Email

nahmed@bcm.edu

Positions

Professor

Pediatrics-Hem-Onc Cell & Gene
Baylor College of Medicine
Houston, TX US

Member

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States

Addresses

TX Childs Feigin Ctr (Office)

Room: TXFC-176012
Houston, TX 77030
United States

Texas Children's Hospital, Clinical Care Center (Clinic)

6701 Fannin St
14th floor
Houston, TX 77030
United States
Phone: (832) 822-4242

Professional Interests

• Bone Marrow Transplantation
• Cell and Gene Therapy

Professional Statement

Dr. Ahmed is a physician scientist engaged in translational research focusing on adoptive immunotherapy with gene-modified effector cells, to improve therapy for brain tumors. Dr Ahmed's initial studies demonstrated that antigen-specific cytotoxic T cells could eradicate established brain tumors in medulloblastoma and Glioblastoma models. Subsequent studies have demonstrated that the tumor-specific T cells, unlike conventional therapies, can effectively target the stem cell compartment in the tumor eradicating experimental tumors in animal models. Aligning with his primary interest is studying the role of T cells in creating a tumor niche and studying T cell migration to distant tumor sites in the brain. Dr. Ahmed therefore has experience in developing and translating cell and gene therapy studies to the clinic. Currently, Dr. Ahmed is the principal investigator on 3 clinical trials targeting Glioblastoma and Osteosarcoma by administering tumor-specific T cells to. All studies are FDA, IRB, RAC and IBC approved.

Websites

Selected Publications

• Fu X, Tao L, Rivera A, Williamson S, Song XT, Ahmed N, Zhang X "A simple and sensitive method for measuring tumor-specific T cell cytotoxicity.." PLoS ONE. 2010;5(7):e11867. Pubmed PMID: 20686618
• Ahmed N, Chizhevsky V "Acute hepatic sequestration associated with pneumococcal infection in a 5-year-old Boy with sickle beta degrees -thalassemia: a case report and review of the literature.." J. Pediatr. Hematol. Oncol.. 2007 Oct;29(10):720-4. Pubmed PMID: 17921856
• Salsman VS, Chow KK, Shaffer DR, Kadikoy H, Li XN, Gerken C, Perlaky L, Metelitsa LS, Gao X, Bhattacharjee M, Hirschi K, Heslop HE, Gottschalk S, Ahmed N "Crosstalk between Medulloblastoma Cells and Endothelium Triggers a Strong Chemotactic Signal Recruiting T Lymphocytes to the Tumor Microenvironment.." PLoS ONE. 2011;6(5):e20267. Pubmed PMID: 21647415
• Ghazi A, Ashoori A, Hanley PJ, Brawley VS, Shaffer DR, Kew Y, Powell SZ, Grossman R, Grada Z, Scheurer ME, Hegde M, Leen AM, Bollard CM, Rooney CM, Heslop HE, Gottschalk S, Ahmed N "Generation of Polyclonal CMV-specific T Cells for the Adoptive Immunotherapy of Glioblastoma.." J. Immunother.. 2012 Feb;35(2):159-68. Pubmed PMID: 22306904