George E Taffet, M.D.
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Positions
- Robert J. Luchi, M.D. Chair
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Geriatric Medicine
Baylor College of Medicine
- Professor
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Medicine-Geriatrics
Baylor College of Medicine
Addresses
- Baylor Clinic Bldg (Office)
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BCM Academic Office
6620 Main St.
Houston, TX 77030
United States
Phone: (713) 798-2293
gtaffet@bcm.edu
Geriatrics website
Education
- Residency at Baylor College of Medicine
- 06/1985 - Houston, TX United States
- Internal Medicine
- Internship at Baylor College of Medicine
- 06/1983 - Houston, TX United States
- Internal Medicine
- MD from Brown University Program in Medicine
- 01/1982 - Providence, RI United States
- Clinical Fellowship at Baylor College of Medicine
- 06/1987 - Houston, United States
- Geriatric
- Post-Doctoral Fellowship at Baylor College of Medicine
- 06/1998 - Houston, United States
- Research Fellowship-Cardiovascular Sciences
Certifications
- Internal Medicine
- American Board of Internal Medicine
- Geriatrics
- American Board of Internal Medicine
Honors & Awards
- Barbara and Corbin J. Robertson, Jr. Presidential Award for Excellence In Education
- Baylor College of Medicine (05/2011)
Professional Interests
- Heart failure: Calcium and aging
- Vascular aging
- Physiology and Biochemistry: using mouse models of human aging and disease
Professional Statement
I have been at BCM since 1982 for my internal medicine training, clinical Geriatrics fellowship, fellowship in cardiovascular research and on the faculty. At Baylor College of Medicine I lead and give all the aging lectures in ARTS (age-related themes) as the culmination of the didactic experience in the medical student’s second year, and I provide clinical opportunities to learn from and about old people all across the care spectrum. This includes house calls, independent living facilities, nursing homes, the hospital and the hospice. I teach Baylor and Methodist medicine residents as an Attending Physician, in conferences, and at the VA and Methodist morning report. I am also a faculty member in the Huffington Center of Aging Biology of Aging Graduate Program, the Physiology Graduate Program, and the Translational Biology and Molecular Medicine Graduate Program.My research interests have been in the area of cardiovascular aging. My early interests centered on aging and endurance exercise training for rats and how exercise improved the heart's ability to fill, its diastolic function. I have remained interested in diastole as heart failure due to diastolic dysfunction is the most common type of heart failure for older people, impacts quality of life and survival, and there are no drugs to treat it. Our approach is to address the underlying aging change that is additive to any disease mediated changes. I am also interested in large artery stiffening with age. Both the artery and cardiac investigations are done in young, old and transgenic mice. However, the goal is clearly to improve the condition of the older people. Additionally, as our group has developed many of the techniques to assess cardiac function in mice, we are a resource to a number of investigators across the Texas Medical Center.
Websites
Selected Publications
- Swan JT, Wagle KC, Thompson-Moore N, Taffet GE "Incidence of cholinesterase inhibitor therapy initiation among hospitalized patients.." J Hosp Med. 2013 Jun;8(6):304-8. Pubmed PMID: 23526817
- Cieslik KA, Trial J, Carlson S, Taffet GE, Entman ML "Aberrant differentiation of fibroblast progenitors contributes to fibrosis in the aged murine heart: role of elevated circulating insulin levels.." FASEB J.. 2013 Apr;27(4):1761-71. Pubmed PMID: 23303205
- Duerrschmid C, Crawford JR, Reineke E, Taffet GE, Trial J, Entman ML, Haudek SB "TNF receptor 1 signaling is critically involved in mediating angiotensin-II-induced cardiac fibrosis.." J. Mol. Cell. Cardiol.. 2013 Apr;57:59-67. Pubmed PMID: 23337087
- Mills WL, Roush RE, Moye J, Kunik ME, Wilson NL, Taffet GE, Naik AD "An educational program to assist clinicians in identifying elder investment fraud and financial exploitation.." Gerontol Geriatr Educ. 2012 Oct;33(4):351-63. Pubmed PMID: 23095220
- Kerfoot BP, Baker H, Pangaro L, Agarwal K, Taffet G, Mechaber AJ, Armstrong EG "An online spaced-education game to teach and assess medical students: a multi-institutional prospective trial.." Acad Med. 2012 Oct;87(10):1443-9. Pubmed PMID: 22914524
- Reineke EL, York B, Stashi E, Chen X, Tsimelzon A, Xu J, Newgard CB, Taffet GE, Taegtmeyer H, Entman ML, O'Malley BW "SRC-2 Coactivator Deficiency Decreases Functional Reserve in Response to Pressure Overload of Mouse Heart.." PLoS ONE. 2012;7(12):e53395. Pubmed PMID: 23300926
- Gurha P, Abreu-Goodger C, Wang T, Ramirez MO, Drumond AL, van Dongen S, Chen Y, Bartonicek N, Enright AJ, Lee B, Kelm RJ, Reddy AK, Taffet GE, Bradley A, Wehrens XH, Entman ML, Rodriguez A "Targeted Deletion of MicroRNA-22 Promotes Stress-Induced Cardiac Dilation and Contractile Dysfunction.." Circulation. 2012 Jun 5;125(22):2751-61. Pubmed PMID: 22570371
- Lloyd EE, Crossland RF, Phillips SC, Marrelli SP, Reddy AK, Taffet GE, Hartley CJ, Bryan RM "Disruption of K2P6.1 Produces Vascular Dysfunction and Hypertension in Mice.." Hypertension. 2011 Oct;58(4):672-8. Pubmed PMID: 21876070
- Sekhar RV, Patel SG, Guthikonda AP, Reid M, Balasubramanyam A, Taffet GE, Jahoor F "Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation.." Am. J. Clin. Nutr.. 2011 Sep;94(3):847-53. Pubmed PMID: 21795440
- Xu J, Lin SC, Chen J, Miao Y, Taffet GE, Entman ML, Wang Y "CCR2 mediates the uptake of bone marrow-derived fibroblast precursors in angiotensin II-induced cardiac fibrosis.." Am. J. Physiol. Heart Circ. Physiol.. 2011 Aug;301(2):H538-47. Pubmed PMID: 21572015
- Hartley CJ, Reddy AK, Madala S, Entman ML, Michael LH, Taffet GE "Doppler velocity measurements from large and small arteries of mice.." Am. J. Physiol. Heart Circ. Physiol.. 2011 Aug;301(2):H269-78. Pubmed PMID: 21572013
- Cheema FN, Abraham NS, Berger DH, Albo D, Taffet GE, Naik AD "Novel approaches to perioperative assessment and intervention may improve long-term outcomes after colorectal cancer resection in older adults.." Ann. Surg.. 2011 May;253(5):867-74. Pubmed PMID: 21183846
- Cieslik KA, Taffet GE, Carlson S, Hermosillo J, Trial J, Entman ML "Immune-inflammatory dysregulation modulates the incidence of progressive fibrosis and diastolic stiffness in the aging heart.." J. Mol. Cell. Cardiol.. 2011 Jan;50(1):248-56. Pubmed PMID: 20974150
- Smiechowska J, Utech A, Taffet G, Hayes T, Marcelli M, Garcia JM "Adipokines in patients with cancer anorexia and cachexia.." J. Investig. Med.. 2010 Mar;58(3):554-9. Pubmed PMID: 20215915
- Alexander NB, Taffet GE, Horne FM, Eldadah BA, Ferrucci L, Nayfield S, Studenski S "Bedside-to-Bench conference: research agenda for idiopathic fatigue and aging.." J Am Geriatr Soc. 2010 May;58(5):967-75. Pubmed PMID: 20722821
- Chintalgattu V, Ai D, Langley RR, Zhang J, Bankson JA, Shih TL, Reddy AK, Coombes KR, Daher IN, Pati S, Patel SS, Pocius JS, Taffet GE, Buja LM, Entman ML, Khakoo AY "Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress.." J. Clin. Invest.. 2010 Feb 1;120(2):472-84. Pubmed PMID: 20071776
- Namiranian K, Lloyd EE, Crossland RF, Marrelli SP, Taffet GE, Reddy AK, Hartley CJ, Bryan RM "Cerebrovascular responses in mice deficient in the potassium channel, TREK-1.." Am. J. Physiol. Regul. Integr. Comp. Physiol.. 2010 Aug;299(2):R461-9. Pubmed PMID: 20357027
- Hartley CJ, Reddy AK, Michael LH, Entman ML, Chintalagattu V, Khakoo AY, Taffet GE "Coronary flow reserve in mice: Effects of age, coronary disease, and vascular loading.." Conf Proc IEEE Eng Med Biol Soc. 2010;1:3780-3. Pubmed PMID: 21096875
- Wagle KC, Natali B, Taffet GE "Cholinesterase inhibitor initiation in hospital setting.." J Am Geriatr Soc. 2011 Oct;59(10):1988-9. Pubmed PMID: 22091527
- Bujak M, Kweon HJ, Chatila K, Li N, Taffet G, Frangogiannis NG "Aging-related defects are associated with adverse cardiac remodeling in a mouse model of reperfused myocardial infarction.." J. Am. Coll. Cardiol.. 2008 Apr 8;51(14):1384-92. Pubmed PMID: 18387441
- Weisleder N, Taffet GE, Capetanaki Y "Bcl-2 overexpression corrects mitochondrial defects and ameliorates inherited desmin null cardiomyopathy.." Proc. Natl. Acad. Sci. U.S.A.. 2004 Jan 20;101(3):769-74. Pubmed PMID: 14715896
- Hyman DJ, Taffet GE "Blood pressure control in the elderly: can you have too much of a good thing?." Curr. Hypertens. Rep.. 2009 Oct;11(5):337-42. Pubmed PMID: 19737450
- Reddy AK, Amador-Noguez D, Darlington GJ, Scholz BA, Michael LH, Hartley CJ, Entman ML, Taffet GE "Cardiac function in young and old Little mice.." J. Gerontol. A Biol. Sci. Med. Sci.. 2007 Dec;62(12):1319-25. Pubmed PMID: 18166681
- Taffet GE, Tate CA "CaATPase content is lower in cardiac sarcoplasmic reticulum isolated from old rats.." Am. J. Physiol.. 1993 May;264(5):H1609-14. Pubmed PMID: 8498573
Memberships
- American Association for the Advancement of Science
- American Geriatrics Society
- Research Committee
- Gerontological Society of America
- Past Chair, Research Committee
- American Federation for Aging Research
- Association of Directors of Geriatric Academic Programs
- American Heart Association
- Basic Science Council
- Texas Geriatrics Society
- Former Board Member
- American Association of Home Care Physicians
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