Email

arimura@bcm.edu

Positions

Instructor

Medicine-Gastroenterology
Baylor College of Medicine
Houston, TX US

Education

BS from Showa Pharmaceutical University

03/2002 - Tokyo, Japan

MS from Showa Pharmaceutical University

03/2004 - Tokyo, Japan

PhD from Kyoto University

07/2009 - Kyoto, Japan

Postdoctoral Fellowship at Kyoto University

08/2009 - Kyoto, Japan

Postdoctoral Fellowship at The University of Tokyo, Assistant Professor at The University of Tokyo

01/2018 - Tokyo, Japan

Research Fellowship at Baylor College of Medicine

12/2019 - Houston, United States

Certifications

Pharmacist (Japan)

Professional Statement

We are working on the creation and application of functional cells using state-of-the-art organoid culture technology and transplantation technology. Our multidisciplinary research ranges from understanding the principles of stem cell differentiation, to new insights into stem cell differentiation including the mechanism of parigenesis (rediscovery of differentiated cell division), to the development of innovative therapeutic concepts through disease-specific cell regulation. By optimizing engraftment protocols, our group aims to develop techniques for mucosal epithelial cell replacement therapy, create next generation humanized mice, and explore the functionality of multi-organoid-derived cells in ectopic environments. Our ultimate goal is to translate these breakthroughs into clinically relevant strategies that will revolutionize regenerative medicine. By bridging the gap between basic biology and translational applications, we will open new horizons in cell-based therapy.

Selected Publications

• Arimura S, To S, Mills JC "Changing fate: how EGFRs "pit" cell vs cell in the stomach." Gastroenterology. 2024;167:441-442.
• Adkins-Threats M*, Arimura S* and Mills JC, et. al. (*Co-1st. authors) "Metabolic regulator ERRγ governs stem cell differentiation into acid-secreting parietal cells." Cell Stem Cell. 2024;31:886-903.
• Arimura S and Yamanashi Y, et. al. "Loss of Dok-3 in non-tumor cells induces malignant conversion of benign epithelial tumors of the intestine." Cancer Research Communications. 2022;2:1590-600.
• Arimura S and Yamanashi Y, et. al. "DOK7 gene therapy benefits mouse models of diseases characterized by defects in the neuromuscular junction." Science. 2014;345:1505-8.

Funding

2023-2028: NIDDK R01 grant : Co-I (PI: Jason C. Mills) - #R01 DK094989-12

NIH/NIDDK

2021-2022: The Texas Medical Center Digestive Diseases Center (TMC-DDC) Pilot/Feasibility Award: PI - #P30DK056338

NIH/NIDDK

2018-2019: Research in A Foreign Country (A special 2-year adopter): PI - #201640201

The Uehara Memorial Foundation (Japan)

2018-2018: Medical and Pharmaceutical Research in A Foreign Country: PI - #2017R1-1

Mochida Memorial Foundation (Japan)

Languages

Japanese