Email

kyle.eagen@bcm.edu

Positions

Assistant Professor and CPRIT Scholar in Cancer Research

Department of Molecular and Cellular Biology
Center for Precision Environmental Health
Baylor College of Medicine
Houston, Texas United States

Member

Stem Cells and Regenerative Medicine Center (STaR)
Baylor College of Medicine
Houston, Texas United States

Member

Center for Cell and Gene Therapy (CAGT)
Baylor College of Medicine
Houston, Texas United States

Member

Therapeutic Innovation Center (THINC)
Baylor College of Medicine
Houston, Texas United States

Member

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States

Faculty Member

Graduate Program in Cancer & Cell Biology
Graduate Program in Genetics & Genomics
Baylor College of Medicine
Houston, Texas United States

Addresses

Baylor College of Medicine (Office)

Michael E. DeBakey Center M512F
One Baylor Plaza, BCM130
Houston, TX 77030
United States
Phone: (713) 798-3560
kyle.eagen@bcm.edu

Baylor College of Medicine (Lab)

Michael E. DeBakey Center M513
One Baylor Plaza, BCM130
Houston, TX 77009
United States
Phone: (713) 798-6082

Education

PhD from Stanford University

01/2017 - Stanford, California United States

Biophysics

BS from Cornell University

05/2008 - Ithaca, New York United States

Biological Sciences

Honors & Awards

NIH Director's Early Independence Award

National Institutes of Health

CPRIT Scholar in Cancer Research

Cancer Prevention and Research Institute of Texas

Distinguished Scientist Award

The Sontag Foundation

Professional Interests

• Nuclear organization
• Epigenetics and chromatin
• Chromosome biology
• Fusion oncoproteins
• Cancer biology and therapeutics
• Genomics and computational biology

Professional Statement

The folding and compaction of DNA in nuclei and chromosomes has fascinated biologists for over a century. Active and inactive genes are located in different regions of the nucleus indicating that the spatial organization of DNA influences proper gene regulation. Various and intricate chromosome 3D folding patterns have been described, but the molecular basis of how these folding patterns arise has not been fully realized. In particular, the spatial segregation of loci into distinct regions, or compartments, of the nucleus impacts diverse areas of biology from aging and cancer to hematopoiesis and olfaction. Additionally, aberrant chromosome compartmentalization in a variety of diseases, including cancer, pathogenically rewires gene expression programs. Defining the pathophysiology of and therapeutically intervening in these diseases will come from molecular insights into how chromosomes are organized within nuclear compartments.

The Eagen Lab combines concepts and approaches from biochemistry with methods and analytical tools from cell biology, molecular biology, pharmacology, genomics, and computational biology to determine the molecular basis of how chromosomes are folded in three dimensions and compartmentalized within nuclei. Our long-term goal is to reveal fundamental principles underlying how the folding of chromosomes within nuclear compartments impacts biological function. This will enable new insights into human disease processes and will serve as a basis for developing pharmacological intervention of aberrant chromatin 3D structure as a novel therapeutic approach for disease treatment.

Websites

Selected Publications

• Rosencrance CD, Ammouri HA, Yu Q, Ge T, Rendleman EJ, Marshal SA, Eagen KP "Chromatin Hyperacetylation Impacts Chromosome Folding by Forming a Nuclear Subcompartment." Mol Cell. 2020 Apr 2;78(1):112-126. Pubmed PMID: 32243828
• Ge T, Rosencrance CD, Eagen KP "Contact Mapping to Unravel Chromosome Folding." Trends Biochem Sci. 2019 Dec 1;44(12):1089-1090. Pubmed PMID: 31677956
• Eagen KP "Principles of Chromosome Architecture Revealed by Hi-C." Trends Biochem Sci. 2018 Jun 1;43(6):469-478. Pubmed PMID: 29685368
• Eagen KP, Hartl TA, Kornberg RD "Stable Chromosome Condensation Revealed by Chromosome Conformation Capture." Cell. 2015 Nov 5;163(4):934-946. Pubmed PMID: 26544940

Funding

Recruitment of First-Time, Tenure-Track Faculty Members - #RR210082

Grant funding from Cancer Prevention & Research Institute of Texas

Chromatin Structure as a Therapeutic Vulnerability in Cancer

R Accelerated Award - #22-25794

Grant funding from Alex’s Lemonade Stand Foundation for Childhood Cancer

GENOME ORIGAMI: Refolding Aberrant Chromosome 3D Structure for Treating NUT Carcinoma

Distinguished Scientist Award

Grant funding from The Sontag Foundation

Transcriptional Regulation and Drug Sensitivity Through Chromosome 3D Structure Rewiring by a Brain Tumor Fusion Oncoprotein

U01 Award - #U01CA294062

Grant funding from National Cancer Institute

Overcoming Limitations of BET Inhibition in NUT Carcinoma