Email

ketkar@bcm.edu

Positions

Assistant Professor

Molecular and Human Genetics
Baylor College of Medicine

Education

MS from Washington University in St. Louis

St Louis, Missouri United States

Genetic Epidemiology

PhD from Washington University in St. Louis

St Louis, Missouri United States

Human and Statistical Genetics

Professional Interests

• Multi-omics data integration (genomics, transcriptomics, epigenomics)
• Functional genomics and transcriptome-guided diagnostics
• Epigenetic regulation in hematologic malignancies
• Rare and undiagnosed genetic diseases
• Precision medicine and equitable access to genomic research
• Interdisciplinary team science and data mining

Professional Statement

As a geneticist and computational biologist my research focuses on the integrative analysis of genomic, transcriptomic, and epigenomic data to advance understanding and diagnosis of rare genetic diseases and hematologic malignancies. With formal training in human and statistical genetics, I sought to bridge the domains of data science and clinical genomics to uncover novel disease mechanisms.

Websites

Selected Publications

• Ketkar S, Dai H, Burrage L, Murdock D, Dawson B, Acosta-Herrera M, Kerick M, Martin J, Wilhelm K, Asmussen JK, Lichtarge O, Center RG, Assassi S, Mayes MD, Lee BH "Integrative exome sequencing and machine learning identify MICB and interferon pathway genes as contributors to SSc risk.." 2025 Jun; Pubmed PMID: 40514331
• Dai H, Ketkar S, Tan T, Atkinson EG, Burrage L, Worley KC, Christopher B, Lyons MA, Assassi S, Mayes MD, Lee B. "Exploring the complexity of systemic sclerosis etiology by trio whole genome sequencing.." 2024; Pubmed PMID: 38970828
• Ketkar S, Burrage LC, Lee BH "RNA sequencing as a diagnostic tool.." 2022 Dec; Pubmed PMID: 36525251
• Ketkar S, Verdoni AM, Smith AM, Bangert CV, Leight ER, Chen DY, Brune MK, Helton NM, Hoock M, George DR, Fronick C, Fulton RS, Ramakrishnan SM, Chang GS, Petti AA, Spencer DH, Miller CA, Ley TJ. "Remethylation of Dnmt3a-/- hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing.." 2020 Feb; Pubmed PMID: 31996479

Memberships

American Society of Human Genetics

American College of Rheumatology