Sandhya Sara Thomas, M.D.
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Sandhya Sara Thomas, M.D.
Associate Professor
Positions
- Associate Professor
-
Medicine-Nephrology
Baylor College of Medicine
Houston, TX US
Education
- BA from Johns Hopkins University
- Baltimore, Maryland
- MD from University of Texas Medical School at Houston
- Houston, Texas United States
- Internship at University of Texas Medical School at Houston
- Houston, Texas United States
- Internal Medicine
- Residency at University of Texas Medical School at Houston
- Houston, Texas United States
- Internal Medicine
- Clinical Fellowship at Columbia University School of Medicine
- New York, New York United States
- Nephrology
- Postdoctoral Fellowship at Baylor College of Medicine
- Houston, Texas United States
- T32 Research Fellowship
Professional Interests
- Research interest in insulin signaling in chronic kidney disease, with clinical interests in glomerular diseases, acute kidney injury, and dialysis.
Professional Statement
Clinical areas of interest include acute and chronic kidney disease (CKD) and glomerular diseases of the kidney.Research interests include evaluating impaired insulin signaling in CKD and the metabolic consequences. The purpose of the proposed research is to investigate the intracellular signaling of insulin in response to CKD. The goal of which is to investigate therapeutic targets to improve insulin signaling and prevent the deleterious consequences of CKD-induced changes in skeletal and cardiac muscle metabolism.
Websites
Selected Publications
- Thomas SS, Dong Y, Zhang L, Mitch WE. "Signal regulatory protein-α interacts with the insulin receptor contributing to muscle wasting in chronic kidney disease.." Kidney Int.. 2013 Aug;308-16. Pubmed PMID: 23515050
- Sandhya S. Thomas, Jiao Wu, Giovanni Davogustto, Michael W. Holliday, Kristin Eckel-Mahan, Daniela Verzola, Giacomo Garibotto, Zhaoyong Hu, William E. Mitch and Heinrich Taegtmeyer "SIRPα Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease." Circ Res. 2022;131:207-21. Pubmed PMID: 35722884
- "Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk.." J Cachexia Sarcopenia Muscle. 2019;10:1210-27. Pubmed PMID: 31507080
- "Molecular mechanisms of insulin resistance in chronic kidney disease.." Kidney Int. 2015;88:1233-9. Pubmed PMID: 26444029
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