Publications

Arabzade A, Zhao Y, Varadharajan S, Chen HC, Jessa S, Rivas B, Stuckert AJ, Solis M, Kardian A, Tlais D, Golbourn BJ, Stanton AJ, Chan YS, Olson C, Karlin KL, Kong K, Kupp R, Hu B, Injac SG, Ngo M, Wang PR, De Leon LA, Sahm F, Kawauchi D, Pfister SM, Lin CY, Hodges HC, Singh I, Westbrook TF, Chintagumpala MM, Blaney SM, Parsons DW, Pajtler KW, Agnihotri S, Gilbertson RJ, Yi J, Jabado N, Kleinman CL, Bertrand KC, Deneen B, Mack SC. ZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma. Cancer Discov. 2021 Mar 19:candisc.1066.2020. doi: 10.1158/2159-8290.CD-20-1066. Online ahead of print.

Carlson JC, Cantu-Gutierrez M, Lozzi B, Huang-Hobbs E, Turner WD, Tepe B, Zhang Y, Herman AM, Rao G, Creighton CJ, Wythe JD, Deneen B. Identification of diverse tumor endothelial cell populations in malignant glioma. Neuro Oncol. 2020 Dec 23:noaa297. doi: 10.1093/neuonc/noaa297. Online ahead of print.PMID: 33367832

Ung K, Tepe B, Pekarek B, Arenkiel BR, Deneen B. Parallel astrocyte calcium signaling modulates olfactory bulb responses. J Neurosci Res. 2020 May 19. doi: 10.1002/jnr.24634. Online ahead of print.

Huang AY, Woo J, Sardar D, Lozzi B, Bosquez Huerta NA, Lin CJ, Felice D, Jain A, Paulucci-Holthauzen A, Deneen B. Region-Specific Transcriptional Control of Astrocyte Function Oversees Local Circuit Activities. Neuron. 2020 Apr 10:S0896-6273(20)30232-4. doi: 10.1016/j.neuron.2020.03.025. Online ahead of print.

Akdemir ES, Huang AY, Deneen B. Astrocytogenesis: where, when, and how. F1000Res. 2020 Apr 2;9:F1000 Faculty Rev-233. doi: 10.12688/f1000research.22405.1. eCollection 2020.

Hatcher A, Yu K, Meyer J, Aiba I, Deneen B, Noebels JL. Pathogenesis of peritumoral hyperexcitability in an immunocompetent CRISPR-based glioblastoma model. J Clin Invest. (2020) Apr 6. pii: 133316. doi: 10.1172/JCI133316. [Epub ahead of print]

Lozzi B, Huang TW, Sardar D, Huang AY, Deneen B. Regionally Distinct Astrocytes Display Unique Transcription Factor Profiles in the Adult Brain. Front Neurosci. (2020) Feb 21;14:61. doi: 10.3389/fnins.2020.00061. eCollection 2020. [pub]

Yu, K., Lin, C.J., Hatcher, A. et al. PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis. Nature (2020). [Epub ahead of print]

Laug D, Huang TW, Huerta NAB, Huang AY, Sardar D, Ortiz-Guzman J, Carlson JC, Arenkiel BR, Kuo CT, Mohila CA, Glasgow SM, Lee HK, Deneen B. (2019) Nuclear factor I-A regulates diverse reactive astrocyte responses after CNS injury. The Journal of Clinical Investigation 2019. Sep 9. pii: 127492. doi: 10.1172/JCI127492. [Epub ahead of print]

Khakh BS, Deneen B. (2019) The Emerging Nature of Astrocyte Diversity. Annu Rev Neurosci. 2019 Jul 8;42:187-207. doi: 10.1146/annurev-neuro-070918-050443

Wang CY, Deneen B, Tzeng SF. (2019) BRCA1/BRCA2-containing complex subunit 3 controls oligodendrocyte differentiation by dynamically regulating lysine 63-linked ubiquitination. Glia. 2019 Sep;67(9):1775-1792. doi: 10.1002/glia.23660. Epub 2019 Jun 11.

Cuevas-Diaz Duran R, Wang CY, Zheng H, Deneen B, Wu JQ (2019) Brain Region-Specific Gene Signatures Revealed by Distinct Astrocyte Subpopulations Unveil Links to Glioma and Neurodegenerative Diseases. eNeuro 2019 Mar-Apr; 6(2): ENEURO.0288-18.2019.

Laug D, Glasgow SM, Deneen B. (2018) A glial blueprint for gliomagenesis. Nature Reviews Neuroscience 2018 May 18 doi: 10.1038/s41583-018-0014-3.

Danussi C, Bose P, Parthasarathy PT, Silberman PC, Van Arnam JS, Vitucci M, Tang OY, Heguy A, Wang Y, Chan TA, Riggins GJ, Sulman EP, Lang F, Creighton CJ, Deneen B, Miller CR, Picketts DJ, Kannan K, Huse JT. (2018) Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling. Nature Communication 2018 Mar 13;9(1):1057.

Kfoury N, Sun T, Yu K, Rockwell N, Tinkum KL, Qi Z, Warrington NM, McDonald P, Roy A, Weir SJ, Mohila CA, Deneen B, Rubin JB. (2018) Cooperative p16 and p21 action protects female astrocytes from transformation. Acta Neuropathol Commun 2018 Feb 20;6(1):12.

Glasgow SM, Carlson J, Zhu W, Chaboub LS, Kang P, Lee HK, Clovis Y, Lozzi B, McEvilly RJ, Rosenfeld MG, Creighton CJ, Lee S-K, Mohila CA, and Deneen B. Glial specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis. Nat Neurosci. 2017 Nov;20(11):1520-8.

Glasgow SM, Deneen B. lnc’edin to Myelin. Neuron. 2017 Jan 18;93(2):252-4.

John Lin CC, Yu K, Hatcher A, Huang TW, Lee HK, Carlson J, Weston MC, Chen F, Zhang Y, Zhu W, Mohila CA, Ahmed N, Patel AJ, Arenkiel BR, Noebels JL, Creighton CJ, Deneen B. Identification of diverse astrocyte populations and their malignant analogs. Nat Neurosci. 2017 Mar;20(3):396-405.**

**Highlighted in Editors Choice, Science Translational Medicine
**Preview in Frontiers of Neuroscience

Wang CY, Deneen B, Tzeng SF. Identification of diverse astrocyte populations and their malignant analogs. J Neurochem. 2017 Oct;143(1):112-25.

Zhu W, Krishna S, Garcia C, Lin CJ, Mitchell BD, Scott KL, Mohila CA, Creighton CJ, Yoo SH, Lee HK, Deneen B. Daam2 driven degradation of VHL promotes gliomagenesis. Elife. 2017 Oct 20;6.

Chaboub LS, Manalo JM, Lee HK, Glasgow SM, Chen F, Kawasaki Y, Akiyama T, Kuo CT, Creighton CJ, Mohila CA, Deneen B. Temporal Profiling of Astrocyte Precursors Reveals Parallel Roles for Asef during Development and after Injury. J Neurosci. 2016 Nov 23;36(47):11904-17.

Lee HK, Chaboub LS, Zhu W, Zollinger D, Rasband MN, Fancy SF, Deneen B. Daam2-PIP5K is a novel regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS. Neuron. 2015 Mar 18;85(6):1227-43.**

**Highlighted in Faculty of 1000

Lee HK, Laug D, Zhu W, Patel JM, Ung K, Arenkiel BR, Fancy SF, Mohila CM, Deneen B. Apcdd1 stimulates oligodendrocyte differentiation after white matter injury. Glia. 2015 Oct;63(10):1840-9.

Molofsky AV, Deneen B. Astrocyte development: A Guide for the Perplexed. Glia. 2015 Aug;63(8):1320-9.

Gallo V, Deneen B. Glial development: The crossroads of regeneration and repair in the CNS. Neuron. 2014 Jul 16;83(2):283-308.

Garcia I, Bhullar PK, Tepe B, Ortiz-Guzman J, Huang L, Herman AM, Chaboub L, Deneen B, Justice NJ, Arenkiel BR. Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes. Brain Struct Funct. 2016 Jan;221(1):1-20.

Glasgow S, Zhu W, Stolt CC, Huang TW, Chen F, LoTurco JJ, Neul JL, Wegner M, Mohila CM, Deneen B. Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes. Nat Neurosci. 2014 Oct;17(10):1322-9.

Lee JS, Xiao J, Patel P, Schade J, Wang J, Deneen B, Erdreich-Epstein A, Song H-R. A novel tumor-promoting role for nuclear factor IA in glioblastomas is mediated through negative regulation of p53, p21, and PAI1. Neuro Oncol. 2014 Jan;16(2):191-203.

Chaboub LS, Deneen B. Astrocyte form and function in the developing central nervous system. Semin Pediatr Neurol. 2013 Dec;20(4):230-5.

Glasgow SM, Laug D, Brawley VS, Zhang Z, Corder A, Yin Z, Wong ST, Li XN, Foster AE, Ahmed N, Deneen B. The miR-223/nuclear factor I-A axis regulates glial precursor proliferation and tumorigenesis in the CNS. J Neurosci. 2013 Aug 14;33(33):13560-8.**

**Featured in Science “Editors Choice”

John Lin CC, Deneen B. Astrocytes: the missing link in neurologic disease? Semin Pediatr Neurol. 2013 Dec;20(4):236-41.

Molofsky AV, Glasgow SM, Chaboub LS, Tsai HH, Murnen AT, Kelley KW, Fancy SP, Yuen TJ, Madireddy L, Baranzini S, Deneen B, Rowitch DH, Oldham MC. Expression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes and direct Sox9-Nfe2l1 interactions. Glia. 2013 Sep;61(9):1518-32.

Chaboub LS, Deneen B. Developmental origins of astrocyte heterogeneity: the final frontier of CNS development. Dev Neurosci. 2012;34(5):379-88.

Fancy SP, Glasgow SM, Finley M, Rowitch DH, Deneen B. Evidence that nuclear factor IA inhibits repair after white matter injury. Ann Neurol. 2012 Aug;72(2):224-33.

Kang P, Lee HK, Glasgow SM, Finley M, Donti T, Gaber ZB, Graham BH, Foster AE, Novitch BG, Gronostajski RM, Deneen B.Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron. 2012 Apr 12;74(1):79-94.**

**Highlighted in Faculty of 1000

Lee HK, Deneen B. Daam2 is required for dorsal patterning via modulation of canonical Wnt signaling in the developing spinal cord. Dev Cell. 2012 Jan 17;22(1):183-96.**

**Highlighted in Faculty of 1000

Molofsky AV, Krencik R, Ullian EM, Tsai HH, Deneen B, Richardson WD, Barres BA, Rowitch DH. Astrocytes and disease: a neurodevelopmental perspective. Genes Dev. 2012 May 1;26(9):891-907.

Deneen B, Denny CT. Loss of p16 pathways stabilizes EWS/FLI1 expression and complements EWS/FLI1 mediated transformation. Oncogene. 2001 Oct 11;20(46):6731-41.

Deneen B, Hamidi H, Denny CT. Functional analysis of the EWS/ETS target gene uridine phosphorylase. Cancer Res. 2003 Jul 15;63(14):4268-74.

Deneen B, Ho R, Lukaszewicz A, Hochstim CJ, Gronostajski RM, Anderson DJ. The transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord. Neuron. 2006 Dec 21;52(6):953-68.

Deneen B, Welford SM, Ho T, Hernandez F, Kurland I, Denny CT. PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins. Mol Cell Biol. 2003 Jun;23(11):3897-908.

Hochstim C, Deneen B, Lukaszewicz A, Zhou Q, Anderson DJ. Identification of positionally distinct astrocyte subtypes whose identities are specified by a homeodomain code. Cell. 2008 May 2;133(3):510-22.

Mukouyama YS, Deneen B, Lukaszewicz A, Novitch BG, Wichterle H, Jessell TM, Anderson DJ. Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1551-6.

Namihira M, Kohyama J, Semi K, Sanosaka T, Deneen B, Taga T, Nakashima K. Committed neuronal precursors confer astrocytic potential on residual neural precursor cells. Dev Cell. 2009 Feb;16(2):245-55.

Page SL, McKim KS, Deneen B, Van Hook TL, Hawley RS. Genetic studies of mei-P26 reveal a link between the processes that control germ cell proliferation in both sexes and those that control meiotic exchange in Drosophila. Genetics. 2000 Aug;155(4):1757-72.

Sekelsky JJ, McKim KS, Messina L, French RL, Hurley WD, Arbel T, Chin GM, Deneen B, Force SJ, Hari KL, Jang JK, Laurençon AC, Madden LD, Matthies HJ, Milliken DB, Page SL, Ring AD, Wayson SM, Zimmerman CC, Hawley RS. Identification of novel Drosophila meiotic genes recovered in a P-element screen. Genetics. 1999 Jun;152(2):529-42.

Song HR, Gonzalez-Gomez I, Suh GS, Commins DL, Sposto R, Gilles FH, Deneen B*, Erdreich-Epstein A*. Nuclear factor IA is expressed in astrocytomas and is associated with improved survival. Neuro Oncol. 2010 Feb;12(2):122-32.

*Equal Contribution

Welford SM, Hebert SP, Deneen B, Arvand A, Denny CT. DNA binding domain-independent pathways are involved in EWS/FLI1-mediated oncogenesis. J Biol Chem. 2001 Nov 9;276(45):41977-84.