Wu Chen

Wu Chen, Ph.D.

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wu.chen@bcm.edu

Instructor: Department of Neuroscience
Baylor College Of Medicine
Houston, Texas United States

Internship at Tulane University: New Orleans, Louisiana United States; Neuroscience, Mentor: Dr. Jeffrey Tasker

PhD from Louisiana Tech University: Ruston, Louisiana United States; Biomedical Engineering, Mentor: Dr. Alan Chiu

Postdoctoral Fellowship at University of Michigan: Ann Arbor, Michigan United States; Neurology, Mentor: Dr. William Stacey

Postdoctoral Fellowship at Baylor College of Medicine: Houston, Texas United States; Neuroscience, Mentor: Dr. Mingshan Xue

Chen W, Cai ZL, Chao ES, Chen H, Longley CM, Hao S, Chao HT, Kim JH, Messier JE, Zoghbi HY, Tang J, Swann JW, Xue M "Stxbp1/Munc18-1 haploinsufficiency impairs inhibition and mediates key neurological features of STXBP1 encephalopathy." eLife. 2020 Feb 19;9:e48705. Pubmed PMID: 32073399
Yin J, Chen W, Chao ES, Soriano S, Wang L, Wang W, Cummock SE, Tao H, Pang K, Liu Z, Pereira FA, Samaco RC, Zoghbi HY, Xue M, Schaaf CP "Otud7a Knockout Mice Recapitulate Many Neurological Features of 15q13.3 Microdeletion Syndrome." Am J Hum Genet. 2018 Feb 1;102(2):296-308. Pubmed PMID: 29395075
Yin J, Chen W, Yang H, Xue M, Schaaf CP "Chrna7 deficient mice manifest no consistent neuropsychiatric and behavioral phenotypes." Sci Rep. 2017 Jan 3;7:39941. Pubmed PMID: 28045139
Luna-Munguia H, Starski P, Chen W, Gliske S, Stacey WC "Control of in vivo ictogenesis via endogenous synaptic pathways." Sci Rep. 2017 May 2;7(1):1311. Pubmed PMID: 28465556

Ure K, Lu H, Wang W, Ito-Ishida A1,2, Wu Z2,4, He LJ, Sztainberg Y, Chen W, Tang J, Zoghbi HY "Restoration of Mecp2 expression in GABAergic neurons is sufficient to rescue multiple disease features in a mouse model of Rett syndrome." eLife. 2016 Jun 21;5:e14198. Pubmed PMID: 27328321
Meng X, Wang W, Lu H, He LJ, Chen W, Chao ES, Fiorotto ML, Tang B, Herrera JA, Seymour ML, Neul JL, Pereira FA, Tang J, Xue M, Zoghbi HY "Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders." eLife. 2016 Jun 21;5:e14199. Pubmed PMID: 27328325
Chen W, Cahoy DO, Tasker JG, Chiu AW "Kernel duration and modulation gain in coupled oscillator model and their implications on the progression of seizures." Network. 2012 May 9;23(1-2):59-75. Pubmed PMID: 22571251
Lee D*, Chen W*#, Kaku HN*, Zhou X*, Chao ES, Soriano A, Kuncheria A, Flores S, Kim JH, Rigo F, Jafar-nejad P, Beaudet AL, Caudill MS, Xue M# "Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome." eLife. 2023 Jan 3;12:e81892. Pubmed PMID: 36594817

Hide 4 publications

AAV-Mediated Gene Replacement Therapy in a mouse model of STXBP1-Related Developmental and Epileptic Encephalopathy: Baylor College of Medicine
Reactivating paternal Ube3a alleviates the disturbance of brain rhythms and sleep in juvenile and adult Angelman syndrome mouse models: Baylor College of Medicine
Transgenic Mouse Models of STXBP1-Related Pediatric Epileptic Encephalopathies: Baylor College of Medicine

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