Katerina Cermakova

Assistant Professor

Email

cermakov@bcm.edu

Positions

Assistant Professor: Department of Biochemistry and Molecular Pharmacology
Baylor College of Medicine
Houston, Texas United States

Addresses

1 Baylor Plz. (Lab)
: N1317 Alkek Building
Houston, TX 77030
United States
katerina.cermakova@bcm.edu

Education

PhD from KU Leuven: Leuven, Belgium

Postdoctoral Training at Institute of Organic Chemistry and Biochemistry: Prague, Czech Republic

Postdoctoral Training at Baylor College of Medicine: Houston, United States

Professional Interests

Structural biology
Intrinsically disordered protein
Transcription and chromatin
Biomolecular NMR
Cancer biology

Selected Publications

Cermakova K*, Demeulemeester J*, Lux V*, Nedomova M, Goldman SR, Smith EA, Srb P, Hexnerova R, Fabry M, Madlikova M, Horejsi M, De Rijck J, Debyser Z, Adelman K, Hodges HC, Veverka V. "A ubiquitous disordered protein interaction module orchestrates transcription elongation.." Science. 2021 Nov 26;374(6571):1113-1121. Pubmed PMID: 34822292
Sharma S*, Cermakova K*, De Rijck J*, Demeulemeester J, Fábry M, El Ashkar S, Lepsik M, Tesina P, Duchoslav V, Novak P, Hubalek M, Srb P, Christ F, Rezacova P, Hodges HC, Debyser Z, Veverka V. "Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation.." PNAS. 2018 Jul 24;115(30):E7053-E7062. Pubmed PMID: 29997176
Hodges HC*, Stanton BZ*, Cermakova K, Chang CY, Miller EL, Kirkland JG, Ku WL, Veverka V, Zhao K, Crabtree GR. "Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers.." Nature Structural and Molecular Biology. 2017 Dec 11;25(1):61-72. Pubmed PMID: 29323272
Mereau H*, De Rijck J*, Cermakova K, Kutz A, Juge S, Demeulemeester J, Gijsbers R, Christ F, Debyser Z, Schwaller J. "Impairing MLL-fusion gene mediated transformation by dissecting critical interactions with the lens epithelial-derived growth factor (LEDGF/p75).." Leukemia. 2013 Jan 15;27(6):1245-53. Pubmed PMID: 23318960

Cermakova K, Hodges HC. "Interaction modules that impart specificity to disordered protein.." Trends in Biochemical Sciences. 2023 Feb 6;48(5):477-490. Pubmed PMID: 36754681
Tesina P*, Cermakova K*, Horejsi M, Prochazkova K, Fabry M, Sharma S, Christ F, Demeulemeester J, Debyser Z, De Rijck J, Veverka V, Rezacova P. "Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif.." Nature Communications. 2015 Aug 5;6(7968) Pubmed PMID: 26245978
Cermakova K, Hodges HC. "Next-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation.." Molecules. 2018 Aug 6;23(8):1958. Pubmed PMID: 30082609
Chambers C, Cermakova K, Chan YS, Kurtz K, Wohlan K, Lewis AH, Wang C, Pham A, Dejmek M, Sala M, Loeza Cabrera M, Aguilar R, Nencka R, Lacorazza D, Rau RE, Hodges HC. "SWI/SNF blockade disrupts PU.1-directed enhancer programs in normal hematopoietic cells and acute myeloid leukemia." Cancer Research. 2023 Apr 4;83(7):983-996. Pubmed PMID: 36662812
Cermakova K, Tesina P, Demeulemeester J, El Ashkar S, Mereau H, Schwaller J, Rezacova P, Veverka V, De Rijck J. "Validation and Structural Characterisation of the LEDGF/p75-MLL Interface as a New Target for the Treatment of MLL-Dependent Leukaemia.." Cancer Research. 2014 Sep 15;74(18):5139-51. Pubmed PMID: 25082813
Cermakova K, Tao L, Dejmek M, Sala M, Montierth MD, Chan YS, Patel I, Chambers C, Loeza Cabrera M, Hoffman D, Parchem RJ, Wang W, Nencka R, Barbieri E, Hodges HC. "Reactivation of the G1 enhancer landscape underlies core circuitry addiction to SWI/SNF.." Nucleic Acids Res.. 2024 Jan 11;52(1):4-21. Pubmed PMID: 37993417