xiangz

Xiang Zhang, Ph.D

Picture

Xiang Zhang, Ph.D

Interim Director

Email

xiangz@bcm.edu

Positions

Interim Director: Lester and Sue Smith Breast Center

William T. Butler, M.D., Endowed Chair for Distinguished Faculty: Baylor College of Medicine

Professor: Molecular and Cellular Biology
Baylor College of Medicine
Houston, TX US

McNair Scholar: Baylor College of Medicine
Houston, Texas United States

Member: Dan L. Duncan Comprehensive Cancer Center

Education

Post-Doctoral Fellowship at Memorial Sloan Kettering Cancer Center: 06/2011 - New York, New York United States

PhD from Columbia University: 05/2006 - New York, New York United States

BS from Fu-Dan University: 01/2000 - Shanghai, China, People's Rep

Honors & Awards

Era of Hope Scholar: Department of Defense Congressionally Directed Medical Research Programs, Breast Cancer Research Program (03/2016 - 03/2021)

NIH Pathway to Independence Award (K99/R00): National Cancer Institute (09/2010 - 09/2014)

Career Catalyst Research Award: Susan G. Komen Foundation (09/2014 - 08/2017)

Excellence in Research: Department of Molecular and Cellular Biology, BCM (08/2016)

Michael E. DeBakey Award for Excellence in Research: Baylor College of Medicine (05/2018)

Sue Eccles Young Investigator Award: Metastasis Research Society (08/2018)

Laura Zisken Prize: Stand Up To Cancer (01/2020 - 01/2021)

Leadership Award: Theresa's Research Foundation (10/2016)

Websites

VIICTR Publications List

Lab Website

Breast Center Website

Selected Publications

Xiang H.-F. Zhang*, X Jin*, S Malladi, YH Wen, E Brogi, M Smid, JA Foekens, and J Massagué. "Bone Metastasis seed pre-selection by the primary tumour stroma." Cell.2013;154(5):1060-73. Pubmed PMID: 3974915
H Wang; C Yu; X Gao; T Welte; A Muscarella; L Tian; J Liu; H Zhao; Z Zhao; J Tao; B Lee; TF Westbrook; STC Wong; JM. Rosen; CK Osborne; Xiang H.-F. Zhang "The Osteogenic Niche Promotes Early-Stage Bone Colonization of Disseminated Breast Cancer Cells." Cancer Cell.2015/February9;27(2):193-210.
T Welte, IS Kim, L Tian, X Gao, H Wang, J Li, XB Holdman, JI Herschkowitz, A Pond, G Xia, S Kurley, T Nguyen, L Liao, LE Dobrolecki, Q Mo, DP Edwards, S Huang, L Xin, J Xu, Y Li, MT Lewis, T Wang, TF Westbrook, JM Rosen*, and Xiang H.-F. Zhang* "Oncogenic mTOR signaling recruits myeloid-derived suppressor cells to promote tumor initiation.." Nature Cell Biology.2016/June;18:632-644.
L Tian, A Goldstein, H Wang, IS Kim, HC Lo, T Welte, K Sheng, L Dobrolecki, X Zhang, N Putluri, T Phung, SA Mani, F Stossi, A Sreekumar, MA Mancini, C Zong, WK Decker, MT Lewis, and Xiang H.-F. Zhang "Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming." Nature.2017/April3;544(7649):250-254.

H Wang, L Tian, A Goldstein, HC Lo, J Liu, K Sheng, G Zbigniew, F Stossi, C Zong, Z Li, MA Mancini and Xiang H.-F. Zhang "Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies." Nature Communications. 2017 8 (15045): DOI: 10.1038/ncomms15045.
H Wang, L Tian, J Liu, A Goldstein, I Bado, W Zhang, BR Arenkiel, Z Li, M Yang, S Du, H Zhao, DR Rowley, STC Wong, Z Gugala, and Xiang H.-F. Zhang "The osteogenic niche is a calcium reservoir of bone micrometastases and confers unexpected therapeutic vulnerability." Cancer Cell. 34 (5): 823-839.
Kim IS, Gao Y, Welte T, Wang H, Liu J, Janghorban M, Sheng K, Niu Y, Goldstein A, Zhao N, Bado I, Lo H-C, ..., Li Y, Mo Q, Westbrook TF, Zong C, Rao A, Sreekumar A, Rosen JM, Zhang XHF "Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms." Nature Cell Biology. 2019 September ; 21 (9): 1113-1126.
Lo HC, Xu Z, Kim IS, Pingel B, Aguirre S, Kodali S, Liu J, Zhang W, Muscarella AM, Hein SM, Krupnick AS, Neilsen JR, Paust S, Rosen JM, Wang H, and Xiang H.-F. Zhang "Resistance to Natural Killer cell immunosurveillance confers a selective advantage to polyclonal metastasis." Nature Cancer. 2020 1 : 709–722.
Muscarella MM, Dai W, Mitchell PG, Zhang W, Wang H, Jia L, Stossi F, Mancini MA, Chiu W, and Xiang H.-F. Zhang "Unique cellular protrusions mediate breast cancer cell migration by tethering to osteogenic cells." NPG Breast Cancer. 2020 September 7; :
Zhang W*, Bado IL*, Hu J, Wan YW, Wu L, Wang H, Gao Y, Jeong HH, Xu Z, Hao X, Lege BM, AI-Ouran R, Li L, Li J, Yu L, Singh S, Lo H-C, Niu M, Liu J, Jiang W, Li Y, Wong STC, Cheng C, Liu Z, Xiang H.-F. Zhang "The bone microenvironment invigorates metastatic seeds for further dissemination." Cell. 2021 April 19; Online ahead of print (*: Equal contribution):
Bado IL*, Zhang W*, Wang H, Hu J, Sarkar P, Liu J, Zbigniew G, Xu Z, Zhang W, Li L, Wan YW, Wu W, Lo H-C, Kim IS, Singh S, Janghorban M, Muscarella A, Goldstein A, Singh P, Jeong HH, Liu C, Huang S, Schiff R, Gaber MW, Liu Z, Ellis MJ, Xiang H.-F. Zhang "The bone microenvironment increases phenotypic plasticity of ER+ breast cancer." Dev. Cell. 2021 April 19; 56 (8): 1100-1117 *: equal contribution.
Zeru Tian, Ling Wu, Chenfei Yu, Yuda Chen, Zhan Xu , Igor Bado , Axel Loredo , Lushun Wang , Hai Wang , Kuan-Lin Wu , Weijie Zhang , Xiang H.-F. Zhang*, Han Xiao* "Harnessing the power of antibodies to fight bone metastasis." Sci. Adv.. 2021 June 23; 7 (eabf2051): * Co-senior authors.
Zhang W, Zhan X, Hao X, He T, Li J, Shen Y, Liu K, Gao Y, Liu J, Edwards DG, Muscarella AM, Wu L, Yu L, Xu L, Chen X, Wu YH, Bado IL, Ding Y, Aguirre S, Wang H, Gugala Z, Satcher RL, Wong STC, Xiang H.-F. Zhang "Bone metastasis initiation is coupled with bone remodeling through osteogenic differentiation of NG2+ cells." Cancer Discovery. 2022 Accepted :