Joseph Michael Hyser, Ph.D.
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Positions
- Associate Professor
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Virology & Microbiology
Baylor College of Medicine
Houston, TX US
- Member
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Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
Addresses
- BCM-Jewish Wing (Lab)
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Room: BCM-824D
Houston, TX 77030
United States
Phone: (713) 798-4514
joseph.hyser@bcm.edu
Education
- Post-doctoral Training from Baylor College Of Medicine
- 01/2010 - Houston, TX United States
- Viroporins, Rotavirus
- Ph.D. from Baylor College Of Medicine
- 01/2007 - Houston, TX United States
- BA from Augustana College
- 05/1999 - Rock Island, IL United States
- Biology, Philosophy
Professional Interests
- Enteric Virus Calcium Channel Blockers
- Exploitation of Host Calcium Signaling Pathways by Microbes
- Characterization of Viral Ion Channels (Viroporins)
- Engineering of human intestinal enteroids
Websites
Latest publications
Selected Publications
- 17. J.L. Perry, N.K. Ramachandran, B. Utama, and J.M. Hyser "Use of Genetically-encoded Calcium Indicators for Live Cell Calcium Imaging and Localization in Virus-infected Cells." Methods. 2015 Nov 15;15(90) Pubmed PMID: 26344758
- Hyser JM, Utama B, Crawford SE, Broughman JR, Estes MK. "Activation of the endoplasmic reticulum calcium sensor STIM1 and store-operated calcium entry by rotavirus requires NSP4 viroporin activity." J. Virol.. 2013;87(4):13579-88. Pubmed PMID: 24109210
- 22. A.C. Strtak, J.L. Perry, M.N. Sharp, A.L. Chang-Graham, T. Farkas, J.M. Hyser "Recovirus NS1-2 has viroporin activity that induces aberrant cellular calcium signaling to facilitate virus replication." mSphere. 2019 Sep 18;4(5) Pubmed PMID: 31533997
- 21. A.L. Chang-Graham, J.L. Perry, A.C. Strtak, N.K. Ramachandran, J.M. Criglar, A.A. Philip, J.T. Patton, M.K. Estes, and J.M. Hyser "Rotavirus calcium dysregulation manifests as dynamic calcium signaling in the cytoplasm and endoplasmic reticulum." Sci Rep. 2019 Jul 25;9(1) Pubmed PMID: 31346185
- Hyser JM, Collinson-Pautz MR, Utama B, Estes MK "Rotavirus Disrupts Calcium Homeostasis by NSP4 Viroporin Activity.." MBio. 2010;1(5) Pubmed PMID: 21151776
- 33. A.L. Chang-Graham, J.L. Perry, M.A. Engevik, K.A. Engevik, F.J. Scribano, J.T. Gebert, H.A. Danhof, J.C. Nelson, J.S. Kellen, A.C. Strtak, N.P. Sastri, M.K. Estes, R.A. Britton, J. Versalovic, J.M. Hyser "Rotavirus induces intercellular calcium waves through ADP signaling." Science. 2020 Nov 20;370:eabc3621. Pubmed PMID: 33214249
Memberships
- American Society for Virology
- American Society for Microbiology
- American Physiology Society
- American Gastroenterological Association
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