Positions
- Instructor
-
Pathology
Baylor College of Medicine
Houston, TX US
- Co-Director, Human Tissue Acquisition and Pathology Shared Resource
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
Addresses
- Baylor College of Medicine (Office)
-
One Baylor Plaza
Department of Pathology and Immunology
Houston, TX 77030
United States
Phone: (713) 798-6795
pcastro@bcm.edu
Education
- PhD from University Of Texas Health Science Center
- 01/2001 - Houston, Texas United States
- Molecular Genetics, Molecular Biology
- BA from University of Pittsburgh
- 05/1992 - Pittsburgh, Pennsylvania United States
Professional Statement
I am the Laboratory Director of the Human Tissue Acquisition and Pathology Core at Baylor College of Medicine. As the Core director, my role is to facilitate the collection, processing and molecular analysis of human tissues and I manage services for histology, immunohistochemistry, and imaging of research tissues from mouse or human origin. My research interests are primarily in the field of cancer biology and my goals are geared toward directly or indirectly impacting the lives and outcomes for cancer patients. This appointment allows me to help facilitate the research of my peers at BCM through tissue distribution and specialized laboratory expertise.Websites
Selected Publications
- Shao L, Zhou Z, Cai Y, Castro P, Dakhov O, Shi P, Bai Y, Ji H, Shen W, Wang J "Celastrol Suppresses Tumor Cell Growth through Targeting an AR-ERG-NF-?B Pathway in TMPRSS2/ERG Fusion Gene Expressing Prostate Cancer.." PLoS ONE.2013;8(3):e58391. Pubmed PMID: 23554889
- Castro P, Giri D, Lamb D, Ittmann M "Cellular senescence in the pathogenesis of benign prostatic hyperplasia.." Prostate.2003/April1;55(1):30-8. Pubmed PMID: 12640658
- Castro PD, Liang JC, Nagarajan L "Deletions of chromosome 5q13.3 and 17p loci cooperate in myeloid neoplasms.." Blood.2000/March15;95(6):2138-43. Pubmed PMID: 10706886
- Castro P, Creighton CJ, Ozen M, Berel D, Mims MP, Ittmann M "Genomic profiling of prostate cancers from African American men.." Neoplasia.2009/March;11(3):305-12. Pubmed PMID: 19242612
- Castro P, Xia C, Gomez L, Lamb DJ, Ittmann M "Interleukin-8 expression is increased in senescent prostatic epithelial cells and promotes the development of benign prostatic hyperplasia.." Prostate. 2004 July 1; 60 (2): 153-9. Pubmed PMID: 15162381
- Kwabi-Addo B, Wang J, Erdem H, Vaid A, Castro P, Ayala G, Ittmann M "The expression of Sprouty1, an inhibitor of fibroblast growth factor signal transduction, is decreased in human prostate cancer.." Cancer Res.. 2004 July 15; 64 (14): 4728-35. Pubmed PMID: 15256439
- Cancer Genome Atlas Research Network. "Comprehensive molecular characterization of urothelial bladder carcinoma.." Nature. 2014 March 20; 507 (7492): 315-322. Pubmed PMID: 24476821
- Castro P, Liang H, Liang JC, Nagarajan L. "A novel, evolutionarily conserved gene family with putative sequence-specific single-stranded DNA-binding activity.." Genomics. 2002 July ; 80 (1): 78-85. Pubmed PMID: 12079286
- Liang H, Castro PD, Ma J, Nagarajan L "Finer delineation and transcript map of the 7q31 locus deleted in myeloid neoplasms.." Cancer Genet. Cytogenet.. 2005 October 15; 162 (2): 151-9. Pubmed PMID: 16213364
- Castro PD, Fairman J, Nagarajan L "The unexplored 5q13 locus: a role in hematopoietic malignancies.." Leuk. Lymphoma. 1998 August ; 30 (41400): 443-8. Pubmed PMID: 9711906
- Pan S, Cheng X, Chen H, Castro PD, Ittmann MM, Hutson AW, Zapata SK, Sifers RN. "ERManI is a target of miR-125b and promotes transformation phenotypes in hepatocellular carcinoma (HCC).." PLoS One. 2013 August 5; 8 (8): e72829. Pubmed PMID: 23940818
- Vital P1, Castro P, Tsang S, Ittmann M. "The senescence-associated secretory phenotype promotes benign prostatic hyperplasia.." Am J Pathol. 2014 March ; 184 (3): 721-731. Pubmed PMID: 24434012
- Vital P, Castro P, Ittmann M. "Oxidative stress promotes benign prostatic hyperplasia.." Prostate. 2015 September 29; : Pubmed PMID: 26417670
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