Email

slee@bcm.edu

Positions

Associate Professor

Biochemistry & Molecular Pharmacology
Baylor College of Medicine
Houston, Texas United States

Core Director

Macromolecular X-Ray Crystallography Core
Baylor College of Medicine
Houston, Texas United States

Member

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States

Member

Center for Drug Discovery
Baylor College of Medicine
Houston, Texas United States

Addresses

Department of Biochemistry (Office)

Baylor College of Medicine
Houston, TX 77030-3498
United States
Phone: (713) 798-4390
slee@bcm.edu

Education

Post-Doctoral Fellowship at Yale University

10/2000 - New Haven, Connecticut United States

Molecular Biophysics and Biochemistry

Post-Doctoral Fellowship at Purdue University

03/1998 - West Lafayette, Indiana United States

Biological Sciences

PhD from Purdue University

08/1997 - West Lafayette, Indiana United States

Biological Sciences

MS from Seoul National University

02/1991 - Seoul, Korea

Chemistry

BS from Seoul National University

02/1989 - Seoul, Korea

Chemistry

Honors & Awards

Beginning Grant-in-Aid Award

American Heart Association Texas Affiliate

New Investigator Award

Department of Defense

International Union of Crystallography Young Scientist Travel Grant

International Union of Crystallography

Korean Government Overseas Scholarship

Korean Government

Frederick N. Andrews Doctoral Fellowship

Purdue University

Undergraduate Scholarship

Korea Scholarship Foundation for Future Leaders

Professional Interests

• Antibiotic Resistance
• Cryo-electron Microscopy and Tomography
• Membranes and Membrane Proteins
• Nano Medicine and Drug Design
• Protein Structure Function and Protein Folding
• Structural Biology and Macromolecular Assemblies by Organism

Professional Statement

The broad and long-term research objective of my laboratory is to provide a molecular understanding of the protein quality control machinery that maintains balance inside mitochondria. On-going research focuses on determining the structure, function, and mechanism of molecular chaperones, membrane-associated proteases, protein kinases, and enzymes using a multi-pronged biochemical and biophysical approach. The goal of our research is to provide a detailed mechanistic understanding of mitochondrial quality control proteins in order to exploit this information for rational structure-based drug development.

Websites

Selected Publications

• Brooks, D., Burke, E., Lee, S. et al. "Heterozygous MAP3K20 variants cause ectodermal dysplasia, craniosynostosis, sensorineural hearing loss, and limb anomalies.." Hum Genet.. 2024;143:279-291. Pubmed PMID: 38451290
• Lee, S., Lee, S.B., Sung, N., Xu, W.W., Chang, C., Kim, H.E., Catic, A. and Tsai, F.T.F. "Structural basis of impaired disaggregase function in the oxidation-sensitive SKD3 mutant causing 3-methylglutaconic aciduria." Nature Commun.. 2023 Apr 11;14:2028. Pubmed PMID: 37041140
• Mercado, J.M., Lee, S., Chang, C., Sung, N., Soong, L., Catic, A. and Tsai, F.T.F. "Atomic structure of the Leishmania spp. Hsp100 N-domain." Proteins. 2022;90:1242-1246. Pubmed PMID: 35122310
• Yap, Z.Y., Efthymiou, S., Seiffert, S., Vargas Parra, K., Lee, S. et al. "Bi-allelic variants in OGDHL cause a neurodevelopmental spectrum disease featuring epilepsy, hearing loss, visual impairment, and ataxia.." Am. J. Hum. Genet.. 2021;108:2368-2384. Pubmed PMID: 34800363

Memberships

American Crystallography Association

Member

American Association for the Advancement of Science

Member