Positions
- Assistant Professor
-
Medicine-Athero & Lipo
Cardiovascular Research Institute (CVRI)
Baylor College of Medicine
Houston, TX US
Addresses
- Cardiovascular Research Institute (CVRI) (Office)
-
Room: BCMD-507D
Houston, TX 77030
United States
Education
- MS from Wuhan University
- 05/1995 - Wuhan, China
- Biochemistry
- BS from Wuhan University
- 05/1992 - Wuhan, China
- Biochemistry
- PhD from University of Rochester
- 05/2004 - Rochester, New York United States
- Pharmacology
- Post-Doctoral Fellowship at Duke University
- 05/2009 - Durham, North Carolina United States
- Cardiovascular Research
Professional Statement
Dr. Xie studies the basic biochemistry of protein prolyl hydroxylation and its important roles of in cardiac function. His particular focuses include the understanding of the molecular mechanisms by which Prolyl Hydroxylase Domain Proteins (PHDs) regulate calcium cycling and cardiac contractile function and how their dysregulation contributes to the pathophysiological development of heart diseases such as cardiac hypertrophy and arrhythmia.Websites
Selected Publications
- Pi X, Schmitt CE, Xie L, Portbury AL, Wu Y, Lockyer P, Dyer LA, Moser M, Bu G, Flynn III EJ, Jin SW, Patterson C. "LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis." Circulation Research. 2012 Aug;111(5):564-574. Pubmed PMID: 22777006
- Xu L, Yates CC, Lockyer P, Xie L, Bevilacqua A, He J, Lander C, Patterson C, Willis M. "MMI-0100 inhibits cardiac fibrosis in myocardial infarction by direct actions on cardiomyocytes and fibroblasts via MK2 inhibition." J Mol Cell Cardiol. 2014 Oct;77:86-101. Pubmed PMID: 25257914
- Pi X, Xie L, Portbury AL, Kumar S, Lockyer P, Li X, Patterson C "NADPH oxidase- generated ROS are required for SDF-1α-stimulated angiogenesis." ATVB. 2014 Sep;34(9):2023-2032. Pubmed PMID: 24990230
- Xie L, Xiao K, Whalen EJ, Forrester MT, Freeman RS, Fong G, Gygi SP, Lefkowitz RJ, Stamler JS "Oxygen-regulated beta2-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL." Science Signaling. 2009 Jul;2(78):ra33. Pubmed PMID: 19584355
- Xie L, Pi X, Mishra A, Fong G, Peng J, Patterson C "PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response." Journal of Clinical Investigation. 2012 Aug;122(8):2827-2836. Pubmed PMID: 3408739
Memberships
- American Heart Association
- Member
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