Positions
- Professor of Surgery
-
Division of Pediatric Surgery
Baylor College of Medicine
- Surgical Director of ECMO
-
Texas Children's Hospital
Addresses
- Texas Children's Hospital (Clinic)
-
Mark A. Wallace Tower
6701 Fannin Street
Houston, TX 77030
United States
Phone: (832) 822-3135
Pediatric Surgery
Education
- Fellowship at Children's Hospital
- 01/2010 - Cincinnati, OH United States
- Internship from University Of California, Los Angeles
- 01/2002 - Los Angeles, CA United States
- Residency from Baylor College Of Medicine
- 01/2008 - Houston, TX United States
- M.D. from Baylor College Of Medicine
- 01/2001 - Houston, TX United States
Certifications
- Board Certified - General Surgery
- American Board of Surgery
- Board Certified - Pediatric Surgery
- American Board of Surgery
Honors & Awards
- STAR Faculty Award for Excellence in Patient Care
- Baylor College of Medicine
Professional Interests
- Pediatric surgery
- Neonatal surgery
- Fetal surgery
Professional Statement
Dr. Timothy C. Lee has particular expertise and clinical interest in fetal surgery, neonatal surgery for all newborns with surgical problems, and in general pediatric surgery. Dr. Lee’s primary focus is on improving clinical care and deriving protocol driven patient care initiatives in the surgical neonatal ICU and within the Texas Children’s Fetal Center. Currently he is a collaborator in a randomized control trial on the benefit of early delivery of gastroschisis patients. Other areas of research interest include patients with congenital diaphragmatic hernia and the use of extracorporeal life support. Dr. Lee is pursuing a Masters in Clinical Research to develop expertise in management and initiation of clinical trials within the neonatal ICU and within the fetal center patient populations.Websites
VIICTR Research Database
Selected Publications
- Lazar DA, Olutoye OO, Cass DL, Fernandes CJ, Welty SE, Johnson KE, Rycus PT, Lee TC "Outcomes of neonates requiring extracorporeal membrane oxygenation for irreversible pulmonary dysplasia: The Extracorporeal Life Support Registry experience*.." Pediatr Crit Care Med. 2012 Mar;13(2):188-90. Pubmed PMID: 21666536
- Lazar DA, Lee TC, Almulhim SI, Pinsky JR, Fitch M, Brandt ML "Transinguinal laparoscopic exploration for identification of contralateral inguinal hernias in pediatric patients.." J. Pediatr. Surg.. 2011 Dec;46(12):2349-52. Pubmed PMID: 22152880
- Chen-An Lee T, Kim ES, Ferrell LB, Brandt ML, Minifee PK, Midgen C, Domingo RP, Kearney DL "Gastric duplication cysts of the pancreas: clinical presentation and surgical management.." Eur J Pediatr Surg. 2011 Dec;21(6):402-4. Pubmed PMID: 21901665
- Lazar DA, Cass DL, Olutoye OO, Kim ES, Welty SE, Fernandes CJ, Lee TC "Venovenous cannulation for extracorporeal membrane oxygenation using a bicaval dual-lumen catheter in neonates.." J. Pediatr. Surg.. 2012 Feb;47(2):430-4. Pubmed PMID: 22325408
- Gwilliam NR, Lazar DA, Brandt ML, Mahoney DH, Wesson DE, Mazziotti MV, Nuchtern JG, Lee TC "An analysis of outcomes and treatment costs for children undergoing splenectomy for chronic immune thrombocytopenia purpura.." J. Pediatr. Surg.. 2012 Aug;47(8):1537-41. Pubmed PMID: 22901913
- Lee TC, Olutoye OO "Evaluation of the prenatally diagnosed mass.." Semin Fetal Neonatal Med. 2012 Aug;17(4):185-91. Pubmed PMID: 22424723
- Lazar DA, Cass DL, Olutoye OO, Welty SE, Fernandes CJ, Rycus PT, Lee TC "The use of ECMO for persistent pulmonary hypertension of the newborn: A decade of experience.." J. Surg. Res.. 2012 Oct;177(2):263-7. Pubmed PMID: 22901797
- Fallon SC, Shekerdemian LS, Olutoye OO, Cass DL, Zamora IJ, Nguyen T, Kim ES, Larimer EL, Lee TC "Initial experience with single-vessel cannulation for venovenous extracorporeal membrane oxygenation in pediatric respiratory failure*.." Pediatr Crit Care Med. 2013 May;14(4):366-73. Pubmed PMID: 23548959
- Lee TC, Barshes NR, Nguyen L, Karpen SJ, Quiros-Tejeira RE, Carter BA, Goss JA "Gastroschisis and biliary atresia in a neonate: uncommon presentation or common precipitant.." Eur J Pediatr Surg. 2005 Dec;15(6):434-6. Pubmed PMID: 16418964
- Hirsch JC, Goldberg C, Bove EL, Salehian S, Lee T, Ohye RG, Devaney EJ "Fontan operation in the current era: a 15-year single institution experience.." Ann. Surg.. 2008 Sep;248(3):402-10. Pubmed PMID: 18791360
- He Y, Lee T, Leong SK "6-Hydroxydopamine induced apoptosis of dopaminergic cells in the rat substantia nigra.." Brain Res.. 2000 Mar 6;858(1):163-6. Pubmed PMID: 10700609
- Barshes NR, Lee T, Goodpasture S, Brunicardi FC, Alejandro R, Ricordi C, Soltes G, Barth M, Hamilton D, Goss JA "Achievement of insulin independence via pancreatic islet transplantation using a remote isolation center: a first-year review.." Transplant. Proc.. 2004 May;36(4):1127-9. Pubmed PMID: 15194393
- Lee TC, Chow KL, Fang P, Schwartz RJ "Activation of skeletal alpha-actin gene transcription: the cooperative formation of serum response factor-binding complexes over positive cis-acting promoter serum response elements displaces a negative-acting nuclear factor enriched in replicating myobla." Mol. Cell. Biol.. 1991 Oct;11(10):5090-100. Pubmed PMID: 1922033
- Brunicardi FC, Atiya A, Moldovan S, Lee TC, Fagan SP, Kleinman RM, Adrian TE, Coy DH, Walsh JH, Fisher WE "Activation of somatostatin receptor subtype 2 inhibits insulin secretion in the isolated perfused human pancreas.." Pancreas. 2003 Nov;27(4):e84-9. Pubmed PMID: 14576502
- Barshes NR, Lee TC, Udell IW, O'Mahoney CA, Carter BA, Karpen SJ, Goss JA "Adult liver transplant candidate attitudes toward graft sharing are not obstacles to split liver transplantation.." Am. J. Transplant.. 2005 Aug;5(8):2047-51. Pubmed PMID: 15996258
- Lee T, Singh R, Yen TY, Macher B "An algorithmic approach to automated high-throughput identification of disulfide connectivity in proteins using tandem mass spectrometry.." Comput Syst Bioinformatics Conf. 2007;6:41-51. Pubmed PMID: 17951811
- Barshes NR, Lee TC, Karpen SJ, Bristow LJ, Quiros-Tejeira RE, Goss JA "Asymptomatic small bowel intussusception associated with post-transplant lymphoproliferative disease.." Pediatr Transplant. 2004 Apr;8(2):196-7. Pubmed PMID: 15049803
- Foster AE, Leen AM, Lee T, Okamura T, Lu A, Vera J, Atkinson R, Bollard CM, Dotti G, Rooney CM "Autologous designer antigen-presenting cells by gene modification of T lymphocyte blasts with IL-7 and IL-12.." J. Immunother..;30(5):506-16. Pubmed PMID: 17589291
- Lee TC, Zhang Y, Schwartz RJ "Bifunctional transcriptional properties of YY1 in regulating muscle actin and c-myc gene expression during myogenesis.." Oncogene. 1994 Apr;9(4):1047-52. Pubmed PMID: 8134108
- Devaney EJ, Lee T, Gelehrter S, Hirsch JC, Ohye RG, Anderson RH, Bove EL "Biventricular repair of atrioventricular septal defect with common atrioventricular valve and double-outlet right ventricle.." Ann. Thorac. Surg.. 2010 Feb;89(2):537-42; discuss. Pubmed PMID: 20103338
- Bhama JK, Ogren JW, Lee T, Fisher WE "Bouveret's syndrome.." Surgery. 2002 Jul;132(1):104-5. Pubmed PMID: 12110804
- Le DT, Ladle BH, Lee T, Weiss V, Yao X, Leubner A, Armstrong TD, Jaffee EM "CD8? Foxp3? tumor infiltrating lymphocytes accumulate in the context of an effective anti-tumor response.." Int. J. Cancer. 2011 Aug 1;129(3):636-47. Pubmed PMID: 20857491
- Savoldo B, Rooney CM, Quiros-Tejeira RE, Caldwell Y, Wagner HJ, Lee T, Finegold MJ, Dotti G, Heslop HE, Goss JA "Cellular immunity to Epstein-Barr virus in liver transplant recipients treated with rituximab for post-transplant lymphoproliferative disease.." Am. J. Transplant.. 2005 Mar;5(3):566-72. Pubmed PMID: 15707412
- Barshes NR, DiBardino DJ, McKenzie ED, Lee TC, Stayer SA, Mallory GB, Karpen SJ, Quiros-Tejeira RE, Carter BA, Fraser CD, Goss JA "Combined lung and liver transplantation: the United States experience.." Transplantation. 2005 Nov 15;80(9):1161-7. Pubmed PMID: 16314780
- Cass DL, Olutoye OO, Ayres NA, Moise KJ, Altman CA, Johnson A, Cassady CI, Lazar DA, Lee TC, Lantin MR "Defining hydrops and indications for open fetal surgery for fetuses with lung masses and vascular tumors.." J. Pediatr. Surg.. 2012 Jan;47(1):40-5. Pubmed PMID: 22244390
- Lee TC, Dreyer ZE, Brandt ML "Conservative surgical treatment of a profoundly immunosuppressed pediatric patient with Boerhaave syndrome.." J. Pediatr. Hematol. Oncol.. 2005 Nov;27(11):616-7. Pubmed PMID: 16282895
- Lazar DA, Ruano R, Cass DL, Moise KJ, Johnson A, Lee TC, Cassady CI, Olutoye OO "Defining liver-up": does the volume of liver herniation predict outcome for fetuses with isolated left-sided congenital diaphragmatic hernia?"." J. Pediatr. Surg.. 2012 Jun;47(6):1058-62. Pubmed PMID: 22703769
- Lee TC, Schwartz RJ "Differential detection of multiple DNA-binding complexes using dissimilar polyanion competitors.." Nucleic Acids Res.. 1992 Jan 11;20(1):140. Pubmed PMID: 1738593
- Lee TC, Shi Y, Schwartz RJ "Displacement of BrdUrd-induced YY1 by serum response factor activates skeletal alpha-actin transcription in embryonic myoblasts.." Proc. Natl. Acad. Sci. U.S.A.. 1992 Oct 15;89(20):9814-8. Pubmed PMID: 1409704
- He Y, Thong PS, Lee T, Leong SK, Mao BY, Dong F, Watt F "Dopaminergic cell death precedes iron elevation in MPTP-injected monkeys.." Free Radic. Biol. Med.. 2003 Sep 1;35(5):540-7. Pubmed PMID: 12927603
- Wilder NS, Kavarana MN, Voepel-Lewis T, Paugh T, Lee T, Ohye RG "Efficacy and safety of aprotinin in neonatal congenital heart operations.." Ann. Thorac. Surg.. 2011 Sep;92(3):958-63. Pubmed PMID: 21871283
- Chik Z, Basu RC, Pendek R, Lee TC, Mohamed Z "Comparative bioavailability study of two salbutamol tablets in healthy adult volunteers.." Int J Clin Pharmacol Ther. 2009 Jun;47(6):413-8. Pubmed PMID: 19473604
- Cass DL, Olutoye OO, Cassady CI, Zamora IJ, Ivey RT, Ayres NA, Olutoye OA, Lee TC "EXIT-to-resection for fetuses with large lung masses and persistent mediastinal compression near birth.." J. Pediatr. Surg.. 2013 Jan;48(1):138-44. Pubmed PMID: 23331806
- Barshes NR, Vanatta JM, Mote A, Lee TC, Schock AP, Balkrishnan R, Brunicardi FC, Goss JA "Health-related quality of life after pancreatic islet transplantation: a longitudinal study.." Transplantation. 2005 Jun 27;79(12):1727-30. Pubmed PMID: 15973176
- Udell IW, Barshes NR, Finegold MJ, Lee TC, Scott JD, Carter B, Karpen S, Goss JA "Hepatitis C viral recurrence in a pediatric patient following liver transplantation.." Pediatr Transplant. 2006 Aug;10(5):617-22. Pubmed PMID: 16857000
- Lee TC, Carrick MM, Scott BG, Hodges JC, Pham HQ "Incidence and clinical characteristics of methicillin-resistant Staphylococcus aureus necrotizing fasciitis in a large urban hospital.." Am. J. Surg.. 2007 Dec;194(6):809-12; discuss. Pubmed PMID: 18005776
- Barshes NR, Lee TC, Brunicardi FC, Mote A, Schock AP, Alejandro R, Ricordi C, Goss JA "Lack of cytomegalovirus transmission after pancreatic islet transplantation.." Cell Transplant. 2004;13(41463):833-8. Pubmed PMID: 15690986
- Lee TC, Lim FY, Keswani SG, Frischer JS, Haberman B, Kingma PS, Habli M, Jaekle RK, Sharp G, Kline-Fath B, Rubio EI, Calvo M, Guimaraes C, Crombleholme TM "Late gestation fetal magnetic resonance imaging-derived total lung volume predicts postnatal survival and need for extracorporeal membrane oxygenation support in isolated congenital diaphragmatic hernia.." J. Pediatr. Surg.. 2011 Jun;46(6):1165-71. Pubmed PMID: 21683216
- Barshes NR, Myers GD, Lee D, Karpen SJ, Lee TC, Patel AJ, Finegold M, Goss JA "Liver transplantation for severe hepatic graft-versus-host disease: an analysis of aggregate survival data.." Liver Transpl.. 2005 May;11(5):525-31. Pubmed PMID: 15838886
- Zamora IJ, Ethun CG, Evans LM, Olutoye OO, Ivey RT, Haeri S, Belfort MA, Lee TC, Cass DL "Maternal morbidity and reproductive outcomes related to fetal surgery.." J. Pediatr. Surg.. 2013 May;48(5):951-5. Pubmed PMID: 23701766
- Udell IW, Barshes NR, Voloyiannis T, Lee TC, Karpen SJ, Carter BA, Finegold M, Goss JA "Neonatal hemochromatosis: radiographical and histological signs.." Liver Transpl.. 2005 Aug;11(8):998-1000. Pubmed PMID: 16035090
- Lee TC, Schwartz RJ "Novel use of a polymeric chromophore in detecting sequence-specific DNA-binding proteins.." BioTechniques. 1993 Sep;15(3):390, 393. Pubmed PMID: 8217147
- Lydon JP, O'Malley BR, Saucedo O, Lee T, Headon DR, Conneely OM "Nucleotide and primary amino acid sequence of porcine lactoferrin.." Biochim. Biophys. Acta. 1992 Aug 17;1132(1):97-9. Pubmed PMID: 1511016
- Barshes NR, Lee TC, Balkrishnan R, Karpen SJ, Carter BA, Goss JA "Orthotopic liver transplantation for biliary atresia: the U.S. experience.." Liver Transpl.. 2005 Oct;11(10):1193-200. Pubmed PMID: 16184564
- Kastrup CJ, Nahrendorf M, Figueiredo JL, Lee H, Kambhampati S, Lee T, Cho SW, Gorbatov R, Iwamoto Y, Dang TT, Dutta P, Yeon JH, Cheng H, Pritchard CD, Vegas AJ, Siegel CD, Macdougall S, Okonkwo M, Thai A, Stone JR, Coury AJ, Weissleder R, Langer R, Anders "Painting blood vessels and atherosclerotic plaques with an adhesive drug depot.." Proc. Natl. Acad. Sci. U.S.A.. 2012 Dec 26;109(52):21444-9. Pubmed PMID: 23236189
- Lee TC, Barshes NR, Brunicardi FC, Alejandro R, Ricordi C, Nguyen L, Goss JA "Procurement of the human pancreas for pancreatic islet transplantation.." Transplantation. 2004 Aug 15;78(3):481-3. Pubmed PMID: 15316380
- Votanopoulos KI, Lee TC, Dominguez EP, Choi YU, Sweeney JF "Propoxur induced pancreatitis after inhalation of baygon pesticide.." Pancreas. 2007 Apr;34(3):379-80. Pubmed PMID: 17414064
- Lee TC, Goss JA, Rooney CM, Heslop HE, Barshes NR, Caldwell YM, Gee AP, Scott JD, Savoldo B "Quantification of a low cellular immune response to aid in identification of pediatric liver transplant recipients at high-risk for EBV infection.." Clin Transplant.;20(6):689-94. Pubmed PMID: 17100717
- Lee TC, Savoldo B, Rooney CM, Heslop HE, Gee AP, Caldwell Y, Barshes NR, Scott JD, Bristow LJ, O'Mahony CA, Goss JA "Quantitative EBV viral loads and immunosuppression alterations can decrease PTLD incidence in pediatric liver transplant recipients.." Am. J. Transplant.. 2005 Sep;5(9):2222-8. Pubmed PMID: 16095501
- Barshes NR, Lee T, Kiliç M, Goss JA "Reconstruction of the hepatic venous outflow in piggyback liver transplantation.." 2004 Jun;2(1):189-95. Pubmed PMID: 15859927
- Lee TC, Barshes NR, Agee EE, O'Mahony CA, Karpen SJ, Carter BA, Bristow JD, Goss JA "Resolution of medically resistant hypothyroidism after liver transplantation for hepatic hemangioendothelioma.." J. Pediatr. Surg.. 2006 Oct;41(10):1783-5. Pubmed PMID: 17011291
- Fallon SC, Lopez ME, Zhang W, Brandt ML, Wesson DE, Lee TC, Rodriguez JR "Risk factors for surgery in pediatric intussusception in the era of pneumatic reduction.." J. Pediatr. Surg.. 2013 May;48(5):1032-6. Pubmed PMID: 23701778
- Tiroch KA, Arora N, Matheny ME, Liu C, Lee TC, Resnic FS "Risk predictors of retroperitoneal hemorrhage following percutaneous coronary intervention.." Am. J. Cardiol.. 2008 Dec 1;102(11):1473-6. Pubmed PMID: 19026298
- Barshes NR, Lee TC, Balkrishnan R, Karpen SJ, Carter BA, Goss JA "Risk stratification of adult patients undergoing orthotopic liver transplantation for fulminant hepatic failure.." Transplantation. 2006 Jan 27;81(2):195-201. Pubmed PMID: 16436962
- Lee TC, Glynn RJ, Peña JM, Paynter NP, Conen D, Ridker PM, Pradhan AD, Buring JE, Albert MA "Socioeconomic Status and Incident Type 2 Diabetes Mellitus: Data from the Women's Health Study.." PLoS ONE. 2011;6(12):e27670. Pubmed PMID: 22194788
- Lee TC, Barshes NR, Washburn WK, Halff GA, Carter BA, Karpen SJ, Bristow LJ, Scott JD, Goss JA "Split-liver transplantation using the left lateral segment: a collaborative sharing experience between two distant centers.." Am. J. Transplant.. 2005 Jul;5(7):1646-51. Pubmed PMID: 15943622
- Hayanga AJ, Mukherjee D, Chang D, Kaiser H, Lee T, Gearhart S, Ahuja N, Freischlag J "Teaching hospital status and operative mortality in the United States: tipping point in the volume-outcome relationship following colon resections?." Arch Surg. 2010 Apr;145(4):346-50. Pubmed PMID: 20404284
- Lee TC, Barshes NR, O'Mahony CA, Nguyen L, Brunicardi FC, Ricordi C, Alejandro R, Schock AP, Mote A, Goss JA "The effect of pancreatic islet transplantation on progression of diabetic retinopathy and neuropathy.." Transplant. Proc.. 2005 Jun;37(5):2263-5. Pubmed PMID: 15964394
- Lee TC, Barshes NR, Agee EE, O'Mahoney CA, Brunicardi FC, Goss JA "The effect of whole organ pancreas transplantation and PIT on diabetic complications.." Curr. Diab. Rep.. 2006 Aug;6(4):323-7. Pubmed PMID: 16879786
- Barshes NR, Udell IW, Lee TC, O'Mahony CA, Karpen SJ, Carter BA, Goss JA "The natural history of hepatitis C virus in pediatric liver transplant recipients.." Liver Transpl.. 2006 Jul;12(7):1119-23. Pubmed PMID: 16799942
- Barshes NR, Lee TC, Udell IW, O'mahoney CA, Karpen SJ, Carter BA, Goss JA "The pediatric end-stage liver disease (PELD) model as a predictor of survival benefit and posttransplant survival in pediatric liver transplant recipients.." Liver Transpl.. 2006 Mar;12(3):475-80. Pubmed PMID: 16498644
- Lee TC, O'Malley PG, Feuerstein I, Taylor AJ "The prevalence and severity of coronary artery calcification on coronary artery computed tomography in black and white subjects.." J. Am. Coll. Cardiol.. 2003 Jan 1;41(1):39-44. Pubmed PMID: 12570942
- Lazar DA, Cassady CI, Olutoye OO, Moise KJ, Johnson A, Lee TC, Cass DL "Tracheoesophageal displacement index and predictors of airway obstruction for fetuses with neck masses.." J. Pediatr. Surg.. 2012 Jan;47(1):46-50. Pubmed PMID: 22244391
- Barshes NR, Lee TC, Goodpastor SE, Balkrishnan R, Schock AP, Mote A, Brunicardi FC, Alejandro R, Ricordi C, Goss JA "Transaminitis after pancreatic islet transplantation.." J. Am. Coll. Surg.. 2005 Mar;200(3):353-61. Pubmed PMID: 15737845
- MacLellan WR, Lee TC, Schwartz RJ, Schneider MD "Transforming growth factor-beta response elements of the skeletal alpha-actin gene. Combinatorial action of serum response factor, YY1, and the SV40 enhancer-binding protein, TEF-1.." J. Biol. Chem.. 1994 Jun 17;269(24):16754-60. Pubmed PMID: 8206998
- Lee TC, Barshes NR, Brunicardi FC, Nguyen L, Goss JA, DeBakey ME "Transplantation of the pancreas and pancreatic islets: has it lived up to its promise?." Curr Surg.;62(3):305-10. Pubmed PMID: 15890213
- Nguyen L, Fagan SP, Lee TC, Aoki N, Itani KM, Berger DH, Awad SS "Use of a predictive equation for diagnosis of acute gangrenous cholecystitis.." Am. J. Surg.. 2004 Nov;188(5):463-6. Pubmed PMID: 15546551
- Morrison CA, Lee TC, Wall MJ, Carrick MM "Use of a trauma service clinical pathway to improve patient outcomes for retained traumatic hemothorax.." World J Surg. 2009 Sep;33(9):1851-6. Pubmed PMID: 19629582
- Lee TC, Savoldo B, Barshes NR, Rooney CM, Heslop HE, Gee AP, Caldwell Y, Scott JD, Goss JA "Use of cytokine polymorphisms and Epstein-Barr virus viral load to predict development of post-transplant lymphoproliferative disorder in paediatric liver transplant recipients.." Clin Transplant.;20(3):389-93. Pubmed PMID: 16824159
- Lee TC, Schwartz RJ "Using proteases to avoid false identification of DNA-protein complexes in gel shift assays.." BioTechniques. 1992 Apr;12(4):486-90. Pubmed PMID: 1503744
Memberships
- American Academy of Pediatrics
- Fellow
- American College of Surgeons
- Associate Fellow
- Association for Academic Surgery
- American Pediatric Surgical Association
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