Tamra Erin Ogilvie
Picture
Tamra Erin Ogilvie
Professor
Positions
- Professor
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Department of Pediatrics
Section of Hematology-Oncology
Baylor College of Medicine
Houston, Texas
- Member
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Dan L Duncan Comprehensive Cancer Center
Education
- Postdoctoral Fellowship at McMaster University
- Hamilton, Ontario Canada
- PhD from McGill University
- Montreal, Quebec Canada
- BSc from Western University
- London, Ontario Canada
Professional Statement
Dr. Tamra Ogilvie's laboratory is entirely dedicated to studying medulloblastoma (MB), the most common malignant primary pediatric brain tumor. The lab has made significant contributions to the underlying cellular and molecular mechanisms regulating MB stem cell fate decisions. This includes identification of MB cells of origin (Nature, 2022), central regulators of MB self-renewal (ie. Nature Cell Biology, 2024; Nature, 2022; Nature Communications, 2020, Molecular Oncology, 2018) and potential diagnostic biomarkers for different MB molecular subgroups (i.e., Cancer Research, 2018).Dr. Ogilvie's lab utilizes biologically relevant mouse xenograft models where human MB cells are implanted into the cerebellum to assess the effects of gain/loss of gene function as well as small molecule inhibitors as potential therapeutics (Cancer Research, 2018, Molecular Oncology, 2018, Communications Biology, 2022, Cell Death Discovery, 2023). Combining multi-omics technologies such as ChIP sequencing, RNA sequencing, single cell RNA sequencing, TurboID and digital spatial profiling of brain tumor tissue with functional assessments both in vitro and in vivo, Dr. Ogilvie has built a highly innovative research program in neuro-oncology and human stem cells.
Dr. Ogilvie's work integrates basic and preclinical studies and is currently divided into 2 major research areas: 1) Novel regulators of Group 3 MB cell fate and 2) New therapeutic strategies for SHH MB tumors. Throughout her career, she has been continuously supported by national and international funding agencies, including grants from the Canada Research Chairs program, CIHR, NSERC, the Brain Tumor Foundation of Canada, as well as the Rally Foundation for Childhood Cancer Research and Alex’s Lemonade Stand Foundation.
Websites
Selected Publications
- Saulnier O, Zagozewski J, Liang L, Hendrikse LD, Layug P, Gordon V, Aldinger KA, Haldipur P, Borlase S, Coudière-Morrison L, Cai T, Martell E, Gonzales NM, Palidwor G, Porter CJ, Richard S, Sharif T, Millen KJ, Doble BW, Taylor MD, Werbowetski-Ogilvie TE. "A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing." Nat Cell Biol. 2024; Pubmed PMID: 39025928
- Borlase S, DeCarlo A, Morrison LC, Liang L, Porter CJ, Ramaswamy V, Werbowetski-Ogilvie TE. "Cross-species analysis of SHH medulloblastoma models reveals significant inhibitory effects of trametinib on tumor progression." Cell Death Discov. 2023; Pubmed PMID: 37726268
- Hendrikse LD, Haldipur P, Saulnier O, […] Doble, BW, Werbowetski-Ogilvie TE*, Millen K*, Suzuki H*, Taylor MD*. "Failure of human rhombic lip differentiation underlies medulloblastoma formation." Nature. 2022; Pubmed PMID: 36446943
- Zagozewski J, Borlase S, Guppy BJ, Coudière-Morrison L, Shahriary GM, Gordon V, Liang L, Cheng S, Porter CJ, Kelley R, Hawkins C, Chan JA, Liang Y, Gong J, Nör C, Saulnier O, Wechsler-Reya RJ, Ramaswamy V, Werbowetski-Ogilvie TE. "Combined MEK and JAK/STAT3 pathway inhibition effectively decreases SHH medulloblastoma tumor progression.." Commun Biol. 2022; Pubmed PMID: 35835937
- Zagozewski J, Shahriary GM, Morrison LC, Saulnier O, Stromecki M, Fresnoza A, Palidwor G, Porter CJ, Forget A, Ayrault O, Hawkins C, Chan JA, Vladoiu MC, Sundaresan L, Arsenio J, Taylor MD, Ramaswamy V, Werbowetski-Ogilvie TE. "An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate." Nat Commun. 2020; Pubmed PMID: 32686664
- Liang L, Coudière-Morrison L, Tatari N, Stromecki M, Fresnoza A, Porter CJ, Del Bigio MR, Hawkins C, Chan JA, Ryken TC, Taylor MD, Ramaswamy V, Werbowetski-Ogilvie TE. "CD271+ Cells Are Diagnostic and Prognostic and Exhibit Elevated MAPK Activity in SHH Medulloblastoma." Cancer Res. 2018; Pubmed PMID: 29930101
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