Positions
- Professor
-
Medicine - Epidemiology & Population Science
Baylor College of Medicine
- Member
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas (TX)
Addresses
- N720 (Lab)
-
Alkek Building
One Baylor Plaza
Houston, TX 77030
United States
Phone: (713) 798-7506
Education
- BS from Lanzhou University
- Lanzhou
- PhD from Chinese Academy of Sciences
- Shanghai
- Postdoctoral Training at Yale University
- New Haven
Professional Interests
- Non-Hodgkin's Lymphoma & Multiple Myeloma
- Environmental Carcinogenesis
- Cancer Epidemiology
- Artificial intelligence
- Cancer Prevention and Interception
Professional Statement
My research aims to elucidate the role of genetic and environmental etiological factors in cancer and to define the precise molecular and cellular events and genetic polymorphisms intersecting with toxicants and infectious pathogens responsible for the epidemiological association, cancer initiation and progression, and clinical outcomes. The translational objective of my research is to develop novel small molecules, monoclonal antibodies, and vaccines for cancer prevention and intervention.Selected Publications
- Yu X, Li W, Deng Q, Liu H, Wang X, Hu H, Cao Y, Xu-Monette ZY, Li L, Zhang M, Lu Z, Young KH, Li Y "MYD88 L265P elicits mutation-specific ubiquitination to drive NF-κB activation and lymphomagenesis." Blood. 2021;137(12):1615-1627. Pubmed PMID: 33025009
- Wang L, Deng Q, Hu H, Liu M, Gong Z, Zhang S, Xu-Monette ZY, Lu Z, Young KH, Ma X, Li Y "Glyphosate induces benign monoclonal gammopathy and promotes multiple myeloma progression in mice." J Hematol Oncol. 2019;12(1):70. Pubmed PMID: 31277689
- Li Y, Gordon MW, Xu-Monette ZY, Visco C, Tzankov A, Zou D, Qiu L, Montes-Moreno S, Dybkaer K, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WW, van Krieken JH, Huang Q, Ai W, Ponzoni M, Ferreri AJ, Winter JN, Go RS, Piris MA, et al "Single nucleotide variation in the TP53 3' untranslated region in diffuse large B-cell lymphoma treated with rituximab-CHOP: a report from the International DLBCL Rituximab-CHOP Consortium Program." Blood. 2013;121(22):4529-40. Pubmed PMID: 23515929
- Chai D, Wang J, Lim JM, Xie X, Yu X, Zhao D, Maza PAMA, Wang Y, Cyril-Remirez D, Young KH, Li Y. "Lipid nanoparticles deliver DNA-encoded biologics and induce potent protective immunity." Mol Cancer. 2025;24(1):12. Pubmed PMID: 39806486
- Chai D, Wang J, Fan C, Lim JM, Wang X, Neeli P, Yu X, Young KH, Li Y. "Remodeling of anti-tumor immunity with antibodies targeting a p53 mutant.." J Hematol Oncol. 2024;17(1):45. Pubmed PMID: 38886748
- i W, Wang R, Wang J, Chai D, Xie X, Young KHH, Cao Y, Li Y, Yu X. "Lasalocid A selectively induces the degradation of MYD88 in lymphomas harboring the MYD88 L265P mutation." Blood. 2024;22:blood.2024026781. Pubmed PMID: 39576960
- Yu X, Li W, Liu H, Wang X, Coarfa C, Cheng C, Yu X, Zeng Z, Cao Y, Young KH, Li Y. "PD-L1 translocation to the plasma membrane enables tumor immune evasion through MIB2 ubiquitination.." J Clin Invest. 2023;41(1):210. Pubmed PMID: 36719382
Memberships
- American Association for Cancer Research
- American Society of Hematology
- American Association for the Advancement of Science
- Society of Toxicology
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