Email

mitch@bcm.edu

Positions

Professor

Medicine-Nephrology
Baylor College of Medicine
Houston, TX US

Addresses

Baylor Clinic (Clinic)

6620 Main
Suite 1375
Houston, TX 77030
United States
Phone: (713) 798-2500

Education

Fellowship at Brigham And Women's Hospital

01/1974 - Boston, MA United States

Fellowship at Johns Hopkins Affiliate Hospitals

01/1973 - Baltimore, MD United States

Residency at Johns Hopkins Affiliate Hospitals

01/1972 - Baltimore, MD United States

Advanced Training from National Cancer Institute

01/1971 - Bethesda, MD United States

Internship at Brigham And Women's Hospital

01/1969 - Boston, MA United States

MD from Harvard Medical School

01/1967 - Boston, MA United States

Certifications

Internal Medicine

American Board of Internal Medicine

Nephrology

American Board of Internal Medicine

Professional Interests

• Control of protein metabolism in catabolic conditions.

Professional Statement

Since I graduated from Medical School, my major activity as a physician has been linked to my professional goals. Both as a physician and an investigator, I have worked to improve the treatment of patients with chronic kidney failure. Consequently, I serve as the physician for patients with chronic kidney failure and in treating them, I have uncovered specific problems that develop in these patients. This has led to the development of methods of ameliorating the problems caused by kidney diseases, including insights into methods for slowing the progress of kidney failure. My experimental efforts have been closely linked to the goal of preventing complications of kidney disease and fortunately, we have made progress in not only determining how kidney damage changes the metabolism of protein in the body but also how the diet can be manipulated to ameliorate clinical problems of patients with chronic kidney failure. Specifically, we have identified how kidney failure changes the metabolism of muscle, resulting in loss of muscle mass and strength. We are working on two different strategies that have the potential of preventing the loss of muscle mass and this is has led to promising results that are being tested in patients with kidney failure.

Websites

Selected Publications

• Mitch WE "2004 Presidential Address: An evaluation of progress toward goals.." J. Am. Soc. Nephrol.. 2005 Mar;16(3):576-82. Pubmed PMID: 15677306
• Du J, Wang X, Miereles C, Bailey JL, Debigare R, Zheng B, Price SR, Mitch WE "Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions.." J. Clin. Invest.. 2004 Jan;113(1):115-23. Pubmed PMID: 14702115
• de Zeeuw D, Remuzzi G, Parving HH, Keane WF, Zhang Z, Shahinfar S, Snapinn S, Cooper ME, Mitch WE, Brenner BM "Albuminuria, a therapeutic target for cardiovascular protection in type 2 diabetic patients with nephropathy.." Circulation. 2004 Aug 24;110(8):921-7. Pubmed PMID: 15302780