Email

agibbs@bcm.edu

Positions

Wofford Cain Chair and Professor

Molecular and Human Genetics
Baylor College of Medicine

Director

Human Genome Sequencing Center
Baylor College of Medicine

Professor

Program in Translational Biology & Molecular Medicine
Baylor College of Medicine

Professor

Program in Integrative Molecular and Biomedical Sciences
Baylor College of Medicine

Professor

HGSC:Faculty-General/Basic
Baylor College of Medicine
Houston, TX US

Member

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States

Addresses

BCM-Alkek Graduate School (Office)

Room: BCMN-N1619
Houston, TX 77030
United States

Education

BS from University Of Melbourne

01/1978 - Melbourne, Australia

PhD from University Of Melbourne

01/1986 - Melbourne, Australia

Post-Doctoral Fellowship at Baylor College Of Medicine

01/1986 - Houston, TX United States

Honors & Awards

Elected to the Institute of Medicine

2011

LSU Chancellor's Distinguished Lectureship

2001

Michael E. DeBakey, M.D., Excellence in Research Award

2000

George R. Sampson Distinguished Research Fellowship

1998-1989

Muscular Dystrophy Association

Postdoctoral Fellowship

1987

American Arthritis Foundation

Postdoctoral Fellowship

1986

Muscular Dystrophy Association of America

Wofford Cain Chair in Molecular and Human Genetics

Professional Interests

• Genome science, human molecular evolution, and molecular basis of inherited disease

Professional Statement

Richard Gibbs is the founder and director of the Human Genome Sequencing Center (HGSC), established at BCM in 1996. The HGSC has a core mission of advancing medical care through research and translation of genomics. The group was one of the five worldwide sites to undertake and complete the Human Genome Project, culminating in contribution of approximately ten percent of the sequence in 2003. The group subsequently collaborated to sequence many key species (Drosophila melanogaster, Brown Norway rat, rhesus macaque, bovine, Dictyostelium discoideum, sea urchin and honey bee genomes) and to generate the first comprehensive map of human genetic variation (the HapMap project). The HGSC now employs more than 180 staff, including eighteen faculty.

Since 2007, new technologies have allowed unprecedented advances in human genetics. The HGSC pioneered whole exome capture methods and published the first diploid sequence of a human, James Watson. Next, we demonstrated the utility of whole genome sequencing for genetic disease discovery and for guiding effective clinical treatments. In 2011, we began deploying these methods into routine clinical practice and now provide full gene sequencing to hundreds of individual patients each month. The HGSC is also part of the national program for systematic discovery of the cause of human single genome defects and has an active bioinformatics program, with research projects involving biologists and computer scientists. To advance the use of genomics in adult clinics the HGSC has developed methods for screening for cardiovascular genetic risk and has recently joined the national All of Us consortium. Problems under study focus on developing tools for generating, manipulating and analyzing genome data.

Websites

Selected Publications

• Jiang Y, Wangler MF, McGuire AL, Lupski JR, Posey JE, Khayat MM, Murdock DR, Sanchez-Pulido L, Ponting CP, Xia F, Hunter JV,Meng Q, Murugan M, Gibbs RA "The phenotypic spectrum of Xia-Gibbs syndrome.." Am J Med Genet A.. 2018;176:1315-1326.
• Xia F, Bainbridge MN, Tan TY, Wangler MF, Scheuerle AE, Zackai EH, Harr MH, Sutton VR, Nalam RL, Zhu W, Nash M, Ryan MM, Yaplito-Lee J, Hunter JV, Deardorff MA, Penney SJ, Beaudet AL, Plon SE, Boerwinkle EA, Lupski JR, Eng CM, Muzny DM, Yang Y, Gibbs RA "De novo truncating mutations in AHDC1 in individuals with syndromic expressive language delay, hypotonia, and sleep apnea.." Am J Hum Genet.. 2014;94:784-9.
• Reid JG, Carroll A, Veeraraghavan N, Dahdouli M, Sundquist A, English A, Bainbridge M, White S, Salerno W, Buhay C, Yu F, Muzny D, Daly R, Duyk G, Gibbs RA, Boerwinkle E "Launching genomics into the cloud: deployment of Mercury, a next generation sequence analysis pipeline.." BMC Bioinformatics.. 2014;15:30.
• Crowley JJ, Hilliard CE, Kim Y, Morgan MB, Lewis LR, Muzny DM, Hawes AC, Sabo A, Wheeler DA, Lieberman JA, Sullivan PF, Gibbs RA "Deep resequencing and association analysis of schizophrenia candidate genes.." Mol. Psychiatry. 2013 Feb;18(2):138-40. Pubmed PMID: 22472875