Positions

Faculty

Division of Surgical Oncology
Baylor College of Medicine

Addresses

Baylor College of Medicine (Lab)

Alkek Building for Biomedical Research
R431B
Houston, TX 77030
United States

Education

PhD from University of Calcutta

West Bengal, India

MSc from University of Calcutta

West Bengal, India

BSc from University of Calcutta

West Bengal, India

Research Fellowship at Baylor College of Medicine

Houston, Texas United States

RNA biology

Professional Interests

• GI Oncology Translational Research
• Combinatorial Therapeutic Strategies
• GI Malignancies
• Endothelial Cell Biology

Professional Statement

Dr. Rajat Bhattacharya is a faculty member in the Michael E. DeBakey Department of Surgery at Baylor College of Medicine. His major research interests are focused on understanding mechanisms of resistance to therapies and developing novel strategies to overcome failure of systemic therapeutics in gastrointestinal (GI) malignancies with a focus on colorectal cancer (CRC). Another area of focus is in understanding the role of the tumor microenvironment and therapeutic interventions on immune modulation in CRC and other GI tumors. Dr. Bhattacharya’s research program integrates tumor biology, high-throughput

combinatorial drug discovery and preclinical animal models with the goal of improving outcomes in patients with GI malignancies.

Websites

Selected Publications

• Ghosh, S, Fan, F, Powell, RT, Park, YS, Stephan, C, Kopetz, ES, Ellis, LM, Bhattacharya, R. "Enhancing efficacy of the MEK inhibitor trametinib with paclitaxel in KRAS-mutated colorectal cancer." Therapeutic Advances in Medical Oncology.;
• Chattopadhyay C, Roszik J, Bhattacharya R, Alauddin M, Mahmud I, Yadugiri S, Ali MM, Khan FS, Prabhu VV, Lorenzi PL, Wei B, Burton E, Morey RR, Lazcano R, Davies MA, Patel SP, Grimm EA "Imipridones inhibit tumor growth and improve survival in an orthotopic liver metastasis mouse model of human uveal melanoma." Br J Cancer.; Pubmed PMID: 39394450
• Ghosh S, Fan F, Powell RT, Roszik J, Park YS, Stephan C, Sebastian M, Tan L, Sorokin AV, Lorenzi PL, Kopetz S, Ellis LM, Bhattacharya R "Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer." Mol Cancer Ther.; Pubmed PMID: 37310170
• Fan F, Ghosh S, Powell R, Roszik J, Park Y, Sobieski M, Sorokin A, Stephan C, Kopetz S, Ellis LM, Bhattacharya R "Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo." PLoS One.; Pubmed PMID: 36952536