rubin R, Koury K, Pedicone LD, Brass CA, Chaudhri E, Albrecht JK "Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial.." Lancet. 2010 Aug 28;376(9742):705-16. Pubmed PMID: 20692693
- Manns MP, Czaja AJ, Gorham JD, Krawitt EL, Mieli-Vergani G, Vergani D, Vierling JM "Diagnosis and management of autoimmune hepatitis.." Hepatology. 2010 Jun;51(6):2193-213. Pubmed PMID: 20513004
- Merwat SN, Vierling JM "HIV Infection and the Liver: The Importance of HCV-HIV Coinfection and Drug-Induced Liver Injury.." Clin Liver Dis. 2011 Feb;15(1):131-52. Pubmed PMID: 21111997
- Muir AJ, Shiffman ML, Zaman A, Yoffe B, de la Torre A, Flamm S, Gordon SC, Marotta P, Vierling JM, Carlos Lopez-Talavera J, Byrnes-Blake K, Fontana D, Freeman J, Gray T, Hausman D, Hunder NN, Lawitz E "Phase 1b study of pegylated interferon lambda 1 with or without ribavirin in patients with chronic genotype 1 hepatitis C virus infection.." Hepatology. 2010 Sep;52(3):822-32. Pubmed PMID: 20564352
- Nguyen NT, Vierling JM "Acute liver failure.." Curr Opin Organ Transplant. 2011 Jun;16(3):289-96. Pubmed PMID: 21519261
- Vierling JM "Autoimmune hepatitis and antigen-specific T regulatory cells: When can we send in the regulators?." Hepatology. 2011 Feb;53(2):385-8. Pubmed PMID: 21274860
- Vierling JM, Hreha G, Wang H, Braun M "The role of biliary epithelial cells in the immunopathogenesis of non-suppurative destructive cholangitis in murine hepatic graft-versus-host disease.." Trans. Am. Clin. Climatol. Assoc.. 2010;122:326-35. Pubmed PMID: 21686235
- Barshes NR, Horwitz IB, Franzini L, Vierling JM, Goss JA "Waitlist mortality decreases with increased use of extended criteria donor liver grafts at adult liver transplant centers.." Am. J. Transplant.. 2007 May;7(5):1265-70. Pubmed PMID: 17359503
- Hu KQ, Vierling JM, Redeker AG "Viral, host and interferon-related factors modulating the effect of interferon therapy for hepatitis C virus infection.." J. Viral Hepat.. 2001 Jan;8(1):41292. Pubmed PMID: 11155147
- Hu KQ, Yu CH, Vierling JM "Up-regulation of intercellular adhesion molecule 1 transcription by hepatitis B virus X protein.." Proc. Natl. Acad. Sci. U.S.A.. 1992 Dec 1;89(23):11441-5. Pubmed PMID: 1360668
- Mizuno M, Brown WR, Vierling JM "Ultrastructural immunocytochemical localization of the asialoglycoprotein receptor in rat hepatocytes.." Gastroenterology. 1984 Oct;87(4):763-9. Pubmed PMID: 6088350
- Coffman KL, Hoffman A, Sher L, Rojter S, Vierling J, Makowka L "Treatment of the postoperative alcoholic liver transplant recipient with other addictions.." Liver Transpl Surg. 1997 May;3(3):322-7. Pubmed PMID: 9346758
- Stribling R, Sussman N, Vierling JM "Treatment of hepatitis C infection.." Gastroenterol. Clin. North Am.. 2006 Jun;35(2):463-86. Pubmed PMID: 16880075
- Watanabe FD, Shackleton CR, Cohen SM, Goldman DE, Arnaout WS, Hewitt W, Colquhoun SD, Fong TL, Vierling JM, Busuttil RW, Demetriou AA "Treatment of acetaminophen-induced fulminant hepatic failure with a bioartificial liver.." Transplant. Proc..;29(41276):487-8. Pubmed PMID: 9123096
- Czaja AJ, Bianchi FB, Carpenter HA, Krawitt EL, Lohse AW, Manns MP, McFarlane IG, Mieli-Vergani G, Toda G, Vergani D, Vierling J, Zeniya M "Treatment challenges and investigational opportunities in autoimmune hepatitis.." Hepatology. 2005 Jan;41(1):207-15. Pubmed PMID: 15690485
- Shackleton CR, Colquhoun SD, Vierling JM "Transplantation of the right hepatic lobe.." N. Engl. J. Med.. 2002 Aug 22;347(8):615-8; author r. Pubmed PMID: 12195588
- Berry WR, Gottesfeld RL, Alter HJ, Vierling JM "Transmission of hepatitis B virus by artificial insemination.." JAMA. 1987 Feb 27;257(8):1079-81. Pubmed PMID: 3806899
- Yu AS, Vierling JM, Colquhoun SD, Arnaout WS, Chan CK, Khanafshar E, Geller SA, Nichols WS, Fong TL "Transmission of hepatitis B infection from hepatitis B core antibody--positive liver allografts is prevented by lamivudine therapy.." Liver Transpl.. 2001 Jun;7(6):513-7. Pubmed PMID: 11443579
- Cosenza CA, Hoffman AL, Friedman ML, Sher LS, Lopez RR, Van Allen R, Brown DH, Fraiman MH, Arnaout W, Vierling J, Makowka L "Transjugular intrahepatic portosystemic shunt: efficacy for the treatment of portal hypertension and impact on liver transplantation.." Am Surg. 1996 Oct;62(10):835-9. Pubmed PMID: 8813166
- Hu KQ, Vierling JM, Siddiqui A "Trans-activation of HLA-DR gene by hepatitis B virus X gene product.." Proc. Natl. Acad. Sci. U.S.A.. 1990 Sep;87(18):7140-4. Pubmed PMID: 2169620
- Steer CJ, James SP, Vierling JM, Hosea SW, Jones EA "The selective hepatic uptake of desialylated peripheral blood mononuclear cells in rabbits.." Gastroenterology. 1980 Nov;79(5):917-23. Pubmed PMID: 7419016
- James SP, Vierling JM, Strober W "The role of the immune response in the pathogenesis of primary biliary cirrhosis.." Semin. Liver Dis.. 1981 Nov;1(4):322-37. Pubmed PMID: 7051311
- Vierling JM "The immunology of hepatitis B.." Clin Liver Dis. 2007 Nov;11(4):727-59, vii-vii. Pubmed PMID: 17981227
- Trépo C, Vierling J, Zeytin FN, Gerlich WH "The first Flaviviridae symposium.." Intervirology. 1997;40(4):279-88. Pubmed PMID: 9612731
- Braun M, Vierling JM "The clinical and immunologic impact of using interferon and ribavirin in the immunosuppressed host.." Liver Transpl.. 2003 Nov;9(11):S79-89. Pubmed PMID: 14586901
- Sher LS, Cosenza CA, Petrovic LM, Rojter S, Hoffman A, Lopez RR, Meehan M, Pan SH, Vierling J, Makowka L "Tacrolimus (FK 506) for rescue of chronic rejection following orthotopic liver transplantation.." Transplant. Proc.. 1996 Apr;28(2):1011-3. Pubmed PMID: 8623212
- Ichiki Y, Bowlus CL, Shimoda S, Ishibashi H, Vierling JM, Gershwin ME "T cell immunity and graft-versus-host disease (GVHD).." Autoimmun Rev. 2006 Jan;5(1):41283. Pubmed PMID: 16338205
- Selmi C, Ceribelli A, Vierling JM "Suspected and unsuspected factors in the multifaceted immunopathology of viral hepatitis.." Semin Immunopathol. 2013 Jan;35(1):41279. Pubmed PMID: 23250654
- Coffman KL, Sher L, Hoffman A, Rojter S, Folk P, Cramer DV, Vierling J, Villamel F, Podesta L, Demetriou A, Makowka L "Survey results of transplant patients' attitudes on xenografting.." Psychosomatics.;39(4):379-83. Pubmed PMID: 9691708
- Howell CD, Yoder TY, Vierling JM "Suppressor function of liver mononuclear cells isolated during murine chronic graft-vs-host disease. II. Role of prostaglandins and interferon-gamma.." Cell. Immunol.. 1992 Mar;140(1):54-66. Pubmed PMID: 1531454
- Howell CD, Yoder TD, Vierling JM "Suppressor function of hepatic mononuclear inflammatory cells during murine chronic graft-vs-host disease. I. Macrophage-enriched cells mediate suppression in the liver.." Cell. Immunol.. 1991 Jan;132(1):256-68. Pubmed PMID: 1829654
- Sussman N, Kaza V, Barshes N, Stribling R, Goss J, O'Mahony C, Zhang E, Vierling J, Frost A "Successful liver transplantation following medical management of portopulmonary hypertension: a single-center series.." Am. J. Transplant.. 2006 Sep;6(9):2177-82. Pubmed PMID: 16796721
- Vierling JM, Steer CJ, Bundy BM, Strober W, Jones EA, Hague NE, Nelson DL "Studies of complement receptors on cytotoxic effector cells in human peripheral blood.." Cell. Immunol.. 1978 Feb;35(2):403-13. Pubmed PMID: 620434
- Gardner KD, Vierling JM "Solids, water, and solutes in papillary region of the rat kidney.." Am. J. Physiol.. 1969 Jul;217(1):58-64. Pubmed PMID: 5785900
- Kowdley KV, Lawitz E, Crespo I, Hassanein T, Davis MN, Demicco M, Bernstein DE, Afdhal N, Vierling JM, Gordon SC, Anderson JK, Hyland RH, Dvory-Sobol H, An D, Hindes RG, Albanis E, Symonds WT, Berrey MM, Nelson DR, Jacobson IM "Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial.." Lancet. 2013 Jun 15;381(9883):2100-7. Pubmed PMID: 23499440
- Firpi RJ, Tran TT, Flores P, Nissen N, Colquhoun S, Shackleton C, Martin P, Vierling JM, Poordad FF "Sirolimus-induced hyperlipidaemia in liver transplant recipients is not dose-dependent.." Aliment. Pharmacol. Ther.. 2004 May 1;19(9):1033-9. Pubmed PMID: 15113371
- Hu KQ, Yu CH, Lee S, Villamil FG, Vierling JM "Simultaneous detection of both hepatitis B virus DNA and hepatitis C virus RNA using a combined one-step polymerase chain reaction technique.." Hepatology. 1995 Apr;21(4):901-7. Pubmed PMID: 7705799
- Gershwin ME, Selmi C, Worman HJ, Gold EB, Watnik M, Utts J, Lindor KD, Kaplan MM, Vierling JM "Risk factors and comorbidities in primary biliary cirrhosis: a controlled interview-based study of 1032 patients.." Hepatology. 2005 Nov;42(5):1194-202. Pubmed PMID: 16250040
- Collisson EA, Nourmand H, Fraiman MH, Cooper CB, Bellamy PE, Farmer DG, Vierling JM, Ghobrial RM, Busuttil RW "Retrospective analysis of the results of liver transplantation for adults with severe hepatopulmonary syndrome.." Liver Transpl.. 2002 Oct;8(10):925-31. Pubmed PMID: 12360435
- Ogert RA, Howe JA, Vierling JM, Kwo PY, Lawitz EJ, McCone J, Schiff ER, Pound D, Davis MN, Gordon SC, Ravendhran N, Rossaro L, Jacobson IM, Ralston R, Chaudhri E, Qiu P, Pedicone LD, Brass CA, Albrecht JK, Barnard RJ, Hazuda DJ, Howe AY "Resistance-associated amino acid variants associated with boceprevir plus pegylated interferon-a2b and ribavirin in patients with chronic hepatitis C in the SPRINT-1 trial.." Antivir. Ther. (Lond.). 2013;18(3):387-97. Pubmed PMID: 23406826
- Fennell RH, Shikes RH, Vierling JM "Relationship of pretransplant hepatobiliary disease to bile duct damage occurring in the liver allograft.." Hepatology.;3(1):84-9. Pubmed PMID: 6295909
- Villamil FG, Vierling JM "Recurrence of viral hepatitis after liver transplantation: insights into management.." Liver Transpl Surg. 1995 Sep;1(5):89-99. Pubmed PMID: 9346605
- Jaffe CJ, Vierling JM, Jones EA, Lawley TJ, Frank MM "Receptor specific clearance by the reticuloendothelial system in chronic liver diseases. Demonstration of defective C3b-specific clearance in primary biliary cirrhosis.." J. Clin. Invest.. 1978 Nov;62(5):1069-77. Pubmed PMID: 711852
- Selmi C, Gershwin ME, Lindor KD, Worman HJ, Gold EB, Watnik M, Utts J, Invernizzi P, Kaplan MM, Vierling JM, Bowlus CL, Silveira MG, Bossi I "Quality of life and everyday activities in patients with primary biliary cirrhosis.." Hepatology. 2007 Dec;46(6):1836-43. Pubmed PMID: 18027862
- Hamid S, Rojter S, Vierling J "Protracted cholestatic hepatitis after the use of prostata.." Ann. Intern. Med.. 1997 Jul 15;127(2):169-70. Pubmed PMID: 9230022
- Vierling JM "Primary biliary cirrhosis and autoimmune cholangiopathy.." Clin Liver Dis. 2004 Feb;8(1):177-94. Pubmed PMID: 15062200
- Peters MG, Shouval D, Bonham A, Vierling JM, Lok AS "Posttransplantation: future therapies.." Semin. Liver Dis.. 2000;20:19-24. Pubmed PMID: 10895440
- Silverman JM, Podesta L, Villamil F, Sher L, Vierling J, Rojter S, Hoffman A, Lopez R, Rosenthal P, Woolf G "Portal vein patency in candidates for liver transplantation: MR angiographic analysis.." Radiology. 1995 Oct;197(1):147-52. Pubmed PMID: 7568813
- Garcia G, Petrovic LM, Vierling JM "Overview of hepatitis B and transplantation in the hepatitis B patient.." Semin. Liver Dis.. 2000;20:41339. Pubmed PMID: 10895437
- Hu KQ, Yu CH, Vierling JM "One-step RNA polymerase chain reaction for detection of hepatitis C virus RNA.." Hepatology. 1993 Aug;18(2):270-4. Pubmed PMID: 7687979
- Vierling JM, Berk PD, Hofmann AF, Martin JF, Wolkoff AW, Scharschmidt BF "Normal fasting-state levels of serum cholyl-conjugated bile acids in Gilbert's syndrome: an aid to the diagnosis.." Hepatology.;2(3):340-3. Pubmed PMID: 7076117
- Goldman DE, Colquhoun SD, Ghobrial RM, Arnaout WS, Farmer DG, Markmann JF, Shackleton CR, Vierling JM, Busuttil RW "Mycotic aneurysm of arterial conduit presenting as massive upper gastrointestinal hemorrhage after liver transplantation.." Liver Transpl Surg. 1998 Sep;4(5):435-6. Pubmed PMID: 9724483
- Shackleton CR, Vierling JM, Nissen N, Martin P, Poordad F, Tran T, Colquhoun SD "Morbidity in live liver donors: standards-based adverse event reporting further refined.." Arch Surg. 2005 Sep;140(9):888-95; discuss. Pubmed PMID: 16172298
- Vierling JM, Villamil FG, Rojter SE, Camacho KB, Goldman DE "Morbidity and mortality of recurrent hepatitis C infection after orthotopic liver transplantation.." J. Viral Hepat.. 1997;4:117-24. Pubmed PMID: 9097290
- Mizuno M, Yamada G, Sugiyama T, Vierling JM, Brown WR "Monoclonal antibodies identifying antigens on distinct domains of rat hepatocytes.." Liver. 1987 Oct;7(5):251-9. Pubmed PMID: 3695813
- Hu KQ, Vierling JM "Molecular diagnostic techniques for viral hepatitis.." Gastroenterol. Clin. North Am.. 1994 Sep;23(3):479-98. Pubmed PMID: 7989090
- Freeman RB, Gish RG, Harper A, Davis GL, Vierling J, Lieblein L, Klintmalm G, Blazek J, Hunter R, Punch J "Model for end-stage liver disease (MELD) exception guidelines: results and recommendations from the MELD Exception Study Group and Conference (MESSAGE) for the approval of patients who need liver transplantation with diseases not considered...." Liver Transpl.. 2006 Dec;12(12):S128-36. Pubmed PMID: 17123284
- Jones EA, Vergalla J, Steer CJ, Bradley-Moore PR, Vierling JM "Metabolism of intact and desialylated alpha 1-antitrypsin.." Clin Sci Mol Med. 1978 Aug;55(2):139-48. Pubmed PMID: 307998
- Saab S, Nguyen S, Ibrahim A, Vierling JM, Tong MJ "Management of patients with cirrhosis in Southern California: results of a practitioner survey.." J. Clin. Gastroenterol.. 2006 Feb;40(2):156-61. Pubmed PMID: 16394878
- Rojter S, Villamil FG, Petrovic LM, Silverman JM, Woolf GM, Podesta LG, Makowka L, Vierling JM "Malignant vascular tumors of the liver presenting as liver failure and portal hypertension.." Liver Transpl Surg. 1995 May;1(3):156-61. Pubmed PMID: 9346558
- Hwang JP, Fisch MJ, Zhang H, Kallen MA, Routbort MJ, Lal LS, Vierling JM, Suarez-Almazor ME "Low rates of hepatitis B virus screening at the onset of chemotherapy.." J Oncol Pract. 2012 Jul;8(4):e32-9. Pubmed PMID: 23180996
- Tran TT, Changsri C, Shackleton CR, Poordad FF, Nissen NN, Colquhoun S, Geller SA, Vierling JM, Martin P "Living donor liver transplantation: histological abnormalities found on liver biopsies of apparently healthy potential donors.." J. Gastroenterol. Hepatol.. 2006 Feb;21(2):381-3. Pubmed PMID: 16509862
- Ilyas JA, O'Mahony CA, Vierling JM "Liver transplantation in autoimmune liver diseases.." Best Pract Res Clin Gastroenterol. 2011 Dec;25(6):765-82. Pubmed PMID: 22117641
- Xu J, Lee G, Wang H, Vierling JM, Maher JJ "Limited role for CXC chemokines in the pathogenesis of alpha-naphthylisothiocyanate-induced liver injury.." Am. J. Physiol. Gastrointest. Liver Physiol.. 2004 Sep;287(3):G734-41. Pubmed PMID: 15130876
- Barshes NR, Hacker CS, Freeman RB, Vierling JM, Goss JA "Justice, administrative law, and the transplant clinician: the ethical and legislative basis of a national policy on donor liver allocation.." J Contemp Health Law Policy. 2007;23(2):200-30. Pubmed PMID: 17642381
- Styne PN, Vierling JM "Isolated perfusion of murine liver in situ: technique and validation.." Am. J. Physiol.. 1985 Dec;249(6):G719-24. Pubmed PMID: 4083353
- Vierling JM, Teperman LW "Introduction to hepatitis B transplantation.." Semin. Liver Dis.. 2000;20:41276. Pubmed PMID: 10895436
- He Y, Wu GD, Sadahiro T, Noh SI, Wang H, Talavera D, Wang H, Vierling JM, Klein AS "Interaction of CD44 and hyaluronic acid enhances biliary epithelial proliferation in cholestatic livers.." Am. J. Physiol. Gastrointest. Liver Physiol.. 2008 Aug;295(2):G305-12. Pubmed PMID: 18556418
- Amankonah TD, Strom CB, Vierling JM, Petrovic LM "Inflammatory pseudotumor of the liver as the first manifestation of Crohn's disease.." Am. J. Gastroenterol.. 2001 Aug;96(8):2520-2. Pubmed PMID: 11513216
- Vierling JM, Shrager R, Rumble WF, Aamodt R, Berman MD, Jones EA "Incorporation of radiocopper into ceruloplasmin in normal subjects and in patients with primary biliary cirrhosis and Wilson's disease.." Gastroenterology. 1978 Apr;74(4):652-60. Pubmed PMID: 631501
- Vierling JM, Nelson DL, Strober W, Bundy DM, Jones EA "In vitro cell-mediated cytotoxicity in primary biliary cirrhosis and chronic hepatitis. Dysfunction of spontaneous cell-mediated cytotoxicity in primary biliary cirrhosis.." J. Clin. Invest.. 1977 Nov;60(5):1116-28. Pubmed PMID: 332716
- Vierling JM "Immunology of acute and chronic hepatic allograft rejection.." Liver Transpl Surg. 1999 Jul;5(4):S1-S20. Pubmed PMID: 10431013
- Peters M, Vierling J, Gershwin ME, Milich D, Chisari FV, Hoofnagle JH "Immunology and the liver.." Hepatology. 1991 May;13(5):977-94. Pubmed PMID: 2030002
- Vierling JM "Immunologic mechanisms of hepatic allograft rejection.." Semin. Liver Dis.. 1992 Feb;12(1):16-27. Pubmed PMID: 1570548
- Vierling JM "Immune disorders of the liver and bile duct.." Gastroenterol. Clin. North Am.. 1992 Jun;21(2):427-49. Pubmed PMID: 1512050
- Hreha G, Jefferson DM, Yu CH, Grubman SA, Alsabeh R, Geller SA, Vierling JM "Immortalized intrahepatic mouse biliary epithelial cells: immunologic characterization and immunogenicity.." Hepatology. 1999 Aug;30(2):358-71. Pubmed PMID: 10421641
- Ayoub WS, Geller SA, Tran T, Martin P, Vierling JM, Poordad FF "Imatinib (Gleevec)-induced hepatotoxicity.." J. Clin. Gastroenterol.. 2005 Jan;39(1):75-7. Pubmed PMID: 15599217
- Vierling JM, Fennell RH "Histopathology of early and late human hepatic allograft rejection: evidence of progressive destruction of interlobular bile ducts.." Hepatology.;5(6):1076-82. Pubmed PMID: 3905558
- Vierling JM "Hepatitis C virus viral assays in the direct-acting antiviral era.." Clin Liver Dis. 2013 Feb;17(1):27-45. Pubmed PMID: 23177281
- Geller SA, Nichols WS, Rojter SE, Chan RC, Petrovic LM, Vierling JM, Makowka L "Hepatitis C virus is not recoverable from liver tissue in cryptogenic cirrhosis: failure to identify hepatitis C virus-RNA using reverse transcription-mediated polymerase chain reaction.." Hum. Pathol.. 1996 Nov;27(11):1161-5. Pubmed PMID: 8912825
- Ghany MG, Ayola B, Villamil FG, Gish RG, Rojter S, Vierling JM, Lok AS "Hepatitis B virus S mutants in liver transplant recipients who were reinfected despite hepatitis B immune globulin prophylaxis.." Hepatology. 1998 Jan;27(1):213-22. Pubmed PMID: 9425940
- Bunnapradist S, Fabrizi F, Vierling J, Martin R, Moudgil A, Kamil E, Jordan S "Hepatitis C therapy with long term remission after renal transplantation.." Int J Artif Organs. 2002 Dec;25(12):1189-93. Pubmed PMID: 12518964
- Hwang JP, Vierling JM, Zelenetz AD, Lackey SC, Loomba R "Hepatitis B virus management to prevent reactivation after chemotherapy: a review.." Support Care Cancer. 2012 Nov;20(11):2999-3008. Pubmed PMID: 22933131
- Finck MH, Reichen J, Vierling JM, Kloppel TM, Brown WR "Hepatic uptake and disposition of human polymeric IgA1 in perfused rat liver: evidence for incomplete biliary excretion and intrahepatic degradation.." Am. J. Physiol.. 1985 Apr;248(4):G450-5. Pubmed PMID: 3985150
- Vierling JM, Ruderman WB, Jaffee BD, Fennell RH, Claman HN "Hepatic lesions in murine chronic graft-versus-host disease to minor histocompatibility antigens. A reproducible model of nonsuppurative destructive cholangitis.." Transplantation. 1989 Oct;48(4):717-8. Pubmed PMID: 2799935
- Vierling JM "Hepatic injury by prescription medication.." Med Sect Proc. 1983;79-86. Pubmed PMID: 6678434
- O'Mahony CA, Vierling JM "Etiopathogenesis of primary sclerosing cholangitis.." Semin. Liver Dis.. 2006 Feb;26(1):41354. Pubmed PMID: 16496229
- Vierling JM, Flores PA "Evolving new therapies of autoimmune hepatitis.." Clin Liver Dis. 2002 Aug;6(3):825-50, ix. Pubmed PMID: 12362583
- Vierling JM "Future Treatment Options in PBC.." Semin. Liver Dis.. 2005 Aug;25(3):347-63. Pubmed PMID: 16143950
- Cobb B, Pockros PJ, Vilchez RA, Vierling JM "HCV RNA viral load assessments in the era of direct-acting antivirals.." Am. J. Gastroenterol.. 2013 Apr;108(4):471-5. Pubmed PMID: 23552304
- Howell CD, Yoder T, Claman HN, Vierling JM "Hepatic homing of mononuclear inflammatory cells isolated during murine chronic graft-vs-host disease.." J. Immunol.. 1989 Jul 15;143(2):476-83. Pubmed PMID: 2472440
- Hwang JP, Vierling JM, Zelenetz AD, Lackey SC, Loomba R "Erratum to: Hepatitis B virus management to prevent reactivation after chemotherapy: a review.." Support Care Cancer. 2013 Apr;21(4):1211. Pubmed PMID: 23354554
- Vierling JM "Epidemiology and clinical course of liver diseases: identification of candidates for hepatic transplantation.." Hepatology.;4(1):84S-94S. Pubmed PMID: 6363265
- Fennell RH, Vierling JM "Electron microscopy of rejected human liver allografts.." Hepatology.;5(6):1083-7. Pubmed PMID: 3905559
- Bruno S, Vierling JM, Esteban R, Nyberg LM, Tanno H, Goodman Z, Poordad F, Bacon B, Gottesdiener K, Pedicone LD, Albrecht JK, Brass CA, Thompson S, Burroughs MH "Efficacy and safety of boceprevir plus peginterferon-ribavirin in patients with HCV G1 infection and advanced fibrosis/cirrhosis.." J. Hepatol.. 2013 Mar;58(3):479-87. Pubmed PMID: 23183529
- Vierling J, Roberts JL, Conway G, Heazlitt R "Effect on cardiac myosin of diverse methods of preparation.." Biochim. Biophys. Acta. 1968 May 6;160(1):53-62. Pubmed PMID: 4231409
- Berk PD, Berman MD, Blitzer BL, Chretien P, Martin JF, Scharschmidt BF, Vierling JM, Wolkoff AW, Vergalla J, Waggoner JG "Effect of splenectomy of hepatic bilirubin clearance in patients with hereditary spherocytosis. Implications for the diagnosis of Gilbert's syndrome.." J. Lab. Clin. Med.. 1981 Jul;98(1):37-45. Pubmed PMID: 7252326
- Woolf GM, Vierling JM "Disappearing intrahepatic bile ducts: the syndromes and their mechanisms.." Semin. Liver Dis.. 1993 Aug;13(3):261-75. Pubmed PMID: 8235716
- Vierling JM, Howell CD "Disappearing bile ducts: immunologic mechanisms.." Hosp. Pract. (Off. Ed.). 1990 Jul 15;25(7):141-50. Pubmed PMID: 2115531
- Geller SA, Dubinsky MC, Poordad FF, Vasiliauskas EA, Cohen AH, Abreu MT, Tran T, Martin P, Vierling JM, Targan SR "Early hepatic nodular hyperplasia and submicroscopic fibrosis associated with 6-thioguanine therapy in inflammatory bowel disease.." Am. J. Surg. Pathol.. 2004 Sep;28(9):1204-11. Pubmed PMID: 15316320
- Hu KQ, Yu CH, Vierling JM "Direct detection of circulating hepatitis C virus RNA using probes from the 5' untranslated region.." J. Clin. Invest.. 1992 Jun;89(6):2040-5. Pubmed PMID: 1318328
- Vierling JM "Diagnosis and treatment of autoimmune hepatitis.." Curr Gastroenterol Rep. 2012 Feb;14(1):25-36. Pubmed PMID: 22179843
- Fontana RJ, Hann HW, Perrillo RP, Vierling JM, Wright T, Rakela J, Anschuetz G, Davis R, Gardner SD, Brown NA "Determinants of early mortality in patients with decompensated chronic hepatitis B treated with antiviral therapy.." Gastroenterology. 2002 Sep;123(3):719-27. Pubmed PMID: 12198698
- Villamil FG, Hu KQ, Yu CH, Lee CH, Rojter SE, Podesta LG, Makowka L, Geller SA, Vierling JM "Detection of hepatitis C virus with RNA polymerase chain reaction in fulminant hepatic failure.." Hepatology. 1995 Nov;22(5):1379-86. Pubmed PMID: 7590651
- Fernandes NF, Redeker AG, Vierling JM, Villamil FG, Fong TL "Cyclosporine therapy in patients with steroid resistant autoimmune hepatitis.." Am. J. Gastroenterol.. 1999 Jan;94(1):241-8. Pubmed PMID: 9934764
- Papadakis KA, Matuk R, Abreu MT, Vasiliauskas EA, Fleshner PR, Lechago J, Tran T, Poordad FF, Martin P, Vierling J, Targan SR "Crohn's ileitis after liver transplantation from a living related donor with Crohn's disease.." Gut. 2004 Sep;53(9):1389-90. Pubmed PMID: 15306609
- Vierling JM "Copper metabolism in primary biliary cirrhosis.." Semin. Liver Dis.. 1981 Nov;1(4):293-308. Pubmed PMID: 7051310
- Choi WC, Arnaout WC, Villamil FG, Demetriou AA, Vierling JM "Comparison of the applicability of two prognostic scoring systems in patients with fulminant hepatic failure.." Korean J. Intern. Med.. 2007 Jun;22(2):93-100. Pubmed PMID: 17616024
- Petrovic LM, Villamil FG, Vierling JM, Makowka L, Geller SA "Comparison of histopathology in acute allograft rejection and recurrent hepatitis C infection after liver transplantation.." Liver Transpl Surg. 1997 Jul;3(4):398-406. Pubmed PMID: 9346770
- Narkewicz MR, Smith D, Silverman A, Vierling J, Sokol RJ "Clearance of chronic hepatitis B virus infection in young children after alpha interferon treatment.." J. Pediatr.. 1995 Nov;127(5):815-8. Pubmed PMID: 7472844
- Perino LE, Vierling JM "Chyloperitoneum with collateral lymphatic drainage involving abdominal skin.." Dig. Dis. Sci.. 1987 Jun;32(6):660-4. Pubmed PMID: 3568953
- Harrison SA, Hamzeh FM, Han J, Pandya PK, Sheikh MY, Vierling JM "Chronic hepatitis C genotype 1 patients with insulin resistance treated with pioglitazone and peginterferon alpha-2a plus ribavirin.." Hepatology. 2012 Aug;56(2):464-73. Pubmed PMID: 22334369
- Mizuno M, Kloppel TM, Nakane PK, Brown WR, Vierling JM "Cellular distribution of the asialoglycoprotein receptor in rat liver. Implications for hepatic accumulation of desialylated lymphocytes.." Gastroenterology. 1984 Jan;86(1):142-9. Pubmed PMID: 6315523
- Gholson CF, Siddiqui A, Vierling JM "Cell surface expression of hepatitis B surface and core antigens in transfected rat fibroblast cell lines.." Gastroenterology. 1990 Apr;98(4):968-75. Pubmed PMID: 2179036
- Jones EA, Vierling JM, Steer CJ, Reichen J "Cell surface receptors in the liver.." Prog Liver Dis. 1979;6:43-80. Pubmed PMID: 396566
- Vierling JM, Steer CJ, Hickman JW, James SP, Jones EA "Cell-mediated cytotoxicity of desialylated human lymphocytes induced by a mitogenic mammalian liver protein.." Gastroenterology. 1978 Sep;75(3):456-61. Pubmed PMID: 680501
- Vierling JM, Teperman LW, Lake JR, Perrillo RP, Peters M, Fried M, Schiff ER "Case studies of the hepatitis B patient: a panel discussion.." Semin. Liver Dis.. 2000;20:29-35. Pubmed PMID: 10895442
- Flamm SL, Lawitz E, Jacobson I, Bourlière M, Hezode C, Vierling JM, Bacon BR, Niederau C, Sherman M, Goteti V, Sings HL, Barnard RO, Howe JA, Pedicone LD, Burroughs MH, Brass CA, Albrecht JK, Poordad F "Boceprevir with peginterferon alfa-2a-ribavirin is effective for previously treated chronic hepatitis C genotype 1 infection.." Clin. Gastroenterol. Hepatol.. 2013 Jan;11(1):81-87.e4. Pubmed PMID: 23064222
- Tsuda M, Moritoki Y, Lian ZX, Zhang W, Yoshida K, Wakabayashi K, Yang GX, Nakatani T, Vierling J, Lindor K, Gershwin ME, Bowlus CL "Biochemical and immunologic effects of rituximab in patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid.." Hepatology. 2012 Feb;55(2):512-21. Pubmed PMID: 22006563
- Vierling JM "Autoimmune cholangiopathy.." Clin Liver Dis. 1999 Aug;3(3):571-84. Pubmed PMID: 11291239
- Vierling JM "Animal models for primary sclerosing cholangitis.." Best Pract Res Clin Gastroenterol. 2001 Aug;15(4):591-610. Pubmed PMID: 11492970
- Vierling JM "Biliary victories: studies of isolated biliary epithelial cells.." J. Lab. Clin. Med.. 1989 Jun;113(6):663-4. Pubmed PMID: 2732615
- Vierling JM "Alcoholic liver injuries--update.." Med Sect Proc. 1983;87-93. Pubmed PMID: 6678435
- Woolf GM, Petrovic LM, Rojter SE, Villamil FG, Makowka L, Podesta LG, Sher LS, Memsic L, Vierling JM "Acute liver failure due to lymphoma. A diagnostic concern when considering liver transplantation.." Dig. Dis. Sci.. 1994 Jun;39(6):1351-8. Pubmed PMID: 8200270
- Woolf GM, Petrovic LM, Rojter SE, Wainwright S, Villamil FG, Katkov WN, Michieletti P, Wanless IR, Stermitz FR, Beck JJ, Vierling JM "Acute hepatitis associated with the Chinese herbal product jin bu huan.." Ann. Intern. Med.. 1994 Nov 15;121(10):729-35. Pubmed PMID: 7944049
- Martin JF, Vierling JM, Wolkoff AW, Scharschmidt BF, Vergalla J, Waggoner JG, Berk PD "Abnormal hepatic transport of indocyanine green in Gilbert's syndrome.." Gastroenterology. 1976 Mar;70(3):385-91. Pubmed PMID: 814028
- Dubinsky MC, Vasiliauskas EA, Singh H, Abreu MT, Papadakis KA, Tran T, Martin P, Vierling JM, Geller SA, Targan SR, Poordad FF "6-thioguanine can cause serious liver injury in inflammatory bowel disease patients.." Gastroenterology. 2003 Aug;125(2):298-303. Pubmed PMID: 12891528
Memberships
- American Association for the Study of Liver Diseases
- President, 2006
- American Gastroenterological Association
- Fellow
- American Liver Foundation:
- (01/1979 - 06/2020)
- American Clinical and Climatological Association
- European Association for the Study of the Liver
- Member (01/1990)
- Asian Pacific Association for the Study of the Liver
- Member (01/2004)
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