Terzah Marie Horton, M.D., Ph.D.
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Positions
- Associate Professor
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Pediatrics-Oncology
Baylor College of Medicine
Houston, TX US
- Member
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Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
- Associate Professor
-
Pediatrics
Hematology/Oncology
Baylor College of Medicine
Houston, Texas United States
Dan L Duncan Cancer Center
Addresses
- Texas Children's Feigin Ctr (Hospital)
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Suite 750
Houston, TX 77030
United States
- Texas Children's Feigin Ctr (Office)
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Suite 750
Houston, TX 77030
United States
- Texas Children's Hospital, Clinical Care Center (Clinic)
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6701 Fannin St., 14th floor
Houston, TX 77030
United States
Phone: (832) 822-4242
Education
- Clinical Fellowship at Texas Children's Cancer Center
- 06/2002 - Houston, Texas United States
- Hematology-Oncology
- Residency at Texas Children's Hospital
- 01/1999 - Houston, Texas United States
- Pediatric Residency
- MD-PhD from Emory University
- 01/1992 - Atlanta, Georgia United States
- AB from Rollins College
- 01/1985 - Winter Park, Texas United States
- history major/music minor
- Advanced Training from Baylor College Of Medicine
- 01/2002 - Houston, TX United States
- Advanced Training from Emory University
- 01/1995 - Atlanta, GA United States
- M.D. from Emory University
- 01/1992 - Atlanta, GA United States
- Ph.D. from Emory University
- 01/1992 - Atlanta, GA United States
- Fellowship at Baylor College of Medicine
- Houston, TX
- Pediatric Hematology and Oncology
- Residency at Baylor College of Medicine
- Houston, TX
- Pediatrics
- Internship at Baylor College of Medicine
- Houston, TX
- Pediatrics
- MD from Emory University School of Medicine
- Atlanta, GA
Certifications
- American Board of Pediatrics
- American Board of Pediatrics, Pediatric Hematology and Oncology
Honors & Awards
- Chair, Young Investigator Committee
- see above
- Children's Oncology Group (01/2015 - 12/2018)
Professional Interests
- Developing new treatment therapies for childhood leukemias and lymphomas
Professional Statement
Our laboratory focuses on the aberration in protein homeostasis in pediatric leukemia and lymphoma.Websites
Professional Development
- Delivering Bad news: Fellows and Residents
- Seminar (Presenter, 2019)
- Sponsor: Texas Children's Cancer Center
- Separate seminars to train residents and fellows in the art of delivering bad news. Required class of both groups.
Selected Publications
- Horton TM, Ames MM, Reid JM, Krailo MD, Pendergrass T, Mosher R, Reaman GH, Seibel NL "A Phase 1 and pharmacokinetic clinical trial of paclitaxel for the treatment of refractory leukemia in children: a Children's Oncology Group study.." Pediatr Blood Cancer. 2008 Apr;50(4):788-92. Pubmed PMID: 17668866
- Horton TM, Pati D, Plon SE, Thompson PA, Bomgaars LR, Adamson PC, Ingle AM, Wright J, Brockman AH, Paton M, Blaney SM "A phase 1 study of the proteasome inhibitor bortezomib in pediatric patients with refractory leukemia: a Children's Oncology Group study.." Clin. Cancer Res.. 2007 Mar 1;13(5):1516-22. Pubmed PMID: 17332297
- Muscal JA, Thompson PA, Horton TM, Ingle AM, Ahern CH, McGovern RM, Reid JM, Ames MM, Espinoza-Delgado I, Weigel BJ, Blaney SM "A phase I trial of vorinostat and bortezomib in children with refractory or recurrent solid tumors: A Children's Oncology Group phase I consortium study (ADVL0916).." Pediatr Blood Cancer. 2013 Mar;60(3):390-5. Pubmed PMID: 22887890
- Horton TM, Ranheim TS, Aquino L, Kusher DI, Saha SK, Ware CF, Wold WS, Gooding LR "Adenovirus E3 14.7K protein functions in the absence of other adenovirus proteins to protect transfected cells from tumor necrosis factor cytolysis.." J. Virol.. 1991 May;65(5):2629-39. Pubmed PMID: 1850036
- Pease CL, Horton TM, McClain KL, Kaplan SL "Aseptic meningitis in a child after systemic treatment with high dose cytarabine.." Pediatr. Infect. Dis. J.. 2001 Jan;20(1):87-9. Pubmed PMID: 11176579
- Horton TM, Gannavarapu A, Blaney SM, D'Argenio DZ, Plon SE, Berg SL "Bortezomib interactions with chemotherapy agents in acute leukemia in vitro.." Cancer Chemother. Pharmacol.. 2006 Jul;58(1):13-23. Pubmed PMID: 16292537
- Horton TM, Stone JD, Yee D, Dreyer Z, Moake JL, Mahoney DH "Case series of thrombotic thrombocytopenic purpura in children and adolescents.." J. Pediatr. Hematol. Oncol.. 2003 Apr;25(4):336-9. Pubmed PMID: 12679653
- Horton T, Hunger SP "Children are not large mice.." Eur. J. Haematol.. 2013 Jun;90(6):535. Pubmed PMID: 23534840
- Kelly KM, Hodgson D, Appel B, Chen L, Cole PD, Horton T, Keller FG "Children's Oncology Group's 2013 blueprint for research: Hodgkin lymphoma.." Pediatr Blood Cancer. 2013 Jun;60(6):972-8. Pubmed PMID: 23255501
- Frugé E, Margolin J, Horton T, Venkateswaran L, Lee D, Yee DL, Mahoney D "Defining and managing career challenges for mid-career and senior stage pediatric hematologist/oncologists.." Pediatr Blood Cancer. 2010 Dec 1;55(6):1180-4. Pubmed PMID: 20589622
- Basu D, Zhang N, Panigrahi AK, Horton TM, Pati D "Development and validation of a fluorogenic assay to measure separase enzyme activity.." Anal. Biochem.. 2009 Sep 15;392(2):133-8. Pubmed PMID: 19497291
- Min DJ, Moskowitz NP, Brownstein C, Lee H, Horton TM, Carroll WL "Diverse pathways mediate chemotherapy-induced cell death in acute lymphoblastic leukemia cell lines.." Apoptosis. 2006 Nov;11(11):1977-86. Pubmed PMID: 17013760
- Horton TM, Berg SL "Educational paper : The development of new therapies for pediatric oncology.." Eur. J. Pediatr.. 2011 May;170(5):555-9. Pubmed PMID: 21190039
- Morrison DJ, Hogan LE, Condos G, Bhatla T, Germino N, Moskowitz NP, Lee L, Bhojwani D, Horton TM, Belitskaya-Levy I, Greenberger LM, Horak ID, Grupp SA, Teachey DT, Raetz EA, Carroll WL "Endogenous knockdown of survivin improves chemotherapeutic response in ALL models.." Leukemia. 2012 Feb;26(2):271-9. Pubmed PMID: 21844871
- Cruz CR, Gerdemann U, Leen AM, Shafer JA, Ku S, Tzou B, Horton TM, Sheehan A, Copeland A, Younes A, Rooney CM, Heslop HE, Bollard CM "Improving T-cell Therapy for Relapsed EBV-Negative Hodgkin Lymphoma by Targeting Upregulated MAGE-A4.." Clin. Cancer Res.. 2011 Nov 15;17(22):7058-66. Pubmed PMID: 21908573
- Horton TM, Graham BH, Corral-Debrinski M, Shoffner JM, Kaufman AE, Beal MF, Wallace DC "Marked increase in mitochondrial DNA deletion levels in the cerebral cortex of Huntington's disease patients.." Neurology. 1995 Oct;45(10):1879-83. Pubmed PMID: 7477986
- Suell MN, Horton TM, Dishop MK, Mahoney DH, Olutoye OO, Mueller BU "Outcomes for children with gallbladder abnormalities and sickle cell disease.." J. Pediatr.. 2004 Nov;145(5):617-21. Pubmed PMID: 15520760
- Rathore N, Eissa HM, Margolin JF, Liu H, Wu MF, Horton T, Kamdar K, Dreyer Z, Steuber P, Rabin KR, Redell M, Allen CE, McClain KL, Guillerman RP, Bollard CM "Pediatric Hodgkin Lymphoma: Are We Over-scanning Our Patients?." Pediatr Hematol Oncol. 2012 Aug;29(5):415-23. Pubmed PMID: 22632168
- Horton TM, Thompson PA, Berg SL, Adamson PC, Ingle AM, Dolan ME, Delaney SM, Hedge M, Weiss HL, Wu MF, Blaney SM "Phase I pharmacokinetic and pharmacodynamic study of temozolomide in pediatric patients with refractory or recurrent leukemia: a Children's Oncology Group Study.." J. Clin. Oncol.. 2007 Nov 1;25(31):4922-8. Pubmed PMID: 17971589
- Blaney SM, Bernstein M, Neville K, Ginsberg J, Kitchen B, Horton T, Berg SL, Krailo M, Adamson PC "Phase I study of the proteasome inhibitor bortezomib in pediatric patients with refractory solid tumors: a Children's Oncology Group study (ADVL0015).." J. Clin. Oncol.. 2004 Dec 1;22(23):4804-9. Pubmed PMID: 15570082
- Horton TM, Blaney SM, Langevin AM, Kuhn J, Kamen B, Berg SL, Bernstein M, Weitman S "Phase I trial and pharmacokinetic study of raltitrexed in children with recurrent or refractory leukemia: a pediatric oncology group study.." Clin. Cancer Res.. 2005 Mar 1;11(5):1884-9. Pubmed PMID: 15756014
- Muscal JA, Thompson PA, Giranda VL, Dayton BD, Bauch J, Horton T, McGuffey L, Nuchtern JG, Dauser RC, Gibson BW, Blaney SM, Su JM "Plasma and cerebrospinal fluid pharmacokinetics of ABT-888 after oral administration in non-human primates.." Cancer Chemother. Pharmacol.. 2010 Feb;65(3):419-25. Pubmed PMID: 19526240
- Horton TM, Jenkins G, Pati D, Zhang L, Dolan ME, Ribes-Zamora A, Bertuch AA, Blaney SM, Delaney SL, Hegde M, Berg SL "Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity.." Mol. Cancer Ther.. 2009 Aug;8(8):2232-42. Pubmed PMID: 19671751
- Thompson PA, Allen CE, Horton T, Jones JY, Vinks AA, McClain KL "Severe neurologic side effects in patients being treated for hemophagocytic lymphohistiocytosis.." Pediatr Blood Cancer. 2009 May;52(5):621-5. Pubmed PMID: 19137570
- Jayanthan A, Howard SC, Trippett T, Horton T, Whitlock JA, Daisley L, Lewis V, Narendran A "Targeting the Bcl-2 family of proteins in Hodgkin lymphoma: in vitro cytotoxicity, target modulation and drug combination studies of the Bcl-2 homology 3 mimetic ABT-737.." Leuk. Lymphoma. 2009 Jul;50(7):1174-82. Pubmed PMID: 19557638
- Gooding LR, Ranheim TS, Tollefson AE, Aquino L, Duerksen-Hughes P, Horton TM, Wold WS "The 10,400- and 14,500-dalton proteins encoded by region E3 of adenovirus function together to protect many but not all mouse cell lines against lysis by tumor necrosis factor.." J. Virol.. 1991 Aug;65(8):4114-23. Pubmed PMID: 1830111
- Horton TM, Sposto R, Brown P, Reynolds CP, Hunger SP, Winick NJ, Raetz EA, Carroll WL, Arceci RJ, Borowitz MJ, Gaynon PS, Gore L, Jeha S, Maurer BJ, Siegel SE, Biondi A, Kearns PR, Narendran A, Silverman LB, Smith MA, Zwaan CM, Whitlock JA "Toxicity assessment of molecularly targeted drugs incorporated into multiagent chemotherapy regimens for pediatric acute lymphocytic leukemia (ALL): review from an international consensus conference.." Pediatr Blood Cancer. 2010 Jul 1;54(7):872-8. Pubmed PMID: 20127846
Projects
- Molecular Mechanisms of bortezomib in T cell leukemia from samples in the clinical trial AALL1231
- NIH (04/2014 - 08/2019)
- Washington DC
- no cost extension
- Development of preclinical testing validation from samples in AAML1031 pediatric acute myeloid leukemia
- Children's Oncology Group (07/2020 - 06/2021)
- Children's Hospital of Philadelphia
Memberships
- American Society for Hematology (ASH)
- Member (01/2002 - 08/2020)
- American Society for Cancer Research (AACR)
- Member (01/2002 - 08/2020)
- American Society of Clinical Oncology (ASCO)
- Member (01/2002 - 08/2020)
- Clinical Oncology Group (COG)
- Leadership, Member (01/2002 - 08/2020)
Funding
- Improving risk allocation and developing novel therapies for children with T-ALL - #1R01CA193776-01 Grant funding from National Institutes of Health
- Identifying Cell Stress proteins that predict Clinical Response in Pediatric AML - #NCI-R01CA164024 Grant funding from National Institutes of Health
Intellectual Property
- UpTo Date: 4 topics
- Copyright (Approved)
- 4 chapters on pediatric leukemia review.
- Co Inventors: C. Phhilip Steuber
Skills
- pediatric oncologist
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