Trung C. Nguyen
Picture
Trung C. Nguyen
Associate Professor
Positions
- Associate Professor
-
Pediatrics-Critical Care
Baylor College of Medicine
Houston, Texas United States
- Core Faculty
-
Center for Translational Research on Inflammatory Diseases (CTRID)
Michael E. DeBakey VA Medical Center
Baylor College of Medicine
Houston, Texas United States
Addresses
- Texas Children's Hospital - Legacy Tower (Clinic)
-
6651 Main Street, Mail Stop: E1420
Houston, TX 77030
United States
Phone: (832) 826-6230
Education
- Fellowship at University of Pittsburgh School of Medicine
- Pittsburgh, Pennsylvania United States
- National Research Service Award Fellowship Training (T32) (NICHD T32 HD40686) in Pediatric Neurointensive Care and Resuscitation Research, 2001-2003
- Residency at New York Hospital - Cornell Medical Center
- New York, New York United States
- Pediatric Chief Residency, 1998-99
- Fellowship at University of Pittsburgh School of Medicine
- Pittsburgh, Pennsylvania United States
- Pediatric Critical Care Medicine Fellowship, 1999-2002
- Residency at New York Hospital - Cornell Medical Center
- New York, New York United States
- Pediatric Residency, 1996-98
- Residency at New York Hospital - Cornell Medical Center
- New York, New York United States
- Pediatric Internship, 1995-96
- MD from University of Virginia School of Medicine
- Charlottesville, Virginia United States
- 1995
- BA from Cornell University
- Ithaca, New York United States
- Biology, 1991
Certifications
- Pediatric Critical Care Medicine
- American Board of Pediatrics
Honors & Awards
- Society of Critical Care Medicine Presidential Citation
- 2015, 2016, 2019, 2020
- Society of Critical Care Medicine, Hematology Specialty Award
- 2013
- Fullbright & Jaworski L.L.P. Faculty Excellence Award for Teaching and Evaluation
- 2011
- Baylor College of Medicine
- Society of Critical Care Medicine Research Citation,
- 2002, 2004, 2008
- Society of Critical Care Medicine Educational Scholarship Award
- 2003
- Society of Critical Care Medicine Annual Scientific Award
- 2001
- Outstanding Medical Teacher Award
- , Cornell University Medical Class of 1999
- Distinguished Alumni Award 2020-2021
- The University of Pittsburgh Department of Critical Care Medicine
- Study Section, Invited Reviewer, March 2020, October 2017
- March 2020, October 2017
- National Heart Lung Blood Institute
- Research Mentorship Award Associate Professor Level
- Department of Pediatrics, Baylor College of Medicine, 2017
- Senior Investigator Abstract Award, 2018
- 9th Congress of the World Federation of Pediatric Intensive & Critical Care Societies, 2018
- #1 Abstract Award at the Michael DeBakey Veterans Affairs Medical Center Research Competition, 2018
- Michael DeBakey Veterans Affairs Medical Center Research Competition, 2018
- Chartered Member - Mentored Clinical and Basic Science Review Committee
- NIH NHLBI (06/2022 - 06/2026)
Websites
Professional Development
- Plasma Therapies and Beyond
- Conference (Presenter, 2015)
- Sponsor: Society of Critical Care 44th Annual Congress
- Pediatric Multiple Organ Dysfunction Syndrome Workshop
- Conference (Presenter, 2015)
- Sponsor: National Institute of Health – Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Sepsis Phenotypes: Targets for Blood Purification
- Conference (Presenter, 2014)
- Sponsor: Acute Dialysis Quality Initiative XIV Consensus Conference
- Multiple Organ Failure Phenotyping
- Conference (Presenter, 2014)
- Sponsor: ” Noon Grand Round, Section of Critical Care, Department of Pediatrics, Texas Children’s Hospital/Baylor College of Medicine
- Red, White and Purple: The Colors of Sepsis-induced Multiple Organ Failure
- Conference (Presenter, 2014)
- Sponsor: Pediatric Grand Round at MD Anderson Cancer Center
- The Evolution of TAMOF Research
- Seminar (Presenter, 2020)
- Sponsor: The University of Pittsburgh Department of Critical Care Medicine Grand Round
- Therapeutic Plasma Exchange in Critical Illness
- Conference (Presenter, 2020)
- Sponsor: World Federation of Pediatric Intensive & Critical Care Societies Congress
- Sepsis-Induced Multiple Organ Dysfunction Syndromes
- Conference (Presenter, 2020)
- Sponsor: Pediatric Current Concepts, Society of Critical Care Medicine 49th Annual Congress
- Thrombocytopenia-Associated Multiple Organ Failure
- Conference (Presenter, 2019)
- Sponsor: Pediatric Critical Care Summit of The Americas, 15th Latin American Congress of Pediatric Intensive Care & 26th Pediatric Critical Care Colloquium U.S.A.
Selected Publications
- • Nguyen TC, Gushiken F, Correa JI, et al. "A recombinant fragment of von Willebrand factor reduces fibrin-rich microthrombi formation in mice with endotoxemia.." Thrombosis Research. 2015 Mar;135((5)):1025-1030. Pubmed PMID: 25769494
- Brubaker LS, Saini A, Nguyen TC, Martinez-Vargas M, Lam FW, Yao Q, Loor MM, Rosengart TK, Cruz MA. "Aberrant Fibrin Clot Structure Visualized Ex Vivo in Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection.." Crit Care Med. 2022 Feb 15;50(6):E557–E568. Pubmed PMID: 35170535
- Nguyen TC, Liu A, Liu L, Ball C, Choi H, May WS, Aboulfatova K, Bergeron AL, Dong JF "Acquired ADAMTS-13 deficiency in pediatric patients with severe sepsis.." Haematologica. 2007 Jan;92(1):121-4. Pubmed PMID: 17229645
- Davis AL, Carcillo JA, Aneja RK, Deymann AJ, Lin JC, Nguyen TC, Okhuysen-Cawley RS, Relvas MS, Rozenfeld RA, Skippen PW, et al "American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock." Crit Care Med. 2017 Jun;45(6):1061-1093. Pubmed PMID: 28509730
- • Weiss SL, Peters MJ, Alhazzani W, … Nguyen TC, et al "Executive summary: surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children.." Intensive Care Med. 2020 Feb;46(Suppl 1):1-9. Pubmed PMID: 32030528
- • Chinn IK, Eckstein OS, Peckham-Gregory EC, Goldberg BR, Forbes LR, Nicholas SK, Mace EM, Vogel TP, Abhyankar HA, Diaz MI, Heslop HE, Krance RA, Martinez CA, Nguyen TC, Bashir DA, Goldman JR et al. "Genetic and Mechanistic Diversity in Pediatric Hemophagocytic Lymphohistiocytosis." Blood. 2018 Jul;132((1)):89-100. Pubmed PMID: 6034641
- Goldman J, Desai MS, McClain KL, Tcharmtchi MH, Kennedy CE, Thompson K, Lam F, Bashir DA, Chinn IK, Goldberg BR, Allen CE, Nguyen TC. "Hepatobiliary Dysfunction and Disseminated Intravascular Coagulation Increase Risk of Mortality in Pediatric Hemophagocytic Lymphohistiocytosis." Pediatr Crit Care Med. 2019 Oct;19((10)):e522-e530. Pubmed PMID: 30113519
- Lin H, Scull BP, Goldberg BR,…Nguyen TC, et al. "IFN-gamma signature in the plasma proteome distinguishes pediatric hemophagocytic lymphohistiocytosis from sepsis and SIRS.." Blood Adv. 2021;5(17):3457-3467. Pubmed PMID: 34461635
- Nguyen TC, Han YY, Kiss JE, Hall MW, Hassett AC, Jaffe R, Orr RA, Janosky J, Carcillo JA "Intensive plasma exchange increases a disintegrin and metalloprotease with thrombospondin motifs-13 activity and reverses organ dysfunction in children with thrombocytopenia-associated multiple organ failure.." Crit. Care Med.. 2008 Oct;36(10):2878-87. Pubmed PMID: 18828196
- • Valladolid C, Martinez-Vargas M, Sekhar N, Lam F, Brown C, Palzkill T, Tischer A, Auton M, Vijayan KV, Rumbaut RE, Nguyen TC, Cruz MA "Modulating the Rate of Fibrin Formation and Clot Structure Attenuates Microvascular Thrombosis in Systemic Inflammation." Blood Adv. 2020 Apr 14;4((7)):1340-1349. Pubmed PMID: 32259201
- • Weiss SL, Peters MJ, Alhazzani W, …Nguyen TC, et al "Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children.." Intensive Care Med. 2020 Feb 7;46(Suppl 1):10-67. Pubmed PMID: 32030529
- • Fortenberry JD, Nguyen T, Grunwell JR, Aneja RK, Wheeler D, Hall M, Fleming G, Tarrago R, Buttram S, Dalton H, et al "Therapeutic Plasma Exchange in Children With Thrombocytopenia-Associated Multiple Organ Failure: The Thrombocytopenia-Associated Multiple Organ Failure Network Prospective Experience." Crit Care Med. 2019 Mar;47((3)):e173-e181. Pubmed PMID: 30531184
- "Secretion of von Willebrand Factor and Suppression of ADAMTS-13 Activity by Markedly High Concentration of Ferritin." Clin Appl Thromb Hemost. 2021; Pubmed PMID: 33539188
Memberships
- American Academy of Pediatrics
- Society of Critical Care Medicine
- Baylor College of Medicine Affiliated Hospital
- Member of Steering Committee
- Pediatric Section Executive Committee of the Society of Critical Care Medicine
- Members-At-Large
- American College of Critical Care Medicine: Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock
- Society of Critical Medicine and European Society of Intensive Care Medicine
- Invited Committee Member
Funding
- Microvascular Thrombosis in Systemic Inflammation - #2R01GM112806
- ( 09/05/2013 - 06/30/2023 ) Grant funding from NIH NIGMS
- Multi-Principal Investigator R01 Role: Principal Investigator
- ADAMTS-13 and Inflammation - #K08 GM83212
- ( 05/01/2008 - 05/31/2014 ) Grant funding from NIH NIGMS
- Principal Investigator No Cost Extension 5/31/2014
- Collaborative Pediatric Critical Care Research Network - #RL1HD107780
- ( 04/01/2021 - 03/31/2026 ) Grant funding from NIH NICHD
- The goal of this study is to implement CPCCRN organization, mount strategies for development of young clinician scientists, and conduct a large-scale multicenter study of personalized, targeted immune modulation in children with sepsis-induced multiple organ dysfunction syndrome.
- Novel Treatment for DIC - #R41 HL135942
- ( 08/20/2018 - 07/30/2020 ) Grant funding from NIH NIGMS
- Small Business Technology Transfer Grant Role: Co-Investigator 8/20/2018-7/31/2019, No Cost Extension 7/30/2020
- Therapeutic and Metabolic Responses of Citrulline vs. Arginine Supplementation - #R01 GM108940
- ( 07/10/2020 - 06/30/2024 ) Grant funding from NIH NIGMS
- The goal of this study is to investigate the metabolic mechanism behind arginine depletion and devise strategies to restore arginine availability in sepsis and septic shock.
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