Qizhi Cathy Yao, M.D., Ph.D.
Picture
Positions
- Professor of Surgery
-
Division of Surgical Oncology
Baylor College of Medicine
- Professor
-
Molecular Virology & Microbiology, Pathology & Immunology
Baylor College of Medicine
Addresses
- Alkek Building for Biomedical Research (Office)
-
Baylor College of Medicine
Houston, TX 77030
United States
Phone: (713) 798-1765
- Molecular Surgeon Research Center R430 (Lab)
-
Baylor College of Medicine
Houston, TX 77030
United States
Phone: (713) 798-1816
Vascular Surgery
Education
- Advanced Training from Emory University
- 01/1997 - Atlanta, GA United States
- PhD from Emory University
- 01/1996 - Atlanta, GA, GA United States
- MS from University of Texas at El Paso
- 01/1990 - El Paso, TX
- MD from Southeast University Medical School
- Nanjing, China
- M.D. from Nanjing University
- 01/1986 - Nanjing, China, People's Rep
Honors & Awards
- Molecular Surgeon Research Achievement Award
- Baylor College of Medicine
- Norton Rose Fulbright Faculty Excellence Award for Teaching & Evaluation
- Baylor College of Medicine
Professional Interests
- Pancreatic cancer immunotherapy
- Pancreatic cancer pathogenesis
- Nanoparticle targeted delivery
Professional Statement
My lab is interested in developing non-infectious HIV virus-like particles (VLPs) as candidate HIV mucosal vaccines for both preventive and therapeutic purposes. In preclinical studies, VLPs formed by structural proteins are highly immunogenic and capable of inducing protective immunity against various viral infections. We have modified vaccine immunogens into chimeric HIV VLPs which contain influenza viral surface glycoprotein HA or other immunologically functional molecules. We have shown that the chimeric HIV VLPs can induce enhanced humoral and cellular immune responses against HIV in a mouse model. We have also studied the basic mechanisms of VLP-induced humoral and cellular immune responses, and other factors that affect these responses. For example, we found that VLP vaccines activate conventional B2 cells and promote B cell differentiation to IgG2a producing plasma cells; that VLP vaccines travel to the lymph nodes upon immunization and can be directly visualized by optical imaging techniques; and that intradermal immunization generates improved responses and might be a preferable delivery route for viral and cancer immunotherapeutic studies involving VLPs. Since dendritic cells (DCs) have long been known to be pivotal in initiating immune responses, we are also interested in how VLPs modulate DC functions and will evaluate the efficacy of VLP-pulsed DC vaccines. In addition, we are interested in testing the efficacy of modified chimeric VLP oral-mucosal immunization in non-human primates. Pancreatic cancer has one of the highest mortality rates and ranks as the third leading cause of cancer death in America. Survival is poor because there are no reliable tests for early diagnosis and no effective therapies to treat metastatic disease. There is a need to better understand the molecular mechanisms of pancreatic cancer tumorigenesis and to develop effective treatments. My lab currently focuses on the study of key molecules in pancreatic cancer, including Mesothelin (MSLN), Trop2 and Fibrinogen (FBG), and in their mechanisms of regulation. We are also interested in the involvement of microRNAs (miR-198) in pancreatic cancer, and how their dysregulation leads to pathogenesis. We are currently exploring tumor-associated molecule targeted therapies and RNA interference delivery by liposomes and PLGA nanoparticles in vivo. In addition, we are interested in developing non-infectious chimeric virus-like particles (VLPs) as a vaccine candidate for pancreatic cancer. Our group has shown that vaccinating mice with chimeric virus-like particles containing MSLN significantly inhibited tumor progression, suggesting a new therapeutic vaccine strategy whereby MSLN is targeted to attempt to control pancreatic cancer progression. We are also employing pancreatic cancer patient-derived xenografts (PDX) mouse model to study the potential of our various therapeutic regimens.Websites
Modulation of miR-198
Baylor College of Medicine graduate starts Speratum CR to bring his own discovery to cancer patients
Videos
Modulation of miR-198
Selected Publications
- Zhang S, Li F, Younes M, Liu H, Chen C, Yao Q "Reduced selenium-binding protein 1 in breast cancer correlates with poor survival and resistance to the anti-proliferative effects of selenium.." PLoS ONE. 2013;8(5):e63702. Pubmed PMID: 23704933
- Bharadwaj U, Marin-Muller C, Li M, Chen C, Yao Q "Mesothelin confers pancreatic cancer cell resistance to TNF-a-induced apoptosis through Akt/PI3K/NF-?B activation and IL-6/Mcl-1 overexpression.." Mol. Cancer. 2011;10:106. Pubmed PMID: 21880146
- Marin-Muller C, Rios A, Anderson D, Siwak E, Yao Q "Complete and repeatable inactivation of HIV-1 viral particles in suspension using a photo-labeled non-nucleoside reverse transcriptase inhibitor.." J. Virol. Methods. 2013 Apr;189(1):125-8. Pubmed PMID: 23384676
- Bharadwaj U, Marin-Muller C, Li M, Chen C, Yao Q "Mesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation.." Carcinogenesis. 2011 Jul;32(7):1013-24. Pubmed PMID: 21515913
- Cubas R, Zhang S, Li M, Chen C, Yao Q "Chimeric Trop2 virus-like particles: a potential immunotherapeutic approach against pancreatic cancer.." J. Immunother.. 2011 Apr;34(3):251-63. Pubmed PMID: 21389873
- Zhang R, Zhang S, Li M, Chen C, Yao Q "Incorporation of CD40 ligand into SHIV virus-like particles (VLP) enhances SHIV-VLP-induced dendritic cell activation and boosts immune responses against HIV.." Vaccine. 2010 Jul 12;28(31):5114-27. Pubmed PMID: 20471443
- Zhang S, Cubas R, Li M, Chen C, Yao Q "Virus-like particle vaccine activates conventional B2 cells and promotes B cell differentiation to IgG2a producing plasma cells.." Mol. Immunol.. 2009 Jun;46(10):1988-2001. Pubmed PMID: 19376580
- Liao D, Lin PH, Yao Q, Chen C "Vascular smooth cell proliferation in perfusion culture of porcine carotid arteries.." Biochem. Biophys. Res. Commun.. 2008 Aug 8;372(4):668-73. Pubmed PMID: 18515073
- Cubas R, Zhang S, Li M, Chen C, Yao Q "Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway.." Mol. Cancer. 2010;9:253. Pubmed PMID: 20858281
- Yang H, Zhang L, Weakley SM, Lin PH, Yao Q, Chen C "Transforming growth factor-beta increases the expression of vascular smooth muscle cell Markers in human multi-lineage progenitor cells.." Med. Sci. Monit.. 2011 Feb 25;17(3):BR55-61. Pubmed PMID: 21358594
- Lin PH, Bush RL, Yao Q, Lam R, Paladugu R, Zhou W, Chen C, Lumsden AB "Abdominal aortic surgery in patients with human immunodeficiency virus infection.." Am. J. Surg.. 2004 Dec;188(6):690-7. Pubmed PMID: 15619485
- Li M, Zhang Y, Liu Z, Bharadwaj U, Wang H, Wang X, Zhang S, Liuzzi JP, Chang SM, Cousins RJ, Fisher WE, Brunicardi FC, Logsdon CD, Chen C, Yao Q "Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression.." Proc. Natl. Acad. Sci. U.S.A.. 2007 Nov 20;104(47):18636-41. Pubmed PMID: 18003899
- Zhang R, Yang H, Li M, Yao Q, Chen C "Acceleration of endothelial-like cell differentiation from CD14+ monocytes in vitro.." Exp. Hematol.. 2005 Dec;33(12):1554-63. Pubmed PMID: 16338499
- Lam R, Lin PH, Alankar S, Yao Q, Bush RL, Chen C, Lumsden AB "Acute limb ischemia secondary to myositis-induced compartment syndrome in a patient with human immunodeficiency virus infection.." J. Vasc. Surg.. 2003 May;37(5):1103-5. Pubmed PMID: 12756362
- Mu H, Ohashi R, Yan S, Chai H, Yang H, Lin P, Yao Q, Chen C "Adipokine resistin promotes in vitro angiogenesis of human endothelial cells.." Cardiovasc. Res.. 2006 Apr 1;70(1):146-57. Pubmed PMID: 16515776
- Yang H, Zhang R, Mu H, Li M, Yao Q, Chen C "Adiponectin promotes endothelial cell differentiation from human peripheral CD14+ monocytes in vitro.." J. Cell. Mol. Med..;10(2):459-69. Pubmed PMID: 16796811
- Kougias P, Weakley SM, Yao Q, Lin PH, Chen C "Arterial baroreceptors in the management of systemic hypertension.." Med. Sci. Monit.. 2010 Jan;16(1):RA1-8. Pubmed PMID: 20037502
- Ohashi R, Mu H, Yao Q, Chen C "Atherosclerosis: immunopathogenesis and immunotherapy.." Med. Sci. Monit.. 2004 Nov;10(11):RA255-60. Pubmed PMID: 15507866
- Nan B, Yang H, Yan S, Lin PH, Lumsden AB, Yao Q, Chen C "C-reactive protein decreases expression of thrombomodulin and endothelial protein C receptor in human endothelial cells.." Surgery. 2005 Aug;138(2):212-22. Pubmed PMID: 16153429
- Yang H, Nan B, Yan S, Li M, Yao Q, Chen C "C-reactive protein decreases expression of VEGF receptors and neuropilins and inhibits VEGF165-induced cell proliferation in human endothelial cells.." Biochem. Biophys. Res. Commun.. 2005 Aug 5;333(3):1003-10. Pubmed PMID: 15975559
- Zhang R, Becnel L, Li M, Chen C, Yao Q "C-reactive protein impairs human CD14+ monocyte-derived dendritic cell differentiation, maturation and function.." Eur. J. Immunol.. 2006 Nov;36(11):2993-3006. Pubmed PMID: 17051617
- Chen C, Nan B, Lin P, Yao Q "C-reactive protein increases plasminogen activator inhibitor-1 expression in human endothelial cells.." Thromb. Res.. 2008;122(1):125-33. Pubmed PMID: 17949793
- Kougias P, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C "Adipocyte-derived cytokine resistin causes endothelial dysfunction of porcine coronary arteries.." J. Vasc. Surg.. 2005 Apr;41(4):691-8. Pubmed PMID: 15874935
- Sribenja S, Li M, Wongkham S, Wongkham C, Yao Q, Chen C "Advances in thymosin beta10 research: differential expression, molecular mechanisms, and clinical implications in cancer and other conditions.." Cancer Invest.. 2009 Dec;27(10):1016-22. Pubmed PMID: 19909017
- Wang X, Liao D, Bharadwaj U, Li M, Yao Q, Chen C "C-reactive protein inhibits cholesterol efflux from human macrophage-derived foam cells.." Arterioscler. Thromb. Vasc. Biol.. 2008 Mar;28(3):519-26. Pubmed PMID: 18096828
- Dhadwal AK, Wang X, Annambhotla S, Lin PH, Yao Q, Chen C "Capsaicin blocks HIV protease inhibitor ritonavir-induced vascular dysfunction in porcine pulmonary arteries.." Med. Sci. Monit.. 2009 Jan;15(1):BR1-5. Pubmed PMID: 19114959
- Chai H, Yan S, Wang H, Zhang R, Lin PH, Yao Q, Chen C "CD40 ligand increases expression of its receptor CD40 in human coronary artery endothelial cells.." Surgery. 2006 Aug;140(2):236-42. Pubmed PMID: 16904975
- Ohashi R, Mu H, Yao Q, Chen C "Cellular and molecular mechanisms of atherosclerosis with mouse models.." Trends Cardiovasc. Med.. 2004 Jul;14(5):187-90. Pubmed PMID: 15261890
- Mu H, Ohashi R, Lin P, Yao Q, Chen C "Cellular and molecular mechanisms of coronary vessel development.." Vasc Med. 2005 Feb;10(1):37-44. Pubmed PMID: 15920999
- Bismuth J, Lin P, Yao Q, Chen C "Ceramide: a common pathway for atherosclerosis?." Atherosclerosis. 2008 Feb;196(2):497-504. Pubmed PMID: 17963772
- Li M, Li W, Kim HJ, Yao Q, Chen C, Fisher WE "Characterization of somatostatin receptor expression in human pancreatic cancer using real-time RT-PCR.." J. Surg. Res.. 2004 Jun 15;119(2):130-7. Pubmed PMID: 15145694
- Wu H, Yao Q, Lumsden A, Chen C "Characterization of two populations of human coronary artery endothelial cells(1).." J. Surg. Res.. 2004 May 1;118(1):38-44. Pubmed PMID: 15093715
- Lü JM, Lin PH, Yao Q, Chen C "Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems.." J. Cell. Mol. Med.. 2010 Apr;14(4):840-60. Pubmed PMID: 19754673
- Chen C, Chai H, Wang X, Lin PH, Yao Q "Chlamydia heat shock protein 60 decreases expression of endothelial nitric oxide synthase in human and porcine coronary artery endothelial cells.." Cardiovasc. Res.. 2009 Sep 1;83(4):768-77. Pubmed PMID: 19443423
- Mussa FF, Chai H, Wang X, Yao Q, Lumsden AB, Chen C "Chlamydia pneumoniae and vascular disease: an update.." J. Vasc. Surg.. 2006 Jun;43(6):1301-7. Pubmed PMID: 16765261
- Mu H, Wang X, Lin PH, Yao Q, Chen C "Chlorotyrosine promotes human aortic smooth muscle cell migration through increasing superoxide anion production and ERK1/2 activation.." Atherosclerosis. 2008 Nov;201(1):67-75. Pubmed PMID: 18281051
- Lin PH, Steinberg JL, Okada T, Zhou W, El Sayed HF, Kougias P, Peden EK, Huynh TT, Yao Q, Chen C "Chronically impaired endothelial vasoreactivity following oversized endovascular introducer sheath placement in porcine iliac arteries: implications for endovascular therapy.." Vascular.;14(6):353-61. Pubmed PMID: 17150156
- Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C "Clinical use and molecular mechanisms of action of extract of Ginkgo biloba leaves in cardiovascular diseases.." Cardiovasc Drug Rev. 2004;22(4):309-19. Pubmed PMID: 15592576
- Cubas R, Li M, Chen C, Yao Q "Colorectal cancer: new advances in immunotherapy.." Cancer Biol. Ther.. 2007 Jan;6(1):41585. Pubmed PMID: 17224640
- Liao D, Wang X, Lin PH, Yao Q, Chen CJ "Covalent linkage of heparin provides a stable anti-coagulation surface of decellularized porcine arteries.." J. Cell. Mol. Med.. 2009 Aug;13(8):2736-43. Pubmed PMID: 19040421
- Chai H, Yan S, Lin P, Lumsden AB, Yao Q, Chen C "Curcumin blocks HIV protease inhibitor ritonavir-induced vascular dysfunction in porcine coronary arteries.." J. Am. Coll. Surg.. 2005 Jun;200(6):820-30. Pubmed PMID: 15922191
- Ramaswami G, Chai H, Yao Q, Lin PH, Lumsden AB, Chen C "Curcumin blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries.." J. Vasc. Surg.. 2004 Dec;40(6):1216-22. Pubmed PMID: 15622377
- Lü JM, Wang X, Marin-Muller C, Wang H, Lin PH, Yao Q, Chen C "Current advances in research and clinical applications of PLGA-based nanotechnology.." Expert Rev. Mol. Diagn.. 2009 May;9(4):325-41. Pubmed PMID: 19435455
- Marin-Muller C, Li M, Chen C, Yao Q "Current understanding and potential immunotherapy for HIV-associated squamous cell carcinoma of the anus (SCCA).." World J Surg. 2009 Apr;33(4):653-60. Pubmed PMID: 19052810
- Feurino LW, Fisher WE, Bharadwaj U, Yao Q, Chen C, Li M "Current update of cytokines in pancreatic cancer: pathogenic mechanisms, clinical indication, and therapeutic values.." Cancer Invest.. 2006 Nov;24(7):696-703. Pubmed PMID: 17118780
- Mu H, Chai H, Lin PH, Yao Q, Chen C "Current update on HIV-associated vascular disease and endothelial dysfunction.." World J Surg. 2007 Apr;31(4):632-43. Pubmed PMID: 17372667
- Cevallos M, Riha GM, Wang X, Yang H, Yan S, Li M, Chai H, Yao Q, Chen C "Cyclic strain induces expression of specific smooth muscle cell markers in human endothelial cells.." Differentiation. 2006 Dec;74(41527):552-61. Pubmed PMID: 17177852
- Riha GM, Wang X, Wang H, Chai H, Mu H, Lin PH, Lumsden AB, Yao Q, Chen C "Cyclic strain induces vascular smooth muscle cell differentiation from murine embryonic mesenchymal progenitor cells.." Surgery. 2007 Mar;141(3):394-402. Pubmed PMID: 17349852
- Obchoei S, Weakley SM, Wongkham S, Wongkham C, Sawanyawisuth K, Yao Q, Chen C "Cyclophilin A enhances cell proliferation and tumor growth of liver fluke-associated cholangiocarcinoma.." Mol. Cancer. 2011;10:102. Pubmed PMID: 21871105
- Li M, Zhai Q, Bharadwaj U, Wang H, Li F, Fisher WE, Chen C, Yao Q "Cyclophilin A is overexpressed in human pancreatic cancer cells and stimulates cell proliferation through CD147.." Cancer. 2006 May 15;106(10):2284-94. Pubmed PMID: 16604531
- Obchoei S, Wongkhan S, Wongkham C, Li M, Yao Q, Chen C "Cyclophilin A: potential functions and therapeutic target for human cancer.." Med. Sci. Monit.. 2009 Nov;15(11):RA221-32. Pubmed PMID: 19865066
- Wang X, Lin P, Yao Q, Chen C "Development of small-diameter vascular grafts.." World J Surg. 2007 Apr;31(4):682-9. Pubmed PMID: 17345123
- Wu H, Riha GM, Yang H, Li M, Yao Q, Chen C "Differentiation and proliferation of endothelial progenitor cells from canine peripheral blood mononuclear cells.." J. Surg. Res.. 2005 Jun 15;126(2):193-8. Pubmed PMID: 15919419
- Li M, Zhang Y, Bharadwaj U, Zhai QJ, Ahern CH, Fisher WE, Brunicardi FC, Logsdon CD, Chen C, Yao Q "Down-regulation of ZIP4 by RNA interference inhibits pancreatic cancer growth and increases the survival of nude mice with pancreatic cancer xenografts.." Clin. Cancer Res.. 2009 Oct 1;15(19):5993-6001. Pubmed PMID: 19755388
- Li M, Wang H, Li F, Fisher WE, Chen C, Yao Q "Effect of cyclophilin A on gene expression in human pancreatic cancer cells.." Am. J. Surg.. 2005 Nov;190(5):739-45. Pubmed PMID: 16226951
- Safaya R, Chai H, Kougias P, Lin P, Lumsden A, Yao Q, Chen C "Effect of lysophosphatidylcholine on vasomotor functions of porcine coronary arteries.." J. Surg. Res.. 2005 Jun 15;126(2):182-8. Pubmed PMID: 15919417
- Chai H, Yang H, Yan S, Li M, Lin PH, Lumsden AB, Yao Q, Chen C "Effects of 5 HIV protease inhibitors on vasomotor function and superoxide anion production in porcine coronary arteries.." J. Acquir. Immune Defic. Syndr.. 2005 Sep 1;40(1):41617. Pubmed PMID: 16123675
- Kougias P, Chai H, Lin PH, Yao Q, Lumsden AB, Chen C "Effects of adipocyte-derived cytokines on endothelial functions: implication of vascular disease.." J. Surg. Res.. 2005 Jun 1;126(1):121-9. Pubmed PMID: 15916985
- Yang H, Li M, Chai H, Yan S, Lin P, Lumsden AB, Yao Q, Chen C "Effects of cyclophilin A on cell proliferation and gene expressions in human vascular smooth muscle cells and endothelial cells.." J. Surg. Res.. 2005 Feb;123(2):312-9. Pubmed PMID: 15680395
- Bharadwaj U, Zhang R, Yang H, Li M, Doan LX, Chen C, Yao Q "Effects of cyclophilin A on myeloblastic cell line KG-1 derived dendritic like cells (DLC) through p38 MAP kinase activation.." J. Surg. Res.. 2005 Jul 1;127(1):29-38. Pubmed PMID: 15964302
- Fu W, Chai H, Yao Q, Chen C "Effects of HIV protease inhibitor ritonavir on vasomotor function and endothelial nitric oxide synthase expression.." J. Acquir. Immune Defic. Syndr.. 2005 Jun 1;39(2):152-8. Pubmed PMID: 15905730
- Ohashi R, Yan S, Mu H, Chai H, Yao Q, Lin PH, Chen C "Effects of homocysteine and ginsenoside Rb1 on endothelial proliferation and superoxide anion production.." J. Surg. Res.. 2006 Jun 15;133(2):89-94. Pubmed PMID: 16271366
- Yan S, Chai H, Wang H, Yang H, Nan B, Yao Q, Chen C "Effects of lysophosphatidylcholine on monolayer cell permeability of human coronary artery endothelial cells.." Surgery. 2005 Sep;138(3):464-73. Pubmed PMID: 16213900
- Zhang R, Bharadwaj U, Li M, Chen C, Yao Q "Effects of pentoxifylline on differentiation, maturation, and function of human CD14+ monocyte-derived dendritic cells.." J. Immunother.. 2007 Jan;30(1):89-95. Pubmed PMID: 17198087
- Cox MW, Fu W, Chai H, Paladugu R, Lin PH, Lumsden AB, Yao Q, Chen C "Effects of progesterone and estrogen on endothelial dysfunction in porcine coronary arteries.." J. Surg. Res.. 2005 Mar;124(1):104-11. Pubmed PMID: 15734487
- Nan B, Lin P, Lumsden AB, Yao Q, Chen C "Effects of TNF-alpha and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells.." Thromb. Res.. 2005;115(5):417-26. Pubmed PMID: 15733976
- Bharadwaj U, Li M, Zhang R, Chen C, Yao Q "Elevated interleukin-6 and G-CSF in human pancreatic cancer cell conditioned medium suppress dendritic cell differentiation and activation.." Cancer Res.. 2007 Jun 1;67(11):5479-88. Pubmed PMID: 17545630
- Jamaluddin MS, Wang X, Wang H, Rafael C, Yao Q, Chen C "Eotaxin increases monolayer permeability of human coronary artery endothelial cells.." Arterioscler. Thromb. Vasc. Biol.. 2009 Dec;29(12):2146-52. Pubmed PMID: 19778943
- Spencer TA, Chai H, Fu W, Ramaswami G, Cox MW, Conklin BS, Lin PH, Lumsden AB, Yao Q, Chen C "Estrogen blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries(1,2).." J. Surg. Res.. 2004 May 1;118(1):83-90. Pubmed PMID: 15093721
- Lin PH, Bush RL, Yao Q, Lumsden AB, Chen C "Evaluation of platelet deposition and neointimal hyperplasia of heparin-coated small-caliber ePTFE grafts in a canine femoral artery bypass model.." J. Surg. Res.. 2004 May 1;118(1):45-52. Pubmed PMID: 15093716
- Weakley SM, Wang H, Yao Q, Chen C "Expression and function of a large non-coding RNA gene XIST in human cancer.." World J Surg. 2011 Aug;35(8):1751-6. Pubmed PMID: 21212949
- Yang H, Li M, Chai H, Yan S, Zhang R, Yao Q, Chen C "Expression and regulation of neuropilins and VEGF receptors by TNF-alpha in human endothelial cells.." J. Surg. Res.. 2004 Dec;122(2):249-55. Pubmed PMID: 15555625
- Wang H, Li M, Lin PH, Yao Q, Chen C "Fluid shear stress regulates the expression of TGF-beta1 and its signaling molecules in mouse embryo mesenchymal progenitor cells.." J. Surg. Res.. 2008 Dec;150(2):266-70. Pubmed PMID: 18547588
- Rodriguez JA, Li M, Yao Q, Chen C, Fisher WE "Gene overexpression in pancreatic adenocarcinoma: diagnostic and therapeutic implications.." World J Surg. 2005 Mar;29(3):297-305. Pubmed PMID: 15696394
- Zhang Y, Chen AY, Li M, Chen C, Yao Q "Ginkgo biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells.." J. Surg. Res.. 2008 Jul;148(1):17-23. Pubmed PMID: 18570926
- Lü JM, Yan S, Jamaluddin S, Weakley SM, Liang Z, Siwak EB, Yao Q, Chen C "Ginkgolic acid inhibits HIV protease activity and HIV infection in vitro.." Med. Sci. Monit.. 2012 Aug 1;18(8):BR293-298. Pubmed PMID: 22847190
- Zhou W, Chai H, Courson A, Lin PH, Lumsden AB, Yao Q, Chen C "Ginkgolide A attenuates homocysteine-induced endothelial dysfunction in porcine coronary arteries.." J. Vasc. Surg.. 2006 Oct;44(4):853-62. Pubmed PMID: 17012008
- Weakley SM, Wang X, Mu H, Lü J, Lin PH, Yao Q, Chen C "Ginkgolide a-gold nanoparticles inhibit vascular smooth muscle proliferation and migration in vitro and reduce neointimal hyperplasia in a mouse model.." J. Surg. Res.. 2011 Nov;171(1):31-9. Pubmed PMID: 21571322
- Lü JM, Yao Q, Chen C "Ginseng compounds: an update on their molecular mechanisms and medical applications.." Curr Vasc Pharmacol. 2009 Jul;7(3):293-302. Pubmed PMID: 19601854
- Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C "Ginsenoside Rb1 blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries.." J. Vasc. Surg.. 2005 May;41(5):861-8. Pubmed PMID: 15886672
- Lü JM, Weakley SM, Yang Z, Hu M, Yao Q, Chen C "Ginsenoside rb1 directly scavenges hydroxyl radical and hypochlorous Acid.." Curr. Pharm. Des.. 2012;18(38):6339-47. Pubmed PMID: 22974003
- Hedayati N, Annambhotla S, Jiang J, Wang X, Chai H, Lin PH, Yao Q, Chen C "Growth hormone-releasing peptide ghrelin inhibits homocysteine-induced endothelial dysfunction in porcine coronary arteries and human endothelial cells.." J. Vasc. Surg.. 2009 Jan;49(1):199-207. Pubmed PMID: 19028051
- Bechara C, Chai H, Lin PH, Yao Q, Chen C "Growth related oncogene-alpha (GRO-alpha): roles in atherosclerosis, angiogenesis and other inflammatory conditions.." Med. Sci. Monit.. 2007 Jun;13(6):RA87-90. Pubmed PMID: 17534244
- Bechara C, Wang X, Chai H, Lin PH, Yao Q, Chen C "Growth-related oncogene-alpha induces endothelial dysfunction through oxidative stress and downregulation of eNOS in porcine coronary arteries.." Am. J. Physiol. Heart Circ. Physiol.. 2007 Nov;293(5):H3088-95. Pubmed PMID: 17873023
- Wang X, Liao D, Lin PH, Yao Q, Chen C "Highly active antiretroviral therapy drugs inhibit in vitro cholesterol efflux from human macrophage-derived foam cells.." Lab. Invest.. 2009 Dec;89(12):1355-63. Pubmed PMID: 19770838
- Jiang J, Fu W, Wang X, Lin PH, Yao Q, Chen C "HIV gp120 induces endothelial dysfunction in tumour necrosis factor-{alpha}-activated porcine and human endothelial cells.." Cardiovasc. Res.. 2010 Jul 15;87(2):366-74. Pubmed PMID: 20083573
- Duffy P, Wang X, Lin PH, Yao Q, Chen C "HIV Nef protein causes endothelial dysfunction in porcine pulmonary arteries and human pulmonary artery endothelial cells.." J. Surg. Res.. 2009 Oct;156(2):257-64. Pubmed PMID: 19540523
- Conklin BS, Fu W, Lin PH, Lumsden AB, Yao Q, Chen C "HIV protease inhibitor ritonavir decreases endothelium-dependent vasorelaxation and increases superoxide in porcine arteries.." Cardiovasc. Res.. 2004 Jul 1;63(1):168-75. Pubmed PMID: 15194474
- Chen C, Lu XH, Yan S, Chai H, Yao Q "HIV protease inhibitor ritonavir increases endothelial monolayer permeability.." Biochem. Biophys. Res. Commun.. 2005 Sep 30;335(3):874-82. Pubmed PMID: 16105660
- Paladugu R, Fu W, Conklin BS, Lin PH, Lumsden AB, Yao Q, Chen C "Hiv Tat protein causes endothelial dysfunction in porcine coronary arteries.." J. Vasc. Surg.. 2003 Sep;38(3):549-55; discuss. Pubmed PMID: 12947275
- Wang X, Mu H, Chai H, Liao D, Yao Q, Chen C "Human immunodeficiency virus protease inhibitor ritonavir inhibits cholesterol efflux from human macrophage-derived foam cells.." Am. J. Pathol.. 2007 Jul;171(1):304-14. Pubmed PMID: 17591975
- Liao D, Wang X, Li M, Lin PH, Yao Q, Chen C "Human protein S inhibits the uptake of AcLDL and expression of SR-A through Mer receptor tyrosine kinase in human macrophages.." Blood. 2009 Jan 1;113(1):165-74. Pubmed PMID: 18922854
- Chen C, Jamaluddin MS, Yan S, Sheikh-Hamad D, Yao Q "Human stanniocalcin-1 blocks TNF-alpha-induced monolayer permeability in human coronary artery endothelial cells.." Arterioscler. Thromb. Vasc. Biol.. 2008 May;28(5):906-12. Pubmed PMID: 18309109
- Li M, Zhang Y, Feurino LW, Wang H, Fisher WE, Brunicardi FC, Chen C, Yao Q "Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer.." Cancer Sci.. 2008 Apr;99(4):733-7. Pubmed PMID: 18307536
- Yao Q, Vuong V, Li M, Compans RW "Intranasal immunization with SIV virus-like particles (VLPs) elicits systemic and mucosal immunity.." Vaccine. 2002 Jun 7;20(19):2537-45. Pubmed PMID: 12057610
- Wang XP, Yazawa K, Templeton NS, Yang J, Liu S, Li Z, Li M, Yao Q, Chen C, Brunicardi FC "Intravenous delivery of liposome-mediated nonviral DNA is less toxic than intraperitoneal delivery in mice.." World J Surg. 2005 Mar;29(3):339-43. Pubmed PMID: 15706434
- Bismuth J, Chai H, Lin PH, Yao Q, Chen C "Lactosylceramide causes endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells.." Med. Sci. Monit.. 2009 Sep;15(9):BR270-4. Pubmed PMID: 19721395
- Mu H, Wang X, Wang H, Lin P, Yao Q, Chen C "Lactosylceramide promotes cell migration and proliferation through activation of ERK1/2 in human aortic smooth muscle cells.." Am. J. Physiol. Heart Circ. Physiol.. 2009 Jul;297(1):H400-8. Pubmed PMID: 19465542
- Naoum JJ, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C "Lymphotoxin-alpha and cardiovascular disease: clinical association and pathogenic mechanisms.." Med. Sci. Monit.. 2006 Jul;12(7):RA121-4. Pubmed PMID: 16810143
- Chen C, Ochoa LN, Kagan A, Chai H, Liang Z, Lin PH, Yao Q "Lysophosphatidic acid causes endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells.." Atherosclerosis. 2012 May;222(1):74-83. Pubmed PMID: 22424734
- Kougias P, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C "Lysophosphatidylcholine and secretory phospholipase A2 in vascular disease: mediators of endothelial dysfunction and atherosclerosis.." Med. Sci. Monit.. 2006 Jan;12(1):RA5-16. Pubmed PMID: 16369478
- Li M, Bharadwaj U, Zhang R, Zhang S, Mu H, Fisher WE, Brunicardi FC, Chen C, Yao Q "Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer.." Mol. Cancer Ther.. 2008 Feb;7(2):286-96. Pubmed PMID: 18281514
- Bharadwaj U, Li M, Chen C, Yao Q "Mesothelin-induced pancreatic cancer cell proliferation involves alteration of cyclin E via activation of signal transducer and activator of transcription protein 3.." Mol. Cancer Res.. 2008 Nov;6(11):1755-65. Pubmed PMID: 19010822
- Chen C, Zhang Y, Zhang L, Weakley SM, Yao Q "MicroRNA-196: critical roles and clinical applications in development and cancer.." J. Cell. Mol. Med.. 2011 Jan;15(1):14-23. Pubmed PMID: 21091634
- Li M, Marin-Muller C, Bharadwaj U, Chow KH, Yao Q, Chen C "MicroRNAs: control and loss of control in human physiology and disease.." World J Surg. 2009 Apr;33(4):667-84. Pubmed PMID: 19030926
- Jamaluddin MS, Weakley SM, Zhang L, Kougias P, Lin PH, Yao Q, Chen C "miRNAs: roles and clinical applications in vascular disease.." Expert Rev. Mol. Diagn.. 2011 Jan;11(1):79-89. Pubmed PMID: 21171923
- Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen CJ "Molecular mechanisms and clinical applications of ginseng root for cardiovascular disease.." Med. Sci. Monit.. 2004 Aug;10(8):RA187-92. Pubmed PMID: 15278009
- Lu JM, Nurko J, Weakley SM, Jiang J, Kougias P, Lin PH, Yao Q, Chen C "Molecular mechanisms and clinical applications of nordihydroguaiaretic acid (NDGA) and its derivatives: An update.." Med. Sci. Monit.. 2010 Apr 28;16(5):RA93-100. Pubmed PMID: 20424564
- Wang X, Chai H, Yao Q, Chen C "Molecular mechanisms of HIV protease inhibitor-induced endothelial dysfunction.." J. Acquir. Immune Defic. Syndr.. 2007 Apr 15;44(5):493-9. Pubmed PMID: 17245228
- Wang X, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C "Mouse models of neointimal hyperplasia: techniques and applications.." Med. Sci. Monit.. 2006 Sep;12(9):RA177-85. Pubmed PMID: 16940942
- Li M, Li ZN, Yao Q, Yang C, Steinhauer DA, Compans RW "Murine leukemia virus R Peptide inhibits influenza virus hemagglutinin-induced membrane fusion.." J. Virol.. 2006 Jun;80(12):6106-14. Pubmed PMID: 16731949
- Weakley SM, Jiang J, Lu J, Wang X, Lin PH, Yao Q, Chen C "Natural antioxidant dihydroxybenzyl alcohol blocks ritonavir-induced endothelial dysfunction in porcine pulmonary arteries and human endothelial cells.." Med. Sci. Monit.. 2011 Aug 22;17(9):BR235-241. Pubmed PMID: 21873935
- Kougias P, Chai H, Lin PH, Yao Q, Lumsden AB, Chen C "Neutrophil antimicrobial peptide alpha-defensin causes endothelial dysfunction in porcine coronary arteries.." J. Vasc. Surg.. 2006 Feb;43(2):357-63. Pubmed PMID: 16476615
- Li M, Yan S, Fisher WE, Chen C, Yao Q "New roles of a neuropeptide cortistatin in the immune system and cancer.." World J Surg. 2005 Mar;29(3):354-6. Pubmed PMID: 15696397
- Mohiuddin I, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C "Nitrotyrosine and chlorotyrosine: clinical significance and biological functions in the vascular system.." J. Surg. Res.. 2006 Jun 15;133(2):143-9. Pubmed PMID: 16360172
- Mu H, Wang X, Lin P, Yao Q, Chen C "Nitrotyrosine promotes human aortic smooth muscle cell migration through oxidative stress and ERK1/2 activation.." Biochim. Biophys. Acta. 2008 Sep;1783(9):1576-84. Pubmed PMID: 18460343
- Lü JM, Nurko J, Jiang J, Weakley SM, Lin PH, Yao Q, Chen C "Nordihydroguaiaretic acid (NDGA) inhibits ritonavir-induced endothelial dysfunction in porcine pulmonary arteries.." Med. Sci. Monit.. 2011 Nov;17(11):BR312-318. Pubmed PMID: 22037733
- Lay MK, Atmar RL, Guix S, Bharadwaj U, He H, Neill FH, Sastry KJ, Yao Q, Estes MK "Norwalk virus does not replicate in human macrophages or dendritic cells derived from the peripheral blood of susceptible humans.." Virology. 2010 Oct 10;406(1):41285. Pubmed PMID: 20667573
- Long J, Zhang Y, Yu X, Yang J, LeBrun DG, Chen C, Yao Q, Li M "Overcoming drug resistance in pancreatic cancer.." Expert Opin. Ther. Targets. 2011 Jul;15(7):817-28. Pubmed PMID: 21391891
- Li M, Yang H, Chai H, Fisher WE, Wang X, Brunicardi FC, Yao Q, Chen C "Pancreatic carcinoma cells express neuropilins and vascular endothelial growth factor, but not vascular endothelial growth factor receptors.." Cancer. 2004 Nov 15;101(10):2341-50. Pubmed PMID: 15476280
- Zhang Y, Li M, Wang H, Fisher WE, Lin PH, Yao Q, Chen C "Profiling of 95 microRNAs in pancreatic cancer cell lines and surgical specimens by real-time PCR analysis.." World J Surg. 2009 Apr;33(4):698-709. Pubmed PMID: 19030927
- Annambhotla S, Bourgeois S, Wang X, Lin PH, Yao Q, Chen C "Recent advances in molecular mechanisms of abdominal aortic aneurysm formation.." World J Surg. 2008 Jun;32(6):976-86. Pubmed PMID: 18259804
- Zhang Y, Li M, Yao Q, Chen C "Recent advances in tumor hypoxia: tumor progression, molecular mechanisms, and therapeutic implications.." Med. Sci. Monit.. 2007 Oct;13(10):RA175-80. Pubmed PMID: 17901861
- Fu W, Conklin BS, Lin PH, Lumsden AB, Yao Q, Chen C "Red wine prevents homocysteine-induced endothelial dysfunction in porcine coronary arteries.." J. Surg. Res.. 2003 Nov;115(1):82-91. Pubmed PMID: 14572777
- Chen C, Jiang J, Lü JM, Chai H, Wang X, Lin PH, Yao Q "Resistin decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells.." Am. J. Physiol. Heart Circ. Physiol.. 2010 Jul;299(1):H193-201. Pubmed PMID: 20435848
- Jamaluddin MS, Weakley SM, Yao Q, Chen C "Resistin: functional roles and therapeutic considerations for cardiovascular disease.." Br. J. Pharmacol.. 2012 Feb;165(3):622-32. Pubmed PMID: 21545576
- Ohashi R, Mu H, Wang X, Yao Q, Chen C "Reverse cholesterol transport and cholesterol efflux in atherosclerosis.." QJM. 2005 Dec;98(12):845-56. Pubmed PMID: 16258026
- Riha GM, Lin PH, Lumsden AB, Yao Q, Chen C "Review: application of stem cells for vascular tissue engineering.." Tissue Eng..;11(41527):1535-52. Pubmed PMID: 16259608
- Weakley SM, Jiang J, Kougias P, Lin PH, Yao Q, Brunicardi FC, Gibbs RA, Chen C "Role of somatic mutations in vascular disease formation.." Expert Rev. Mol. Diagn.. 2010 Mar;10(2):173-85. Pubmed PMID: 20214536
- Zhang Y, Li M, Yao Q, Chen C "Roles and mechanisms of copper transporting ATPases in cancer pathogenesis.." Med. Sci. Monit.. 2009 Jan;15(1):RA1-5. Pubmed PMID: 19114980
- Wang X, Chai H, Lin PH, Yao Q, Chen C "Roles and mechanisms of human immunodeficiency virus protease inhibitor ritonavir and other anti-human immunodeficiency virus drugs in endothelial dysfunction of porcine pulmonary arteries and human pulmonary artery endothelial cells.." Am. J. Pathol.. 2009 Mar;174(3):771-81. Pubmed PMID: 19218343
- Zhang L, Jamaluddin MS, Weakley SM, Yao Q, Chen C "Roles and mechanisms of microRNAs in pancreatic cancer.." World J Surg. 2011 Aug;35(8):1725-31. Pubmed PMID: 21222121
- Sribenja S, Wongkham S, Wongkham C, Yao Q, Chen C "Roles and Mechanisms of ß-Thymosins in Cell Migration and Cancer Metastasis: An Update.." Cancer Invest.. 2013 Feb;31(2):103-10. Pubmed PMID: 23320791
- Yao Q, Li M, Yang H, Chai H, Fisher W, Chen C "Roles of cyclophilins in cancers and other organ systems.." World J Surg. 2005 Mar;29(3):276-80. Pubmed PMID: 15706440
- Riha GM, Lin PH, Lumsden AB, Yao Q, Chen C "Roles of hemodynamic forces in vascular cell differentiation.." Ann Biomed Eng. 2005 Jun;33(6):772-9. Pubmed PMID: 16078617
- Chen C, Li M, Chai H, Yang H, Fisher WE, Yao Q "Roles of neuropilins in neuronal development, angiogenesis, and cancers.." World J Surg. 2005 Mar;29(3):271-5. Pubmed PMID: 15696396
- Chen C, Li M, Yang H, Chai H, Fisher W, Yao Q "Roles of thymosins in cancers and other organ systems.." World J Surg. 2005 Mar;29(3):264-70. Pubmed PMID: 15706436
- Yan S, Wang X, Chai H, Wang H, Yao Q, Chen C "Secretoneurin increases monolayer permeability in human coronary artery endothelial cells.." Surgery. 2006 Aug;140(2):243-51. Pubmed PMID: 16904976
- Wang X, Chai H, Wang Z, Lin PH, Yao Q, Chen C "Serum amyloid A induces endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells.." Am. J. Physiol. Heart Circ. Physiol.. 2008 Dec;295(6):H2399-408. Pubmed PMID: 18931033
- Wang H, Riha GM, Yan S, Li M, Chai H, Yang H, Yao Q, Chen C "Shear stress induces endothelial differentiation from a murine embryonic mesenchymal progenitor cell line.." Arterioscler. Thromb. Vasc. Biol.. 2005 Sep;25(9):1817-23. Pubmed PMID: 15994439
- Wang H, Yan S, Chai H, Riha GM, Li M, Yao Q, Chen C "Shear stress induces endothelial transdifferentiation from mouse smooth muscle cells.." Biochem. Biophys. Res. Commun.. 2006 Aug 4;346(3):860-5. Pubmed PMID: 16793021
- Zhang R, Li M, Chen C, Yao Q "SHIV virus-like particles bind and activate human dendritic cells.." Vaccine. 2004 Nov 25;23(2):139-47. Pubmed PMID: 15531030
- Li M, Becnel LS, Li W, Fisher WE, Chen C, Yao Q "Signal transduction in human pancreatic cancer: roles of transforming growth factor beta, somatostatin receptors, and other signal intermediates.." Arch. Immunol. Ther. Exp. (Warsz.).;53(5):381-7. Pubmed PMID: 16314822
- Huang C, Li M, Chen C, Yao Q "Small interfering RNA therapy in cancer: mechanism, potential targets, and clinical applications.." Expert Opin. Ther. Targets. 2008 May;12(5):637-45. Pubmed PMID: 18410245
- Lin PH, Chen C, Bush RL, Yao Q, Lumsden AB, Hanson SR "Small-caliber heparin-coated ePTFE grafts reduce platelet deposition and neointimal hyperplasia in a baboon model.." J. Vasc. Surg.. 2004 Jun;39(6):1322-8. Pubmed PMID: 15192575
- Chen C, Chai H, Wang X, Jiang J, Jamaluddin MS, Liao D, Zhang Y, Wang H, Bharadwaj U, Zhang S, Li M, Lin P, Yao Q "Soluble CD40 ligand induces endothelial dysfunction in human and porcine coronary artery endothelial cells.." Blood. 2008 Oct 15;112(8):3205-16. Pubmed PMID: 18658029
- Celinski SA, Fisher WE, Amaya F, Wu YQ, Yao Q, Youker KA, Li M "Somatostatin receptor gene transfer inhibits established pancreatic cancer xenografts.." J. Surg. Res.. 2003 Nov;115(1):41-7. Pubmed PMID: 14572771
- Li M, Wang X, Li W, Li F, Yang H, Wang H, Brunicardi FC, Chen C, Yao Q, Fisher WE "Somatostatin receptor-1 induces cell cycle arrest and inhibits tumor growth in pancreatic cancer.." Cancer Sci.. 2008 Nov;99(11):2218-23. Pubmed PMID: 18823376
- Li M, Fisher WE, Kim HJ, Wang X, Brunicardi CF, Chen C, Yao Q "Somatostatin, somatostatin receptors, and pancreatic cancer.." World J Surg. 2005 Mar;29(3):293-6. Pubmed PMID: 15706439
- Yu X, Zhang Y, Chen C, Yao Q, Li M "Targeted drug delivery in pancreatic cancer.." Biochim. Biophys. Acta. 2010 Jan;1805(1):97-104. Pubmed PMID: 19853645
- Yao Q, Zhang R, Guo L, Li M, Chen C "Th cell-independent immune responses to chimeric hemagglutinin/simian human immunodeficiency virus-like particles vaccine.." J. Immunol.. 2004 Aug 1;173(3):1951-8. Pubmed PMID: 15265929
- Cheng C, Wang X, Weakley SM, Kougias P, Lin PH, Yao Q, Chen C "The soybean isoflavonoid equol blocks ritonavir-induced endothelial dysfunction in porcine pulmonary arteries and human pulmonary artery endothelial cells.." J. Nutr.. 2010 Jan;140(1):41615. Pubmed PMID: 19923382
- Zhang Y, Feurino LW, Zhai Q, Wang H, Fisher WE, Chen C, Yao Q, Li M "Thymosin Beta 4 is overexpressed in human pancreatic cancer cells and stimulates proinflammatory cytokine secretion and JNK activation.." Cancer Biol. Ther.. 2008 Mar;7(3):419-23. Pubmed PMID: 18094619
- Li M, Zhang Y, Zhai Q, Feurino LW, Fisher WE, Chen C, Yao Q "Thymosin beta-10 is aberrantly expressed in pancreatic cancer and induces JNK activation.." Cancer Invest.. 2009 Mar;27(3):251-6. Pubmed PMID: 19194824
- Mu H, Ohashi R, Yang H, Wang X, Li M, Lin P, Yao Q, Chen C "Thymosin beta10 inhibits cell migration and capillary-like tube formation of human coronary artery endothelial cells.." Cell Motil. Cytoskeleton. 2006 Apr;63(4):222-30. Pubmed PMID: 16496302
- Yao Q, Doan LX, Zhang R, Bharadwaj U, Li M, Chen C "Thymosin-alpha1 modulates dendritic cell differentiation and functional maturation from human peripheral blood CD14+ monocytes.." Immunol. Lett.. 2007 Jun 15;110(2):110-20. Pubmed PMID: 17532057
- Li M, Feurino LW, Li F, Wang H, Zhai Q, Fisher WE, Chen C, Yao Q "Thymosinalpha1 stimulates cell proliferation by activating ERK1/2, JNK, and increasing cytokine secretion in human pancreatic cancer cells.." Cancer Lett.. 2007 Apr 8;248(1):58-67. Pubmed PMID: 16828224
- Yan S, Li M, Chai H, Yang H, Lin PH, Yao Q, Chen C "TNF-alpha decreases expression of somatostatin, somatostatin receptors, and cortistatin in human coronary endothelial cells.." J. Surg. Res.. 2005 Feb;123(2):294-301. Pubmed PMID: 15680393
- Li M, Zhang R, Li F, Wang H, Kim HJ, Becnel L, Yao Q, Chen C, Fisher WE "Transfection of SSTR-1 and SSTR-2 inhibits Panc-1 cell proliferation and renders Panc-1 cells responsive to somatostatin analogue.." J. Am. Coll. Surg.. 2005 Oct;201(4):571-8. Pubmed PMID: 16183496
- Cubas R, Li M, Chen C, Yao Q "Trop2: a possible therapeutic target for late stage epithelial carcinomas.." Biochim. Biophys. Acta. 2009 Dec;1796(2):309-14. Pubmed PMID: 19683559
- Cubas R, Zhang S, Kwon S, Sevick-Muraca EM, Li M, Chen C, Yao Q "Virus-like particle (VLP) lymphatic trafficking and immune response generation after immunization by different routes.." J. Immunother..;32(2):118-28. Pubmed PMID: 19238010
- Doan LX, Li M, Chen C, Yao Q "Virus-like particles as HIV-1 vaccines.." Rev. Med. Virol..;15(2):75-88. Pubmed PMID: 15484204
- Zhang Y, Chen C, Yao Q, Li M "ZIP4 upregulates the expression of neuropilin-1, vascular endothelial growth factor, and matrix metalloproteases in pancreatic cancer cell lines and xenografts.." Cancer Biol. Ther.. 2010 Feb;9(3):236-42. Pubmed PMID: 20023433
- Zhang Y, Bharadwaj U, Logsdon CD, Chen C, Yao Q, Li M "ZIP4 regulates pancreatic cancer cell growth by activating IL-6/STAT3 pathway through zinc finger transcription factor CREB.." Clin. Cancer Res.. 2010 Mar 1;16(5):1423-30. Pubmed PMID: 20160059
- Marin-Muller, C., Li, D., Lü, J.M., Liang, Z, Vega-Martínez, O., Crawford, S.E., Estes, M.K., Fisher, W.E., Chen, C. and Yao, Q "Nanoparticle-Mediated Therapy with miR-198 Sensitizes Pancreatic Cancer to Gemcitabine Treatment through Downregulation of VCP-Mediated Autophagy." Pharmaceutics.; Pubmed PMID: 15082038
- LaPlante, E., Liu, D., Petrosyan, V., Yao, Q and Milosavljevic, A "XDec analysis of Cell-intrinsic and Heterotypic Interactions (XDec-CHI) reveals distinct immunosuppressive interactions across subtypes of pancreatic ductal adenocarcinoma." iScience.; Pubmed PMID: 36274954
- Marin-Muller, C., Li, D., Bharadwaj, U., Li, M., Chen, C., Fisher, WE., Mo, Q., Hung, MC., Yao Q "A Tumorigenic Factor Interactome Connected Through Tumor Suppressor MicroRNA-198 in Human Pancreatic Cancer." Clinical Cancer Research.; Pubmed PMID: 3920728
- Cubas R, Zhang S, Li M, Chen C, Yao Q "Trop2 virus-like particles activate broad anti-tumor immune responses and effectively control pancreatic cancer progression." Journal of Immunotherapy.;
Memberships
- American Association for the Advancement of Science
- American Association for Cancer Research
- Association for Academic Surgery
- American Association of Immunologists
- Society of Chinese Bioscientists in America
- American Society for Virology
- National Academy of Inventors
- Fellow
Log In to edit your profile
