Email

ssthomas@bcm.edu

Positions

Assistant Professor

Medicine-Nephrology
Baylor College of Medicine
Houston, TX US

Education

BA from Johns Hopkins University

Baltimore, Maryland

MD from University of Texas Medical School at Houston

Houston, Texas United States

Internship at University of Texas Medical School at Houston

Houston, Texas United States

Internal Medicine

Residency at University of Texas Medical School at Houston

Houston, Texas United States

Internal Medicine

Clinical Fellowship at Columbia University School of Medicine

New York, New York United States

Nephrology

Post-Doctoral Fellowship at Baylor College of Medicine

07/2013 - Houston, Texas United States

Basic Science Research

Professional Interests

• Research interest in insulin signaling in chronic kidney disease, with clinical interests in glomerular diseases, acute kidney injury, and dialysis.

Professional Statement

Clinical areas of interest include acute and chronic kidney disease (CKD) and glomerular diseases of the kidney.

Research interests include evaluating impaired insulin signaling in CKD and the metabolic consequences. The purpose of the proposed research is to investigate the intracellular signaling of insulin in response to CKD. The goal of which is to investigate therapeutic targets to improve insulin signaling and prevent the deleterious consequences of CKD-induced changes in skeletal and cardiac muscle metabolism.

Websites

Selected Publications

• Thomas SS, Dong Y, Zhang L, Mitch WE. "Signal regulatory protein-α interacts with the insulin receptor contributing to muscle wasting in chronic kidney disease.." Kidney Int.. 2013 Aug;308-16. Pubmed PMID: 23515050
• Thomas SS, Mitch WE. "Mechanisms stimulating muscle wasting in chronic kidney disease: the roles of the ubiquitin-proteasome system and myostatin.." Clin Exp Nephrol.. 2013 Apr;174-82. Pubmed PMID: 23292175
• Sandhya S. Thomas, Jiao Wu, Giovanni Davogustto, Michael W. Holliday, Kristin Eckel-Mahan, Daniela Verzola, Giacomo Garibotto, Zhaoyong Hu, William E. Mitch and Heinrich Taegtmeyer "SIRPα Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease." ;