Positions
- Assistant Professor
-
Pediatrics
Neurology
Baylor College of Medicine
Houston, TX US
- TCH faculty scholar
-
Texas Children's Hospital
Addresses
- Jan and Dan Duncan Neurological Research Institute (Office)
-
1250 Moursund St.
Room: 0950.21
Houston, TX 77030
United States
Education
- PhD from Zhejiang University
- 06/2018 - Hangzhou, Zhejiang China
- Neurobiology
- Postdoctoral Fellowship at Baylor College of Medicine
- 08/2023 - Houston, Texas United States
- BS from Nanjing agricultural University
- 06/2012 - Nanjing, Jiangsu China
- Biotechnology
Professional Statement
Obesity serves as a pivotal risk factor for diabetes, fatty liver diseases, cardiovascular disorders, and cancer. Obesity arises from an imbalance between energy intake and expenditure, predominantly orchestrated by the central nervous system (CNS). Our research focuses on the interplay between the central nervous system and systemic energy homeostasis. The ultimate goal is to identify therapeutic targets for combating obesity and metabolic disease.Websites
Selected Publications
- He Y*, Brouwers B*, Liu H*, et al. "Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior.." Nat Med. 2022; Pubmed PMID: 36536256
- Li V L*, He Y*, Contrepois K, et al. "An exercise-inducible metabolite that suppresses feeding and obesity." Nature. 2022 Jun 15;
- He Y, Wei M, Wu Y, Qin H, Li W, Ma X, Cheng J, Ren J, Shen Y, Chen Z, Sun B, Huang FD, Shen Y, Zhou YD. "Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate.." Nat Commun.. 2019 Mar 13; Pubmed PMID: 30867420
- Liu H*, He Y*, Bai J*, et al. "Hypothalamic Grb10 enhances leptin signalling and promotes weight loss.." Nat Metab.. 2023; Pubmed PMID: 36593271
- Yang He* Hailan Liu* Na Yin* , et al. "Barbadin Potentiates Long-Term Effects of Lorcaserin on POMC Neurons and Weight Loss." J Neurosci.. 2021 Jun 30; Pubmed PMID: 34031163
- Hailan Liu*, Yang He*, et al. "Defining vitamin D receptor expression in the brain using a novel VDRCre mouse." J Comp Neurol..; Pubmed PMID: 33368246
- Mishra I, Xie WR, Bournat JC, He Y, et al. "Protein tyrosine phosphatase receptor δ serves as the orexigenic asprosin receptor." Cell Metab. 2022; Pubmed PMID: 35298903
- Liu, H*., He, Y*., Liu, H*., Brouwers, B*., Yin, N., Lawler, K., ... & Xu, Y. "Neural circuits expressing the serotonin 2C receptor regulate memory in mice and humans." Sci Adv. 2024 Jun 28;10(26):eadl2675. Pubmed PMID: 38941473
- Li, Y*., Cacciottolo, T. M*., Yin, N*., He, Y*., Liu, H., Liu, H., ... & Farooqi, I. S. "Loss of transient receptor potential channel 5 causes obesity and postpartum depression." Cell. 2024 Jul 2; Pubmed PMID: 38959890
- Liu, H., Liu, Z., Wong, H. K., Xu, N., Liu, Q., Li, Y., ... & He, Y. "Therapeutic strategies against metabolic imbalance in a male mouse model with 5-HT2CR loss-of-function." Endocrinology. 2024 May 27;165(7) Pubmed PMID: 38815086
- Liu, H., Bean, J. C., Li, Y., Yu, M., Ginnard, O. Z., Conde, K. M., ... He, Y (corresponding author) & Xu, Y. "Distinct basal forebrain-originated neural circuits promote homoeostatic feeding and suppress hedonic feeding in male mice." Nat Metab. 2024 Aug 7; Pubmed PMID: 39112722
Funding
- Targeting olfactory neural pathways to combat obesity - #DK140538
- $2,018,470.00 (09/01/2024 - 08/31/2029) Grant funding from NIH
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