Positions
- Professor
-
Integrative Physiology/Pautler
Baylor College of Medicine
Houston, TX US
Education
- Ph.D. from Carnegie Mellon University
- 01/1999 - Pittsburgh, PA United States
- B.S. from Colorado State University
- 01/1993 - Fort Collins, CO United States
Professional Interests
- Gene Expression
- Axonal Transport
- Biomedical Imaging
- Alzheimer's Disease
- Neurophysiology
Professional Statement
Dr. Pautler develops and applies methodologies that permit high- resolution images of the structure and function of the brain in intact, living animals. Her current research efforts build upon the new technique that she developed known as Manganese Enhanced MRI (MEMRI) neuronal tract tracing. Manganese ion, Mn2+, is a calcium analogue and can enter neurons through calcium (Ca2+) channels. Furthermore, Mn2+ is transported along microtubules via fast axonal transport and is also paramagnetic, rendering it MRI detectable in spin-lattice (T1)-weighted MRI images. It is therefore possible to utilize MRI to repeatedly measure dynamic changes in signal intensity, reflective of fast axonal transport of Mn2+ ion, within the same animal before and during disease progression. One main project in Dr. Pautler's lab involves utilizing MEMRI to longitudinally elucidate in vivo changes in axonal transport rates in the central nervous system of mouse models of Alzheimer's Disease (AD) as symptoms evolve. Axonal transport deficits have been observed in flies and cultured rodent neurons exposed to excess amyloid precursor protein (APP) or amyloid-beta, but neither the molecular basis of the transport deficit nor the temporal relationship of the transport deficit and the acquisition of AD are known.Websites
Selected Publications
- Inoue T1, Griffin DM2, Huq R1, Samuel EL3, Ruano SH1, Stinnett G1, Majid TJ2, Beeton C1,2, Tour JM4, Pautler RG5,6. "Characterization of a novel MR-detectable nanoantioxidant that mitigates the recall immune response." NMR Biomed. 2016 Oct;29((10)):1436-44. Pubmed PMID: 27552925
- Bitner BR, Marcano DC, Berlin JM, Fabian RH, Cherian L, Culver JC, Dickinson ME, Robertson CS, Pautler RG, Kent TA, Tour JM "Antioxidant carbon particles improve cerebrovascular dysfunction following traumatic brain injury.." ACS Nano. 2012 Sep 25;6(9):8007-14. Pubmed PMID: 22866916
- Dustin D1, Hall BM2, Annapragada A3, Pautler RG4. "Neuroimaging in Alzheimer's disease: preclinical challenges toward clinical efficacy.." Transl Res.. 2016 Sep;175:37-53. Pubmed PMID: 27033146
- Majid T, Ali YO, Venkitaramani DV, Jang MK, Lu HC, Pautler RG. "In vivo axonal transport deficits in a mouse model of fronto-temporal dementia.." Neuroimage Clin. 2014 Mar 31;4:711-7. Pubmed PMID: 24936422
- Loehr JA, Stinnett GR, Hernández-Rivera M, Roten WT, Wilson LJ, Pautler RG, Rodney GG. "Eliminating Nox2 reactive oxygen species production protects dystrophic skeletal muscle from pathological calcium influx assessed in vivo by manganese-enhanced magnetic resonance imaging.." J Physiol. 2016 Nov 1;594(21):6395-6405. Pubmed PMID: 27555555
- Samuel EL, Marcano DC, Berka V, Bitner BR, Wu G, Potter A, Fabian RH, Pautler RG, Kent TA, Tsai AL, Tour JM. "Highly efficient conversion of superoxide to oxygen using hydrophilic carbon clusters.." Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2343-8. Pubmed PMID: 25675492
- Massaad CA, Amin SK, Hu L, Mei Y, Klann E, Pautler RG "Mitochondrial superoxide contributes to blood flow and axonal transport deficits in the Tg2576 mouse model of Alzheimer's disease.." PLoS ONE. 2010;5(5):e10561. Pubmed PMID: 20479943
- Smith KD, Kallhoff V, Zheng H, Pautler RG "In vivo axonal transport rates decrease in a mouse model of Alzheimer's disease.." Neuroimage. 2007 May 1;35(4):1401-8. Pubmed PMID: 17369054
- Holth JK, Bomben VC, Reed JG, Inoue T, Younkin L, Younkin SG, Pautler RG, Botas J, Noebels JL "Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy.." J. Neurosci.. 2013 Jan 23;33(4):1651-9. Pubmed PMID: 23345237
Memberships
- ISMRM
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