Positions
- Professor
-
Biochemistry and Molecular Biology
Baylor College of Medicine
Houston, TX US
Primary Appointment
- Charles C. Bell Professor
-
Biochemistry and Molecular Biology
Baylor College of Medicine
- Director
-
CryoEM Core
Baylor College of Medicine
- Co-Director
-
Center for Computational and Integrative Biomedical Research (CIBR)
Baylor College of Medicine
Houston, Texas United States
- Member
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Addresses
- Office (Office)
-
Baylor College of Medicine
BCMN-N420
Houston, TX 77030
United States
Phone: (713) 798-9020
sludtke@bcm.edu
Education
- PhD from Rice University
- 06/1996 - Houston, Texas United States
- Physics
- MA from Rice University
- 06/1993 - Houston, Texas United States
- Physics
- BS from Caltech
- 06/1990 - Pasadena, California United States
- Physics
Honors & Awards
- Burton Medal
- Microscopy Society of America (01/2008)
- HAMBP (Houston Area Molecular Biophysics Program) Fellow
- Houston Area Molecular Biophysics Program (01/1992 - 01/1996)
- NRSA (Institutional) Fellow
- NRSA (01/1996 - 01/1997)
- NRSA (Individual) Fellow
- NRSA (01/1998 - 01/1999)
Professional Interests
- Cryo-electron Microscopy and Tomography
- Quantitative Image Processing Algorithm Development
- Structural Biology and Macromolecular Assemblies
- Membranes and Membrane Proteins
- Protein Structure-Function and Protein Folding
- Antibiotic Resistance
Professional Statement
My group focuses on CryoEM/CryoET and quantitative image processing, applying these techniques to a wide range of biological systems ranging from individual macromolecules to whole cells. For the last 20 years my group has been developing the EMAN software suite for both high resolution single particle analysis as well as in-situ and in-vitro tomography. This software has been used on a large fraction of the structures in the EMDatabank, and with over 30,000 downloads is one of the most widely used in the field. In addition to developing new image processing methods such as deep learning applications and bispectral analysis, my group engages in a wide range of biological projects, from the high resolution structure and dynamics of individual molecules to the study of functioning macromolecular assemblies within the cell. Over the last 3-5 years, cryoEM has experienced a renaissance, largely due to the development of revolutionary direct detector technology, making this field directly competitive with X-ray crystallography for high resolution structural analysis, and providing many unique capabilities, such as in-situ structural biology. This is an exciting time for the cryoEM field, with many opportunities to substantially advance our fundamental understanding of biomolecular interactions.Websites
Videos
Selected Publications
- Kim SJ, Fernandez-Martinez J, Nudelman I, Shi Y, ..., Ludtke SJ, Akey CW, Chait BT, Sali A, Rout MP "Integrative structure and functional anatomy of a nuclear pore complex." Nature. 2018;555(7697):475-482. Pubmed PMID: 29539637
- Chen M, Dai W, Sun SY, Jonasch D, He CY, Schmid MF, Chiu W, Ludtke SJ "Convolutional neural networks for automated annotation of cellular cryo-electron tomograms." Nature Meth.. 2017;14(10):983-985. Pubmed PMID: 28846087
- Yi P, Wang Z, Feng Q, Chou CK, Pintilie GD, Shen H, Foulds CE, Fan G, Serysheva I, Ludtke SJ, Schmid MF, Hung MC, Chiu W, O'Malley BW "Structural and Functional Impacts of ER Coactivator Sequential Recruitment." Mol. Cell. 2017;67(5):733-743. Pubmed PMID: 28844863
- J.M. Bell, M. Chen, P.R. Baldwin & S.J. Ludtke "High Resolution Single Particle Refinement in EMAN2.1." Methods. 2016;100:25-34. Pubmed PMID: 26931650
- R.N. Irobalieva, J.M. Fogg, D.J. Catanese, T. Sutthibutpong, M. Chen, A.K. Barker, S.J. Ludtke, S.A. Harris, M.F. Schmid, W. Chiu & L. Zechiedrich "Structural diversity of supercoiled DNA." Nat. Commun.. 2015;6:8440. Pubmed PMID: 26455586
- G. Fan, M.L. Baker, Z. Wang, M.R. Baker, P.A. Sinyagovskiy, W. Chiu, S.J. Ludtke & I.I. Serysheva "Gating machinery of InsP3R channels revealed by electron cryomicroscopy." Nature. 2015;527:336-341. Pubmed PMID: 26458101
Memberships
- Biophysical Society
- Member (01/1992)
- Microscopy Society of America
- Member (01/1998)
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