Theodore G Wensel, Ph.D.
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Positions
- The Robert A. Welch Chair in Chemistry
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Biochemistry and Molecular Pharmacology
Baylor College of Medicine
Houston, Texas United States
Addresses
- Wensel Lab (Office)
-
N430/N403 Alkek Bldg.
Dept. of Biochemistry & Molecular Biology
Houston, TX 77030
United States
Phone: (713) 798-6994
twensel@bcm.edu
Education
- Postdoctoral from Stanford University
- 02/1988 - Stanford, California United States
- Biophysical Chemistry, Time-resolved fluorescence
- Ph.D. from University Of California, Davis
- 08/1984 - Davis, California United States
- Physical Chemistry
Websites
Selected Publications
- Dosey TL, Wang Z, Fan G, Zhang Z, Serysheva II, Chiu W, Wensel TG "Structures of TRPV2 in distinct conformations provide insight into role of the pore turret." Nat Struct Mol Biol. 2019 Jan;26(1):40-49. Pubmed PMID: 30598551
- Dharmat R, Eblimit A, Robichaux MA, Zhang Z, Nguyen TT, Jung SY, He F, Jain A, Li Y, Qin J, Overbeek P, Roepman R, Mardon G, Wensel TG, Chen R "SPATA7 maintains a novel photoreceptor-specific zone in the distal connecting cilium." J Cell Biol. 2018 Aug;217:2851-2865. Pubmed PMID: 29899041
- Agosto MA, Anastassov IA, Wensel TG. "Differential epitope masking reveals synapse-specific complexes of TRPM1.." Vis Neurosci. 2018; Pubmed PMID: 29370879
- Yu B, Egbejimi A, Dharmat R, Xu P, Zhao Z, Long B, Miao H, Chen R, Wensel TG, Cai J, Chen Y. "Phagocytosed photoreceptor outer segments activate mTORC1 in the retinal pigment epithelium.." Sci Signal. 2018; Pubmed PMID: 29844054
- Galaz-Montoya M, Wright SJ, Rodriguez GJ, Lichtarge O, Wensel TG. "β2-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway.." J Biol Chem. 2017;292(24):9967-9974. Pubmed PMID: 28442571
- He F, Agosto MA, Anastassov IA, Tse DY, Wu SM, Wensel TG "Phosphatidylinositol-3-phosphate is light-regulated and essential for survival in retinal rods.." Sci Rep. 2016 Jun 1;6:26978. Pubmed PMID: 27245220
- Wensel TG, Zhang Z, Anastassov IA, Gilliam JC, He F, Schmid MF, Robichaux MA. "Structural and molecular bases of rod photoreceptor morphogenesis and disease.." Prog Retin Eye Res. 2016 Jun 22;in press. Pubmed PMID: 27352937
- Sung YM, Wilkins AD, Rodriguez GJ, Wensel TG, Lichtarge O "Intramolecular allosteric communication in dopamine D2 receptor revealed by evolutionary amino acid covariation.." Proc Natl Acad Sci U S A.. 2016 Mar 29;113(13):3539-44. Pubmed PMID: 26979958
- Zhang Z, He F, Constantine R, Baker ML, Baehr W, Schmid MF, Wensel TG, Agosto MA. "Domain organization and conformational plasticity of the G protein effector, PDE6.." J Biol Chem. 2015 May 15;290(20):12833-43. Pubmed PMID: 25809480
- Kang HJ, Wilkins AD, Lichtarge O, Wensel TG "Determinants of endogenous ligand specificity divergence among metabotropic glutamate receptors.." J Biol Chem. 2015 Jan;290(5):2870-2878. Pubmed PMID: 25519912
- Kang HJ, Menlove K, Ma J, Wilkins A, Lichtarge O, Wensel TG "Selectivity and Evolutionary Divergence of Metabotropic Glutamate Receptors for Endogenous Ligands and G Proteins Coupled to Phospholipase C or TRP Channels." J Biol Chem. 2014 Sep 5;M114.574483. Pubmed PMID: 25193666
- Agosto MA, Zhang Z, He F, Anastassov IA, Wright SJ, McGehee J, Wensel TG "Oligomeric State of Purified TRPM1, a Protein Essential for Dim Light Vision." J Biol Chem. 2014 Aug 11;M114.593780. Pubmed PMID: 25112866
- Wang S, Tan KL, Agosto MA, Xiong B, Yamamoto S, Sandoval H, Jaiswal M, Bayat V, Zhang K, Charng WL, David G, Duraine L, Venkatachalam K, Wensel TG, Bellen HJ "The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration." PLoS Biol. 2014 Apr 29;12(4):e1001847. Pubmed PMID: 24781186
- Sandoval IM, Price BA, Gross AK, Chan F, Sammons JD, Wilson JH, Wensel TG "Abrupt Onset of Mutations in a Developmentally Regulated Gene during Terminal Differentiation of Post-Mitotic Photoreceptor Neurons." PLoS One. 2014;9(9):e10835. Pubmed PMID: 25264759
- Arshavsky VY, Wensel TG. "Timing is everything: GTPase regulation in phototransduction.." Ophthalmol. Vis. Sci.. 2013 Nov 21;54(12):7725-33. Pubmed PMID: 24265205
- Gilliam JC, Chang JT, Sandoval IM, Zhang Y, Li T, Pittler SJ, Chiu W, Wensel TG "Three-dimensional architecture of the rod sensory cilium and its disruption in retinal neurodegeneration.." Cell. 2012 Nov 21;151(5):1029-41. Pubmed PMID: 23178122
- Price BA, Sandoval IM, Chan F, Nichols R, Roman-Sanchez R, Wensel TG, Wilson JH "Rhodopsin gene expression determines rod outer segment size and rod cell resistance to a dominant-negative neurodegeneration mutant.." PLoS ONE. 2012;7(11):e49889. Pubmed PMID: 23185477
- Price BA, Sandoval IM, Chan F, Simons DL, Wu SM, Wensel TG, Wilson JH "Mislocalization and Degradation of Human P23H-Rhodopsin-GFP in a Knockin Mouse Model of Retinitis Pigmentosa.." Invest. Ophthalmol. Vis. Sci.. 2011 Dec;52(13):9728-36. Pubmed PMID: 22110080
- Gilliam JC, Wensel TG "TRP channel gene expression in the mouse retina.." Vision Res.. 2011 Dec 8;51(23):2440-52. Pubmed PMID: 22037305
- Chan F, Hauswirth WW, Wensel TG, Wilson JH "Efficient mutagenesis of the rhodopsin gene in rod photoreceptor neurons in mice.." Nucleic Acids Res.. 2011 Aug 1;39(14):5955-66. Pubmed PMID: 21478169
- Baehr W, Wensel T, Hageman G, Wu S, Zack D "Retinal ganglion cells: Development, function, and disease.." Vision Res.. 2011 Jan 28;51(2):223. Pubmed PMID: 21251506
- Moiseenkova-Bell V, Wensel TG "Functional and Structural Studies of TRP Channels Heterologously Expressed in Budding Yeast.." Adv. Exp. Med. Biol.. 2011;704:25-40. Pubmed PMID: 21290288
- Mojumder DK, Concepcion FA, Patel SK, Barkmeier AJ, Carvounis PE, Wilson JH, Holz ER, Wensel TG "Evaluating retinal toxicity of intravitreal caspofungin in the mouse eye.." Invest. Ophthalmol. Vis. Sci.. 2010 Nov;51(11):5796-803. Pubmed PMID: 20505203
- Rodriguez GJ, Yao R, Lichtarge O, Wensel TG "Evolution-guided discovery and recoding of allosteric pathway specificity determinants in psychoactive bioamine receptors.." Proc. Natl. Acad. Sci. U.S.A.. 2010 Apr 27;107(17):7787-92. Pubmed PMID: 20385837
- Budzynski E, Gross AK, McAlear SD, Peachey NS, Shukla M, He F, Edwards M, Won J, Hicks WL, Wensel TG, Naggert JK, Nishina PM "Mutations of the opsin gene (Y102H and I307N) lead to light-induced degeneration of photoreceptors and constitutive activation of phototransduction in mice.." J. Biol. Chem.. 2010 May 7;285(19):14521-33. Pubmed PMID: 20207741
- Jeffrey BG, Morgans CW, Puthussery T, Wensel TG, Burke NS, Brown RL, Duvoisin RM "R9AP stabilizes RGS11-G beta5 and accelerates the early light response of ON-bipolar cells.." Vis. Neurosci.. 2010 Mar;27(1):9-17. Pubmed PMID: 20100392
- Mancuso JJ, Qian Y, Long C, Wu GY, Wensel TG "Distribution of RGS9-2 in neurons of the mouse striatum.." J. Neurochem.. 2010 Feb;112(3):651-61. Pubmed PMID: 19912469
- Yao CK, Lin YQ, Ly CV, Ohyama T, Haueter CM, Moiseenkova-Bell VY, Wensel TG, Bellen HJ "A synaptic vesicle-associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis.." Cell. 2009 Sep 4;138(5):947-60. Pubmed PMID: 19737521
- Mojumder DK, Wensel TG "Topical mydriatics affect light-evoked retinal responses in anesthetized mice.." Invest. Ophthalmol. Vis. Sci.. 2010 Jan;51(1):567-76. Pubmed PMID: 19661232
- Mojumder DK, Qian Y, Wensel TG "Two R7 regulator of G-protein signaling proteins shape retinal bipolar cell signaling.." J. Neurosci.. 2009 Jun 17;29(24):7753-65. Pubmed PMID: 19535587
- Mancuso JJ, Larson AM, Wensel TG, Saggau P "Multiphoton adaptation of a commercial low-cost confocal microscope for live tissue imaging.." J Biomed Opt. 2009 May;14(3):34048. Pubmed PMID: 19566340
- Wensel TG "Signal transducing membrane complexes of photoreceptor outer segments.." Vision Res.. 2008 Sep;48(20):2052-61. Pubmed PMID: 18456304
- Chen CK, Burns ME, He W, Wensel TG, Baylor DA, Simon MI "Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1.." Nature. 2000 Feb 3;403(6769):557-60. Pubmed PMID: 10676965
- He W, Cowan CW, Wensel TG "RGS9, a GTPase accelerator for phototransduction.." Neuron. 1998 Jan;20(1):95-102. Pubmed PMID: 9459445
- Wensel TG, Gross AK, Chan F, Sykoudis K, Wilson JH "Rhodopsin-EGFP knock-ins for imaging quantal gene alterations.." Vision Res.. 2005 Dec;45(28):3445-53. Pubmed PMID: 16139321
- Angleson JK, Wensel TG "A GTPase-accelerating factor for transducin, distinct from its effector cGMP phosphodiesterase, in rod outer segment membranes." Neuron. 1993 Nov;11(5):939-49. Pubmed PMID: 8240815
- Melia TJ, Cowan CW, Angleson JK, Wensel TG "A comparison of the efficiency of G protein activation by ligand-free and light-activated forms of rhodopsin." Biophys. J.. 1997 Dec;73(6):3182-91. Pubmed PMID: 9414230
- Sowa ME, He W, Wensel TG, Lichtarge O "A regulator of G protein signaling interaction surface linked to effector specificity.." Proc. Natl. Acad. Sci. U.S.A.. 2000 Feb 15;97(4):1483-8. Pubmed PMID: 10677488
- Wang Q, Zhang X, Zhang L, He F, Zhang G, Jamrich M, Wensel TG "Activation-dependent hindrance of photoreceptor G protein diffusion by lipid microdomains.." J. Biol. Chem.. 2008 Oct 31;283(44):30015-24. Pubmed PMID: 18713731
- Hu G, Wensel TG "Characterization of R9AP, a membrane anchor for the photoreceptor GTPase-accelerating protein, RGS9-1.." Meth. Enzymol.. 2004;390:178-96. Pubmed PMID: 15488178
- Hu G, Zhang Z, Wensel TG "Activation of RGS9-1GTPase acceleration by its membrane anchor, R9AP.." J. Biol. Chem.. 2003 Apr 18;278(16):14550-4. Pubmed PMID: 12560335
- Melia TJ, Malinski JA, He F, Wensel TG "Enhancement of phototransduction protein interactions by lipid surfaces.." J. Biol. Chem.. 2000 Feb 4;275(5):3535-42. Pubmed PMID: 10652348
- Zhang X, Wensel TG, Kraft TW "GTPase regulators and photoresponses in cones of the eastern chipmunk.." J. Neurosci.. 2003 Feb 15;23(4):1287-97. Pubmed PMID: 12598617
- Cowan CW, Fariss RN, Sokal I, Palczewski K, Wensel TG "High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods.." Proc. Natl. Acad. Sci. U.S.A.. 1998 Apr 28;95(9):5351-6. Pubmed PMID: 9560279
- Malinski JA, Zera EM, Angleson JK, Wensel TG "High affinity interactions of GTPgammaS with the heterotrimeric G protein, transducin. Evidence at high and low protein concentrations.." J. Biol. Chem.. 1996 May 31;271(22):12919-24. Pubmed PMID: 8662740
- Zhang Z, Melia TJ, He F, Yuan C, McGough A, Schmid MF, Wensel TG "How a G protein binds a membrane.." J. Biol. Chem.. 2004 Aug 6;279(32):33937-45. Pubmed PMID: 15173184
- Zera EM, Molloy DP, Angleson JK, Lamture JB, Wensel TG, Malinski JA "Low affinity interactions of GDPbetaS and ribose- or phosphoryl-substituted GTP analogues with the heterotrimeric G protein, transducin.." J. Biol. Chem.. 1996 May 31;271(22):12925-31. Pubmed PMID: 8662741
- Malinski JA, Wensel TG "Membrane stimulation of cGMP phosphodiesterase activation by transducin: comparison of phospholipid bilayers to rod outer segment membranes.." Biochemistry. 1992 Oct 6;31(39):9502-12. Pubmed PMID: 1327116
- He F, Seryshev AB, Cowan CW, Wensel TG "Multiple zinc binding sites in retinal rod cGMP phosphodiesterase, PDE6alpha beta.." J. Biol. Chem.. 2000 Jul 7;275(27):20572-7. Pubmed PMID: 10787404
- Ramdas L, Disher RM, Wensel TG "Nucleotide exchange and cGMP phosphodiesterase activation by pertussis toxin inactivated transducin.." Biochemistry. 1991 Dec 17;30(50):11637-45. Pubmed PMID: 1661143
- Sowa ME, He W, Slep KC, Kercher MA, Lichtarge O, Wensel TG "Prediction and confirmation of a site critical for effector regulation of RGS domain activity.." Nat. Struct. Biol.. 2001 Mar;8(3):234-7. Pubmed PMID: 11224568
- Hu G, Wensel TG "R9AP, a membrane anchor for the photoreceptor GTPase accelerating protein, RGS9-1.." Proc. Natl. Acad. Sci. U.S.A.. 2002 Jul 23;99(15):9755-60. Pubmed PMID: 12119397
- Krispel CM, Chen D, Melling N, Chen YJ, Martemyanov KA, Quillinan N, Arshavsky VY, Wensel TG, Chen CK, Burns ME "RGS expression rate-limits recovery of rod photoresponses.." Neuron. 2006 Aug 17;51(4):409-16. Pubmed PMID: 16908407
- Lyubarsky AL, Naarendorp F, Zhang X, Wensel T, Simon MI, Pugh EN "RGS9-1 is required for normal inactivation of mouse cone phototransduction.." Mol. Vis.. 2001 Mar 20;7:71-8. Pubmed PMID: 11262419
- Slep KC, Kercher MA, He W, Cowan CW, Wensel TG, Sigler PB "Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A.." Nature. 2001 Feb 22;409(6823):1071-7. Pubmed PMID: 11234020
- Moiseenkova-Bell VY, Stanciu LA, Serysheva II, Tobe BJ, Wensel TG "Structure of TRPV1 channel revealed by electron cryomicroscopy.." Proc. Natl. Acad. Sci. U.S.A.. 2008 May 27;105(21):7451-5. Pubmed PMID: 18490661
- Wensel TG, He F, Malinski JA "Purification, reconstitution on lipid vesicles, and assays of PDE6 and its activator G protein, transducin.." Methods Mol. Biol.. 2005;307:289-313. Pubmed PMID: 15988071
- Madabushi S, Gross AK, Philippi A, Meng EC, Wensel TG, Lichtarge O "Evolutionary trace of G protein-coupled receptors reveals clusters of residues that determine global and class-specific functions.." J. Biol. Chem.. 2004 Feb 27;279(9):8126-32. Pubmed PMID: 14660595
- Angleson JK, Wensel TG "Enhancement of rod outer segment GTPase accelerating protein activity by the inhibitory subunit of cGMP phosphodiesterase.." J. Biol. Chem.. 1994 Jun 10;269(23):16290-6. Pubmed PMID: 8206935
- He F, Mao M, Wensel TG "Enhancement of phototransduction g protein-effector interactions by phosphoinositides.." J. Biol. Chem.. 2004 Mar 5;279(10):8986-90. Pubmed PMID: 14699118
- Dharmat R, Eblimit A, Robichaux MA, Zhang Z, Nguyen TT, Jung SY, He F, Jain A, Li Y, Qin J, Overbeek P, Roepman R, Mardon G, Wensel TG, Chen R. "SPATA7 maintains a novel photoreceptor-specific zone in the distal connecting cilium." J Cell Biol. 2018; Pubmed PMID: 29899041
- He F, Nichols RM, Kailasam L, Wensel TG, Agosto MA "Critical Role for Phosphatidylinositol-3 Kinase Vps34/PIK3C3 in ON-Bipolar Cells." Invest Ophthalmol Vis Sci. 2019 Jul;60(8):2861-2874. Pubmed PMID: 31260037
- Agosto MA, Anastassov IA, Robichaux MA, Wensel TG "A Large Endoplasmic Reticulum-Resident Pool of TRPM1 in Retinal ON-Bipolar Cells." eNeuro. 2018;10.1523/ENEURO.0143-18.2018 [doi]. Pubmed PMID: 30027108
- Agosto, M.A., Wensel, T.G. "LRRTM4 is a member of the transsynaptic complex between rod photoreceptors and bipolar cells." J. Comp. Neurol.. 2020; Pubmed PMID: 32390181
- Go YM, Zhang J, Fernandes J, Litwin C, Chen R, Wensel TG, Jones DP, Cai J, Chen Y. "MTOR-initiated metabolic switch and degeneration in the retinal pigment epithelium." FASEB J.. 2020; Pubmed PMID: 32721041
- Wensel, T. G. "Phosphoinositides in Retinal Function and Disease." Cells. 2020; Pubmed PMID: 32252387
- Terrón-Díaz ME, Wright SJ, Agosto MA, Lichtarge O, Wensel TG. "Residues and residue pairs of evolutionary importance differentially direct signaling bias of D2 dopamine receptors.." J. Biol. Chem.. 2019; Pubmed PMID: 31676688
- Tang J, Robichaux MA, Wu KL, Pei J, Nguyen NT, Zhou Y, Wensel TG, Xiao H. "Single-Atom Fluorescence Switch: A General Approach toward Visible-Light-Activated Dyes for Biological Imaging.." J. Am. Chem. Soc.. 2019; Pubmed PMID: 31450884
- Huh E, Agosto MA, Wensel TG, Lichtarge O. "Coevolutionary signals in metabotropic glutamate receptors capture residue contacts and long-range functional interactions." J Biol Chem.. 2033 Feb 17;299(4):103030. Pubmed PMID: 36806686
- Salinas SA, et al. "An ELF4 hypomorphic variant results in NK cell deficiency.." JCI Insight. 2022;7(223):e155481. Pubmed PMID: 36477361
- Robichaux MA, Nguyen V, Chan F, Kailasam L, He F, Wilson JH, Wensel TG. "Subcellular localization of mutant P23H rhodopsin in an RFP fusion knock-in mouse model of retinitis pigmentosa.." Dis Model Mech.. 2022; Pubmed PMID: 35275162
- Potter VL, Moye AR, Robichaux MA, Wensel TG. "Super-resolution microscopy reveals photoreceptor-specific subciliary location and function of ciliopathy-associated protein CEP290." JCI Insight. 2021;6(20):e145256. Pubmed PMID: 34520396
- Rajala A, He F, Anderson RE, Wensel TG, Rajala RVS. "Loss of Class III Phosphoinositide 3-Kinase Vps34 Results in Cone Degeneration.." Biology (Basel). 2020;9(11):12502-12520. Pubmed PMID: 33171845
- Huh E, Gallion J, Agosto MA, Wright SJ, Wensel TG, Lichtarge O. "Recurrent high-impact mutations at cognate structural positions in class A G protein-coupled receptors expressed in tumors.." Proc Natl Acad Sci U S A. 2021;118(51):e2113373118. Pubmed PMID: 34916293
- Agosto MA, Adeosun AAR, Kumar N, Wensel TG. "The mGluR6 ligand-binding domain, but not the C-terminal domain, is required for synaptic localization in retinal ON-bipolar cells.." J Biol Chem.. 2021;297(6):101418. Pubmed PMID: 34793838
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