Na Li

Na Li, Ph.D.

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Na Li, Ph.D.

Professor

Phone

713-798-2335

Email

nal@bcm.edu

Positions

Professor: Medicine
Cardiovascular Research
Baylor College of Medicine

Faculty Member: Development, Disease Models and Therapeutics (DDMT) Graduate Program
Baylor College of Medicine

Faculty Member: Immunology & Microbiology Graduate Program
Baylor College of Medicine

Education

Postdoctoral Fellowship at Baylor College Of Medicine: 01/2012 - Houston, TX United States

PhD from China Pharmaceutical University: 07/2008 - Nanjing, China, People's Rep

Professional Interests

To investigate novel molecular mechanisms underlying cardiac arrhythmias and cardiomyopathy.

Professional Statement

Cardiac arrhythmias can dramatically disrupt heart function and even be life-threatening. These irregular heartbeats may stem from faulty ion transporters or tissue remodeling. Our research is driving innovation in three key areas:

1. Inflammatory Signaling in Atrial Fibrillation (AF) Pathogenesis: AF, the most common arrhythmia among adults, is becoming increasingly prevalent. We're diving deep into the connections between risk factors and AF pathophysiology, with a spotlight on inflammasome and FKBP5 signaling pathways to uncover groundbreaking insights.

2. Cardiac Conduction Disorder (CCD): CCD is widespread among those with heart failure, cardiomyopathy, or genetic conditions. Severe cases often require pacemaker implantation. Our mission is to decode the molecular underpinnings of CCD and pioneer novel therapies to transform patient care.

3. Rare Cardiac Arrhythmia - TANGO2 Deficiency Disorder (TDD): The TANGO2 gene is vital for cellular functions, especially in intracellular transport and Golgi organization. Mutations in TANGO2 can trigger TDD, a rare condition marked by metabolic crises. These episodes, spurred by infections, fasting, or stress, can cause severe cardiac arrhythmias, muscle breakdown (rhabdomyolysis), and brain disease (encephalopathy). We're leveraging genetic mouse models to unravel the molecular mechanisms of TDD and test potential therapies in preclinical trials.

The Li Lab is supported by research grants from the National Institutes of Health and the American Heart Association, fueling our quest to combat cardiac arrhythmias with cutting-edge science and innovative solutions.