Neil J McKenna, Ph.D.
Picture
Neil J McKenna, Ph.D.
Associate Professor
Positions
- Associate Professor
-
Mol & Cell Biology-O'Malley
Baylor College of Medicine
Houston, TX US
- Member
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
Education
- Advanced Training from Baylor College Of Medicine
- 01/2002 - Houston, TX United States
- PhD from National University Of Ireland
- 12/1995 - Galway, Ireland
Professional Statement
I am interested in applying biocuration to archived 'omics datasets to mechanize cellular signaling pathways.Websites
An integrated 'omics knowledgebase for cellular signaling pathways
Selected Publications
- Bissig-Choisat B, Alves-Bezerra M et al. "A human liver chimeric mouse model for non-alcoholic fatty liver disease." J Hep Reports. 2021 Apr;
- Scott A. Ochsner, Rudolf T. Pillich & Neil J. McKenna "Consensus transcriptional regulatory networks of coronavirus-infected human cells." Sci Data. 2020 Sep 20;7:314. Pubmed PMID: 32963239
- Ochsner SA, Abraham D, Martin K, Ding W, McOwiti A, Kankanamge W, Wang Z, Andreano K, Hamilton RA, Chen Y, Hamilton A, Gantner ML, Dehart M, Qu S, McKenna NJ "The Signaling Pathways Project, an integrated 'omics knowledgebase for mammalian cellular signaling pathways." Sci Data. 2019 Oct 31;6 Pubmed PMID: 31672983
- Jagodnik KM, Koplev S, Jenkins SL, Ohno-Machado L, Paten B, Schurer SC, Dumontier M, Verborgh R, Bui A, Ping P, McKenna NJ, Madduri R, Pillai A, Ma'ayan A "Developing a framework for digital objects in the Big Data to Knowledge (BD2K) commons: Report from the Commons Framework Pilots workshop." J Biomed Inform. 2017;71:49-57. Pubmed PMID: 28501646
- Lauren B. Becnel, Scott A. Ochsner, Yolanda F. Darlington, Apollo McOwiti, Wasula H. Kankanamge, Michael Dehart, Alexey Naumov, Neil J. McKenna "Discovering relationships between nuclear receptor signaling pathways, genes, and tissues in Transcriptomine." Sci Signal. 2017 Apr 26;10
- Darlington YF, Naumov A, McOwiti A, Kankanamge WH, Becnel LB, McKenna NJ "Improving the discoverability, accessibility, and citability of omics datasets: a case report.." J Am Med Inform Assoc. 2016;24:388-393. Pubmed PMID: 27413121
- Ochsner SA, Watkins CM, McOwiti A, Xu X, Darlington YF, Dehart MD, Cooney AJ, Steffen DL, Becnel LB, McKenna NJ "Transcriptomine, a web resource for nuclear receptor signaling transcriptomes.." Physiol. Genomics. 2012 Sep 4;44(17):853-63. Pubmed PMID: 22786849
- McKenna NJ, Howard CL, Aufiero M, Easton-Marks J, Steffen DL, Becnel LB, Magnuson MA, McIndoe RA, Cartailler JP "Research Resource: dkCOIN, the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) Consortium Interconnectivity Network: A Pilot Program to Aggregate Research Resources Generated by Multiple Research Consortia.." Mol. Endocrinol.. 2012 Oct;26(10):1675-81. Pubmed PMID: 22734043
- Lanz RB, McKenna NJ, Onate SA, Albrecht U, Wong J, Tsai SY, Tsai MJ, O'Malley BW "A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex.." Cell. 1999 Apr 2;97(1):17-27. Pubmed PMID: 10199399
- Pradhan A, Khalaf H, Ochsner SA, Sreenivasan R, Koskinen J, Karlsson M, Karlsson J, McKenna NJ, Orbán L, Olsson PE "Activation of NF-kB Protein Prevents the Transition from Juvenile Ovary to Testis and Promotes Ovarian Development in Zebrafish.." J. Biol. Chem.. 2012 Nov 2;287(45):37926-38. Pubmed PMID: 22988238
- McKenna NJ, O'Malley BW "An issue of tissues: divining the split personalities of selective estrogen receptor modulators.." Nat. Med.. 2000 Sep;6(9):960-2. Pubmed PMID: 10973303
- Hartig SM, Feng Q, Ochsner SA, Xiao R, McKenna NJ, McGuire SE, He B "Androgen receptor agonism promotes an osteogenic gene program in preadipocytes.." Biochem. Biophys. Res. Commun.. 2013 May 3;434(2):357-62. Pubmed PMID: 23567971
- O'Malley BW, McKenna NJ "Coactivators and corepressors: what's in a name?." Mol. Endocrinol.. 2008 Oct;22(10):2213-4. Pubmed PMID: 18701638
- McKenna NJ, O'Malley BW "Combinatorial control of gene expression by nuclear receptors and coregulators.." Cell. 2002 Feb 22;108(4):465-74. Pubmed PMID: 11909518
- Anakk S, Watanabe M, Ochsner SA, McKenna NJ, Finegold MJ, Moore DD "Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis.." J. Clin. Invest.. 2011 Jan 4;121(1):86-95. Pubmed PMID: 21123943
- McKenna NJ "Discovery-driven research and bioinformatics in nuclear receptor and coregulator signaling.." Biochim. Biophys. Acta. 2011 Aug;1812(8):808-17. Pubmed PMID: 21029773
- McKenna NJ, Nawaz Z, Tsai SY, Tsai MJ, O'Malley BW "Distinct steady-state nuclear receptor coregulator complexes exist in vivo.." Proc. Natl. Acad. Sci. U.S.A.. 1998 Sep 29;95(20):11697-702. Pubmed PMID: 9751728
- Defranco DB, Margolis R, McKenna N "Editorial: molecular endocrinology articles in the spotlight for October 2012.." Mol. Endocrinol.. 2012 Oct;26(10):1645. Pubmed PMID: 23023930
- McKenna NJ "EMBO Retinoids 2011: mechanisms, biology and pathology of signaling by retinoic acid and retinoic acid receptors.." Nucl Recept Signal. 2012;10:e003. Pubmed PMID: 22438793
- Hartig SM, He B, Newberg JY, Ochsner SA, Loose DS, Lanz RB, McKenna NJ, Buehrer BM, McGuire SE, Marcelli M, Mancini MA "Feed-forward inhibition of androgen receptor activity by glucocorticoid action in human adipocytes.." Chem. Biol.. 2012 Sep 21;19(9):1126-41. Pubmed PMID: 22999881
- McKenna NJ, O'Malley BW "From ligand to response: generating diversity in nuclear receptor coregulator function.." J. Steroid Biochem. Mol. Biol.. 2000 Nov 30;74(5):351-6. Pubmed PMID: 11162944
- Ochsner SA, Steffen DL, Hilsenbeck SG, Chen ES, Watkins C, McKenna NJ "GEMS (Gene Expression MetaSignatures), a Web resource for querying meta-analysis of expression microarray datasets: 17beta-estradiol in MCF-7 cells.." Cancer Res.. 2009 Jan 1;69(1):23-6. Pubmed PMID: 19117983
- Cheskis BJ, McKenna NJ, Wong CW, Wong J, Komm B, Lyttle CR, O'Malley BW "Hierarchical affinities and a bipartite interaction model for estrogen receptor isoforms and full-length steroid receptor coactivator (SRC/p160) family members.." J. Biol. Chem.. 2003 Apr 11;278(15):13271-7. Pubmed PMID: 12540843
- Ennis MP, McGrath-Linden SJ, McKenna NJ, McCann JJ, Irvine GB, Williams CH "Membrane-bound peptidases of Helix aspersa.." Biochem. Soc. Trans.. 1991 Aug;19(3):295S. Pubmed PMID: 1783135
- McKenna NJ, Cooney AJ, DeMayo FJ, Downes M, Glass CK, Lanz RB, Lazar MA, Mangelsdorf DJ, Moore DD, Qin J, Steffen DL, Tsai MJ, Tsai SY, Yu R, Margolis RN, Evans RM, O'Malley BW "Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas.." Mol. Endocrinol.. 2009 Jun;23(6):740-6. Pubmed PMID: 19423650
- McKenna NJ, O'Malley BW "Minireview: nuclear receptor coactivators--an update.." Endocrinology. 2002 Jul;143(7):2461-5. Pubmed PMID: 12072374
- Becnel LB, McKenna NJ "Minireview: progress and challenges in proteomics data management, sharing, and integration.." Mol. Endocrinol.. 2012 Oct;26(10):1660-74. Pubmed PMID: 22902541
- McKenna NJ, DeFranco DB "Molecular endocrinology: A portal for enhanced access and utility of the nuclear receptor signaling atlas (NURSA) web resource.." Mol. Endocrinol.. 2009 Jun;23(6):739. Pubmed PMID: 19470797
- Ochsner SA, Steffen DL, Stoeckert CJ, McKenna NJ "Much room for improvement in deposition rates of expression microarray datasets.." Nat. Methods. 2008 Dec;5(12):991. Pubmed PMID: 19034265
- McKenna NJ, Xu J, Nawaz Z, Tsai SY, Tsai MJ, O'Malley BW "Nuclear receptor coactivators: multiple enzymes, multiple complexes, multiple functions.." J. Steroid Biochem. Mol. Biol..;69(41280):41345. Pubmed PMID: 10418975
- McKenna NJ, Lanz RB, O'Malley BW "Nuclear receptor coregulators: cellular and molecular biology.." Endocr. Rev.. 1999 Jun;20(3):321-44. Pubmed PMID: 10368774
- Lanz RB, Jericevic Z, Zuercher WJ, Watkins C, Steffen DL, Margolis R, McKenna NJ "Nuclear Receptor Signaling Atlas (www.nursa.org): hyperlinking the nuclear receptor signaling community.." Nucleic Acids Res.. 2006 Jan 1;34:D221-6. Pubmed PMID: 16381851
- McKenna NJ, O'Malley BW "Nuclear receptors, coregulators, ligands, and selective receptor modulators: making sense of the patchwork quilt.." Ann. N. Y. Acad. Sci.. 2001 Dec;949:41338. Pubmed PMID: 11795367
- Rowe SM, Coughlan SJ, McKenna NJ, Garrett E, Kieback DG, Carney DN, Headon DR "Ovarian carcinoma-associated TaqI restriction fragment length polymorphism in intron G of the progesterone receptor gene is due to an Alu sequence insertion.." Cancer Res.. 1995 Jul 1;55(13):2743-5. Pubmed PMID: 7796397
- Schupp M, Cristancho AG, Lefterova MI, Hanniman EA, Briggs ER, Steger DJ, Qatanani M, Curtin JC, Schug J, Ochsner SA, McKenna NJ, Lazar MA "Re-expression of GATA2 cooperates with peroxisome proliferator-activated receptor-gamma depletion to revert the adipocyte phenotype.." J. Biol. Chem.. 2009 Apr 3;284(14):9458-64. Pubmed PMID: 19136559
- Ochsner SA, Watkins CM, Lagrone BS, Steffen DL, McKenna NJ "Research resource: tissue-specific transcriptomics and cistromics of nuclear receptor signaling: a web research resource.." Mol. Endocrinol.. 2010 Oct;24(10):2065-9. Pubmed PMID: 20685849
- DeFranco DB, McKenna NJ "Signals from NURSA.." Mol. Endocrinol.. 2009 Dec;23(12):1939. Pubmed PMID: 19934347
- McKenna NJ, O'Malley BW "SnapShot: NR Coregulators.." Cell. 2010 Oct 1;143(1):172-172.e1. Pubmed PMID: 20887900
- McKenna NJ, O'Malley BW "SnapShot: Nuclear Receptors I.." Cell. 2010 Sep 3;142(5):822-822.e1. Pubmed PMID: 20813267
- McKenna NJ, O'Malley BW "SnapShot: Nuclear Receptors II.." Cell. 2010 Sep 17;142(6):986-986.e1. Pubmed PMID: 20850017
- Spencer TE, Jenster G, Burcin MM, Allis CD, Zhou J, Mizzen CA, McKenna NJ, Onate SA, Tsai SY, Tsai MJ, O'Malley BW "Steroid receptor coactivator-1 is a histone acetyltransferase.." Nature. 1997 Sep 11;389(6647):194-8. Pubmed PMID: 9296499
- McKenna NJ, O'Malley BW "Teaching resources. An interactive course in nuclear receptor signaling: concepts and models.." Sci. STKE. 2005 Aug 30;2005(299):tr22. Pubmed PMID: 16131668
- McKenna NJ, Kieback DG, Carney DN, Fanning M, McLinden J, Headon DR "A germline TaqI restriction fragment length polymorphism in the progesterone receptor gene in ovarian carcinoma.." Br. J. Cancer. 1995 Mar;71(3):451-5. Pubmed PMID: 7880723
- Scott A. Ochsner, Rudolf T. Pillich & Neil J. McKenna "Consensus transcriptional regulatory networks of coronavirus-infected human cells." Sci Data. 2020 Sep; Pubmed PMID: 32963239
- Zapata RC, Chaudry BS, Valencia ML, Zhang D, Ochsner SA, McKenna NJ, Osborn O "Conserved immunomodulatory transcriptional networks underlie antipsychotic-induced weight gain." Transl Psychiatry. 2021 Jul;11:10.1038/s41398-021-01528-y. Pubmed PMID: 34294678
Funding
- DKNET COORDINATING UNIT: AN INFORMATION NETWORK FOR FAIR RESOURCES AND DATA - #DK097771 (09/01/2017 - 09/01/2022) Grant funding from NIDDK
- DKNET provides FAIR data and metadata services to the NIDDK-funded research community. I lead the Signaling Pathways Project component, the goal of which is to use biocurated 'omics datasets to create a hypothesis generation environment for bench researchers.
Log In to edit your profile
