Positions

Associate Professor

Medicine-Gastroenterology
Baylor College of Medicine
Houston, TX US

Addresses

Baylor College of Medicine (Lab)

1 Baylor Plaza
Houston, TX 77030
United States
Phone: (713) 798-2887
Ru.Chen@bcm.edu

Baylor College of Medicine (Office)

1 Baylor Plaza
Houston, TX 77030
United States
Phone: (713) 798-2887
Ru.Chen@bcm.edu

Education

PhD from University of Washington

Seattle, Washington United States

Pathology

Professional Interests

• • Tumorigenesis of GI cancer • Genomic and proteomic alterations in tumor progression • Biomarkers for diagnostics and therapeutics • IBD associated colorectal cancer

Professional Statement

My laboratory is studying tumorigenesis of GI-tract cancers, focusing on discovering novel genomic and proteomic alterations associated with GI cancers, and translating this knowledge into novel diagnostic and therapeutic approaches for pancreatic cancer and colorectal cancer. Our work in pancreatic cancer focuses on dissecting the signaling pathways and protein interaction networks that orchestrate tumor growth, invasion and metastasis to develop diagnostic and prognostic biomarkers. Another focus of our lab is studying neoplastic progression of colitis-associated colorectal cancer. Our studies have discovered novel molecular abnormalities as a field defect in early tumorigenesis of colorectal cancer. More recently, we are interrogating the complex interplays between gut microbiota and host response, and investigating how they affect the development of colorectal cancer.

Selected Publications

• Pan S, Chen R. "Pathological implication of protein post-translational modifications in cancer." Mol Aspects Med. 2022;86:101097.
• Tsai HY, Bronner MP, March JK, Valentine JF, Shroyer NF, Lai LA, Brentnall TA, Pan S, Chen R. "Metabolic targeting of NRF2 potentiates the efficacy of the TRAP1 inhibitor G-TPP through reduction of ROS detoxification in colorectal cancer." Cancer Lett. 2022;549:215915.
• Pan S, Brand RE, Lai LA, Dawson DW, Donahue TR, Kim S, Khalaf NI, Othman MO, Fisher WE, Bronner MP, Simeone DM, Brentnall TA, Chen R. "Proteome heterogeneity and malignancy detection in pancreatic cyst fluids." Clin Transl Med.. 2021;11(8):e506.
• Pan S, Brentnall TA, Chen R "Proteome alterations in pancreatic ductal adenocarcinoma." Cancer Lett. 2020;469:429-436.