Baylor College of Medicine

Yaping Pan, Ph.D.

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Pan

Yaping Pan, Ph.D.

Assistant Professor

Email

Yaping.Pan@bcm.edu

Positions

Assistant Professor: Biochemistry-M Zhou Lab
Baylor College of Medicine
Houston, TX US

Addresses

Baylor College of Medicine (Office)
: BCM-Smith Medical Research Bldg
Room: BCMS-334
Houston, TX 77030
United States
Phone: (713) 798-3938
Yaping.Pan@bcm.edu

Education

BS from Fudan University: 06/1999 - Shanghai, China; Pharmacology

PhD from Peking Union Medical College: 06/2004 - Beijing, China; Pharmacology

Post-Doctoral Fellowship at Baylor College of Medicine: 09/2005 - Houston, Texas United States; Neuroscience

Post-Doctoral Fellowship at Columbia University: 04/2011 - New York, New York United States; Physiology

Professional Statement

My research focuses on understanding structure, function and modulation of ion channels and transporters.

Websites

Selected Publications

Cao Y*, Pan Y*, Huang H*, Jin X, Levin EJ, Kloss B, Zhou M. "Gating of the TrkH ion channel by its associated RCK protein TrkA." Nature. 2013 Apr 18;496(7445):317-322. Pubmed PMID: 3726529
Pan Y, Levin EJ, Quick M, Zhou M. "Potentiation of the Kv1 family K+ channel by cortisone analogues." ACS Chemical Biology. 2012 Oct 19;7(10):1641-1646. Pubmed PMID: 3567311
Pan Y, Weng J, Levin EJ, Zhou M. "Oxidation of NADPH inhibits ball-and-chain type inactivation by restraining the chain." Proceedings of the National Academy of Scienc. 2011 Apr 5;108(14):5885-90. Pubmed PMID: 3078402
Pan Y, Weng J, Kabaleeswaran V, Li H, Cao Y, Bhosle R, Zhou M. "Cortisone dissociates Shaker family K+ channels from their Beta subunits." Nature Chemical Biology. 2008 Nov;4(11):708-14. Pubmed PMID: 2633621

Pan Y, Weng J, Cao Y, Bhosle R, Zhou M. "Functional coupling between the Kv1.1 channel and aldoketoreductase Kvbeta1." Journal of Biological Chemistry. 2008 Mar 28;283(13):8634-8642. Pubmed PMID: 2417172
Pan Y, Ren Z, Gao S, Shen J, Wang L, Xu Z, Yu Y, Bachina P, Zhang H, Fan X, Laganowsky A, Yan N, Zhou M. "Structural basis of ion transport and inhibition in ferroportin." Nature Communications. 2020 Nov;11(1):5686. Pubmed PMID: 33173040
Wilbon AS, Shen J, Ruchala P, Zhou M, Pan Y. "Structural basis of ferroportin inhibition by minihepcidin PR73." PLoS Biology. 2023 Jan;21(1):e3001936. Pubmed PMID: 36649314
Shen J, Wilbon AS, Zhou M, Pan Y. "Mechanism of Ca2+ transport by ferroportin." eLife. 2023 Jan;12:e82947. Pubmed PMID: 36648329

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Funding

Structure and mechanism of mammalian ferroportin - #R01HL157473: The major goal of this project is to understand the mechanism of iron transport and inhibition in ferroportin at the atomic resolution.